Вопросы вирусологии. 2015; 60: 18-23
Генетическая стабильность HA-, Na- и NS-генов рекомбинантного векторного вируса Flu-NS1-124-Omp16 (H5N1), экспрессирующего бруцеллезный ген
Садикалиева С. О., Султанкулова К. Т., Шораева К. А., Строчков В. М., Червякова О. В., Зайцев В. Л., Табынов К. К., Сандыбаев Н. Т., Сансызбай А. Р., Егоров А. Ю.
Аннотация
Список литературы
1. Racloz V., Schelling E., Chitnis N., Roth F., Zinsstag J. Persistence of brucellosis in pastoral systems. Rev. Sci. Tech. 2013; 32 (1): 61–70.
2. Food and Agriculture Organization of the United Nations (FAO) (2010). Brucella melitensis in Eurasia and the Middle East. Proc. FAO technical meeting in collaboration with WHO and OIE, May 2009, Rome. FAO Animal Production and Health Proceedings No. 10. FAO, Rome. Available at: www.fao.org/docrep/012/i1402e/i1402e00.pdf ( Accessed on 5 April 2013).
3. Egorov A., Brandt S., Sereinig S., Romanova J., Ferko B., Katinger D. et.al. Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cells. J. Virol. 1998; 72(8): 6437–41.
4. Fernandez-Sesma A. The influenza virus NS1 protein: inhibitor of innate and adaptive immunity. Infect. Disord. Drug Targets. 2007; 7(4): 336–43.
5. Ferko B., Stasakova J., Romanova J., Kittel C., Sereinig S. Katinger H. et al. Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes. J. Virol. 2004; 78: 13037–45.
6. Garcia-Sastre A., Biron C.A. Type 1 interferons and the virus-host relationship: a lesson in detente. Science. 2006; 312: 879–82.
7. Строчков В.М., Червякова О.В., Султанкулова К.Т., Мамадалиев С.М., Зайцев В.Л., Шораева К.А. и др. Рекомбинантные штаммы А/AstanaRG/6:2/2009 и А/AstanaRG/5:3/2009 вируса гриппа, полученные методом обратной генетики. В кн.: Материалы международной конференции «Современное состояние генетики в Казахстане». Алматы; 2010; 63–5.
8. Игнатьева А.В., Руднева И.А., Тимофеева Т.А., Шилов А. A., Забережный А.Д., Алипер Т.И. и др. Высокопродуктивный вирусреассортант, содержащий гемагглютинин и нейраминидазу пандемического вируса гриппа A/MOSCOW/01/2009(Н1N1). Вопросы вирусологии. 2011; 56 (4): 9–14.
9. Гоцкина Т.М., Рыскельдинова Ш.Ж., Асанжанова Н.Н., Кыдырбаев Ж.К., Кожамкулов Е.М., Инкарбеков Д.И. и др. Возможность использования морских свинок как модельных животных для изучения иммунобиологических свойств рекомбинантных вирусов гриппа А, экспрессирующих бруцеллезные белки L7/L12 и Omp16. В кн.: Материалы международной научной конференции молодых ученых «Инновационное развитие науки в обеспечении биологической безопасности». Гвардейский; 2013; 47–54.
10. De Wit E., Spronken M.I., Bestebroer T.M., Rimmelzwaan G.F., Osterhaus A.D., Fouchier R.A. Efficient generation and growth of influenza virus A/PR/8/34 from eight cDNA fragments. Virus Res. 2004; 103(1-2): 155–61.
11. Hoffmann E., Neumann G., Kawaoka Y., Hobom G., Webster R.G. A DNA transfection system for generation of influenza A virus from eight plasmids. Proc. Natl. Acad. Sci. USA. 2010; 97(11): 6108–13.
12. Ставицкий С.Б., Носков А.Н., Кравченко Т.Б. Молекулярная вакцина для профилактики бруцеллеза. Патент РФ № 2285538, 2006.
13. WHO Guidance on development of influenza vaccine reference viruses by reverse genetics. Available at: whqlibdoc.who.int/hq/2005/WHO_CDS_CSR_GIP_2005.6.pdf.
