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Рецепт. 2019; : 599-611

Психологический и фармакологический аспекты лечения посттравматического стрессового расстройства и виртуальная зависимость

Шолойко Н. В., Матвеева Е. В., Лысенко А. С., Лысенко Т. И.

Аннотация

Современное общество подвергается влиянию многих стрессовых явлений. Войны, болезни, теракты, конфликты и другие негативные проявления подвергают опасности психофизическое здоровье человека. Поэтому посттравматическое стрессовое расстройство (ПТСР) способно оказывать существенное влияние на социальную активность человека. Однако использование разных промышленных лекарственных средств (ЛС), лекарств растительного происхождения и психотерапия могут поспособствовать улучшению качества жизни пациентов. Современные медиатехнологии тесно связаны с повседневной жизнью человека. Поэтому использование виртуального пространства может играть роль отвлекающей терапии (игры, социальные сети, покупки и другая деятельность). Подобная активность вследствие желания уйти от травмирующего события получила название «эскейпинг». Быстрый доступ к разной информации, услугам, товарам, общению, развлечениям позволяет человеку отвлечься от тяжелых эмоций. Человек способен проводить много свободного времени в виртуальном пространстве с целью отвлечься от болезненных воспоминаний или событий. К сожалению, это может поспособствовать развитию виртуальной зависимости. Проблемы с использованием виртуального пространства могут усугубить негативные события в реальной жизни. Например, к таким факторам можно отнести финансовые трудности вследствие использования азартных игр. Также вероятно дальнейшее развитие трудностей в учебе, работе и в общении с родственниками и друзьями. Стоит отметить, что виртуальная зависимость может способствовать суицидальному поведению. Поэтому человек с ПТСР на фоне виртуальной зависимости подвергается дополнительным рискам. Эта статья посвящена некоторым психологическим и фармакологическим аспектам возникновения и лечения ПТСР, а также проявлению виртуальной зависимости на фоне этой проблемы. Важно проводить дальнейшие исследования для лучшего понимания механизмов развития этих нарушений и путей решения.

Список литературы

1. Williams A.C. de C., Baird E. (2016) Special considerations for the treatment of pain from torture and war. Curr. Anasthesiol. Rep., vol. 6, no 4, pp. 319–326.

2. MKB-10 (1995) Mezhdunarodnaya statisticheskaya klassifikatsiya bolezney i problem, svyazannykh so zdorov'yem: 10-y peresmotr: v 3 t. T. 1. CH. 1. Per. s angl. M. Maksimovoy, S. Chemyakinoy, L. Safronovoy [International statistical classification of diseases and related health problems: 10th [tenth] revision: in 3 V., V. 1, P. 1, translation from English M.Maksimova, S.Chemiakina, L. Safronov]. Geneva: World Health Organization, publishing house "Medicine", 697 p.

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4. Сhiba H., Oe M., Uchimura N. (2015) Patients with posttraumatic stress disorder with comorbid major depressive disorder require a higher dose of psychotropic drugs. Kurume medical journal, vol. 62, no 1–2, pp. 23–28.

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8. Agibalova T., Aleksandrovskii YU., Bocheeva E. (2015) Posttravmaticheskoe stressovoe rasstroistvo [Posttraumatic stress disorder]. Rostov n/D: Izd-vo RostGMU, 624 p.

9. Raspopin E. (2016) Metody izucheniya i otsenki psikhicheskikh sostoyaniy [Methods of study and evaluation of mental states]. Izvestiya Ural’skogo federal’nogo universiteta. Ser. 1: Problemy obrazovaniya, nauki i kul’tury [News of Ural Federal University. Series 1: Problems of education, science and culture], vol. 22, no 4 (156), pp. 129–137.

10. Amelina L., Nikolaev V., Bulgakova O. (2016) Osobennosti psikhoemotsional'nogo napryazheniya roditeley detey s addiktivnym povedeniyem [Especially emotional stress parents of children with addictive behavior]. Psychophysiology News, vol. 1, pp. 56–60.

