Рецепт. 2018; : 119-127
Атопический дерматит:настоящее и будущее фармакотерапии
Аннотация
Атопический дерматит (АД) - изнуряющее заболевание, которое существенно нарушает качество жизни у одного из 4 детей и одного из 10 взрослых. Современное лечение АД является комплексным, включающим симптоматическую терапию, направленную на подавление воспалительного ответа и восстановление барьерной функции кожи, снижение частоты обострений заболевания, профилактику вторичной инфекции кожи. Системная терапия АД показана пациентам с тяжелым заболеванием, рефрактерным к адекватному топическому лечению. Доступные в настоящее время препараты направлены на снижение воспаления, подавляя и/или модулируя иммунный ответ, и таким образом косвенно улучшают функцию кожного барьера, приводящую к уменьшению клинических признаков и симптомов.
Список литературы
1. Ahrens B. (2015) Chemokine levels in serum of children with atopic dermatitis with regard to severity and sensitization status. Pediatric Allergy and Immunology, vol. 26, no 7, pp. 634-640.
2. Bager P. (2016) Filaggrin genotype and skin diseases independent of atopic dermatitis in childhood. Pediatric Allergy and Immunology, vol. 27, no 2, pp. 162-168.
3. Breuer K. (2014) Predictors of benefit from an atopic dermatitis education programme. Pediatric Allergy and Immunology, vol. 25, no 5, pp. 489-495.
4. Cipriani F. (2014) Recent advances in epidemiology and prevention of atopic eczema. Pediatric Allergy and Immunology, vol. 25, no 7, pp. 630-638.
5. Gerbens L.A.A. (2016) Evaluation of the measurement properties of symptom measurement instruments for atopic eczema: a systematic review. Allergy, vol. 72, no 1, pp. 146-163.
6. Howell M.D. (2015) Past, present, and future for biologic intervention in atopic dermatitis. Allergy, vol. 70, no 8, pp. 887-896.
7. Lee E. (2016) Atopic dermatitis phenotype with early onset and high serum IL-13 is linked to the new development of bronchial hyperresponsiveness in school children. Allergy, vol. 71, no 5, pp. 692-700.
8. Luger T. (2015) Pimecrolimus in atopic dermatitis: Consensus on safety and the need to allow use in infants. Pediatric Allergy and Immunology, vol. 26, no 4, pp. 306-315.
9. Simon S., Bieber T. (2014) Systemic therapy for atopic dermatitis. Allergy, vol. 69, no 1, pp. 46-55.
10. Wang S.S. (2014) Vitamin D deficiency is associated with diagnosis and severity of childhood atopic dermatitis. Pediatric Allergy and Immunology, vol. 25, no 1, pp. 30-35.
11. Wollenberg A. (2013) Atopic dermatitis and skin allergies - update and outlook. Allergy, vol. 68, no 12, pp. 1509-1519.
12. Wollenberg A. (2016) ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and pediatric patients. JEADV, vol. 30, pp. 729-747.
Recipe. 2018; : 119-127
Atopic dermatitis: the present and the future of pharmacotherapy
Abstract
References
1. Ahrens B. (2015) Chemokine levels in serum of children with atopic dermatitis with regard to severity and sensitization status. Pediatric Allergy and Immunology, vol. 26, no 7, pp. 634-640.
2. Bager P. (2016) Filaggrin genotype and skin diseases independent of atopic dermatitis in childhood. Pediatric Allergy and Immunology, vol. 27, no 2, pp. 162-168.
3. Breuer K. (2014) Predictors of benefit from an atopic dermatitis education programme. Pediatric Allergy and Immunology, vol. 25, no 5, pp. 489-495.
4. Cipriani F. (2014) Recent advances in epidemiology and prevention of atopic eczema. Pediatric Allergy and Immunology, vol. 25, no 7, pp. 630-638.
5. Gerbens L.A.A. (2016) Evaluation of the measurement properties of symptom measurement instruments for atopic eczema: a systematic review. Allergy, vol. 72, no 1, pp. 146-163.
6. Howell M.D. (2015) Past, present, and future for biologic intervention in atopic dermatitis. Allergy, vol. 70, no 8, pp. 887-896.
7. Lee E. (2016) Atopic dermatitis phenotype with early onset and high serum IL-13 is linked to the new development of bronchial hyperresponsiveness in school children. Allergy, vol. 71, no 5, pp. 692-700.
8. Luger T. (2015) Pimecrolimus in atopic dermatitis: Consensus on safety and the need to allow use in infants. Pediatric Allergy and Immunology, vol. 26, no 4, pp. 306-315.
9. Simon S., Bieber T. (2014) Systemic therapy for atopic dermatitis. Allergy, vol. 69, no 1, pp. 46-55.
10. Wang S.S. (2014) Vitamin D deficiency is associated with diagnosis and severity of childhood atopic dermatitis. Pediatric Allergy and Immunology, vol. 25, no 1, pp. 30-35.
11. Wollenberg A. (2013) Atopic dermatitis and skin allergies - update and outlook. Allergy, vol. 68, no 12, pp. 1509-1519.
12. Wollenberg A. (2016) ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and pediatric patients. JEADV, vol. 30, pp. 729-747.
