Акушерство и Гинекология Санкт-Петербурга. 2017; : 35-39
Современные методы исследования в гинекологии
Аннотация
Метаболомика - наука, изучающая совокупность всех низкомолекулярных метаболитов клетки. В обзоре представлены общие данные о метаболомике и оценке возможностей в диагностике заболеваний женского организма.
Метаболомический метод исследования еще далек от клинического применения и требует дальнейшего изучения. Тем не менее, возможно, с помощью этого метода удастся ответить на многие вопросы, остающиеся без ответа в настоящее время.
Список литературы
1. Adamski J., Suhre K. Metabolomics platforms for genome wide association studies - linking the genome to the metabolome. Curr Opin Biotechnol. 2013, Feb; 24 (1): 39-47. DOI: 10.1016/j.copbio.2012.10.003.
2. Adamson P.C., Krupp K., Freeman A.H., Klausner J.D., Reingold A.L., Madhivanan P. Prevalence & correlates of primary infertility among young women in Mysore, India. Indian J. Med. Res. 2011, Oct; 134: 440-446.
3. Ajduk A.1., Zernicka-Goetz M. Quality control of embryo development. Mol. Aspects Med. 2013, Oct; 34 (5): 903-918. DOI: 10.1016/j.mam.2013.03.001.
4. BaskindN.E., McRaeC., Sharma V., Fisher J. Understanding subfertility at a molecular level in the female through the application of nuclear magnetic resonance (NMR) spectroscopy. Hum. Reprod. Update. 2011; 17 (2): 228-241. DOI: 10.1093/humupd/dmq039.
5. Botros L., Sakkas D., Seli E. Metabolomics and its application for non-invasive embryo assessment in IVF. Mol. Hum. Reprod. 2008, Dec; 14 (12): 679-690. DOI: 10.1093/molehr/gan066.
6. Brison D.R., Houghton F.D., Falconer D., Roberts S.A., Hawkhead J., Humpherson P.G. et al. Identification of viable embryos in IVF by non-invasive measurement of amino acid turnover. Hum Reprod. 2004, Oct; 19 (10): 2319-2324. DOI:10.1093/humrep/deh409.
7. Bromer J.G., Seli E. Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics. Curr. Opin. Obstet. Gynecol. 2008, Jun; 20 (3): 234-241. DOI: 10.1097/GCO.0b013e3282fe723d.
8. Bushnik T., Cook J.L., Yuzpe A.A., Tough S., Collins J. Estimating the prevalence of infertility in Canada. Hum. Reprod. 2012, Mar; 27 (3): 738-746. DOI: 10.1093/humrep/der465.
9. D'Alessandro A., Giardina B., Gevi F., Timperio AM.,Zolla L. Clinical metabolomics: the next stage of clinical biochemistry. Blood Transfus. 2012, May; 10, Suppl 2: s19-24. DOI: 10.2450/2012.005S.
10. Lewis G.D., AsnaniA., Gerszten R.E. Application of metabolomics to cardiovascular biomarker and pathway discovery. J. Am. Coll. Cardiol. 2008, Jul 8; 52 (2): 117-123. DOI: 10.1016/j.jacc.2008.03.043.
11. MontagM., Toth B.,StrowitzkiT. New approaches to embryo selection. Reprod. Biomed. Online. 2013, Nov; 27 (5): 539-546. DOI: 10.1016/j.rbmo.2013.05.013.
12. MosalanejadL., KhodabakshiKoolee A. Looking at Infertility Treatment through The Lens of The Meaning of Life: The Effect of Group Logotherapy on Psychological Distress in Infertile Women. Int. J. Fertil. Steril. 2013, Jan; 6 (4): 224-231.
13. Nagy Z.P.,SakkasD.,BehrB. Symposium: innovative techniques in human embryo viability assessment. Non-invasive assessment of embryo viability by metabolomic profiling of culture media ('metabolomics'). Reprod. Biomed. Online. 2008, Oct; 17 (4): 502-507.
14. Nel-Themaat L., NagyZ.P. A review of the promises and pitfalls of oocyte and embryo metabolomics. Placenta. 2011, Sep; 32 Suppl. 3: S257-263. DOI: 10.1016/j.placenta.2011.05.011.
15. Nicholson J.K., Lindon J.C., Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 1999; 29 (11): 1181-1189.
16. O'Gorman A., Wallace M., Cottell E., Gibney M.J., McAuliffe F.M., Wingfield M. et al. Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence. Reproduction. 2013, Aug 21; 146 (4): 389-395. DOI: 10.1530/REP-13-0184.
17. Pauling L., Robinson A.B., Teranishi R., Cary P Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography. Proc. Natl. Acad. Sci. USA. 1971; 68 (10): 2374-2376.
