Рецепт. 2021; 24: 558-574
Цинкосодержащие лекарственные препараты: от клинической фармакологии до фармацевтической помощи (часть 1)
https://doi.org/10.34883/PI.2021.24.4.012Аннотация
Цинк является вторым по распространенности после железа микроэлементом в организме человека и содержится преимущественно в мышцах и костях, красных кровяных тельцах. Рекомендованным биомаркером статуса цинка в организме является уровень его концентрации в плазме крови. Это связано с тем, что данный уровень цинка находится под строгим гомеостатическим контролем. В статье уделено внимание исторической роли цинка в медицине, описана его биологическая и физиологическая роль в организме, связанные с ним фармакодинамические эффекты лекарственных препаратов. Систематизирована информация по показаниям к применению и противопоказаниям (в т. ч. применение во время беременности), нежелательным реакциям и лекарственным взаимодействиям с позиции причинно-следственных связей, опирающихся на биохимические, фармакодинамические и фармакокинетические особенности соединений цинка. Установлено, что соли цинка обладают низкой биодоступностью (зависят от типа соединения и лекарственной формы), всасываются в тонком кишечнике с участием нескольких транспортеров, а почки и желудочно-кишечный тракт обеспечивают важную роль в поддержании гомеостаза цинка.
Список литературы
1. Eades M.D. (1995) Vitaminy i mineral’nyye veshchestva: Polnyy meditsinskiy spravochnik [Vitamins and Minerals: Complete Medical Guide]. St. Petersburg: AO «Komplekt». (in Russian)
2. Borisov V.V. (2018) Mikroelementy selen i tsink v organizme zhenshchiny i muzhchiny: problemy i resheniya [Trace elements selenium and zinc in the body of women and men: problems and solutions]. Consilium Medicum, no. 7, pp. 63–68.
3. Rainsford K.O., Milanino R., Sorenson J.R.J., Veio G.P. (1998) Copper and Zinc in Inflammatory and Degenerative Diseases, U.S.A.: Springer Science + Business Media Dordrecht.
4. Baranovsky A.Yu. (2008) Diyetologiya: Rukovodstvo [Dietetics: Guide]. St. Petersburg: Sputnik vracha. (in Russian)
5. Garmaza Yu.M., Slobozhanina Ye.I. (2021) Sovremennyye biomarkery otsenki metabolicheskogo statusa tsinkav organizme cheloveka i ikh laboratorno-diagnosticheskaya znachimost’(obzor) [Modern biomarkers for assessing the metabolic status of zinc in the human body and their laboratory diagnostic significance (review)]. Laboratornaya diagnostika. Vostochnaya Yevropa, no. 1, pp. 31–41.
6. Carolyn D. Berdanier, Johanna T. Dwyer, David Heber (2013) Handbook of Nutrition and Food, USAЗ: CRC Press.
7. The International Society for Zinc Biology. Available at: http://zinc-net.com/ISZB/index.html (accessed July 27, 2021).
8. Felicia N. Ekeha, Nkiru E. Ekechukwuab, Chimdinma F. Chukwumaa, Ifeanyi Oscar N. Aguziea, Chinenye M. Ohanua, Chike Ebidoa, Stanley N. Oluaha (2019) Mixed vitamin C and zinc diet supplements co-administered with artemether drug improved haematological profile and survival of mice infected with Plasmodium berghei, Food Science and Human Wellness, no 3, pp. 275–282.
9. Joseph I. Boullata, Vincent T. Armenti (2010) Handbook of Drug-Nutrient Interactions, USA: Humana Press.
10. Mallappa Kumara Swamy, Jayanta Kumar Patra, Gudepalya Renukaiah Rudramurthy (2019) Medicinal plants: chemistry, pharmacology, and therapeutic applications, U.S.A.: CRC Press, Taylor & Francis Group.
11. Whittlesea C., Hodson K. (2019) Clinical pharmacy and therapeutics, UК: Elsevier.
12. Ritter J., Lewis L., Mant T., Ferro A. (2008) A textbook of clinical pharmacology and therapeutics, UK: Hodder Arnold.
13. Chisholm-Burns M., Schwinghammer T., Wells B., Malone P., DiPiro J., Kolesar J., Katz M., Matthias K. (2016) Pharmacotherapy Principles & Practice, USA: McGraw-Hill Education.
