Рецепт. 2022; : 61-68
Актуальные акценты витамина D для «золотого» возраста
https://doi.org/10.34883/PI.2022.25.1.003Аннотация
Целью данного обзора было представить результаты исследований, указывающих на значимость эффектов и уровня витамина D для организма, особенно в «золотом» возрасте. Известно, что реализация эффектов витамина D в организме происходит с участием «негеномного» и «геномного» механизмов. Рецепторы витамина D (VDR) были обнаружены более чем в 40 типах тканей и клеток организма. В обзоре приведены результаты ряда исследований, подтверждающих протективное значение оптимизации уровня витамина D в организме для снижения риска развития многих заболеваний, в том числе влияние на течение и исход COVID-19, а также исследований, указывающих на взаимосвязь уровня витамина D в крови с процессами старения. Рассмотрены рекомендуемые на сегодняшний день профилактические и терапевтические дозы приема холекальциферола, алгоритм его назначения пациентам с артериальной гипертензией. Подчеркивается необходимость персонифицированного выбора целевого уровня витамина D в крови с учетом заболеваний и его исходного уровня у пациента.
Список литературы
1. Decree of the Ministry of Health of the Republic of Belarus № 180 of November 20, 2012. Health requirements for the population: norms of physiological needs in energy and nutrients for different populations of the Republic of Belarus. Available at: https://pravo.by/document/?guid=3961&p0=W21226679p. (in Russian)
2. Kedrova I.I. Calcium and vitamin D in the nutritional intake of elderly men and women. Topical issues of diagnosis and therapy in elderly patients. Proceedings of the Republican scientific and practical conference dedicated to the Elderly People’s Day. Minsk. 2013:93–95. (in Russian)
3. Jankovskaja L.V., Povoroznjuk V.V., Balackaja N.I. Consumption of food with vitamins and minerals residents of the western Region of Belarus. Zdravoohranenie. 2012;2:48–52. (in Russian)
4. Mithal A., Wahl D.A., Bonjour J.P. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos. Int. 2009;20:1807–1820. doi: 10.1007/s00198-009-0954-6.
5. Rudenka E., Rudenka A., Kastrytskaya O. Vitamin D status in residents of Belarus: analysis of the three-year data. Standardy medyczne: pediatria. 2015;12(5):859–863. doi: 10.1001/jamanetworkopen.202019722.
6. Norman A.W. Vitamin D Receptor: New Assignments for an Already Busy Receptor. Endocrinology. 2006;147(12):5542–5548. doi: 10.1210/en.2006-0946.
7. Raharusuna P., Priambada S., Budiarti C. Patterns of COVID-19 mortality and vitamin D: an Indonesian study. Emerginnova. 2020. Available at: https://ssrn.com/abstract=3585561 (accessed 16 June 2021).
8. Xu Q., Parks C.G., DeRoo L.A. Multivitamin use and telomere length in women. Am J Clin Nutr. 2009;89(6):1857–1863. doi: 10.3945/ajcn.2008.26986.
9. Richards J.B., Valdes A.M, Gardner J.P. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am. J. Clin. Nutr. 2007;86:1420–1425. doi: 10.1093/ajcn/86.5.1420.
10. Liu J.J., Prescott J., Giovannucci E. Plasma vitamin D biomarkers and leukocyte telomere length. Am. J. Epidemiol. 2013;177:1411–1417. doi: 10.1093/aje/kws435.
11. Płudowski P., Karczmarewicz E., Bayer M. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe – recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol. 2013;64:319–327. doi: 10.5603/ep.2013.0012.
