Рецепт. 2018; : 10-25
Факторы, влияющие на водно-спиртовую экстракцию флавоноидовиз травы золотарника канадского
Аннотация
В водно-спиртовых извлечениях, полученных из травы золотарника канадского, идентифицированы следующие флавоноиды: рутин, изокверцитрин, гвайяверин и гиперозид. Установлена динамика состава флавоноидов при разных условиях водно-спиртовой экстракции. Подобраны следующие оптимальные условия: концентрация спирта Р (60%, об/об); температура экстракции - 80 °С; продолжительность экстракции - 1,5 ч; кратность экстракции - однократная; соотношение сырья и экстрагента - 1:50; измельченность порошка сырья - 500. В результате дисперсионного анализа выявлено, что наиболее критическим фактором, влияющим на содержание флавоноидов в полученных извлечениях, являлась продолжительность экстракции.
Список литературы
1. Karpova V. (2005) Flora Resp. Belarus’: meditsinskoe i hozyaistvennoe znachenie : v 3 t. [Flora of the Republic of Belarus: medical and economic importance: in 3 volumes]. Vitebsk: VGMU, 165-168 pp. (in Russian)
2. Poleschuk E. (2017) Zolotarnik kanadskii [Canadian goldenrod] [Elektronnii resurs]. Available at: http://mrik.gov.by/ru/advertising-ru/viewArchiveNews/vrednoe-vozdejstvie-dikorastuschix- rastenij-6332/
3. Muravskii S. (2012) Raspoyasavshiesya chuzhaki [Rampant strangers]. Rodnaya priroda, no 10, pp. 8-11.
4. (2017) Reestr lekarstvennih sredstv Resp. Belarus’ [Elektronnii resurs]. Tsentr ekspertiz i ispitanii v zdravoohranenii [Register of medicines of the Republic of Belarus. The centre of examinations and tests in health service]. Minsk. Available at: http://www.rceth.by.
5. Savchenko L. (2016) Poluchenie ekstraktsionnogo preparata protivovospalitel’nogo i mochegonnogo deistviya iz travi zolotarnika kanadskogo [Preparation of the extraction drug of anti-inflammatory and diuretic action from the canadian goldenrod herb]. Izvestiya Samarskogo nauch. tsentra RAN, vol. 18, no 2, pp. 195-198.
6. Eurорeаn Рhаrmаcороeiа: EDQM. 9th Editiоn [Elektronnii resurs]. Available at: http://www. edqm.eu/
7. British Pharmacopoeia [Elektronnii resurs]. Available at: https://www.pharmacopoeia.com/
8. (1991) Trava zolotarnika kanadskogo: FS 42-2777-91. Vved. 09.07.91. [Canadian goldenrod herb]. M: Farmakopeinii gosudarstvennii komitet, 6 p.
9. Schilcher H. (1988) Nachweis der aquaretischen Wirkung von Birkenblätter und Gold- rutenauszügen im Tierversuch. Urologe, vol. 28, pp. 274-280.
10. Apati P.G. (2003) Antioxidant constituents in Solidago canadensis L. and its traditional phytopharmaceuticals (PhD Thesis). Hungarian Academy of Sciences. Budapest, 19 p.
11. Marks M. (2016) Development of an HPLC post-column antioxidant assay for Solidago canadensis radical scavengers. Natura Product Research, vol. 30, no 5, pp. 536-543.
12. Tao J.I.A.N.G. (2004) A survey of chemical and pharmacological studies on Solidago. J. of Chinese Integrative Medicine, vol. 4, no 4, pp. 430-435.
13. (2013) Proizvodstvo lekarstvennih sredstv. Nadlezhaschaya praktika viraschivaniya, sbora, hraneniya lekarstvennogo rastitel’nogo sir’ya = Vitvorchasts’ lekavih srodkaў. Nalezhnaya praktika viroshchvannya, zboru, zahoўvannyalekavairaslіnnaisiravіni: TKP 450-2012 (02041). Vved. 01.03.13. [Drug manufacturing. Suitable practice in the cultivation, harvesting and storage of medicinal plant raw material]. Minsk : Departament farmatsevticheskoi promishlennosti, 14 p.
14. (2003) WHO guidelines on good agricultural and collections practices (GACP) for medicinal plants.
15. Geneva: World Health Organization, 72 p.
16. Moiseev D.V. (2011) Identifikatsiya flavonoidov v rasteniyah metodom VEZHH. Him.-farm. zhurn., vol. 45, no 1, pp. 35-38.
17. Mabry T.J. (1970) The systematic identification of flavonoids. Berlin: Springer-Verland, 354 p.
18. Barz W. (1975) The Flavonoids. New York: Acad. Press, 1204 p.
19. Sheryakov A. (2012) Gosudarstvennaya farmakopeya Resp. Belarus’ (GF RB II): v 2-h t. [State Pharmacopoeia of the Republic of Belarus]. Molodechno: Pobeda, 1220 s.
20. Lukashov R.I. (2013) Kolichestvennoe opredelenie flavonoidov igidroksikorichnih kislot v tsvetkah rudbekii shershavoi [Quantitation of flavonoids and hydroxy-cinnamic acids in the flowers of Rudbeckia hirta]. Retsept, no 5, pp. 95-105.
