Новые подходы к лечению флавивирусных инфекций

Статья в Elpub

Вопросы вирусологии. 2015; 60: 5-9

Новые подходы к лечению флавивирусных инфекций

Морозова О. В., Исаева Е. И., Вязов С. О.

Аннотация

Поскольку спонтанный мутагенез и быстрые перестройки квазивидов РНК-содержащих флавивирусов, а также отсутствие вирусных и клеточных систем репарации РНК приводят к устойчивости к индивидуальным изначально эффективным противовирусным препаратам, рекомендуют комбинированную терапию нуклеозидными и ненуклеозидными ингибиторами вирусных ферментов в сочетании с иммуномодуляторами. Применение специфических иммуноглобулинов не только не обеспечивает полной элиминации большинства флавивирусов, но может приводить к усилению их инфекционности вследствие проникновения комплексов вирионов со специфичными антителами в клетки с рецепторами для Fс-фрагментов иммуноглобулинов.

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Problems of Virology. 2015; 60: 5-9

New approaches to the treatment of the flavivirus infections

Morozova O. V., Isaeva E. I., Viazov S. O.

Abstract

Since spontaneous mutagenesis and quasi-species rearrangements of the ma-containing viruses, as well as an absence of both viral and cellular RNA reparation systems, causes resistance to originally effective antiviral drugs, combination therapy with nucleoside and non-nucleoside inhibitors of the viral enzymes in combination with immunomodulators is recommended. The use of specific immunoglobulins does not result in complete elimination of the flaviviruses but rather in possible antibody-dependent enhancement of the flavivirus infection by means of increased penetration of complexes of virions with specific antibodies into cells with receptors for Fc-fragments of immunoglobulins.

References