Рецепт. 2018; : 466-472
Изучение структурно-механических свойств пасты для терапии онихомикозов
Аннотация
Грибковые поражения ногтей являются одной из наиболее распространенных и сложных в лечении дерматологических патологий. Местное лечение онихомикоза в большинстве случаев является единственным приемлемым методом терапии прежде всего из-за ее высокой безопасности. Терапия антимикотическими лаками достаточно эффективна только в случае лечения поверхностной белой и дистально-латеральной форм онихомикоза при незначительной длительности заболевания. Также их широкое использование ограничивает длительность применения и высокая затратность лечения.
Кафедрой технологии лекарств Запорожского государственного медицинского университета в результате комплексных физико-химических, фармакотехнологических и микробиологических исследований предложен состав мягкой лекарственной формы для терапии микозов ногтей – пасты, содержащей комбинацию неспецифических антимикотических веществ (2-меркаптобензтиазол, хинозол) и онихолитиков (салициловая и бензойная кислоты).
Целью настоящей работы является изучение структурно-механических свойств разработанной мазевой композиции для возможности объективной фармакотехнологической оценки ее консистентных свойств.
Выявлено, что прочностные характеристики мазевой композиции на эмульсионной основе можно отнести к удовлетворительным, в структуре представлены как коагуляционные, так и конденсационные связи. Рассчитанные значения коэффициентов динамического течения мягкой лекарственной формы для наружного применения количественно подтверждают удовлетворительную степень распределения системы во время нанесения на ногтевые пластины или во время технологических операций изготовления.
Список литературы
1. Sergeev Yu., Mokina E., Sergeev A. (2013) Mestnaya i kombinirovannaya terapiya onihomikozov. Posobie dlya vrachei [Local and combined therapy of onychomycoses. Manual for doctors]. M.: Nats. akad. mikol., 40 p. (in Russian)
2. Veselov A. (2013) Novii podhod k topicheskoi terapii onihomikozov [The new approach to the topical therapy of onychomycoses]. Klin. mikrobiol. antimikrob. himioter., vol. 15, no 1, pp. 23–34.
3. Salei O., Dyudyun A., Gladishev V., Luts’ V. (2014) Efektivnіst’ kompleksnogo, kombіnovanogo lіkuvannya hvorih na onіhomіkoz [Eff ectiveness of complex, combined treatment of patients with onychomycosis]. Dermatovenerologiya. Kosmetologiya. Seksopatologiya, no 1–4, pp. 186–191.
4. Luts’ V., Kolicheva N., Gladishev V., Lisyans’ka A. (2017) Obgruntuvannya optimal’nih kontsentratsіi aktivnih farmatsevtichnih іngredієntіv u kombіnovanih m’yakih lіkars’kih formah [Substantiation of the optimal concentrations of active pharmaceutical ingredients in combination soft pharmaceutical forms]. Farmatsevtichnii zhurnal, no 5, pp. 33–37.
5. Luts’ V. (2017) O tselesoobraznosti sozdaniya kombinirovannih lekarstvennih form dlya naruzhnogo primeneniya s mebetizolom i hinozolom [On the advisability of creating combined dosage forms for external use with mebetisol and chinosol]. Suchasnі aspekti meditsini і farmatsії-2017 : materіali Vseukr. nauk.-prakt. konf. mol. vchenih ta studentіv z mіzhnarod. uchastyu (11–12 travnya 2017 r.) [Modern aspects of medicine and pharmacy 2017: Materials of the All-Ukrainian Scientifi c and Practical Conference of Young Scientists and Students with International Participation]. Zaporіzhzhya, ZDMU, pp. 150–151.
6. Shikova Yu., Lihoded V., Bulgakova A. (2013) Sravnitel’noe izuchenie reologicheskih svoistv mazi na emul’sionnoi i gelevoi osnovah [The comparative examination of rheologic properties of ointment on emulsion and gel bases]. Meditsinskii al’manah, no 2 (26), pp. 194–196.
7. Yaremchuk A.A. (2012) Obosnovanie sostava mnogokomponentnoi mazi dlya lecheniya gnoinih ran v pervoi faze ranevogo protsessa [The motivation of the composition of the multicomponent ointment for treatment of the festering wounds in the fi rst phase of wound process]. Vestnik farmatsii, no 3 (57), pp. 39–46.
8. Kovalev V. (2016) Izuchenie reologicheskih svoistv mazi s suhim ekstraktom list’ev topolya kitaiskogo [Rheological properties study of the ointment with a thick extract of Chinese poplar leaves]. Vestnik farmatsii, no 1 (71), pp. 15–20.
9. Gladishev V., Kuchina L., Burlaka B., Biryuk I. (2013) Issledovanie reologicheskih svoistv myagkoi nazal’noi lekarstvennoi formi diltiazema [Investigation of the rheological properties of the soft nasal dosage form of diltiazem]. Aktual’nі pitannya farmatsevtichnoї і medichnoї nauki ta praktiki, no 1 (11), pp. 69–72.
