Рецепт. 2021; : 684-702
Цинкосодержащие лекарственные препараты: от клинической фармакологии до фармацевтической помощи (часть 2)
https://doi.org/10.34883/PI.2021.24.5.007Аннотация
Избыток цинка в организме встречается крайне редко, в отличие от его дефицита. Приводится подробная характеристика состояний гипо- и гиперцинкемии. Цинкосодержащие лекарственные препараты могут применяться перорально и наружно. В статье приводятся рекомендации по off-label применению препаратов цинка, что выразилось в определении дополнительных потребительских групп населения, которым можно рекомендовать цинкосодержащие препараты в рамках комплексной фармацевтической помощи. Дополнительно показана взаимосвязь влияния цинка на течение коронавирусной инфекции COVID-19. Установлено, что в Республике Беларусь зарегистрировано 5 цинкосодержащих препаратов. Для соединений цинка рассчитано содержание элементарного цинка в каждой дозированной единице лекарственной формы. Разработан алгоритм оказания фармацевтическим работником грамотной фармацевтической помощи (в т. ч. фармацевтического консультирования) потребителю, обратившемуся в аптеку с запросом о приобретении цинкосодержащих препаратов.
Список литературы
1. Borisov V.V. (2018) Mikroelementy selen i tsink v organizme zhenshchiny i muzhchiny: problemy i resheniya [Trace elements selenium and zinc in the body of women and men: problems and solutions]. Consilium Medicum, no 7, pp. 63–68.
2. Joseph I. Boullata, Vincent T. Armenti (2010) Handbook of Drug-Nutrient Interactions, USA: Humana Press.
3. Mallappa Kumara Swamy, Jayanta Kumar Patra, Gudepalya Renukaiah Rudramurthy (2019) Medicinal plants: chemistry, pharmacology, and therapeutic applications, U.S.A.: CRC Press, Taylor & Francis Group.
4. Whittlesea C., Hodson K. (2019) Clinical pharmacy and therapeutics, UК: Elsevier.
5. A.Yu. Baranovsky (2008) Diyetologiya: Rukovodstvo [Dietetics: A Guide]. St. Petersburg: Sputnik vracha. (in Russian)
6. Ritter J., Lewis L., Mant T., Ferro A. (2008) A textbook of clinical pharmacology and therapeutics, UK: Hodder Arnold.
7. Eades M.D. (1995) Vitaminy i mineral’nyye veshchestva: Polnyy meditsinskiy spravochnik [Vitamins and Minerals: A Complete Medical Guide]. St. Petersburg: AO «Komplekt». (in Russian)
8. Chisholm-Burns M., Schwinghammer T., Wells B., Malone P., DiPiro J., Kolesar J., Katz M., Matthias K. (2016) Pharmacotherapy Principles & Practice, USA: McGraw-Hill Education.
9. Michael D. Coleman (2005) Human Drug Metabolism: An Introduction, UK: John Wiley & Sons, Ltd.
10. Deyl M.M., Formen Dzh.K. (1998) Rukovodstvo po immunofarmakologii [Immunopharmacology Guide]. Moscow: Meditsina.
11. Yovanovich L., Yermakov V. (2020) Znacheniye selena i tsinka v preduprezhdenii i lechenii nekotorykh zabolevaniy. Obzor. [The importance of selenium and zinc in the prevention and treatment of certain diseases. Review]. Biogeochemical innovations under the conditions of the biosphere technogenesis correction, no 1, pp. 71–83.
12. Nuralieva R.M. (2020) Effektivnost’ primeneniya preparatov tsinka v kompleksnoy terapii neotlozhnykh sostoyaniy u detey [The effectiveness of the use of zinc preparations in the complex therapy of emergency conditions in children]. Dostizheniya nauki i obrazovaniya, no 5 (59), pp. 76–78. (in Russian)
13. Abdullakhuzhayeva G.Kh., Nazhmutdinova D.A. (2020) Znacheniye defitsita tsinka pri infektsionnykh zabolevaniyakh [Significance of zinc deficiency in infectious diseases]. Mezhdunarodnyy akademicheskiy vestnik, no 1 (45), pp. 18–19.
14. Reyestry UP Tsentr ekspertiz i ispytaniy v zdravookhranenii [Registers of the Unitary Enterprise «Center for Expertise and Testing in Health Care»]. Available at: http://www.rceth.by (accessed July 21, 2021).
15. World Health Organization, Food and Agriculture Organization of the United Nations (2002) Human Vitamin and Mineral Requirements. Report of a joint FAO/WHO expert consultation Bangkok, Thailand, Rome.