21. Arquimentes G. (2011) Diuretic and potassium-sparing effect of isoquercitrin An active flavonoid of Tropaeolum majus L. Journal of Ethnopharmacology, no 134, pp. 210-215.
22. Tarahovskii Yu. (2013) Flavonoidi: biohimiya, biofizika, meditsina [Flavonoids: Biochemistry, Biophysics, Medicine]. Puschino: Sunchrobook, 310 p. (in Russian)
Recipe. 2018; : 10-25
Factors with influence on the hydroalcoholic extraction of flavonoids from the Canadian goldenrod herb
Abstract
References
1. Karpova V. (2005) Flora Resp. Belarus’: meditsinskoe i hozyaistvennoe znachenie : v 3 t. [Flora of the Republic of Belarus: medical and economic importance: in 3 volumes]. Vitebsk: VGMU, 165-168 pp. (in Russian)
2. Poleschuk E. (2017) Zolotarnik kanadskii [Canadian goldenrod] [Elektronnii resurs]. Available at: http://mrik.gov.by/ru/advertising-ru/viewArchiveNews/vrednoe-vozdejstvie-dikorastuschix- rastenij-6332/
3. Muravskii S. (2012) Raspoyasavshiesya chuzhaki [Rampant strangers]. Rodnaya priroda, no 10, pp. 8-11.
4. (2017) Reestr lekarstvennih sredstv Resp. Belarus’ [Elektronnii resurs]. Tsentr ekspertiz i ispitanii v zdravoohranenii [Register of medicines of the Republic of Belarus. The centre of examinations and tests in health service]. Minsk. Available at: http://www.rceth.by.
5. Savchenko L. (2016) Poluchenie ekstraktsionnogo preparata protivovospalitel’nogo i mochegonnogo deistviya iz travi zolotarnika kanadskogo [Preparation of the extraction drug of anti-inflammatory and diuretic action from the canadian goldenrod herb]. Izvestiya Samarskogo nauch. tsentra RAN, vol. 18, no 2, pp. 195-198.
6. Eurorean Rharmacoroeia: EDQM. 9th Edition [Elektronnii resurs]. Available at: http://www. edqm.eu/
7. British Pharmacopoeia [Elektronnii resurs]. Available at: https://www.pharmacopoeia.com/
8. (1991) Trava zolotarnika kanadskogo: FS 42-2777-91. Vved. 09.07.91. [Canadian goldenrod herb]. M: Farmakopeinii gosudarstvennii komitet, 6 p.
9. Schilcher H. (1988) Nachweis der aquaretischen Wirkung von Birkenblätter und Gold- rutenauszügen im Tierversuch. Urologe, vol. 28, pp. 274-280.
10. Apati P.G. (2003) Antioxidant constituents in Solidago canadensis L. and its traditional phytopharmaceuticals (PhD Thesis). Hungarian Academy of Sciences. Budapest, 19 p.
11. Marks M. (2016) Development of an HPLC post-column antioxidant assay for Solidago canadensis radical scavengers. Natura Product Research, vol. 30, no 5, pp. 536-543.
12. Tao J.I.A.N.G. (2004) A survey of chemical and pharmacological studies on Solidago. J. of Chinese Integrative Medicine, vol. 4, no 4, pp. 430-435.
13. (2013) Proizvodstvo lekarstvennih sredstv. Nadlezhaschaya praktika viraschivaniya, sbora, hraneniya lekarstvennogo rastitel’nogo sir’ya = Vitvorchasts’ lekavih srodkaў. Nalezhnaya praktika viroshchvannya, zboru, zahoўvannyalekavairaslіnnaisiravіni: TKP 450-2012 (02041). Vved. 01.03.13. [Drug manufacturing. Suitable practice in the cultivation, harvesting and storage of medicinal plant raw material]. Minsk : Departament farmatsevticheskoi promishlennosti, 14 p.
14. (2003) WHO guidelines on good agricultural and collections practices (GACP) for medicinal plants.
15. Geneva: World Health Organization, 72 p.
16. Moiseev D.V. (2011) Identifikatsiya flavonoidov v rasteniyah metodom VEZHH. Him.-farm. zhurn., vol. 45, no 1, pp. 35-38.
17. Mabry T.J. (1970) The systematic identification of flavonoids. Berlin: Springer-Verland, 354 p.
18. Barz W. (1975) The Flavonoids. New York: Acad. Press, 1204 p.
19. Sheryakov A. (2012) Gosudarstvennaya farmakopeya Resp. Belarus’ (GF RB II): v 2-h t. [State Pharmacopoeia of the Republic of Belarus]. Molodechno: Pobeda, 1220 s.
20. Lukashov R.I. (2013) Kolichestvennoe opredelenie flavonoidov igidroksikorichnih kislot v tsvetkah rudbekii shershavoi [Quantitation of flavonoids and hydroxy-cinnamic acids in the flowers of Rudbeckia hirta]. Retsept, no 5, pp. 95-105.
21. Arquimentes G. (2011) Diuretic and potassium-sparing effect of isoquercitrin An active flavonoid of Tropaeolum majus L. Journal of Ethnopharmacology, no 134, pp. 210-215.
22. Tarahovskii Yu. (2013) Flavonoidi: biohimiya, biofizika, meditsina [Flavonoids: Biochemistry, Biophysics, Medicine]. Puschino: Sunchrobook, 310 p. (in Russian)