10. Romanіna D. (2016) Vivchennya reologіchnih vlastivostei m’yakoї lіkars’koї formi prazіkvantelu dlya zovnіshn’ogo zastosuvannya [Rheological properties study of the soft dosage form of praziquantel]. Farmatsevtichnii zhurnal, no 1, pp. 39–44.
11. Gnit’ko I., Gladishev V., Lisyanskaya A., Biryuk I. (2016) Izuchenie konsistentnih svoistv geleobraznogo shampunya s minoksidilom [The study of consistent properties of gelatinous shampoo with minoxidil]. Aktual’nі pitannya farmatsevtichnoї і medichnoї nauki ta praktiki, no 1 (20), pp. 43–47.
12. Gnіt’ko І. (2016) Vivchennya strukturno-mehanіchnih vlastivostei krema z mіnoksidilom [Study of the structural and mechanical properties of a cream containing minoxidil]. Farmatsevtichnii zhurnal, no 3–4, pp. 55–59.
13. Nagornaya N. (2014) Study of consistent properties of vinpocetine intranasal dosage form. Zaporozhskii meditsinskii zhurnal, no 5 (86), pp. 97–100.
14. Kurinnoi A., Rizhov A., Gladishev V., Solov’eva V. (2012) Izuchenie konsistentnih svoistv instillyatsionnogo linimenta-gelya dlya terapii gnoino-vospalitel’nih zabolevanii chelyustnolitsevoi oblasti [The study of the consistent properties installation liniment gel for the treatment of purulent-infl ammatory diseases of maxillofacial region ]. Zaporozhskii meditsinskii zhurnal, no 6 (75), pp. 66–67.
15. Pantyuhin A.V. (2013) Reologicheskie modeli uprugo-vyazkih lekarstvennih form [Rheological models in elastic and viscous medicinal forms]. Sovremennie problemi nauki i obrazovaniya, no 1, pp. 1–7.
16. Koritnyuk R., Zagorii G., Tarasenko V. (2012) Nekotorie voprosi reologii myagkih lekarstvennih form [Some questions of soft dosage forms rheology]. Zb. nauk. prats’ spіvrobіt. NMAPO іmenі P.L. Shupika, no 21 (4), pp. 430–437.
17. Almohamad Zhumaa Abdullah, Gladishev V., Burlaka B., Maletskii N. (2013) Izuchenie reologicheskih svoistv nazal’noi lekarstvennoi formi kaptoprila [Investigation of the rheological properties of the nasal dosage form of kaptopril] . Zaporozhskii meditsinskii zhurnal, no 6 (81), pp. 78–80.
Recipe. 2018; : 466-472
Study of structural and mechanical characteristics of the paste for onychomycosis therapy
Abstract
Nail onychomycosis is a one of the most widespread and complicated in dermatologic pathology treatment. Topical treatment of onychomycosis in the most cases is the only one acceptable method of therapy mainly because of its high safety. Therapy with antimycotic varnishes is eff ective enough only in case of treatment the surface white and distal-lateral form of onychomycosis and insignifi cant duration of disease. Also their wide using is limited by the duration of use and high cost of treatment.
As a result of the complex physico-chemical, pharmacotechnological and microbiological investigations carried out on the department of technology of drugs Zaporozhye State Medical University a composition of semisolid dosage form for the nail mycosis – paste containing the combination of antimycotic substances (2-mercaptobenzthiazol, chinozol) and onycholytic (salicylic and benzoic acids) was proposed.
The aim of this work is study of structural and mechanical characteristics of the developed ointment composition for possibility of objective pharmacotechnological evaluation its consistent characteristics.
It was revealed that strength properties of ointment composition on the emulsive base seems to be satisfactory, the coagulatory and condensation bond are presented in structure. Calculated factors of dynamic fl owing of semisolid dosage form for external use quantitatively confi rms the satisfactory degree of system distribution during application on the nail plates or technological operations of manufacturing.
References
1. Sergeev Yu., Mokina E., Sergeev A. (2013) Mestnaya i kombinirovannaya terapiya onihomikozov. Posobie dlya vrachei [Local and combined therapy of onychomycoses. Manual for doctors]. M.: Nats. akad. mikol., 40 p. (in Russian)
2. Veselov A. (2013) Novii podhod k topicheskoi terapii onihomikozov [The new approach to the topical therapy of onychomycoses]. Klin. mikrobiol. antimikrob. himioter., vol. 15, no 1, pp. 23–34.
3. Salei O., Dyudyun A., Gladishev V., Luts’ V. (2014) Efektivnіst’ kompleksnogo, kombіnovanogo lіkuvannya hvorih na onіhomіkoz [Eff ectiveness of complex, combined treatment of patients with onychomycosis]. Dermatovenerologiya. Kosmetologiya. Seksopatologiya, no 1–4, pp. 186–191.