18. PreisK.A., SeidelG.Jr., GardnerD.K. Metabolic markers of developmental competence for in vitro-matured mouse oocytes. Reproduction. 2005; 130 (4): 475-483. DOI: 10.1530/rep.1.00831.
19. Revelli A., Delle Piane L., Casano S., Molinari E., Massobrio M., Rinaudo P Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics. Reprod. Biol. Endocrinol. 2009, May 4; 7: 40. DOI: 10.1186/1477-7827-7-40.
20. Seli E., Botros L., Sakkas D., Burns D.H. Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertil. Steril. 2008, Dec; 90 (6): 2183-2189. DOI: 10.1016/j.fertn-stert.2008.07.1739.
21. Spratlin J.L., Serkova N.J., Eckhardt S.G. Clinical applications of metabolomics in oncology: a review. Clin. Cancer Res. 2009; 15 (2): 431-440. DOI: 10.1016/j.fertnstert.2008.07.1739.
22. VergouwC.G., Botros L.L., Roos P., Lens J.W., Schats R., Hompes P.G. et al. Metab-olomic profiling by near-infrared spectroscopy as a tool to assess embryo viability: a novel, non-invasive method for embryo selection. Hum. Reprod. 2008, Jul; 23 (7): 1499-1504. DOI: 10.1093/humrep/den111.
23. Wallace M., Cottell E., Gibney M.J., McAuliffe F.M., Wingfield M., Brennan L. An investigation into the relationship between the metabolic profile of follicular fluid, oocyte developmental potential, and implantation outcome. Fertil. Steril. 2012, May; 97 (5): 1078-1084.e1-8. DOI: 10.1016/j.fertnstert.2012.01.122.
24. Wang S.X. The past, present, and future of embryo selection in in vitro fertilization: Frontiers in Reproduction Conference. Yale J. Biol. Med. 2011, Dec; 84 (4): 487-490.
25. Zhang G.F., Sadhukhan S., Tochtrop G.P., BrunengraberH. Metabolomics, pathway regulation, and pathway discovery. J. Biol. Chem. 2011, Jul 8; 286 (27): 23631-23635. DOI: 10.1074/jbc.R110.171405.
26. Лохов П.Г., Арчаков А.И. Масс-спектрометрические методы в метаболомике. Биомедицинская химия, 2008; 54 (5): 497-511.
Obstetrics and Gynaecology of Saint-Petersburg. 2017; : 35-39
Contemporary research methods in gynecology
Abstract
Metabolomics-science that studies the set of all cells of low molecular weight metabolites. The review presents general information on metabolomics and assessment capabilities in the diagnosis of diseases of the female body.
Metabolomichesky method of research is still far from clinical application and requires further study. However, possibly due to the use of this method it will be able to answer many questions still unanswered.
References
1. Adamski J., Suhre K. Metabolomics platforms for genome wide association studies - linking the genome to the metabolome. Curr Opin Biotechnol. 2013, Feb; 24 (1): 39-47. DOI: 10.1016/j.copbio.2012.10.003.
2. Adamson P.C., Krupp K., Freeman A.H., Klausner J.D., Reingold A.L., Madhivanan P. Prevalence & correlates of primary infertility among young women in Mysore, India. Indian J. Med. Res. 2011, Oct; 134: 440-446.
3. Ajduk A.1., Zernicka-Goetz M. Quality control of embryo development. Mol. Aspects Med. 2013, Oct; 34 (5): 903-918. DOI: 10.1016/j.mam.2013.03.001.
4. BaskindN.E., McRaeC., Sharma V., Fisher J. Understanding subfertility at a molecular level in the female through the application of nuclear magnetic resonance (NMR) spectroscopy. Hum. Reprod. Update. 2011; 17 (2): 228-241. DOI: 10.1093/humupd/dmq039.
5. Botros L., Sakkas D., Seli E. Metabolomics and its application for non-invasive embryo assessment in IVF. Mol. Hum. Reprod. 2008, Dec; 14 (12): 679-690. DOI: 10.1093/molehr/gan066.
6. Brison D.R., Houghton F.D., Falconer D., Roberts S.A., Hawkhead J., Humpherson P.G. et al. Identification of viable embryos in IVF by non-invasive measurement of amino acid turnover. Hum Reprod. 2004, Oct; 19 (10): 2319-2324. DOI:10.1093/humrep/deh409.
7. Bromer J.G., Seli E. Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics. Curr. Opin. Obstet. Gynecol. 2008, Jun; 20 (3): 234-241. DOI: 10.1097/GCO.0b013e3282fe723d.