16. Bryukhanov V.M., Zverev YA.F., Lampatov V.V., Zharikov A.Yu., Talalayeva O.S. (2014) Lektsii po farmakologii dlya vysshego meditsinskogo i farmatsevticheskogo obrazovaniya [Pharmacology lectures for higher medical and pharmaceutical education]. Barnaul: Spektr. (in Russian)
17. Babak O.Ya., Belovol A.N., Chekman I.S. (2012) Klinicheskaya farmakologiya [Clinical pharmacology]. Kiev: VSY «Meditsina». (in Russian)
18. Ivashkin V.T., Lapina T.L. (2003) Ratsional’naya farmakoterapiya zabolevaniy organov pishchevareniya: Rukovodstvo dlya praktikuyushchikh vrachey [Rational Pharmacotherapy of Diseases of the Digestive System: A Guide for Practitioners]. Moscow: Litterra. (in Russian)
19. Carolyn D. Berdanier, Johanna T. Dwyer, David Heber (2013) Handbook of Nutrition and Food, USAЗ: CRC Press.
20. Garmaza YU.M., Slobozhanina Ye.I. (2021) Sovremennyye biomarkery otsenki metabolicheskogo statusa tsinkav organizme cheloveka i ikh laboratorno-diagnosticheskaya znachimost’ (obzor) [Modern biomarkers for assessing the metabolic status of zinc in the human body and their laboratory diagnostic significance (review)]. Laboratornaya diagnostika. Vostochnaya Yevropa, no 1, pp. 31–41.
21. Gromova O.A., Torshin I.Yu. (2020) Vazhnost’ tsinka dlya podderzhaniya aktivnosti belkov vrozhdennogo protivovirusnogo immuniteta: analiz publikatsiy, posvyashchennykh COVID-19 [The Importance of Zinc for Maintaining the Activity of Innate Antiviral Immunity Proteins: Analysis of COVID-19 Publications]. Profilakticheskaya meditsina, no 3, pp. 131–139.
22. The International Society for Zinc Biology. Available at: http://zinc-net.com/ISZB/index.html (accessed July 27, 2021).
23. Wiffen P., Mitchell M., Snelling M., Stoner N. (2017) Oxford Handbook of Clinical Pharmacy, U.K.: Oxford University Press.
24. DiPiro J., Talbert R., Yee G., Matzke G., Wells B., Michael Posey L. (2016) Pharmacotherapy: a pathophysiologic approach, USA: McGraw-Hill Education.
25. Papadakis M., McPhee S., Rabow M. (2019) CURRENT Medical Diagnosis & Treatment, USA: McGraw-Hill Education.
26. Astafiev V.A. (2013) Osnovy farmakologii s retsepturoy: uchebnoye posobiye [Fundamentals of Pharmacology with Formulation: A Tutorial]. Moscow: KNORUS. (in Russian)
27. Drogovoz S.M., Gudzenko L.P., Butko YA.L., Drogovoz I.V. (2010) Pobochnoye deystviye lekarstv: uchebnik-spravochnik [Side effects of drugs: a reference book]. Kharkov: СММ. (in Russian)
28. Felicia N.Ekeha, Nkiru E.Ekechukwuab, Chimdinma F.Chukwumaa, Ifeanyi Oscar N.Aguziea, Chinenye M.Ohanua, Chike Ebidoa, Stanley N.Oluaha (2019) Mixed vitamin C and zinc diet supplements co-administered with artemether drug improved haematological profile and survival of mice infected with Plasmodium berghei, Food Science and Human Wellness, no 3, pp. 275–282.
29. Pyrochkin V.M.(2011) Klinicheskaya farmakologiya v terapevticheskoy praktike [Clinical pharmacology in therapeutic practice]. Grodno: GrGMU. (in Russian)
30. World Health Organization (2011) Zinc supplementation to improve treatment outcomes among children diagnosed with respiratory infections, WHO technical staff.
31. Whalen K., Sharma S., Velpandian T. (2019) Lippincott Illustrated Reviews: Pharmacology. South Asian Edition, India: Wolters Kluwer.
32. Waqas Ullah Khan, Daniel W. Sellen (2011) Zinc supplementation in the management of diarrhea, World Health Organization.
33. Blenkinsopp A., Duerden M., Blenkinsopp J. (2018) Symptoms in the pharmacy a guide to the management of common illnesses, U.S.A.: Wiley- Blackwell.
34. Bennett P.N., Brown M.J., Sharma P. (2012) Clinical pharmacology, UК: Elsevier.
35. Wells B., DiPiro J., Schwinghammer T., DiPiro C. (2015) Pharmacotherapy Handbook, USA: McGraw-Hill Education.
36. Ian Darnton-Hill (2013) Zinc supplementation and growth in children, World Health Organization.
37. Katzung B.G. (2018) Basic & Clinical Pharmacology, USA: McGraw-Hill Education.
38. Wiffen P., Mitchell M., Snelling M., Stoner N. (2017) Oxford Handbook of Clinical Pharmacy, U.K.: Oxford University Press.
