Журналов:     Статей:        

Рецепт. 2018; : 330-337

Возможности заместительной терапии гормоном роста при хронической сердечной недостаточности

Романовский А. А., Данилова Л. И., Лущик М. Л., Ярошевич Н. А., Романовская Н. В., Варава Н. К.

Аннотация

Проведена трехмесячная заместительная терапия гормоном роста у 15 пациентов с дефицитом соматотропина и хронической сердечной недостаточностью. При этом у пациентов улучшились показатели качества жизни, увеличилась фракция выброса левого желудочка и уменьшилась концентрация мозгового натрийуретического пептида в крови. Никаких существенных изменений аналогичных показателей в сравнении с исходным уровнем не наблюдалось в контрольной группе (14 пациентов).

Список литературы

1. (2010) Natsionalnyie rekomendatsii. Diagnostika i lechenie hronicheskoy serdechnoy nedostatochnosti [National recommendations. Diagnosis and treatment of chronic heart failure]. Minsk, 64 p.

2. Bondarenko I., Shpagina O. (2014) Gormon rosta v lechenii hronicheskoy serdechnoy nedostatochnosti [Growth hormone in the treatment of chronic heart failure]. Effektivnaya farmakoterapiya, vol. 6, no 53.

3. Ken K.Y.Ho. (2007) Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia. European Journal of Endocrinology, vol. 157, pp. 695-700.

4. Rose´n T., Bengtsson B. (1990) Premature mortality due to cardiovascular disease in hypopituitarism. Lancet, no 336, pp. 285-288.

5. Juul A., Scheike T., DavidsenM., Gyllenborg J., Jørgensen T. (2002) Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case- control study. Circulation, vol. 106, pp. 939-944.

6. Petretta M., Colao A.R., Fontanella L., de Caterina M. (2007) NT-proBNP, IGF-I and survival in patients with chronic heart failure. Growth Horm IGF Res., vol. 17, pp. 288-296

7. Barkan A.L., Clemmons D.R., Molitch M.E., Stewart P.M., Young W.F.Jr. (2000) Growth hormone therapy for hypopituitary adults: time for re-appraisal. Trends EndocrinolMetab, vol. 11 (6), pp. 238-45.

8. Owens G., Balfour D., Biller B.M. (2004) Clinical Presentation and Diagnosis: Growth Hormone Deficiency in Adults. American Journal of Managed Care, pp. S424-S430.

9. Murray Robert D. (2003) Adult growth hormone replacement: current understanding. Current Opinion in Pharmacology, 3.6, pp. 642-49.

10. Sacca L. (2009) Heart failure as a multiple hormonal deficiency syndrome. Circ Heart Fail, no 2, pp. 151-156.

11. Jorgen Isgaard Michele Arcopinto. (2015) GH and the cardiovascular system: an update on a topic at heart. Endocrine, no 48, pp. 25-35.

12. Antonio Cittadini, Lavinia Saldamarco. (2009) Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction. J ClinEndocrinolMetab., vol. 94 (9), pp. 3329-3336.

Recipe. 2018; : 330-337

Possibility of the growth hormone replacement therapy in chronic heart failure

Romanovskiy A. ., Danilova L. ., Lushchik M. ., Yaroshevich N. ., Romanovskaya N. ., Varava N. .

Abstract

A three-month replacement therapy with growth hormone was performed in 15 patients with somatotropin deficiency and chronic heart failure. The quality of life improved in patients, increased left ventricular ejection fraction and the concentration of brain natriuretic peptide in the blood decreased. No significant changes were observed in the same parameters with the baseline level in the control (14 patients).
References

1. (2010) Natsionalnyie rekomendatsii. Diagnostika i lechenie hronicheskoy serdechnoy nedostatochnosti [National recommendations. Diagnosis and treatment of chronic heart failure]. Minsk, 64 p.

2. Bondarenko I., Shpagina O. (2014) Gormon rosta v lechenii hronicheskoy serdechnoy nedostatochnosti [Growth hormone in the treatment of chronic heart failure]. Effektivnaya farmakoterapiya, vol. 6, no 53.

3. Ken K.Y.Ho. (2007) Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia. European Journal of Endocrinology, vol. 157, pp. 695-700.

4. Rose´n T., Bengtsson B. (1990) Premature mortality due to cardiovascular disease in hypopituitarism. Lancet, no 336, pp. 285-288.

5. Juul A., Scheike T., DavidsenM., Gyllenborg J., Jørgensen T. (2002) Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case- control study. Circulation, vol. 106, pp. 939-944.

6. Petretta M., Colao A.R., Fontanella L., de Caterina M. (2007) NT-proBNP, IGF-I and survival in patients with chronic heart failure. Growth Horm IGF Res., vol. 17, pp. 288-296

7. Barkan A.L., Clemmons D.R., Molitch M.E., Stewart P.M., Young W.F.Jr. (2000) Growth hormone therapy for hypopituitary adults: time for re-appraisal. Trends EndocrinolMetab, vol. 11 (6), pp. 238-45.

8. Owens G., Balfour D., Biller B.M. (2004) Clinical Presentation and Diagnosis: Growth Hormone Deficiency in Adults. American Journal of Managed Care, pp. S424-S430.

9. Murray Robert D. (2003) Adult growth hormone replacement: current understanding. Current Opinion in Pharmacology, 3.6, pp. 642-49.

10. Sacca L. (2009) Heart failure as a multiple hormonal deficiency syndrome. Circ Heart Fail, no 2, pp. 151-156.

11. Jorgen Isgaard Michele Arcopinto. (2015) GH and the cardiovascular system: an update on a topic at heart. Endocrine, no 48, pp. 25-35.

12. Antonio Cittadini, Lavinia Saldamarco. (2009) Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction. J ClinEndocrinolMetab., vol. 94 (9), pp. 3329-3336.