8. Bushnik T., Cook J.L., Yuzpe A.A., Tough S., Collins J. Estimating the prevalence of infertility in Canada. Hum. Reprod. 2012, Mar; 27 (3): 738-746. DOI: 10.1093/humrep/der465.
9. D'Alessandro A., Giardina B., Gevi F., Timperio AM.,Zolla L. Clinical metabolomics: the next stage of clinical biochemistry. Blood Transfus. 2012, May; 10, Suppl 2: s19-24. DOI: 10.2450/2012.005S.
10. Lewis G.D., AsnaniA., Gerszten R.E. Application of metabolomics to cardiovascular biomarker and pathway discovery. J. Am. Coll. Cardiol. 2008, Jul 8; 52 (2): 117-123. DOI: 10.1016/j.jacc.2008.03.043.
11. MontagM., Toth B.,StrowitzkiT. New approaches to embryo selection. Reprod. Biomed. Online. 2013, Nov; 27 (5): 539-546. DOI: 10.1016/j.rbmo.2013.05.013.
12. MosalanejadL., KhodabakshiKoolee A. Looking at Infertility Treatment through The Lens of The Meaning of Life: The Effect of Group Logotherapy on Psychological Distress in Infertile Women. Int. J. Fertil. Steril. 2013, Jan; 6 (4): 224-231.
13. Nagy Z.P.,SakkasD.,BehrB. Symposium: innovative techniques in human embryo viability assessment. Non-invasive assessment of embryo viability by metabolomic profiling of culture media ('metabolomics'). Reprod. Biomed. Online. 2008, Oct; 17 (4): 502-507.
14. Nel-Themaat L., NagyZ.P. A review of the promises and pitfalls of oocyte and embryo metabolomics. Placenta. 2011, Sep; 32 Suppl. 3: S257-263. DOI: 10.1016/j.placenta.2011.05.011.
15. Nicholson J.K., Lindon J.C., Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 1999; 29 (11): 1181-1189.
16. O'Gorman A., Wallace M., Cottell E., Gibney M.J., McAuliffe F.M., Wingfield M. et al. Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence. Reproduction. 2013, Aug 21; 146 (4): 389-395. DOI: 10.1530/REP-13-0184.
17. Pauling L., Robinson A.B., Teranishi R., Cary P Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography. Proc. Natl. Acad. Sci. USA. 1971; 68 (10): 2374-2376.
18. PreisK.A., SeidelG.Jr., GardnerD.K. Metabolic markers of developmental competence for in vitro-matured mouse oocytes. Reproduction. 2005; 130 (4): 475-483. DOI: 10.1530/rep.1.00831.
19. Revelli A., Delle Piane L., Casano S., Molinari E., Massobrio M., Rinaudo P Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics. Reprod. Biol. Endocrinol. 2009, May 4; 7: 40. DOI: 10.1186/1477-7827-7-40.
20. Seli E., Botros L., Sakkas D., Burns D.H. Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertil. Steril. 2008, Dec; 90 (6): 2183-2189. DOI: 10.1016/j.fertn-stert.2008.07.1739.
21. Spratlin J.L., Serkova N.J., Eckhardt S.G. Clinical applications of metabolomics in oncology: a review. Clin. Cancer Res. 2009; 15 (2): 431-440. DOI: 10.1016/j.fertnstert.2008.07.1739.
22. VergouwC.G., Botros L.L., Roos P., Lens J.W., Schats R., Hompes P.G. et al. Metab-olomic profiling by near-infrared spectroscopy as a tool to assess embryo viability: a novel, non-invasive method for embryo selection. Hum. Reprod. 2008, Jul; 23 (7): 1499-1504. DOI: 10.1093/humrep/den111.
23. Wallace M., Cottell E., Gibney M.J., McAuliffe F.M., Wingfield M., Brennan L. An investigation into the relationship between the metabolic profile of follicular fluid, oocyte developmental potential, and implantation outcome. Fertil. Steril. 2012, May; 97 (5): 1078-1084.e1-8. DOI: 10.1016/j.fertnstert.2012.01.122.
24. Wang S.X. The past, present, and future of embryo selection in in vitro fertilization: Frontiers in Reproduction Conference. Yale J. Biol. Med. 2011, Dec; 84 (4): 487-490.
25. Zhang G.F., Sadhukhan S., Tochtrop G.P., BrunengraberH. Metabolomics, pathway regulation, and pathway discovery. J. Biol. Chem. 2011, Jul 8; 286 (27): 23631-23635. DOI: 10.1074/jbc.R110.171405.
26. Lokhov P.G., Archakov A.I. Mass-spektrometricheskie metody v metabolomike. Biomeditsinskaya khimiya, 2008; 54 (5): 497-511.