11. Molostova N., Shcherbakova E. (2016) Psikhofiziologicheskiye i psikhosotsial'nyye osnovaniya vliyaniya detsko-roditel'skikh otnosheniy na emotsional'nuyu ustoychivost' mladshikh shkol'nikov [The psychophysiological and psychosocial bases of influence child-parent relations on emotional stability of younger schoolchild]. Vestnik psikhofiziologii, vol. 1, pp. 34–43.

12. Philipovich V. (2015) Prediktory zhiznestoykosti lichnosti pri nevrozakh i v norme [Predictors of personality hardiness in both neurotic and normal condition]. Medychna psykholohiya, no 3, pp. 7–12.

13. Chorna T. (2015) Klinika, diagnostika i printsipy psikhoterapii trevozhno-fobicheskikh rasstroystv [Clinical presentation, diagnosis and principles of psychotherapeutic correction of anxiety and phobic disorders]. Medychna psykholohiya, 3, pp. 83–86.

14. Popiel A., Zawadzki B., Pragłowska E., Teichman Y. (2015) Prolonged exposure, paroxetine and the combination in the treatment of PTSD following a motor vehicle accident. A randomized clinical trial – The "TRAKT" study. J. Behav. Ther. Exp. Psychiatry, vol. 48, pp. 17–26.

15. Zhu H., Qiu C., Meng Y. (2015) Altered spontaneous neuronal activity in chronic posttraumatic stress disorder patients before and after a 12-week paroxetine treatment. J. Affect. Disord., vol. 174, pp. 257–264.

16. Lewis R.J., Kemp P.M., Johnson R.D. (2015) Paroxetine in Postmortem Fluids and Tissues from Nine Aviation Accident Victims. J. Anal. Toxicol., vol. 39, no 8, pp. 637–641.

17. Kamo T., Maeda M., Oe M. (2016) Dosage, effectiveness, and safety of sertraline treatment for posttraumatic stress disorder in a Japanese clinical setting: a retrospective study. BMC Psychiatry, vol. 16, no1, p. 434.

18. Li W., Ma Y.B., Yang Q. (2017) Effect and safety of sertraline for treat posttraumatic stress disorder: a multicenter randomised controlled study. Int. J. Psychiatry. Clin. Pract., vol. 21, no2, pp. 151–155.

19. Pilkinton P., Berry C., Norrholm S. (2016) An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder. Psychopharmacol Bull., vol. 46, no 2, pp. 8–17.

20. Baniasadi M., Hosseini G., Fayyazi Bordbar M.R. (2014) Effect of pregabalin augmentation in treatment of patients with combat-related chronic posttraumatic stress disorder: a randomized controlled trial. J. Psychiatr. Pract., vol. 20, no 6, pp. 419–427.

21. Bicknell L.M., McFaddin C.L., Fernandez M., Parekh P. (2017) Imipramine-induced hyperpigmentation. Cutis, vol. 100, no 3, pp. 8–10.

22. Kessing L.V., Bukh J.D. (2013) Amitriptyline versus placebo for major depression. Ugeskr Laeger, vol. 175, no 34, pp. 1875–1877.

23. Arnsten A.F.T., Raskind M.A., Taylor F.B., Connor D.F. (2015) The effects of stress exposure on prefrontal cortex translating bacic research into successful treatments for post-traumatic stress disorder. Neurobiology of stress, vol. 1, pp. 89–99.

24. Murrough J.W., Yaqubi S., Sayed S., Charmey D.S. (2015) Emerging drugs for the treatment of anxiety. Expert. Opin. Emerg. Drugs, vol. 20, no 3, pp. 393–406.

25. Jeffreys M., Capehart B., Friedman M.J. (2012) Pharmacotherapy for posttraumatic stress disorder: review with clinical applications. J. Rehabil. Res. Dev., vol. 49, no 5, pp. 703–715.

