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Детская хирургия. Журнал им. Ю.Ф. Исакова. 2022; 26: 314-320

Эндоскопические вмешательства при пороках развития и заболеваниях поджелудочной железы у детей

Солодинина Е. Н., Соколов Ю. Ю., Ефременков А. М., Зыкин А. П., Фомичёва Н. В., Шапкина А. Н., Пыхтеев Д. А., Кауфов М. Х.

https://doi.org/10.55308/1560-9510-2022-26-6-314-320

Аннотация

Введение. Пороки развития и заболевания поджелудочной железы (ПЖ) сложны и сопряжены с риском развития осложнений. Внедрение интервенционной эндоскопии – одно из направлений, позволяющих решить данную проблему.
Материал и методы. В исследование включены 24 пациента в возрасте от 3 до 17 лет, которым выполнено 36 интервенционных эндоскопических вмешательств.
Результаты. Транспапиллярные вмешательства выполнены 10 детям, у всех выявлены аномалии протоковой системы ПЖ. Стеноз дистальных отделов панкреатических протоков выявлен у 3 больных, которым выполнено стентирование Вирсунгова протока. Вирсунголитиаз подтверждён в 3 наблюдениях, из них аномалия протоков в виде неполной расщеплённой железы выявлена у 2 пациентов. Разделённая ПЖ выявлена у 1 больного, что потребовало сфинктеротомии малого дуоденального сосочка. Трансмуральные вмешательства выполнены в 13 наблюдениях: пункция у 7 пациентов с интра- или парапанкреатическими кистозными образованиями, дренирование у 6 – с панкреатическими псевдокистами. Комбинированное лечение (транспапиллярное и трансмуральное вмешательства) выполнено одному ребёнку с травматическим разрывом ПЖ.
Обсуждение. Этиология панкреатита у детей связана с аномалиями развития и генетическими факторами. Ведущим патогенетическим фактором развития осложнений является гипертензия в протоках ПЖ. Традиционные оперативные вмешательства при панкреатите часто травматичны и сопровождаются высоким риском осложнений. Внедрение менее инвазивных методик, таких как интервенционная эндоскопия, позволяет решить проблему при некоторых заболеваниях ПЖ.
Заключение. Транспапиллярные вмешательства могут эффективно устранить гипертензию в протоках ПЖ при их дилатации и вирсунголитиазе. Трансмуральные вмешательства могут применяться для уточнения этиологии кистозных образований ПЖ, а также для дренирования панкреатических псевдокист.

Список литературы

1. Kumar S., Ooi C.Y., Werlin S., et al. Risk factors associated with pediatric acute recurrent and chronic pancreatitis: lessons from INSPPIRE. JAMA Pediatr. 2016; 170: 562–9. https://doi.org/10.1001/jamapediatrics.2015.4955

2. Liu Q.Y., Gugig R., Troendle D.M., et al. The roles of endoscopic ultrasound and endoscopic retrograde cholangiopancreatography in the evaluation and treatment of chronic pancreatitis in children: a position paper from the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Pancreas Committee. J Pediatr Gastroenterol Nutr. 2020; 70(5): 681–93. https://doi.org/10.1097/MPG.0000000000002664

3. Солодинина Е.Н., Соколов Ю.Ю., Ефременков А.М., Фомичева Н.В., Зыкин А.П., Уткина Т.В. Эндосонография панкреатобилиарной области у детей. Первый опыт. Детская хирургия. 2021; 25(6): 368–74. https://doi.org/10.55308/1560-9510-2021-25-6-368-374

4. Oracz G., Pertkiewicz J., Kierkus J., et al. Efficiency of pancreatic duct stenting therapy in children with chronic pancreatitis. Gastrointest Endosc. 2014; 80(6): 1022–9. https://doi.org/10.1016/j.gie.2014.04.001

5. Li Z.S., Wang W., Liao Z,. et al. A long-term follow-up study on endoscopic management of children and adolescents with chronic pancreatitis. Am J Gastroenterol. 2010; 105(8): 1884–92. https://doi.org/10.1038/ajg.2010.85

6. Lightdale J.R., Acosta R., Shergill A.K., et al. American Society for Gastrointestinal Endoscopy. Modifications in endoscopic practice for pediatric patients. Gastrointest Endosc. 2014; 79(5): 699–710. https://doi.org/10.1016/j.gie.2013.08.014