12. Pigarova E.A., Rozhinskaya L.Y., Belaya J.E. Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults. Problems of Endocrinology. 2016;62(4):75. doi:org/10.14341/probl201662460-84. (in Russian)
13. Yankouvskaya L.V., Snezhitskiy V.A., Mamedov M.N. Effect of Cholecalciferol and Diuretics as Components of Combination Antihypertensive Therapy on Plasma Renin Activity and Endothelial Function in Patients With Arterial Hypertension. Kardiologiia. 2017;57(8):140–150. doi: org/10.18087/cardio.2017.8.10015. (in Russian)
14. Jankovskaja L.V., Slobodskaja N.S. Effect of Cholecalciferol and Diuretics as Components of Combination Antihypertensive Therapy on Plasma Renin Activity and Endothelial Function in Patients With Arterial Hypertension. Recept. 2016;5:542–553. (in Russian)
15. Jakubova L.V., Kezhun L.V., Semjachkina-Glushkovskaja O.V. Alterations of plasma renin activity and endothelial function in patients with arterial hypertension during therapy with an angiotensin-converting enzyme inhibitor and cholecalciferol. Recept. 2017;20 (6):568–577. (in Russian)
16. Jankovskaja L.V., Snezhickij V.A., Mamedov M.N. Effect of Cholecalciferol and Diuretics as Components of Combination Antihypertensive Therapy on Plasma Renin Activity and Endothelial Function in Patients With Arterial Hypertension. Kardiologiia. 2017;8:34–39. doi: org/10.18087/cardio.2017.8.10015. (in Russian)
17. Jankovskaja L.V., Snezhickij V.A., Ljalikov S.A. Effect of prophylactic doses of cholecalciferol in subjects with arterial hypertension on the indices of calcium-phosphorus exchange and vitamin D level improvement. Medicinskie novosti. 2015;12:33–36. (in Russian)
18. Grant W.B., Lahore H., McDonnell S.L. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. McDonnell. Nutrients. 2020;12:988. doi: 10.3390/nu12040988.
19. Garland C.F., Gorham E.D., Mohr S.B. Vitamin D for cancer prevention: Global perspective. Ann. Epidemiol. 2009;196:468–483. doi: 10.1016/j.annepidem.2009.03.021.
20. Niet S., Coffiner M., Silva St. A Randomized Study to Compare a Monthly to a Daily Administration of Vitamin D3 Supplementation. Nutrients. 2018;10(6). doi: 10.3390/nu10060659.
21. Jakubova L.V., Slobodskaja N.S. The frequency of occurrence of risk factors for the development of D-deficiency and the effectiveness of using a high dose of cholecalciferol in the elderly in general medical practice. Medicinskie novosti. 2020;3:47–50. (in Russian)
Recipe. 2022; : 61-68
Actual Vitamin D Accents for the Golden Age Population
https://doi.org/10.34883/PI.2022.25.1.003Abstract
The purpose of this review was to present the results of studies indicating the significance of vitamin D effects and levels in the body, especially among the golden age population. It is known that the implementation of vitamin D effects in the body proceeds with the involvement of both non-genomic and genomic mechanisms. Vitamin D receptors (VDRs) have been found in over 40 types of tissues and cells in the body. The review presents the results of several studies confirming the protective value of optimizing the level of vitamin D in the body in order to reduce the risk of developing many diseases, including the effect on the course and outcome of COVID-19, as well as studies indicating a relationship between blood vitamin D levels and aging. The currently recommended prophylactic and therapeutic doses of cholecalciferol intake, the algorithm for its appointment to patients with arterial hypertension are described. The author emphasizes the need for a personalized choice of the target vitamin D blood levels taking into account patient conditions and baseline vitamin D blood levels.
References
1. Decree of the Ministry of Health of the Republic of Belarus № 180 of November 20, 2012. Health requirements for the population: norms of physiological needs in energy and nutrients for different populations of the Republic of Belarus. Available at: https://pravo.by/document/?guid=3961&p0=W21226679p. (in Russian)
2. Kedrova I.I. Calcium and vitamin D in the nutritional intake of elderly men and women. Topical issues of diagnosis and therapy in elderly patients. Proceedings of the Republican scientific and practical conference dedicated to the Elderly People’s Day. Minsk. 2013:93–95. (in Russian)
3. Jankovskaja L.V., Povoroznjuk V.V., Balackaja N.I. Consumption of food with vitamins and minerals residents of the western Region of Belarus. Zdravoohranenie. 2012;2:48–52. (in Russian)
4. Mithal A., Wahl D.A., Bonjour J.P. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos. Int. 2009;20:1807–1820. doi: 10.1007/s00198-009-0954-6.