26. Lim K., See Y.M., Lee J.A. (2017) Systematic Review of the Effectiveness of Medical Cannabis for Psychiatric, Movement and Neurodegenerative Disorders. Clin. Psychopharmacol. Neurosci., vol. 15, no4, pp. 301–312.

27. Grant S., Pedersen E.R., Neighbors C. (2016) Associations of Posttraumatic Stress Disorder Symptoms With Marijuana and Synthetic Cannabis Use Among Young Adult U.S. Veterans: A Pilot Investigation. J. Stud. Alcohol. Drugs, vol. 77, no 3, pp. 509–514.

28. Cohen N.L., Heinz A.J., Ilgen M., Bonn-Miller M.O. (2016) Pain, Cannabis Species, and Cannabis Use Disorders. J. Stud. Alcohol. Drugs, vol. 77, no 3, pp. 515–520.

29. Diomidous M., Chardalias K., Magita A. (2016) Social and Psychological Effects of the Internet Use. Acta. Inform Med., vol. 24, no 1, pp. 66–8. doi: 10.5455/aim.2016.24.66-68.

30. Deleuze J., Maurage P., Schimmenti A. (2019) Escaping reality through videogames is linked to an implicit preference for virtual over real-life stimuli. J. Affect Disord., vol. 245, pp. 1024–1031. doi: 10.1016/j.jad.2018.11.078.

31. Kim D.J., Kim K., Lee H.W. (2017) Internet Game Addiction, Depression, and Escape From Negative Emotions in Adulthood: A Nationwide Community Sample of Korea. J. Nerv. Ment. Dis, vol. 205, no 7, pp. 568–573. doi: 10.1097/NMD.0000000000000698.

Recipe. 2019; : 599-611

Psychological and Pharmacological Treatment Aspects of Posttraumatic Stress Disorder and Virtual Addiction

Sholojko N. , Matveeva E. , Lysenko O. , Lysenko T.

Abstract

Modern society is influenced by many stressful phenomena. Wars, diseases, acts of terrorism, conflicts and other negative manifestations endanger the psycho-physical health of a person. Therefore, posttraumatic stress disorder (PTSD) can have a significant impact on human social activity. However, the use of different industrial medicines (drugs), herbal medicines and psychotherapy can contribute to improving of patients’ quality of life. Modern media technologies are closely related to the daily life of a person. Therefore, the use of virtual space can play the role of distraction therapy (games, social networks, shopping and other activities). Such an activity due to the desire to get away from the traumatic event was called "Escaping". Quick access to various information, services, goods, communication, entertainment allows a person to escape from heavy emotions. A person is able to spend a lot of free time in virtual space in order to distract from painful memories or events. Unfortunately, this can contribute to the development of virtual addiction. Problems using the virtual space can exacerbate the negative events in real life. For example, such factors include financial difficulties due to the use of gambling games. It is also likely that further development of difficulties in school, work and in communication with relatives and friends. It is worth noting that virtual addiction can contribute to suicidal behavior. Therefore, a person with PTSD on the background of virtual addiction is subject to additional risks. This article is devoted to certain psychological and pharmacological aspects of the onset and treatment of PTSD, as well as the manifestation of virtual addiction against the background of these problems. It is important to conduct further research to better understand the mechanisms of development of these disorders and solutions.

References

1. Williams A.C. de C., Baird E. (2016) Special considerations for the treatment of pain from torture and war. Curr. Anasthesiol. Rep., vol. 6, no 4, pp. 319–326.

2. MKB-10 (1995) Mezhdunarodnaya statisticheskaya klassifikatsiya bolezney i problem, svyazannykh so zdorov'yem: 10-y peresmotr: v 3 t. T. 1. CH. 1. Per. s angl. M. Maksimovoy, S. Chemyakinoy, L. Safronovoy [International statistical classification of diseases and related health problems: 10th [tenth] revision: in 3 V., V. 1, P. 1, translation from English M.Maksimova, S.Chemiakina, L. Safronov]. Geneva: World Health Organization, publishing house "Medicine", 697 p.

