РОЛЬ ПЛАЦЕНТАРНЫХ РАССТРОЙСТВ СРЕДИ ФАКТОРОВ РИСКА ВОЗНИКНОВЕНИЯ ИЗОЛИРОВАННОЙ ГИПОСПАДИИ

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Детская хирургия. Журнал им. Ю.Ф. Исакова. 2018; 22: 288-291

РОЛЬ ПЛАЦЕНТАРНЫХ РАССТРОЙСТВ СРЕДИ ФАКТОРОВ РИСКА ВОЗНИКНОВЕНИЯ ИЗОЛИРОВАННОЙ ГИПОСПАДИИ

Николаев В. В., Солонцов Ю. Н., Протасов А. А.

https://doi.org/10.18821/1560-9510-2018-22-6-288-291

Аннотация

Список литературы

1. Holmes L.B. Common Malformations. Oxford University Press, Oxford, New York. Auckland.2012;37-4:109-15.

2. Leung A.K., Robson W. L. Hypospadias: an update. Asian J Androl. 2007; 9(1):16-22.

3. Utsch B., Albers N., Ludwig M. Genetic and molecular aspects of hypospadias. Eur J. Pediatr Surg. 2004;14(5):297-302.

4. Bergman J.E. Loane M. Vrijheid M., Pierini, A., Nijman R.J., Addor M. C., Barisic I., et al. Epidemiology of hypospadias in Europe: a registry-based study. World J. Urol. 2015; 33:2159-67.

5. Sutherland R.W., Wiener J.S., Hicks J.P., Marcelli M., Gonzales E. T. Jr., Roth D. R., Lamb D. J. Androgen receptor gene mutations are rarely associated with isolated penile hypospadias. J. Urol 1996; 156(2 Pt 2):828-31.

6. Alléra A., Herbst M. A., Grifﬁn J.E., Wilson J.D., Schweikert H., McPhaul M. J. Mutations of the androgen receptor coding sequence are infrequent in patients with isolated hypospadias. J. Clin Endocrinol Metab.1995; 80(9):2697-9.

7. Kalfa N., Cassorla F., Audran F., Oulad Abdennabi I., Philibert P., et al. Polymorphisms of MAMLD1 gene in hypospadias. J. Pediatr Urol. 2011;7:585-91.

8. Van der Zanden L.F., van Rooij I.A., Feitz W.F., Vermeulen S.H., Kiemeney L. A., et al. Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation? J. Clin. Endocrinol Metab. 2010; 95: 2384-90.

9. Liu B., Wang Z., Lin G., et al. Activating transcription factor 3 is upregulated in hypospadias. Pediatr Res 2005; 58: 1280- 3.

10. Beleza-Meireles A., Töhönen V., Söderhäll C., Schwentner C., Radmayr C., Kockum I., et al. Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadias. Eur. J. Endocrinol 2008; 158: 729-39.

11. Mouriquand P. `Etiological aspects of hypospadias`. Dialogues in Pediatric Urology.2007, 28(4): стр?

12. Шабалов Н. П. Неонаталогия: книга., М.: 2006. 1 том: 38-39.

13. Шабалов Н. П. Неонаталогия: книга., М.: 2006;1 том.: 88.

14. Paulozzi L. J. International trends in rates of hypospadias and cryptorchidism. Enviro Health Perspect. 1999; 107(4): 297-302.

15. Савельева Г. М., Кулаков В. И., Стрижаков А. Н и др.; Акушерство /учебник. Под редакцией Г. М. Савельевой. М.: Медицина. 2000: 281.

Russian Journal of Pediatric Surgery. 2018; 22: 288-291

THE ROLE OF PLACENTAL DISORDERS AMONG RISK FACTORS IN THE FORMATION OF ISOLATED HYPOSPADIAS

Nikolaev V. V., Solontsov Y. N., Protasov A. A.

https://doi.org/10.18821/1560-9510-2018-22-6-288-291

Abstract

Aim of the study. The incidence of hypospadias increased by 2-3 times within the last 50 years. Changes in the frequency occurred mostly due to the gain of the distal isolated forms. The etiology of the majority of cases of the isolated hypospadias isn’t clear. The study of the origin hypospadias is at a stage of the search and assessment of the value of risk factors. The multifactorial pathology is supposed to be caused by changes in an organism of the mother, a placenta and environment factors. Our research is devoted to the assessment of placental factors in the formation of hypospadias. Material and Methods. We have performed a retrospective questionnaire among parents of 99 children with the isolated forms of hypospadias. The special attention was paid to the collecting of the family anamnesis, including data on diseases of reproductive organs, both at parents and at the immediate family in the male line and also data on a occupation, addictions (smoking) of parents. Information was also collected about the peculiarities of the course of the prenatal period and the outcome of childbirth. On the basis of the obtained data, an assessment of the influence of various “parental” factors on the formation of the isolated hypospadias forms in their sons is given. Results. In 4 out of 99 cases, the origin of isolated hypospadias has been caused by genetic deviations. Primary diseases of reproductive organs in parents have been noted as follow: in fathers in 18 of 95 cases, and in mothers in 12 cases. Most often the placenta pathology in the first trimester of pregnancy was shown by the threat of a spontaneous miscarriage (in 35 cases from 95). Placental disturbances during all pregnancy were accompanied by premature births in 25 cases. In 22 cases placental disorders were shown by a fetus arrest of development. Conclusions. In our research placental disturbances were the most frequent risk factors in the formation of the isolated hypospadias.

References

1. Holmes L.B. Common Malformations. Oxford University Press, Oxford, New York. Auckland.2012;37-4:109-15.

2. Leung A.K., Robson W. L. Hypospadias: an update. Asian J Androl. 2007; 9(1):16-22.

3. Utsch B., Albers N., Ludwig M. Genetic and molecular aspects of hypospadias. Eur J. Pediatr Surg. 2004;14(5):297-302.

4. Bergman J.E. Loane M. Vrijheid M., Pierini, A., Nijman R.J., Addor M. C., Barisic I., et al. Epidemiology of hypospadias in Europe: a registry-based study. World J. Urol. 2015; 33:2159-67.

7. Kalfa N., Cassorla F., Audran F., Oulad Abdennabi I., Philibert P., et al. Polymorphisms of MAMLD1 gene in hypospadias. J. Pediatr Urol. 2011;7:585-91.

9. Liu B., Wang Z., Lin G., et al. Activating transcription factor 3 is upregulated in hypospadias. Pediatr Res 2005; 58: 1280- 3.

11. Mouriquand P. `Etiological aspects of hypospadias`. Dialogues in Pediatric Urology.2007, 28(4): str?

12. Shabalov N. P. Neonatalogiya: kniga., M.: 2006. 1 tom: 38-39.

13. Shabalov N. P. Neonatalogiya: kniga., M.: 2006;1 tom.: 88.

14. Paulozzi L. J. International trends in rates of hypospadias and cryptorchidism. Enviro Health Perspect. 1999; 107(4): 297-302.

15. Savel'eva G. M., Kulakov V. I., Strizhakov A. N i dr.; Akusherstvo /uchebnik. Pod redaktsiei G. M. Savel'evoi. M.: Meditsina. 2000: 281.

РОЛЬ ПЛАЦЕНТАРНЫХ РАССТРОЙСТВ СРЕДИ ФАКТОРОВ РИСКА ВОЗНИКНОВЕНИЯ ИЗОЛИРОВАННОЙ ГИПОСПАДИИ

Аннотация

THE ROLE OF PLACENTAL DISORDERS AMONG RISK FACTORS IN THE FORMATION OF ISOLATED HYPOSPADIAS

Abstract

События