7. Barth B.A., Banerjee S., Bhat Y.M., et al. Equipment for pediatric endoscopy. Gastrointest Endosc. 2012; 76: 8–17. https://doi.org/10.1016/j.gie.2012.02.023

8. Tringali A., Thomson M., Dumonceau J.M., et al. Pediatric gastrointestinalendoscopy: European Society of Gastrointestinal Endoscopy (ESGE) and European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Guideline Executive summary. Endoscopy. 2017; 49: 83–91. https://doi.org/10.1055/s-0042-111002

9. Abu-El-Haija M., Kumar S., Quiros J.A., et al. Management of acute pancreatitis in the pediatric population: a clinical report from the north american society for pediatric gastroenterology, hepatology and nutrition pancreas committee. J Pediatr Gastroenterol Nutr. 2018; 66(1): 159–76. https://doi.org/10.1097/MPG.0000000000001715

10. Nabi Z., Lakhtakia S., Basha J., et al. Endoscopic drainage of pancreatic fluid collections: long-term outcomes in children. Dig Endosc. 2017; 29(7): 790–7. https://doi.org/10.1111/den.12884

11. Troendle D.M., Fishman D.S., Barth B.A., et al. Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis: data from the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) Study. Pancreas. 2017; 46(6): 764–9. https://doi.org/10.1097/MPA.0000000000000848

12. Enestvedt B.K., Tofani C., Lee D.Y., et al. Endoscopic retrograde cholangiopancreatography in the pediatric population is safe and efficacious. J.Pediatr Gastroenterol Nutr. 2013; 57: 649–54. https://doi.org/10.1097/MPG.0b013e31829e0bb6

13. Iqbal C.W., Baron T.H., Moir C.R., et al. Post-ERCP pancreatitis in pediatric patients. J Pediatr Gastroenterol Nutr. 2009; 49: 430–4. https://doi.org/10.1097/01.mpg.0000361657.54810.19

14. Dumonceau J.M., Delhaye M., Tringali A., et al. Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Updated August 2018. Endoscopy. 2019; 51(2): 179–93. https://doi.org/10.1055/a-0822-0832

15. Ang T.L., Teoh A.Y.B. Endoscopic ultrasonography-guided drainage of pancreatic fluid collections. Dig Endosc. 2017; 29(4): 463–71. https://doi.org/10.1111/den.12797

16. Старков Ю.Г., Замолодчиков Р.Д., Джантуханова С.В., Выборный М.И., Лукич К.В., Ибрагимов А.С., Гончаров И.М., Лаврентьева В.Ю. Результаты внутреннего дренирования псевдокист поджелудочной железы под контролем эндо-УЗИ. Анналы хирургической гепатологии. 2019; 24(1): 43–52. https://doi.org/10.16931/1995-5464.2019143-52

17. Дурлештер В.М., Генрих С.Р., Макаренко А.В., Киракосян Д.С. Современный подход к лечению псевдокист поджелудочной железы: систематический обзор. Кубанский научный медицинский вестник. 2021; 28(4): 85–99. https://doi.org/10.25207/1608-6228-2021-28-4-85-99

18. Watanabe Y., Mikata R., Yasui S., et al. Short- and long-term results of endoscopic ultrasound-guided transmural drainage for pancreatic pseudocysts and walled-off necrosis. World J Gastroenterol. 2017; 23(39): 7110–8. https://doi.org/10.3748/wjg.v23.i39.7110

19. Ramesh J., Bang J.Y., Trevino J., Varadarajulu S. Endoscopic ultrasound-guided drainage of pancreatic fluid collections in children. J Pediatr Gastroenterol Nutr. 2013; 56(1): 30–5. https://doi.org/10.1097/MPG.0b013e318267c113

20. Raina A., Conrad M.A., Sahn B., et al. Endoscopic ultrasound with or without fine-needle aspiration has a meaningful impact on clinical care in the pediatric population. Endosc Ultrasound. 2017; 6(3): 195–200. https://doi.org/10.4103/eus.eus_2_17

21. Козлов Ю.А., Неустроев В.Г., Латыпов В.Х. и др. Эндоскопическое дренирование панкреатических псевдокист под ультразвуковым контролем у детей. Эндоскопическая хирургия. 2018; 24(4): 57–60. https://doi.org/10.17116/endoskop20182404157