3. Davydow D.S., Lease E.D., Reyes J.D. (2015) Posttraumatic stress disorder in organ transplant recipients: a systematic review. Gen. Hosp. Psychiatry, vol. 35, no 5, pp. 387–398.

4. Shiba H., Oe M., Uchimura N. (2015) Patients with posttraumatic stress disorder with comorbid major depressive disorder require a higher dose of psychotropic drugs. Kurume medical journal, vol. 62, no 1–2, pp. 23–28.

5. Izquiero I., Furini C.R.G., Myskiw J.C. (2016) Fear memory. Physiol. rev., vol. 96, pp. 695–750.

6. Gradus J.L. (2017) Prevalence and prognosis of stress disorders: a review of the epidemiology. Clinical epidemiology, vol. 9, pp. 251–260.

7. Rigoli M.M., Silva G.R., de Olivera F.R. (2016) The role of memory in posttraumatic stress disorder: implication for clinical practice. Trends psychiatry psychother., vol. 38, no 3, pp. 119–127.

8. Agibalova T., Aleksandrovskii YU., Bocheeva E. (2015) Posttravmaticheskoe stressovoe rasstroistvo [Posttraumatic stress disorder]. Rostov n/D: Izd-vo RostGMU, 624 p.

9. Raspopin E. (2016) Metody izucheniya i otsenki psikhicheskikh sostoyaniy [Methods of study and evaluation of mental states]. Izvestiya Ural’skogo federal’nogo universiteta. Ser. 1: Problemy obrazovaniya, nauki i kul’tury [News of Ural Federal University. Series 1: Problems of education, science and culture], vol. 22, no 4 (156), pp. 129–137.

10. Amelina L., Nikolaev V., Bulgakova O. (2016) Osobennosti psikhoemotsional'nogo napryazheniya roditeley detey s addiktivnym povedeniyem [Especially emotional stress parents of children with addictive behavior]. Psychophysiology News, vol. 1, pp. 56–60.

11. Molostova N., Shcherbakova E. (2016) Psikhofiziologicheskiye i psikhosotsial'nyye osnovaniya vliyaniya detsko-roditel'skikh otnosheniy na emotsional'nuyu ustoychivost' mladshikh shkol'nikov [The psychophysiological and psychosocial bases of influence child-parent relations on emotional stability of younger schoolchild]. Vestnik psikhofiziologii, vol. 1, pp. 34–43.

12. Philipovich V. (2015) Prediktory zhiznestoykosti lichnosti pri nevrozakh i v norme [Predictors of personality hardiness in both neurotic and normal condition]. Medychna psykholohiya, no 3, pp. 7–12.

13. Chorna T. (2015) Klinika, diagnostika i printsipy psikhoterapii trevozhno-fobicheskikh rasstroystv [Clinical presentation, diagnosis and principles of psychotherapeutic correction of anxiety and phobic disorders]. Medychna psykholohiya, 3, pp. 83–86.

14. Popiel A., Zawadzki B., Pragłowska E., Teichman Y. (2015) Prolonged exposure, paroxetine and the combination in the treatment of PTSD following a motor vehicle accident. A randomized clinical trial – The "TRAKT" study. J. Behav. Ther. Exp. Psychiatry, vol. 48, pp. 17–26.

15. Zhu H., Qiu C., Meng Y. (2015) Altered spontaneous neuronal activity in chronic posttraumatic stress disorder patients before and after a 12-week paroxetine treatment. J. Affect. Disord., vol. 174, pp. 257–264.