14. Michael D. Coleman (2005) Human Drug Metabolism: An Introduction, UK: John Wiley & Sons, Ltd.
15. Deyl M.M., Formen Dzh.K. (1998) Rukovodstvo po immunofarmakologii [Immunopharmacology Guide]. Moscow: Meditsina.
16. Bennett P.N., Brown M.J., Sharma P. (2012) Clinical pharmacology, UК: Elsevier.
17. Yovanovich L., Yermakov V. (2020) Znacheniye selena i tsinka v preduprezhdenii i lechenii nekotorykh zabolevaniy. Obzor. [The importance of selenium and zinc in the prevention and treatment of certain diseases. Review]. Biogeochemical innovations under the conditions of the biosphere technogenesis correction, no 1, pp. 71–83.
18. DiPiro J., Talbert R., Yee G., Matzke G., Wells B., Michael Posey L. (2016) Pharmacotherapy: a pathophysiologic approach, USA: McGraw-Hill Education.
19. Nuralieva R.M. (2020) Effektivnost’ primeneniya preparatov tsinka v kompleksnoy terapii neotlozhnykh sostoyaniy u detey [Effectiveness of the use of zinc preparations in the complex therapy of emergency conditions in children]. Dostizheniya nauki i obrazovaniya, no 5 (59), pp. 76–78.
20. Astafiev V.A. (2013) Osnovy farmakologii s retsepturoy: uchebnoye posobiye [Fundamentals of Pharmacology with Formulation: Tutorial]. Moscow: KNORUS. (in Russian)
21. Katzung B.G. (2018) Basic & Clinical Pharmacology, USA: McGraw-Hill Education.
22. Reyestry UP Tsentr ekspertiz i ispytaniy v zdravookhranenii [Registers of the Unitary Enterprise“Center for Expertise and Testing in Health Care”]. Available at: http://www.rceth.by (accessed July 21, 2021).
23. Abdullakhuzhayeva G.Kh., Nazhmutdinova D.A. (2020) Znacheniye defitsita tsinka pri infektsionnykh zabolevaniyakh [Significance of zinc deficiency in infectious diseases]. Mezhdunarodnyy akademicheskiy vestnik, no 1 (45), pp. 18–19.
24. World Health Organization, Food and Agriculture Organization of the United Nations (2002) Human Vitamin and Mineral Requirements. Report of a joint FAO/WHO expert consultation Bangkok, Thailand, Rome.
25. Joachimiak M.P. (2021) Zinc against COVID-19? Symptom surveillance and deficiency risk groups. PLOS Neglected Tropical Diseases, no 15(1):e0008895. doi.org/10.1371/journal.pntd.0008895.
26. ATC/DDD Index 2021. WHO Collaborating Centre for Drug Statistics Methodology Available at: https://www.whocc.no/atc_ddd_index (accessed July 21, 2021).
27. World Health Organization (2007) Production of zinc tablets and zinc oral solutions: guidelines for programme managers and pharmaceutical manufacturers, WHO Library.
28. Blenkinsopp A., Duerden M., Blenkinsopp J. (2018) Symptoms in the pharmacy a guide to the management of common illnesses, U.S.A.: WileyBlackwell.
29. Bryukhanov V.M., Zverev YA.F., Lampatov V.V., Zharikov A.Yu., Talalayeva O.S. (2014) Lektsii po farmakologii dlya vysshego meditsinskogo i farmatsevticheskogo obrazovaniya [Pharmacology lectures for higher medical and pharmaceutical education]. Barnaul: Spektr. (in Russian)
30. Kubanova A.A., Kisina V.I., Blatun L.A., Vavilov A.M. and etc. (2005) Ratsional’naya farmakoterapiya zabolevaniy kozhi i infektsiy, peredavayemykh polovym putem: Rukovodstvo dlya praktikuyushchikh vrachey [Rational Pharmacotherapy for Skin Diseases and Sexually Transmitted Infections: Guide for Practitioners]. Moscow: Litterra. (in Russian)
31. Babak O.Ya., Belovol A.N., Chekman I.S. (2012) Klinicheskaya farmakologiya [Clinical pharmacology]. Kiev: VSY «Meditsina». (in Russian)
32. Ivashkin V.T., Lapina T.L. (2003) Ratsional’naya farmakoterapiya zabolevaniy organov pishchevareniya: Rukovodstvo dlya praktikuyushchikh vrachey [Rational Pharmacotherapy of Diseases of the Digestive System: A Guide for Practitioners]. Moscow: Litterra. (in Russian)
33. Whalen K., Sharma S., Velpandian T. (2019) Lippincott Illustrated Reviews: Pharmacology. South Asian Edition, India: Wolters Kluwer.
34. Schlossberg David, Samuel Rafik (2017) Antibiotics manual: a guide to commonly used antimicrobials, USA: Wiley.
35. Gersch, Carolyn J., Heimgartner, Nicole M., Rebar, Cherie R., Willis, Laura M. (2017) Pharmacology made incredibly easy! U.S.A., Philadelphia: Wolters Kluwer Health.
