Рецепт. 2021; : 323-331
Микробиота желудочно-кишечного тракта и иммунитет
https://doi.org/10.34883/PI.2021.24.3.002Аннотация
Микробиота желудочно-кишечного тракта (ЖКТ) состоит из динамичного многовидового сообщества, живущего в определенной нише во взаимной синергии с организмом-хозяином. Недавние результаты показали роль микробиоты ЖКТ в модуляции иммунитета хозяина и развитии и прогрессировании заболеваний. Пробиотики определяются как живые микроорганизмы, которые при их назначении в адекватных количествах приносят пользу для здоровья хозяина. Среди прочего пробиотики имеют иммуномодулирующие свойства, которые обычно реализуются непосредственно, увеличивая активность макрофагов или естественных клетоккиллеров, модулируя секрецию иммуноглобулинов или цитокинов, или косвенно, усиливая эпителиальный барьер кишечника, изменяя секрецию слизи и конкурентно исключая другие (патогенные) бактерии.
Список литературы
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Recipe. 2021; : 323-331
The Gut Microbiota and Immunity
https://doi.org/10.34883/PI.2021.24.3.002Abstract
The gut microbiota consists of a dynamic multispecies community living within a particular niche in a mutual synergy with the host organism. Recent findings have revealed the roles for the gut microbiota in the modulation of host immunity and the development and progression of diseases. Nutritional modulation of the immune system has applications within the clinical setting, but can also have a role in healthy population. Probiotics are living microorganisms that, in specific conditions, confer a health benefit to the host. Among others, probiotics have immunomodulatory properties that act directly by increasing the activity of macrophages or natural killer cells, modulating the secretion of immunoglobulins or cytokines, or indirectly by enhancing the gut epithelial barrier, altering the mucus secretion, and competitively excluding other (pathogenic) bacteria.
References
1. Human Microbiome Project Consortium (2012) Structure, function and diversity of the healthy human microbiome. Nature, vol.86, pp.207–214. doi: 10.1038/nature11234.
2. Human Microbiome Project Consortium (2012) A framework for human microbiome research. Nature, vol. 486, pp. 215–221. doi: 10.1038/nature11209.
3. Stoma I., Karpov I. (2018) The human microbiome. Minsk : Dr. Design, 122 p. (in Russian)
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5. Li X., Liu L., Cao Z., Li W., Li H., Lu C., Yang X., Liu Y. (2020) Gut microbiota as an "invisible organ" that modulates the function of drugs. Biomed. Pharmacother., vol.121, 109653. doi: 10.1016/j.biopha.2019.109653.
6. Rinninella E., Raoul P., Cintoni M., Franceschi F., Miggiano G.A.D., Gasbarrini A., Mele M.C. (2019) What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms, vol.7, pp.14. doi: 10.3390/microorganisms7010014.
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21. Allaire J.M., Crowley S.M., Law H.T., Chang S.-Y., Ko H.-J., Vallance B.A. (2018) The intestinal epithelium: central coordinator of mucosal immunity. Trends Immunol., vol.39, no 9, pp.677–696. doi: 10.1016/j.it.2018.04.002.
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24. Dong L., Xie J., Wang Y., Zuo D. (2020) Gut microbiota and immune responses. Adv. Exp. Med. Biol., vol.238, pp. 65–193. doi: 10.1007/978-981-15-2385-4_10.
25. Anand S., Mande S.S. (2018) Diet, microbiota and gut-lung connection. Front. Microbiol., vol.9, pp.2147. doi: 10.3389/fmicb.2018.02147.
26. El Aidy S., Dinan T.G., Cryan J.F. (2014) Immune modulation of the brain-gut-microbe axis. Front. Microbiol., vol. 5, pp. 146. doi: 10.3389/fmicb.2014.00146
27. Guillemard E., Tondu F., Lacoin F., Schrezenmeir J. (2010) Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Br. J. Nutr., vol.103, pp.58–68. doi: 10.1017/S0007114509991395.
28. Kataoka K. (2016) The intestinal microbiota and its role in human health and disease. J. Med. Invest., vol.63, no 1–2, pp.27–37. doi: 10.2152/jmi.63.27.
29. Turchet P., Laurenzano M., Auboiron S., Antoine J.M. (2003) Effect of fermented milk containing the probiotic Lactobacillus casei DN-114001 on winter infections in free-living elderly subjects: A randomised, controlled pilot study. J. Nutr. Health Aging, vol.7, pp.75–77.
30. La Fata G., Weber P., Hasan Mohajeri M. (2018) Probiotics and the gut immune system: Indirect regulation. Probiotics Antimicrob. Prot., vol.10, pp.11–21. doi: 10.1007/s12602-017
31. Weyh C., Krüger K., Strasser B. (2020) Physical activity and diet shape the immune system during aging. Nutrients, vol.20, no 12, p.622. doi: 10.3390/nu12030622
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36. Mañé J., Pedrosa E., Lorén V., Gassull M.A., Espadaler J., Cuñé J., Audivert S., Bonachera M.A., Cabré E. (2011) A mixture of Lactobacillus plantarum CECT 7315 and CECT 7316 enhances systemic immunity in elderly subjects. A dose-response, double-blind, placebo-controlled, randomized pilot trial. Nutr. Hosp., vol.26, pp.228–235.
37. Luoto R., Ruuskanen O., Waris M., Kalliomaki M., Salminen S., Isolauri E. (2014) Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: a randomized, placebo-controlled trial. J. Allergy Clin. Immunol., vol.133, pp.405–13. doi: 10.1016/j.jaci.2013.08.020
38. Waki N., Matsumoto M., Fukui Y., Suganuma H. (2014) Effects of probiotic Lactobacillus brevis KB290 on incidence of influenza infection among schoolchildren: an open-label pilot study. Lett Appl Microbiol., vol.59, pp.565–571. doi: 10.1111/lam.12340
39. Namba K., Hatano M., Yaeshima T., Takase M., Suzuki K. (2010) Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly. Biosci Biotechnol. Biochem., vol. 74, pp. 939–845. doi: 10.1271/bbb.90749
40. Turner R.B., Woodfolk J.A., Borish L., Steinke J.W., Patrie J.T., Muehling L.M. (2017) Effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection – a randomised controlled trial. Benef. Microbes, vol.8, pp.207–215. doi: 10.3920/BM2016.0160
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