Russian Journal of Pediatric Surgery. 2022; 26: 314-320

Endoscopic interventions for pancreas malformations and diseases in children

Solodinina E. N., Sokolov Yu. Yu., Efremenkov A. M., Zykin A. P., Fomicheva N. V., Shapkina A. N., Pykhteev D. A., Kaufov M. H.

https://doi.org/10.55308/1560-9510-2022-26-6-314-320

Abstract

Introduction. Malformations and diseases of the pancreas are associated with the risk of complications. Interventional endoscopy is one of the ways to solve this problem.
Material and methods. 24 patients (3–17 y.o.) were included in the study. 36 interventional endoscopic interventions were performed.
Results. Transpapillary interventions were performed in 10 patients, all of them had anomalies of the ductal system. Stenosis of the distal pancreatic ducts was detected in 3 cases, in which stenting of the Wirsung duct was performed. Virsungolithiasis was confirmed in 3 cases, in which an anomaly of the ducts in the form of an incomplete split gland was detected in 2 patients. Pancreas divisum was detected in 1 patient, which required sphincterotomy of the minor duodenal papilla. Transmural interventions were performed in 13 cases: puncture – in 7 patients with intra- or parapancreatic cystic formations; drainage – in 6 patients with pancreatic pseudocysts. One child with traumatic rupture of the pancreas had a combined intervention (transpapillary and transmural).
Discussion. The etiology of pancreatitis in children is associated with developmental anomalies and genetic factors. The leading pathogenetic factor in the development of complications is hypertension in the ducts of the gland. Traditional surgical interventions for pancreatitis are often traumatic and are accompanied by a high risk of complications. The introduction of minimally invasive techniques, such as interventional endoscopy, can solve the problem in some diseases of the pancreas.
Conclusion. Transpapillary interventions can effectively eliminate hypertension in the pancreatic ducts in case of their dilatation and virsungolithiasis. Transmural interventions can be used to clarify the etiology of pancreatic cysts, as well as to drain pancreatic pseudocysts.

References

1. Kumar S., Ooi C.Y., Werlin S., et al. Risk factors associated with pediatric acute recurrent and chronic pancreatitis: lessons from INSPPIRE. JAMA Pediatr. 2016; 170: 562–9. https://doi.org/10.1001/jamapediatrics.2015.4955

2. Liu Q.Y., Gugig R., Troendle D.M., et al. The roles of endoscopic ultrasound and endoscopic retrograde cholangiopancreatography in the evaluation and treatment of chronic pancreatitis in children: a position paper from the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Pancreas Committee. J Pediatr Gastroenterol Nutr. 2020; 70(5): 681–93. https://doi.org/10.1097/MPG.0000000000002664

3. Solodinina E.N., Sokolov Yu.Yu., Efremenkov A.M., Fomicheva N.V., Zykin A.P., Utkina T.V. Endosonografiya pankreatobiliarnoi oblasti u detei. Pervyi opyt. Detskaya khirurgiya. 2021; 25(6): 368–74. https://doi.org/10.55308/1560-9510-2021-25-6-368-374

4. Oracz G., Pertkiewicz J., Kierkus J., et al. Efficiency of pancreatic duct stenting therapy in children with chronic pancreatitis. Gastrointest Endosc. 2014; 80(6): 1022–9. https://doi.org/10.1016/j.gie.2014.04.001

5. Li Z.S., Wang W., Liao Z,. et al. A long-term follow-up study on endoscopic management of children and adolescents with chronic pancreatitis. Am J Gastroenterol. 2010; 105(8): 1884–92. https://doi.org/10.1038/ajg.2010.85

6. Lightdale J.R., Acosta R., Shergill A.K., et al. American Society for Gastrointestinal Endoscopy. Modifications in endoscopic practice for pediatric patients. Gastrointest Endosc. 2014; 79(5): 699–710. https://doi.org/10.1016/j.gie.2013.08.014

7. Barth B.A., Banerjee S., Bhat Y.M., et al. Equipment for pediatric endoscopy. Gastrointest Endosc. 2012; 76: 8–17. https://doi.org/10.1016/j.gie.2012.02.023

