ГЕНЕТИКА ВЕЗИКОУРЕТЕРАЛЬНОГО РЕФЛЮКСА

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Детская хирургия. Журнал им. Ю.Ф. Исакова. 2018; 22: 193-198

ГЕНЕТИКА ВЕЗИКОУРЕТЕРАЛЬНОГО РЕФЛЮКСА

Шахновский Д. С., Зоркин С. Н., Савостьянов К. В., Пушков А. А.

https://doi.org/10.18821/1560-9510-2018-22-4-193-198

Аннотация

Первичный везикоуретеральный рефлюкс (ВУР) - это наиболее частое урологическое нарушение у детей, встречающееся у 1-2% детского населения и 30-40% детей с инфекциями мочевых путей. Чётко установлен наследственный и семейный характер ВУР, в нескольких исследованиях сообщалось, что у братьев и сестёр в семьях с ВУР частота рефлюкса в сравнении с детским населением в целом повышается. Семейное распределение ВУР свидетельствует о том, что генетические факторы играют важную роль в его патогенезе, но пока не был выделен единичный основной ген или локус ВУР, и большинство исследователей в настоящее время признают, что ВУР является генетически гетерогенным заболеванием. Улучшение технологий сканирования генома и постоянно совершенствуемые знания о генетической основе ВУР должны помочь глубже понять его патогенез.

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Russian Journal of Pediatric Surgery. 2018; 22: 193-198

GENETICS OF VESICOURETERAL REFLUX

Shakhnovskiy D. S., Zorkin S. N., Savost’Anov K. V., Pushkov A. A.

https://doi.org/10.18821/1560-9510-2018-22-4-193-198

Abstract

Primary vesicoureteral reflux (VUR) is known to be the most common urological anomaly in children, witch affects 1-2% of pediatric population and 30-40% of children, developing urinary tract infections (UTIs). The hereditary and familial nature of VUR is well established and in several studies was proved that siblings of children with VUR have a higher incidence of reflux than it is in general pediatric population. Familial clustering of VUR implies that genetic factors have an important role in its pathogenesis, but to date no single major locus or gene for VUR has been identified and most researchers acknowledge that VUR is genetically heterogeneous. Improvements in genome wide scan techniques and continuously increasing knowledge of the genetic basis of VUR should lead us to further insights on VUR pathogenesis.

References