14. Leclercq S., Harms J.S., Oliveira S.C. Enhanced efficacy of DNA vaccines against an intracellular bacterial pathogen by genetic adjuvants. Curr. Pharm. Biotechnol. 2003; 4: 99–107.
15. Pasquevich K.A., Estein S.M., Garcia Samartino C., Zwerdling A., Coria L.M., Barrionuevo P. et al. Immunization with recombinant Brucella spp. outer membrane proteins Omp16 or Omp19 in adjuvant induces specific CD41 and CD81 T cells as well as systemic and oral protection against Brucella abortus infection. Infect. Immun. 2008; 77(1): 436–45.
16. Luo D., Ni B., Li P., Shi W., Zhang S., Han Y. et al. Protective immunity elicited by a divalentDNAvaccine encoding both the L7/L12 and Omp16 genes of Brucella abortus in BALB/c mice. Infect. Immun. 2006; 74: 2734–41.
17. Wang X., Li M., Zheng H., Muster T., Palese P., Beg A.A. et al. Influenza A virus protein prevents activation of NFk-B and induction of alpha/bets interferon. J. Virol. 2000; 74(24): 11566–73.
18. Kochs G., Martínez-Sobrido L., Lienenklaus S., Weiss S., GarcíaSastre A., Staeheli P. Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene. J. Gen. Virol. 2009; 90 (12): 2990–4.
19. Liu M. Zhang Y., Liu C.G., Pan W.Q., Liu C.N., Yang T. Generation of High-yield vaccine strain wholly derived from Avian Influenza Viruses by Reverse Genetics. Chin. J. Biotech. 2006; 22: 720–6.
20. Stech J., Garn H., Wegmann M., Wagner R., Klenk H.D. A new approach to an influenza live vaccine: modification of the cleavage site of hemagglutinin. Nat. Med. 2005; 11(6): 683–9.
21. Hoffmann E., Webster R. G. Unidirectional RNA polymerase I-polymerase II transcription system for the generation of influenza A virus from eight plasmids. J. Gen. Virol. 2000; 81(12): 2843–7.
Problems of Virology. 2015; 60: 18-23
Genetic stability of the HA, NA, and NS genes of the recombinant vector virus FluNS1-124-Omp16 (H5N1) expressing the brucellar gene
Sadikaliyeva S. O., Sultankulova K. T., Shorayeva K. A., Strochkov V. M., Chervyakova O. V., Zaitsev V. L., Tabynov K. K., Sandybayev N. T., Sansyzbay A. R., Egorov A. Yu.
Abstract
References
1. Racloz V., Schelling E., Chitnis N., Roth F., Zinsstag J. Persistence of brucellosis in pastoral systems. Rev. Sci. Tech. 2013; 32 (1): 61–70.
2. Food and Agriculture Organization of the United Nations (FAO) (2010). Brucella melitensis in Eurasia and the Middle East. Proc. FAO technical meeting in collaboration with WHO and OIE, May 2009, Rome. FAO Animal Production and Health Proceedings No. 10. FAO, Rome. Available at: www.fao.org/docrep/012/i1402e/i1402e00.pdf ( Accessed on 5 April 2013).
3. Egorov A., Brandt S., Sereinig S., Romanova J., Ferko B., Katinger D. et.al. Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cells. J. Virol. 1998; 72(8): 6437–41.
4. Fernandez-Sesma A. The influenza virus NS1 protein: inhibitor of innate and adaptive immunity. Infect. Disord. Drug Targets. 2007; 7(4): 336–43.
5. Ferko B., Stasakova J., Romanova J., Kittel C., Sereinig S. Katinger H. et al. Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes. J. Virol. 2004; 78: 13037–45.
6. Garcia-Sastre A., Biron C.A. Type 1 interferons and the virus-host relationship: a lesson in detente. Science. 2006; 312: 879–82.
7. Strochkov V.M., Chervyakova O.V., Sultankulova K.T., Mamadaliev S.M., Zaitsev V.L., Shoraeva K.A. i dr. Rekombinantnye shtammy A/AstanaRG/6:2/2009 i A/AstanaRG/5:3/2009 virusa grippa, poluchennye metodom obratnoi genetiki. V kn.: Materialy mezhdunarodnoi konferentsii «Sovremennoe sostoyanie genetiki v Kazakhstane». Almaty; 2010; 63–5.