Recipe. 2021; 24: 558-574
Zinc-Containing Medicines: from Clinical Pharmacology to Pharmaceutical Care (Part 1)
https://doi.org/10.34883/PI.2021.24.4.012Abstract
Цинк является вторым по распространенности после железа микроэлементом в организме человека и содержится преимущественно в мышцах и костях, красных кровяных тельцах. Рекомендованным биомаркером статуса цинка в организме является уровень его концентрации в плазме крови. Это связано с тем, что данный уровень цинка находится под строгим гомеостатическим контролем. В статье уделено внимание исторической роли цинка в медицине, описана его биологическая и физиологическая роль в организме, связанные с ним фармакодинамические эффекты лекарственных препаратов. Систематизирована информация по показаниям к применению и противопоказаниям (в т. ч. применение во время беременности), нежелательным реакциям и лекарственным взаимодействиям с позиции причинно-следственных связей, опирающихся на биохимические, фармакодинамические и фармакокинетические особенности соединений цинка. Установлено, что соли цинка обладают низкой биодоступностью (зависят от типа соединения и лекарственной формы), всасываются в тонком кишечнике с участием нескольких транспортеров, а почки и желудочно-кишечный тракт обеспечивают важную роль в поддержании гомеостаза цинка.
References
1. Eades M.D. (1995) Vitaminy i mineral’nyye veshchestva: Polnyy meditsinskiy spravochnik [Vitamins and Minerals: Complete Medical Guide]. St. Petersburg: AO «Komplekt». (in Russian)
2. Borisov V.V. (2018) Mikroelementy selen i tsink v organizme zhenshchiny i muzhchiny: problemy i resheniya [Trace elements selenium and zinc in the body of women and men: problems and solutions]. Consilium Medicum, no. 7, pp. 63–68.
3. Rainsford K.O., Milanino R., Sorenson J.R.J., Veio G.P. (1998) Copper and Zinc in Inflammatory and Degenerative Diseases, U.S.A.: Springer Science + Business Media Dordrecht.
4. Baranovsky A.Yu. (2008) Diyetologiya: Rukovodstvo [Dietetics: Guide]. St. Petersburg: Sputnik vracha. (in Russian)
5. Garmaza Yu.M., Slobozhanina Ye.I. (2021) Sovremennyye biomarkery otsenki metabolicheskogo statusa tsinkav organizme cheloveka i ikh laboratorno-diagnosticheskaya znachimost’(obzor) [Modern biomarkers for assessing the metabolic status of zinc in the human body and their laboratory diagnostic significance (review)]. Laboratornaya diagnostika. Vostochnaya Yevropa, no. 1, pp. 31–41.
6. Carolyn D. Berdanier, Johanna T. Dwyer, David Heber (2013) Handbook of Nutrition and Food, USAZ: CRC Press.
7. The International Society for Zinc Biology. Available at: http://zinc-net.com/ISZB/index.html (accessed July 27, 2021).
8. Felicia N. Ekeha, Nkiru E. Ekechukwuab, Chimdinma F. Chukwumaa, Ifeanyi Oscar N. Aguziea, Chinenye M. Ohanua, Chike Ebidoa, Stanley N. Oluaha (2019) Mixed vitamin C and zinc diet supplements co-administered with artemether drug improved haematological profile and survival of mice infected with Plasmodium berghei, Food Science and Human Wellness, no 3, pp. 275–282.
9. Joseph I. Boullata, Vincent T. Armenti (2010) Handbook of Drug-Nutrient Interactions, USA: Humana Press.
10. Mallappa Kumara Swamy, Jayanta Kumar Patra, Gudepalya Renukaiah Rudramurthy (2019) Medicinal plants: chemistry, pharmacology, and therapeutic applications, U.S.A.: CRC Press, Taylor & Francis Group.
11. Whittlesea C., Hodson K. (2019) Clinical pharmacy and therapeutics, UK: Elsevier.
12. Ritter J., Lewis L., Mant T., Ferro A. (2008) A textbook of clinical pharmacology and therapeutics, UK: Hodder Arnold.
13. Chisholm-Burns M., Schwinghammer T., Wells B., Malone P., DiPiro J., Kolesar J., Katz M., Matthias K. (2016) Pharmacotherapy Principles & Practice, USA: McGraw-Hill Education.