5. Rudenka E., Rudenka A., Kastrytskaya O. Vitamin D status in residents of Belarus: analysis of the three-year data. Standardy medyczne: pediatria. 2015;12(5):859–863. doi: 10.1001/jamanetworkopen.202019722.
6. Norman A.W. Vitamin D Receptor: New Assignments for an Already Busy Receptor. Endocrinology. 2006;147(12):5542–5548. doi: 10.1210/en.2006-0946.
7. Raharusuna P., Priambada S., Budiarti C. Patterns of COVID-19 mortality and vitamin D: an Indonesian study. Emerginnova. 2020. Available at: https://ssrn.com/abstract=3585561 (accessed 16 June 2021).
8. Xu Q., Parks C.G., DeRoo L.A. Multivitamin use and telomere length in women. Am J Clin Nutr. 2009;89(6):1857–1863. doi: 10.3945/ajcn.2008.26986.
9. Richards J.B., Valdes A.M, Gardner J.P. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am. J. Clin. Nutr. 2007;86:1420–1425. doi: 10.1093/ajcn/86.5.1420.
10. Liu J.J., Prescott J., Giovannucci E. Plasma vitamin D biomarkers and leukocyte telomere length. Am. J. Epidemiol. 2013;177:1411–1417. doi: 10.1093/aje/kws435.
11. Płudowski P., Karczmarewicz E., Bayer M. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe – recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol. 2013;64:319–327. doi: 10.5603/ep.2013.0012.
12. Pigarova E.A., Rozhinskaya L.Y., Belaya J.E. Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults. Problems of Endocrinology. 2016;62(4):75. doi:org/10.14341/probl201662460-84. (in Russian)
13. Yankouvskaya L.V., Snezhitskiy V.A., Mamedov M.N. Effect of Cholecalciferol and Diuretics as Components of Combination Antihypertensive Therapy on Plasma Renin Activity and Endothelial Function in Patients With Arterial Hypertension. Kardiologiia. 2017;57(8):140–150. doi: org/10.18087/cardio.2017.8.10015. (in Russian)
14. Jankovskaja L.V., Slobodskaja N.S. Effect of Cholecalciferol and Diuretics as Components of Combination Antihypertensive Therapy on Plasma Renin Activity and Endothelial Function in Patients With Arterial Hypertension. Recept. 2016;5:542–553. (in Russian)
15. Jakubova L.V., Kezhun L.V., Semjachkina-Glushkovskaja O.V. Alterations of plasma renin activity and endothelial function in patients with arterial hypertension during therapy with an angiotensin-converting enzyme inhibitor and cholecalciferol. Recept. 2017;20 (6):568–577. (in Russian)
16. Jankovskaja L.V., Snezhickij V.A., Mamedov M.N. Effect of Cholecalciferol and Diuretics as Components of Combination Antihypertensive Therapy on Plasma Renin Activity and Endothelial Function in Patients With Arterial Hypertension. Kardiologiia. 2017;8:34–39. doi: org/10.18087/cardio.2017.8.10015. (in Russian)
17. Jankovskaja L.V., Snezhickij V.A., Ljalikov S.A. Effect of prophylactic doses of cholecalciferol in subjects with arterial hypertension on the indices of calcium-phosphorus exchange and vitamin D level improvement. Medicinskie novosti. 2015;12:33–36. (in Russian)
18. Grant W.B., Lahore H., McDonnell S.L. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. McDonnell. Nutrients. 2020;12:988. doi: 10.3390/nu12040988.
19. Garland C.F., Gorham E.D., Mohr S.B. Vitamin D for cancer prevention: Global perspective. Ann. Epidemiol. 2009;196:468–483. doi: 10.1016/j.annepidem.2009.03.021.
20. Niet S., Coffiner M., Silva St. A Randomized Study to Compare a Monthly to a Daily Administration of Vitamin D3 Supplementation. Nutrients. 2018;10(6). doi: 10.3390/nu10060659.
21. Jakubova L.V., Slobodskaja N.S. The frequency of occurrence of risk factors for the development of D-deficiency and the effectiveness of using a high dose of cholecalciferol in the elderly in general medical practice. Medicinskie novosti. 2020;3:47–50. (in Russian)