Recipe. 2021; : 684-702
Zinc-Containing Medicines: from Clinical Pharmacology to Pharmaceutical Care (Part 2)
https://doi.org/10.34883/PI.2021.24.5.007Abstract
Zinc deficiency is much more common than its excess. A detailed description of the states of hypo- and hyperzinkemia is given. Zinc-containing medicines can be used orally and externally. The article provides recommendations on the off-label use of zinc medicines, which resulted in the identification of certain consumer groups of the population, who can be additionally recommended zinc-containing medicines within pharmaceutical care. Additionally, the effect of zinc on the course of coronavirus infection COVID-19 was shown. It was revealed that 5 zinc-containing medicines are registered in the Republic of Belarus. For zinc compounds, the content of elemental zinc in each dosage unit of the dosage form was calculated. There was developed the algorithm for a pharmacist to provide pharmaceutical care (including pharmaceutical consulting) to a consumer with a question about the purchase of zinc-containing medicines.
References
1. Borisov V.V. (2018) Mikroelementy selen i tsink v organizme zhenshchiny i muzhchiny: problemy i resheniya [Trace elements selenium and zinc in the body of women and men: problems and solutions]. Consilium Medicum, no 7, pp. 63–68.
2. Joseph I. Boullata, Vincent T. Armenti (2010) Handbook of Drug-Nutrient Interactions, USA: Humana Press.
3. Mallappa Kumara Swamy, Jayanta Kumar Patra, Gudepalya Renukaiah Rudramurthy (2019) Medicinal plants: chemistry, pharmacology, and therapeutic applications, U.S.A.: CRC Press, Taylor & Francis Group.
4. Whittlesea C., Hodson K. (2019) Clinical pharmacy and therapeutics, UK: Elsevier.
5. A.Yu. Baranovsky (2008) Diyetologiya: Rukovodstvo [Dietetics: A Guide]. St. Petersburg: Sputnik vracha. (in Russian)
6. Ritter J., Lewis L., Mant T., Ferro A. (2008) A textbook of clinical pharmacology and therapeutics, UK: Hodder Arnold.
7. Eades M.D. (1995) Vitaminy i mineral’nyye veshchestva: Polnyy meditsinskiy spravochnik [Vitamins and Minerals: A Complete Medical Guide]. St. Petersburg: AO «Komplekt». (in Russian)
8. Chisholm-Burns M., Schwinghammer T., Wells B., Malone P., DiPiro J., Kolesar J., Katz M., Matthias K. (2016) Pharmacotherapy Principles & Practice, USA: McGraw-Hill Education.
9. Michael D. Coleman (2005) Human Drug Metabolism: An Introduction, UK: John Wiley & Sons, Ltd.
10. Deyl M.M., Formen Dzh.K. (1998) Rukovodstvo po immunofarmakologii [Immunopharmacology Guide]. Moscow: Meditsina.
11. Yovanovich L., Yermakov V. (2020) Znacheniye selena i tsinka v preduprezhdenii i lechenii nekotorykh zabolevaniy. Obzor. [The importance of selenium and zinc in the prevention and treatment of certain diseases. Review]. Biogeochemical innovations under the conditions of the biosphere technogenesis correction, no 1, pp. 71–83.
12. Nuralieva R.M. (2020) Effektivnost’ primeneniya preparatov tsinka v kompleksnoy terapii neotlozhnykh sostoyaniy u detey [The effectiveness of the use of zinc preparations in the complex therapy of emergency conditions in children]. Dostizheniya nauki i obrazovaniya, no 5 (59), pp. 76–78. (in Russian)
13. Abdullakhuzhayeva G.Kh., Nazhmutdinova D.A. (2020) Znacheniye defitsita tsinka pri infektsionnykh zabolevaniyakh [Significance of zinc deficiency in infectious diseases]. Mezhdunarodnyy akademicheskiy vestnik, no 1 (45), pp. 18–19.
14. Reyestry UP Tsentr ekspertiz i ispytaniy v zdravookhranenii [Registers of the Unitary Enterprise «Center for Expertise and Testing in Health Care»]. Available at: http://www.rceth.by (accessed July 21, 2021).
15. World Health Organization, Food and Agriculture Organization of the United Nations (2002) Human Vitamin and Mineral Requirements. Report of a joint FAO/WHO expert consultation Bangkok, Thailand, Rome.
