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Рецепт. 2018; : 786-797

Лечение ревматоидного артрита, ассоциированного с инфекцией Chlamydophila pneumoniae

Сорока Н. Ф., Костюк С. А., Шаруба С. В.

Аннотация

Несмотря на внедрение в ревматологическую практику генно-инженерных биологических препаратов, обладающих мощным иммуносупрессивным эффектом и с успехом при- меняющихся для лечения разнообразной ревматической патологии как у нас в стране, так и за рубежом, ревматоидный артрит по-прежнему остается чрезвычайно сложной проблемой для ревматологов во всем мире. В ситуациях, когда традиционная противовоспалительная терапия оказывается малоэффективной, гипотеза ассоциации инфекции и ревматоидного артрита становится актуальной. Согласно современным данным, одним из патогенов, с которым может быть ассоциирован артрит и который может влиять на течение и эффективность лечения ревматоидного артрита, является Chlamydophila pneumoniae. В статье представлены результаты комплексного лечения ревматоидного артрита, ассоциированного с инфекцией Chlamydophila pneumoniae.

Список литературы

1. Kunder E. (2015) Reaktivnyy artrit [Reactive arthritis]. Meditsinskiye novosti, no 11, pp. 8-13.

2. Belov B., Shubin S., Balabanova R., Erdes Sh. (2015) Reakctivnyye artrity [Reactive arthritis].

3. Nauchno-Prakticheskaya Revmatologiya, vol. 53, no 4, pp. 414-420.

4. Zeidler H., Hudson A.P. (2016) Causality of Chlamydiae in arthritis and spondiloarthritis: a plea for increased translational research. Curr. Rheum. Rep., vol. 18, no 9, pp. 10. doi: 10.1007/s11926- 015-0559-3.

5. Rihl M. (2016) Update in reactive arthritis. Z Rheumatol., vol. 75, no 9, pp. 869-877.

6. Wilkinson N.Z. (1998) Lack of correlation between the detection of Chlamydia trachomatis DNA in synovial fluid from patients with a range of rheumatic diseases and the presence of an antichlamydial immune response. Arthritis Rheum., vol. 41, no 5, pp. 845-854.

7. Schumacher H.R. (1999) Lower prevalence of Chlamydia pneumoniae DNA compared with Chlamydia trachomatis DNA in synovial tissue of arthritis patients. Arthritis Rheum., vol. 42, no 9, pp. 1889-1893.

8. Gérard H.C. (2000) Chlamydia pneumoniae present in the human synovium are viable and metabolically active. Microb. Pathog., vol. 29, no 1, pp. 17-24.

9. Cascina A. (2002) Cutaneous vasculitis and reactive arthritis following respiratory infection due to Chlamydia pneumoniae: report of a case. Clin. Exp. Rheum., vol. 20, no 6, pp. 845-847.

10. Takeda H.J. (2002) A patient with adult Still’s disease with an increased Chlamydia pneumoniae antibody titer. Infect. Chemother., vol. 8, no 3, pp. 262-265.

11. Ardeniz O. (2005) Chlamydia pneumoniae arthritis in a patient with common variable immunodeficiency. Ann. Allergy Asthma Immunol., vol. 94, no 4, pp. 504-508.

12. Contini C. (2011) Detection of Chlamydophila pneumoniae in patients with arthritis: significance and diagnostic value. Rheum. Int., vol. 31, no 10, pp. 1307-1313.

13. Feng X.G. (2011) Recent Chlamydia pneumoniae infection is highly associated with active ankylosing spondylitis in a Chinese cohort. Scand. J. Rheum., vol. 40, no 4, pp. 289-291.

14. Rizzo A. (2012) The role of Chlamydia and Chlamydophila infections in reactive arthritis. Intern. Med., vol. 51, no 1, pp. 113-117.

Recipe. 2018; : 786-797

Treatment of rheumatoid arthritis associated with Chlamydophila pneumoniae infection

Soroka N. ., Kostyuk S. ., Sharuba S. .

Abstract

Despite the introduction into rheumatology practice genetically engineered biological agents which have a powerful immunosuppressive effect, and are successfully used to treat a variety of rheumatic diseases in our country and abroad, rheumatoid arthritis is still an extremely difficult problem for rheumatologists around the world. In situations where traditional anti-inflammatory therapy is ineffective, the hypothesis of association of infection and rheumatoid arthritis becomes relevant. According to modern data, one of the pathogens with which arthritis can be associated and which can affect the course and effectiveness of the treatment of rheumatoid arthritis, is Chlamydophila pneumoniae. The article presents the results of complex treatment of rheumatoid arthritis associated with Chlamydophila pneumoniae infection.
References

1. Kunder E. (2015) Reaktivnyy artrit [Reactive arthritis]. Meditsinskiye novosti, no 11, pp. 8-13.

2. Belov B., Shubin S., Balabanova R., Erdes Sh. (2015) Reakctivnyye artrity [Reactive arthritis].

3. Nauchno-Prakticheskaya Revmatologiya, vol. 53, no 4, pp. 414-420.

4. Zeidler H., Hudson A.P. (2016) Causality of Chlamydiae in arthritis and spondiloarthritis: a plea for increased translational research. Curr. Rheum. Rep., vol. 18, no 9, pp. 10. doi: 10.1007/s11926- 015-0559-3.

5. Rihl M. (2016) Update in reactive arthritis. Z Rheumatol., vol. 75, no 9, pp. 869-877.

6. Wilkinson N.Z. (1998) Lack of correlation between the detection of Chlamydia trachomatis DNA in synovial fluid from patients with a range of rheumatic diseases and the presence of an antichlamydial immune response. Arthritis Rheum., vol. 41, no 5, pp. 845-854.

7. Schumacher H.R. (1999) Lower prevalence of Chlamydia pneumoniae DNA compared with Chlamydia trachomatis DNA in synovial tissue of arthritis patients. Arthritis Rheum., vol. 42, no 9, pp. 1889-1893.

8. Gérard H.C. (2000) Chlamydia pneumoniae present in the human synovium are viable and metabolically active. Microb. Pathog., vol. 29, no 1, pp. 17-24.

9. Cascina A. (2002) Cutaneous vasculitis and reactive arthritis following respiratory infection due to Chlamydia pneumoniae: report of a case. Clin. Exp. Rheum., vol. 20, no 6, pp. 845-847.

10. Takeda H.J. (2002) A patient with adult Still’s disease with an increased Chlamydia pneumoniae antibody titer. Infect. Chemother., vol. 8, no 3, pp. 262-265.

11. Ardeniz O. (2005) Chlamydia pneumoniae arthritis in a patient with common variable immunodeficiency. Ann. Allergy Asthma Immunol., vol. 94, no 4, pp. 504-508.

12. Contini C. (2011) Detection of Chlamydophila pneumoniae in patients with arthritis: significance and diagnostic value. Rheum. Int., vol. 31, no 10, pp. 1307-1313.

13. Feng X.G. (2011) Recent Chlamydia pneumoniae infection is highly associated with active ankylosing spondylitis in a Chinese cohort. Scand. J. Rheum., vol. 40, no 4, pp. 289-291.

14. Rizzo A. (2012) The role of Chlamydia and Chlamydophila infections in reactive arthritis. Intern. Med., vol. 51, no 1, pp. 113-117.