14. Michael D. Coleman (2005) Human Drug Metabolism: An Introduction, UK: John Wiley & Sons, Ltd.
15. Deyl M.M., Formen Dzh.K. (1998) Rukovodstvo po immunofarmakologii [Immunopharmacology Guide]. Moscow: Meditsina.
16. Bennett P.N., Brown M.J., Sharma P. (2012) Clinical pharmacology, UK: Elsevier.
17. Yovanovich L., Yermakov V. (2020) Znacheniye selena i tsinka v preduprezhdenii i lechenii nekotorykh zabolevaniy. Obzor. [The importance of selenium and zinc in the prevention and treatment of certain diseases. Review]. Biogeochemical innovations under the conditions of the biosphere technogenesis correction, no 1, pp. 71–83.
18. DiPiro J., Talbert R., Yee G., Matzke G., Wells B., Michael Posey L. (2016) Pharmacotherapy: a pathophysiologic approach, USA: McGraw-Hill Education.
19. Nuralieva R.M. (2020) Effektivnost’ primeneniya preparatov tsinka v kompleksnoy terapii neotlozhnykh sostoyaniy u detey [Effectiveness of the use of zinc preparations in the complex therapy of emergency conditions in children]. Dostizheniya nauki i obrazovaniya, no 5 (59), pp. 76–78.
20. Astafiev V.A. (2013) Osnovy farmakologii s retsepturoy: uchebnoye posobiye [Fundamentals of Pharmacology with Formulation: Tutorial]. Moscow: KNORUS. (in Russian)
21. Katzung B.G. (2018) Basic & Clinical Pharmacology, USA: McGraw-Hill Education.
22. Reyestry UP Tsentr ekspertiz i ispytaniy v zdravookhranenii [Registers of the Unitary Enterprise“Center for Expertise and Testing in Health Care”]. Available at: http://www.rceth.by (accessed July 21, 2021).
23. Abdullakhuzhayeva G.Kh., Nazhmutdinova D.A. (2020) Znacheniye defitsita tsinka pri infektsionnykh zabolevaniyakh [Significance of zinc deficiency in infectious diseases]. Mezhdunarodnyy akademicheskiy vestnik, no 1 (45), pp. 18–19.
24. World Health Organization, Food and Agriculture Organization of the United Nations (2002) Human Vitamin and Mineral Requirements. Report of a joint FAO/WHO expert consultation Bangkok, Thailand, Rome.
25. Joachimiak M.P. (2021) Zinc against COVID-19? Symptom surveillance and deficiency risk groups. PLOS Neglected Tropical Diseases, no 15(1):e0008895. doi.org/10.1371/journal.pntd.0008895.
26. ATC/DDD Index 2021. WHO Collaborating Centre for Drug Statistics Methodology Available at: https://www.whocc.no/atc_ddd_index (accessed July 21, 2021).
27. World Health Organization (2007) Production of zinc tablets and zinc oral solutions: guidelines for programme managers and pharmaceutical manufacturers, WHO Library.
28. Blenkinsopp A., Duerden M., Blenkinsopp J. (2018) Symptoms in the pharmacy a guide to the management of common illnesses, U.S.A.: WileyBlackwell.
29. Bryukhanov V.M., Zverev YA.F., Lampatov V.V., Zharikov A.Yu., Talalayeva O.S. (2014) Lektsii po farmakologii dlya vysshego meditsinskogo i farmatsevticheskogo obrazovaniya [Pharmacology lectures for higher medical and pharmaceutical education]. Barnaul: Spektr. (in Russian)
30. Kubanova A.A., Kisina V.I., Blatun L.A., Vavilov A.M. and etc. (2005) Ratsional’naya farmakoterapiya zabolevaniy kozhi i infektsiy, peredavayemykh polovym putem: Rukovodstvo dlya praktikuyushchikh vrachey [Rational Pharmacotherapy for Skin Diseases and Sexually Transmitted Infections: Guide for Practitioners]. Moscow: Litterra. (in Russian)
31. Babak O.Ya., Belovol A.N., Chekman I.S. (2012) Klinicheskaya farmakologiya [Clinical pharmacology]. Kiev: VSY «Meditsina». (in Russian)
32. Ivashkin V.T., Lapina T.L. (2003) Ratsional’naya farmakoterapiya zabolevaniy organov pishchevareniya: Rukovodstvo dlya praktikuyushchikh vrachey [Rational Pharmacotherapy of Diseases of the Digestive System: A Guide for Practitioners]. Moscow: Litterra. (in Russian)
33. Whalen K., Sharma S., Velpandian T. (2019) Lippincott Illustrated Reviews: Pharmacology. South Asian Edition, India: Wolters Kluwer.
34. Schlossberg David, Samuel Rafik (2017) Antibiotics manual: a guide to commonly used antimicrobials, USA: Wiley.
35. Gersch, Carolyn J., Heimgartner, Nicole M., Rebar, Cherie R., Willis, Laura M. (2017) Pharmacology made incredibly easy! U.S.A., Philadelphia: Wolters Kluwer Health.