4. Luts’ V., Kolicheva N., Gladishev V., Lisyans’ka A. (2017) Obgruntuvannya optimal’nih kontsentratsіi aktivnih farmatsevtichnih іngredієntіv u kombіnovanih m’yakih lіkars’kih formah [Substantiation of the optimal concentrations of active pharmaceutical ingredients in combination soft pharmaceutical forms]. Farmatsevtichnii zhurnal, no 5, pp. 33–37.
5. Luts’ V. (2017) O tselesoobraznosti sozdaniya kombinirovannih lekarstvennih form dlya naruzhnogo primeneniya s mebetizolom i hinozolom [On the advisability of creating combined dosage forms for external use with mebetisol and chinosol]. Suchasnі aspekti meditsini і farmatsії-2017 : materіali Vseukr. nauk.-prakt. konf. mol. vchenih ta studentіv z mіzhnarod. uchastyu (11–12 travnya 2017 r.) [Modern aspects of medicine and pharmacy 2017: Materials of the All-Ukrainian Scientifi c and Practical Conference of Young Scientists and Students with International Participation]. Zaporіzhzhya, ZDMU, pp. 150–151.
6. Shikova Yu., Lihoded V., Bulgakova A. (2013) Sravnitel’noe izuchenie reologicheskih svoistv mazi na emul’sionnoi i gelevoi osnovah [The comparative examination of rheologic properties of ointment on emulsion and gel bases]. Meditsinskii al’manah, no 2 (26), pp. 194–196.
7. Yaremchuk A.A. (2012) Obosnovanie sostava mnogokomponentnoi mazi dlya lecheniya gnoinih ran v pervoi faze ranevogo protsessa [The motivation of the composition of the multicomponent ointment for treatment of the festering wounds in the fi rst phase of wound process]. Vestnik farmatsii, no 3 (57), pp. 39–46.
8. Kovalev V. (2016) Izuchenie reologicheskih svoistv mazi s suhim ekstraktom list’ev topolya kitaiskogo [Rheological properties study of the ointment with a thick extract of Chinese poplar leaves]. Vestnik farmatsii, no 1 (71), pp. 15–20.
9. Gladishev V., Kuchina L., Burlaka B., Biryuk I. (2013) Issledovanie reologicheskih svoistv myagkoi nazal’noi lekarstvennoi formi diltiazema [Investigation of the rheological properties of the soft nasal dosage form of diltiazem]. Aktual’nі pitannya farmatsevtichnoї і medichnoї nauki ta praktiki, no 1 (11), pp. 69–72.
10. Romanіna D. (2016) Vivchennya reologіchnih vlastivostei m’yakoї lіkars’koї formi prazіkvantelu dlya zovnіshn’ogo zastosuvannya [Rheological properties study of the soft dosage form of praziquantel]. Farmatsevtichnii zhurnal, no 1, pp. 39–44.
11. Gnit’ko I., Gladishev V., Lisyanskaya A., Biryuk I. (2016) Izuchenie konsistentnih svoistv geleobraznogo shampunya s minoksidilom [The study of consistent properties of gelatinous shampoo with minoxidil]. Aktual’nі pitannya farmatsevtichnoї і medichnoї nauki ta praktiki, no 1 (20), pp. 43–47.
12. Gnіt’ko І. (2016) Vivchennya strukturno-mehanіchnih vlastivostei krema z mіnoksidilom [Study of the structural and mechanical properties of a cream containing minoxidil]. Farmatsevtichnii zhurnal, no 3–4, pp. 55–59.
13. Nagornaya N. (2014) Study of consistent properties of vinpocetine intranasal dosage form. Zaporozhskii meditsinskii zhurnal, no 5 (86), pp. 97–100.
14. Kurinnoi A., Rizhov A., Gladishev V., Solov’eva V. (2012) Izuchenie konsistentnih svoistv instillyatsionnogo linimenta-gelya dlya terapii gnoino-vospalitel’nih zabolevanii chelyustnolitsevoi oblasti [The study of the consistent properties installation liniment gel for the treatment of purulent-infl ammatory diseases of maxillofacial region ]. Zaporozhskii meditsinskii zhurnal, no 6 (75), pp. 66–67.
15. Pantyuhin A.V. (2013) Reologicheskie modeli uprugo-vyazkih lekarstvennih form [Rheological models in elastic and viscous medicinal forms]. Sovremennie problemi nauki i obrazovaniya, no 1, pp. 1–7.
16. Koritnyuk R., Zagorii G., Tarasenko V. (2012) Nekotorie voprosi reologii myagkih lekarstvennih form [Some questions of soft dosage forms rheology]. Zb. nauk. prats’ spіvrobіt. NMAPO іmenі P.L. Shupika, no 21 (4), pp. 430–437.
17. Almohamad Zhumaa Abdullah, Gladishev V., Burlaka B., Maletskii N. (2013) Izuchenie reologicheskih svoistv nazal’noi lekarstvennoi formi kaptoprila [Investigation of the rheological properties of the nasal dosage form of kaptopril] . Zaporozhskii meditsinskii zhurnal, no 6 (81), pp. 78–80.