16. Bryukhanov V.M., Zverev YA.F., Lampatov V.V., Zharikov A.Yu., Talalayeva O.S. (2014) Lektsii po farmakologii dlya vysshego meditsinskogo i farmatsevticheskogo obrazovaniya [Pharmacology lectures for higher medical and pharmaceutical education]. Barnaul: Spektr. (in Russian)
17. Babak O.Ya., Belovol A.N., Chekman I.S. (2012) Klinicheskaya farmakologiya [Clinical pharmacology]. Kiev: VSY «Meditsina». (in Russian)
18. Ivashkin V.T., Lapina T.L. (2003) Ratsional’naya farmakoterapiya zabolevaniy organov pishchevareniya: Rukovodstvo dlya praktikuyushchikh vrachey [Rational Pharmacotherapy of Diseases of the Digestive System: A Guide for Practitioners]. Moscow: Litterra. (in Russian)
19. Carolyn D. Berdanier, Johanna T. Dwyer, David Heber (2013) Handbook of Nutrition and Food, USAZ: CRC Press.
20. Garmaza YU.M., Slobozhanina Ye.I. (2021) Sovremennyye biomarkery otsenki metabolicheskogo statusa tsinkav organizme cheloveka i ikh laboratorno-diagnosticheskaya znachimost’ (obzor) [Modern biomarkers for assessing the metabolic status of zinc in the human body and their laboratory diagnostic significance (review)]. Laboratornaya diagnostika. Vostochnaya Yevropa, no 1, pp. 31–41.
21. Gromova O.A., Torshin I.Yu. (2020) Vazhnost’ tsinka dlya podderzhaniya aktivnosti belkov vrozhdennogo protivovirusnogo immuniteta: analiz publikatsiy, posvyashchennykh COVID-19 [The Importance of Zinc for Maintaining the Activity of Innate Antiviral Immunity Proteins: Analysis of COVID-19 Publications]. Profilakticheskaya meditsina, no 3, pp. 131–139.
22. The International Society for Zinc Biology. Available at: http://zinc-net.com/ISZB/index.html (accessed July 27, 2021).
23. Wiffen P., Mitchell M., Snelling M., Stoner N. (2017) Oxford Handbook of Clinical Pharmacy, U.K.: Oxford University Press.
24. DiPiro J., Talbert R., Yee G., Matzke G., Wells B., Michael Posey L. (2016) Pharmacotherapy: a pathophysiologic approach, USA: McGraw-Hill Education.
25. Papadakis M., McPhee S., Rabow M. (2019) CURRENT Medical Diagnosis & Treatment, USA: McGraw-Hill Education.
26. Astafiev V.A. (2013) Osnovy farmakologii s retsepturoy: uchebnoye posobiye [Fundamentals of Pharmacology with Formulation: A Tutorial]. Moscow: KNORUS. (in Russian)
27. Drogovoz S.M., Gudzenko L.P., Butko YA.L., Drogovoz I.V. (2010) Pobochnoye deystviye lekarstv: uchebnik-spravochnik [Side effects of drugs: a reference book]. Kharkov: SMM. (in Russian)
28. Felicia N.Ekeha, Nkiru E.Ekechukwuab, Chimdinma F.Chukwumaa, Ifeanyi Oscar N.Aguziea, Chinenye M.Ohanua, Chike Ebidoa, Stanley N.Oluaha (2019) Mixed vitamin C and zinc diet supplements co-administered with artemether drug improved haematological profile and survival of mice infected with Plasmodium berghei, Food Science and Human Wellness, no 3, pp. 275–282.
29. Pyrochkin V.M.(2011) Klinicheskaya farmakologiya v terapevticheskoy praktike [Clinical pharmacology in therapeutic practice]. Grodno: GrGMU. (in Russian)
30. World Health Organization (2011) Zinc supplementation to improve treatment outcomes among children diagnosed with respiratory infections, WHO technical staff.
31. Whalen K., Sharma S., Velpandian T. (2019) Lippincott Illustrated Reviews: Pharmacology. South Asian Edition, India: Wolters Kluwer.
32. Waqas Ullah Khan, Daniel W. Sellen (2011) Zinc supplementation in the management of diarrhea, World Health Organization.
33. Blenkinsopp A., Duerden M., Blenkinsopp J. (2018) Symptoms in the pharmacy a guide to the management of common illnesses, U.S.A.: Wiley- Blackwell.
34. Bennett P.N., Brown M.J., Sharma P. (2012) Clinical pharmacology, UK: Elsevier.
35. Wells B., DiPiro J., Schwinghammer T., DiPiro C. (2015) Pharmacotherapy Handbook, USA: McGraw-Hill Education.
36. Ian Darnton-Hill (2013) Zinc supplementation and growth in children, World Health Organization.
37. Katzung B.G. (2018) Basic & Clinical Pharmacology, USA: McGraw-Hill Education.
38. Wiffen P., Mitchell M., Snelling M., Stoner N. (2017) Oxford Handbook of Clinical Pharmacy, U.K.: Oxford University Press.