8. Tringali A., Thomson M., Dumonceau J.M., et al. Pediatric gastrointestinalendoscopy: European Society of Gastrointestinal Endoscopy (ESGE) and European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Guideline Executive summary. Endoscopy. 2017; 49: 83–91. https://doi.org/10.1055/s-0042-111002

9. Abu-El-Haija M., Kumar S., Quiros J.A., et al. Management of acute pancreatitis in the pediatric population: a clinical report from the north american society for pediatric gastroenterology, hepatology and nutrition pancreas committee. J Pediatr Gastroenterol Nutr. 2018; 66(1): 159–76. https://doi.org/10.1097/MPG.0000000000001715

10. Nabi Z., Lakhtakia S., Basha J., et al. Endoscopic drainage of pancreatic fluid collections: long-term outcomes in children. Dig Endosc. 2017; 29(7): 790–7. https://doi.org/10.1111/den.12884

11. Troendle D.M., Fishman D.S., Barth B.A., et al. Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis: data from the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) Study. Pancreas. 2017; 46(6): 764–9. https://doi.org/10.1097/MPA.0000000000000848

12. Enestvedt B.K., Tofani C., Lee D.Y., et al. Endoscopic retrograde cholangiopancreatography in the pediatric population is safe and efficacious. J.Pediatr Gastroenterol Nutr. 2013; 57: 649–54. https://doi.org/10.1097/MPG.0b013e31829e0bb6

13. Iqbal C.W., Baron T.H., Moir C.R., et al. Post-ERCP pancreatitis in pediatric patients. J Pediatr Gastroenterol Nutr. 2009; 49: 430–4. https://doi.org/10.1097/01.mpg.0000361657.54810.19

14. Dumonceau J.M., Delhaye M., Tringali A., et al. Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Updated August 2018. Endoscopy. 2019; 51(2): 179–93. https://doi.org/10.1055/a-0822-0832

15. Ang T.L., Teoh A.Y.B. Endoscopic ultrasonography-guided drainage of pancreatic fluid collections. Dig Endosc. 2017; 29(4): 463–71. https://doi.org/10.1111/den.12797

16. Starkov Yu.G., Zamolodchikov R.D., Dzhantukhanova S.V., Vybornyi M.I., Lukich K.V., Ibragimov A.S., Goncharov I.M., Lavrent'eva V.Yu. Rezul'taty vnutrennego drenirovaniya psevdokist podzheludochnoi zhelezy pod kontrolem endo-UZI. Annaly khirurgicheskoi gepatologii. 2019; 24(1): 43–52. https://doi.org/10.16931/1995-5464.2019143-52

17. Durleshter V.M., Genrikh S.R., Makarenko A.V., Kirakosyan D.S. Sovremennyi podkhod k lecheniyu psevdokist podzheludochnoi zhelezy: sistematicheskii obzor. Kubanskii nauchnyi meditsinskii vestnik. 2021; 28(4): 85–99. https://doi.org/10.25207/1608-6228-2021-28-4-85-99

18. Watanabe Y., Mikata R., Yasui S., et al. Short- and long-term results of endoscopic ultrasound-guided transmural drainage for pancreatic pseudocysts and walled-off necrosis. World J Gastroenterol. 2017; 23(39): 7110–8. https://doi.org/10.3748/wjg.v23.i39.7110

19. Ramesh J., Bang J.Y., Trevino J., Varadarajulu S. Endoscopic ultrasound-guided drainage of pancreatic fluid collections in children. J Pediatr Gastroenterol Nutr. 2013; 56(1): 30–5. https://doi.org/10.1097/MPG.0b013e318267c113

20. Raina A., Conrad M.A., Sahn B., et al. Endoscopic ultrasound with or without fine-needle aspiration has a meaningful impact on clinical care in the pediatric population. Endosc Ultrasound. 2017; 6(3): 195–200. https://doi.org/10.4103/eus.eus_2_17

21. Kozlov Yu.A., Neustroev V.G., Latypov V.Kh. i dr. Endoskopicheskoe drenirovanie pankreaticheskikh psevdokist pod ul'trazvukovym kontrolem u detei. Endoskopicheskaya khirurgiya. 2018; 24(4): 57–60. https://doi.org/10.17116/endoskop20182404157