8. Ignat'eva A.V., Rudneva I.A., Timofeeva T.A., Shilov A. A., Zaberezhnyi A.D., Aliper T.I. i dr. Vysokoproduktivnyi virusreassortant, soderzhashchii gemagglyutinin i neiraminidazu pandemicheskogo virusa grippa A/MOSCOW/01/2009(N1N1). Voprosy virusologii. 2011; 56 (4): 9–14.
9. Gotskina T.M., Ryskel'dinova Sh.Zh., Asanzhanova N.N., Kydyrbaev Zh.K., Kozhamkulov E.M., Inkarbekov D.I. i dr. Vozmozhnost' ispol'zovaniya morskikh svinok kak model'nykh zhivotnykh dlya izucheniya immunobiologicheskikh svoistv rekombinantnykh virusov grippa A, ekspressiruyushchikh brutselleznye belki L7/L12 i Omp16. V kn.: Materialy mezhdunarodnoi nauchnoi konferentsii molodykh uchenykh «Innovatsionnoe razvitie nauki v obespechenii biologicheskoi bezopasnosti». Gvardeiskii; 2013; 47–54.
10. De Wit E., Spronken M.I., Bestebroer T.M., Rimmelzwaan G.F., Osterhaus A.D., Fouchier R.A. Efficient generation and growth of influenza virus A/PR/8/34 from eight cDNA fragments. Virus Res. 2004; 103(1-2): 155–61.
11. Hoffmann E., Neumann G., Kawaoka Y., Hobom G., Webster R.G. A DNA transfection system for generation of influenza A virus from eight plasmids. Proc. Natl. Acad. Sci. USA. 2010; 97(11): 6108–13.
12. Stavitskii S.B., Noskov A.N., Kravchenko T.B. Molekulyarnaya vaktsina dlya profilaktiki brutselleza. Patent RF № 2285538, 2006.
13. WHO Guidance on development of influenza vaccine reference viruses by reverse genetics. Available at: whqlibdoc.who.int/hq/2005/WHO_CDS_CSR_GIP_2005.6.pdf.
14. Leclercq S., Harms J.S., Oliveira S.C. Enhanced efficacy of DNA vaccines against an intracellular bacterial pathogen by genetic adjuvants. Curr. Pharm. Biotechnol. 2003; 4: 99–107.
15. Pasquevich K.A., Estein S.M., Garcia Samartino C., Zwerdling A., Coria L.M., Barrionuevo P. et al. Immunization with recombinant Brucella spp. outer membrane proteins Omp16 or Omp19 in adjuvant induces specific CD41 and CD81 T cells as well as systemic and oral protection against Brucella abortus infection. Infect. Immun. 2008; 77(1): 436–45.
16. Luo D., Ni B., Li P., Shi W., Zhang S., Han Y. et al. Protective immunity elicited by a divalentDNAvaccine encoding both the L7/L12 and Omp16 genes of Brucella abortus in BALB/c mice. Infect. Immun. 2006; 74: 2734–41.
17. Wang X., Li M., Zheng H., Muster T., Palese P., Beg A.A. et al. Influenza A virus protein prevents activation of NFk-B and induction of alpha/bets interferon. J. Virol. 2000; 74(24): 11566–73.
18. Kochs G., Martínez-Sobrido L., Lienenklaus S., Weiss S., GarcíaSastre A., Staeheli P. Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene. J. Gen. Virol. 2009; 90 (12): 2990–4.
19. Liu M. Zhang Y., Liu C.G., Pan W.Q., Liu C.N., Yang T. Generation of High-yield vaccine strain wholly derived from Avian Influenza Viruses by Reverse Genetics. Chin. J. Biotech. 2006; 22: 720–6.
20. Stech J., Garn H., Wegmann M., Wagner R., Klenk H.D. A new approach to an influenza live vaccine: modification of the cleavage site of hemagglutinin. Nat. Med. 2005; 11(6): 683–9.
21. Hoffmann E., Webster R. G. Unidirectional RNA polymerase I-polymerase II transcription system for the generation of influenza A virus from eight plasmids. J. Gen. Virol. 2000; 81(12): 2843–7.
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