Рецепт. 2022; : 46-51
Изучение противовирусной активности Гроприносина в отношении возбудителя коронавирусной инфекции SARS CoV-2 in vitro
https://doi.org/10.34883/PI.2022.25.1.005Аннотация
Противовирусные свойства Гроприносина исследованы в отношении коронавируса человека SARS-CoV-2 на монослойной культуре клеток почки африканской зеленой мартышки (Vero E6) методом оценки ингибирования цитопатического действия вируса. Полученные данные свидетельствуют о высоком противовирусном действии препарата в отношении возбудителя коронавирусной инфекции человека COVID-19.
Список литературы
1. Votyakov V.I., Boreko E.I., Vladyko G.V. (1986) Pervichnoe izuchenie antivirusnyh svojstv sinteticheskih i prirodnyh soedinenij. Metod. Rekomendacii [Primary detection of antiviral properties of synthetic and natural compounds. Method. Recommendations]. Minsk, 26 p. (in Russian)
2. Kishkurno E.P., Amvros’eva T.V., Karpov I.A. (2007) K voprosu o terapii eenterovirusnyh infekcij [On the Therapy of Enterovirus Infections]. Medicina, no 2 (57), pp. 79–82. (in Russian)
3. L’vov D.K., Al’hovskij S.V. (2020) Istoki pandemii COVID-19: ekologiya i genetika koronavirusov (Betacoronavirus: Coronaviridae) SARS-CoV, SARSCoV-2 (podrod Sarbecovirus), MERS-CoV (podrod Merbecovirus) [Origins of the COVID-19 Pandemic: Ecology and Genetics of Coronaviruses (Betacoronavirus: Coronaviridae) SARS-CoV, SARS-CoV-2 (Sarbecovirus subgenus), MERS-CoV (Merbecovirus subgenus)]. Voprosy virusologii, vol. 65, no 2, pp. 62–70. (in Russian)
4. Savenkova M.S., Balaktreva G.M., Rumyanceva I.G.(2017) Pokazaniya i opyt primeneniya inozina pranobeksa v pediatricheskoj praktike [Indications and Results of Inosin Pranobex Administration in Pediatric Practice]. Pediatriya (Pril. K zhurn. Consilium Medicum), vol. 4, pp. 52–55. (in Russian)
5. Sergienko E.N., Shmeleva N.P., Germanenko I.G. (2009) Gripp u detej: kliniko-epidemiologicheskie osobennosti i novye vozmozhnosti terapii [Influenza in Children: Clinical and Epidemiological Features and New Methods of Therapy]. Medicinskie novosti, no 14, pp. 71–74. (in Russian)
6. Shchelkanov M.Yu., Kolobuhina L.V., L’vov D.K. (2013) Koronavirusy cheloveka (Nidovirales, Coronaviridae): vozrosshij uroven’ epidemicheskoj opasnosti [Human Coronaviruses (Nidovirales, Coronaviridae): Increased Epidemic Risk]. Lechashchij vrach, no 10, pp. 49–54. (in Russian)
7. Fung K.P. (1989) A computer program in basic for estimation of ED50 and LD50. Comput. Biol. Med.,vol. 19, no 2, pp. 131-135.
Recipe. 2022; : 46-51
Study of Antiviral Activity of Groprinosin against SARS CoV-2 Coronavirus Infection Agent in Vitro
https://doi.org/10.34883/PI.2022.25.1.005Abstract
The antiviral properties of Groprinosin were studied against the human coronavirus SARSCoV-2 in a monolayer culture of African green monkey kidney cells (Vero E6) using the method of assessment of the inhibition of the cytopathic action of the virus. The data obtained reveal a high antiviral effect of the medicinal product against the pathogen of human coronavirus infection COVID-19.
References
1. Votyakov V.I., Boreko E.I., Vladyko G.V. (1986) Pervichnoe izuchenie antivirusnyh svojstv sinteticheskih i prirodnyh soedinenij. Metod. Rekomendacii [Primary detection of antiviral properties of synthetic and natural compounds. Method. Recommendations]. Minsk, 26 p. (in Russian)
2. Kishkurno E.P., Amvros’eva T.V., Karpov I.A. (2007) K voprosu o terapii eenterovirusnyh infekcij [On the Therapy of Enterovirus Infections]. Medicina, no 2 (57), pp. 79–82. (in Russian)
3. L’vov D.K., Al’hovskij S.V. (2020) Istoki pandemii COVID-19: ekologiya i genetika koronavirusov (Betacoronavirus: Coronaviridae) SARS-CoV, SARSCoV-2 (podrod Sarbecovirus), MERS-CoV (podrod Merbecovirus) [Origins of the COVID-19 Pandemic: Ecology and Genetics of Coronaviruses (Betacoronavirus: Coronaviridae) SARS-CoV, SARS-CoV-2 (Sarbecovirus subgenus), MERS-CoV (Merbecovirus subgenus)]. Voprosy virusologii, vol. 65, no 2, pp. 62–70. (in Russian)
4. Savenkova M.S., Balaktreva G.M., Rumyanceva I.G.(2017) Pokazaniya i opyt primeneniya inozina pranobeksa v pediatricheskoj praktike [Indications and Results of Inosin Pranobex Administration in Pediatric Practice]. Pediatriya (Pril. K zhurn. Consilium Medicum), vol. 4, pp. 52–55. (in Russian)
5. Sergienko E.N., Shmeleva N.P., Germanenko I.G. (2009) Gripp u detej: kliniko-epidemiologicheskie osobennosti i novye vozmozhnosti terapii [Influenza in Children: Clinical and Epidemiological Features and New Methods of Therapy]. Medicinskie novosti, no 14, pp. 71–74. (in Russian)
6. Shchelkanov M.Yu., Kolobuhina L.V., L’vov D.K. (2013) Koronavirusy cheloveka (Nidovirales, Coronaviridae): vozrosshij uroven’ epidemicheskoj opasnosti [Human Coronaviruses (Nidovirales, Coronaviridae): Increased Epidemic Risk]. Lechashchij vrach, no 10, pp. 49–54. (in Russian)
7. Fung K.P. (1989) A computer program in basic for estimation of ED50 and LD50. Comput. Biol. Med.,vol. 19, no 2, pp. 131-135.