16. Lewis R.J., Kemp P.M., Johnson R.D. (2015) Paroxetine in Postmortem Fluids and Tissues from Nine Aviation Accident Victims. J. Anal. Toxicol., vol. 39, no 8, pp. 637–641.

17. Kamo T., Maeda M., Oe M. (2016) Dosage, effectiveness, and safety of sertraline treatment for posttraumatic stress disorder in a Japanese clinical setting: a retrospective study. BMC Psychiatry, vol. 16, no1, p. 434.

18. Li W., Ma Y.B., Yang Q. (2017) Effect and safety of sertraline for treat posttraumatic stress disorder: a multicenter randomised controlled study. Int. J. Psychiatry. Clin. Pract., vol. 21, no2, pp. 151–155.

19. Pilkinton P., Berry C., Norrholm S. (2016) An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder. Psychopharmacol Bull., vol. 46, no 2, pp. 8–17.

20. Baniasadi M., Hosseini G., Fayyazi Bordbar M.R. (2014) Effect of pregabalin augmentation in treatment of patients with combat-related chronic posttraumatic stress disorder: a randomized controlled trial. J. Psychiatr. Pract., vol. 20, no 6, pp. 419–427.

21. Bicknell L.M., McFaddin C.L., Fernandez M., Parekh P. (2017) Imipramine-induced hyperpigmentation. Cutis, vol. 100, no 3, pp. 8–10.

22. Kessing L.V., Bukh J.D. (2013) Amitriptyline versus placebo for major depression. Ugeskr Laeger, vol. 175, no 34, pp. 1875–1877.

23. Arnsten A.F.T., Raskind M.A., Taylor F.B., Connor D.F. (2015) The effects of stress exposure on prefrontal cortex translating bacic research into successful treatments for post-traumatic stress disorder. Neurobiology of stress, vol. 1, pp. 89–99.

24. Murrough J.W., Yaqubi S., Sayed S., Charmey D.S. (2015) Emerging drugs for the treatment of anxiety. Expert. Opin. Emerg. Drugs, vol. 20, no 3, pp. 393–406.

25. Jeffreys M., Capehart B., Friedman M.J. (2012) Pharmacotherapy for posttraumatic stress disorder: review with clinical applications. J. Rehabil. Res. Dev., vol. 49, no 5, pp. 703–715.

26. Lim K., See Y.M., Lee J.A. (2017) Systematic Review of the Effectiveness of Medical Cannabis for Psychiatric, Movement and Neurodegenerative Disorders. Clin. Psychopharmacol. Neurosci., vol. 15, no4, pp. 301–312.

27. Grant S., Pedersen E.R., Neighbors C. (2016) Associations of Posttraumatic Stress Disorder Symptoms With Marijuana and Synthetic Cannabis Use Among Young Adult U.S. Veterans: A Pilot Investigation. J. Stud. Alcohol. Drugs, vol. 77, no 3, pp. 509–514.

28. Cohen N.L., Heinz A.J., Ilgen M., Bonn-Miller M.O. (2016) Pain, Cannabis Species, and Cannabis Use Disorders. J. Stud. Alcohol. Drugs, vol. 77, no 3, pp. 515–520.

29. Diomidous M., Chardalias K., Magita A. (2016) Social and Psychological Effects of the Internet Use. Acta. Inform Med., vol. 24, no 1, pp. 66–8. doi: 10.5455/aim.2016.24.66-68.

30. Deleuze J., Maurage P., Schimmenti A. (2019) Escaping reality through videogames is linked to an implicit preference for virtual over real-life stimuli. J. Affect Disord., vol. 245, pp. 1024–1031. doi: 10.1016/j.jad.2018.11.078.

31. Kim D.J., Kim K., Lee H.W. (2017) Internet Game Addiction, Depression, and Escape From Negative Emotions in Adulthood: A Nationwide Community Sample of Korea. J. Nerv. Ment. Dis, vol. 205, no 7, pp. 568–573. doi: 10.1097/NMD.0000000000000698.