Детская хирургия. Журнал им. Ю.Ф. Исакова. 2022; 26: 29-34
Применение анестезирующих и лечебных свойств ксенона при подготовке детей к пластическому закрытию ран
https://doi.org/10.55308/1560-9510-2022-26-1-29-34Аннотация
Введение. В обзоре представлены экспериментальные и клинические исследования по использованию ксенона в субнаркотической концентрации для обезболивания и лечения острого стрессового расстройства. Процесс подготовки ран к пластическому закрытию у детей длительный и болезненный, требующий проведения большого количества анестезий при перевязках, что приводит к когнитивным нарушениям, сказываясь на памяти, и обучаемости. Каждый третий ребёнок, переживший тяжёлую травму, страдает острым стрессовым расстройством: нарушение сна, эмоциональная неуравновешенность, тревожность, замкнутость, неадекватность поступков. Ксенон (Хе) является нетоксичным анестетиком, в концентрации 20–50% не только обезболивает, но и купирует острое стрессовое расстройство, проявляет седативные и антистрессорные свойства, нормализует сон.
Цель исследования – изучить литературные данные о возможности использования субнаркотических концентраций Хе для обезболивания и купирования острого стрессового расстройства на этапе подготовки ребёнка к пластическому закрытию раневого дефекта.
Материал и методы. Анализ литературных данных проведён в поисковых системах PubMed, Scopus, eLIBRARY, Сyberleninka на английском и русском языках с использованием ключевых запросов: «Xenon», «Xenon and anesthesia», «Xenon therapy» «Actions of Xenon», «Лечение обширных ран у детей», «Острое стрессовое расстройство».
По результатам проведённого анализа литературы планируется выполнить исследование о возможности использования субнаркотических концентраций Хе для обезболивания и лечения острого стрессового расстройства на этапе подготовки ребёнка к пластическому закрытию раневого дефекта.
Результаты. Анализ данных проведённых исследований показал нетоксичность Хе, что даёт возможность его неоднократного применения для анестезии у детей. То, что Хе уменьшает проявления тревожного, депрессивного и психосоматического симптомов у больных с острыми и хроническими стрессовыми расстройствами, позволяет рассчитывать на его положительные эффекты в лечении детей с обширными ранами травматического происхождения на этапе подготовки их к пластическому закрытию.
Заключение. Практическое отсутствие в имеющейся научной литературе исследование по оценке эффективности применения субнаркотических концентраций Хе, при перевязках обширных ран на этапе подготовки раневого процесса к пластическому закрытию у детей с острыми стрессовыми расстройствами, обосновывает проведение соответствующего научного исследования.
Список литературы
1. Митиш В.А., Налбандян Р.Т., Исхаков О.С., Сидоров С.В., Басаргин Д.Ю., Багаев В.Г., Коваленко М.И., Мединский П.В., Соков С.Л. Особенности оказания специализированной хирургической помощи пострадавшим при землетрясении в Непале. Раны и раневые инфекции. 2016; 3(4): 34–49. Mitish V.A., Nalbandyan R.T., Iskhakov O.S., Sidorov S.V., Basargin D.Yu., Bagaev V.G., Kovalenko M.I., Medinskiy P.V., Sokov S.L. Specifics of rescuing specialized surgical operation for earthquake-stricken in Nepal. Rany I ranevye infekcii. 2016; 3(4): 34–49. (in Russian)
2. Багаев В.Г., Саратовский А.С., Митиш В.А., Пужицкий Л.Б., Мединский П.А., Журавлев Н.А., Басаргин Д.Ю., Воробьев Д.А. Медицинская помощь пострадавшим детям Гаити. Анестезиология и реаниматология. 2011; 1: 27–9. Bagaev V.G., Saratovskiy A.S., Mitish V.A., Puzhitskiy L.B., Medinskiy P.A., Zhuravlev N.A., Basargin D.Yu., Vorobyev D.A. Medical care provision to the victim children of Haiti. Anesthesiologiya I reanimanjlogiya . 2011; 1: 27–9. (in Russian)
3. Блатун Л.А., Чекмарева И.А., Митиш В.А., Пасхалова Ю.С., Ушаков А.А., Крутиков М.Г., Вишневская Г.А., Бобровников А.Э., Магомедова С.Д., Мединский П.В., Налбандян Р.Т., Соков С.Л., Борисов И.В., Усу Вуйую О.Ю., Муньос Сэпэда П.А. Гнойнонекротические поражения кожи и мягких тканей. Тактика местного медикаментозного лечения. Гастроэнтерология. Хирургия. Интенсивная терапия. Consilium Medicum. 2019; 2: 53–62. Blatun L.A., Chekmareva I.A., Mitish V.A., Paskhalova I.S., Ushakov A.A., Krutikov M.G., Vishnevskaya G.A., Bobrovnikov A.E., Magomedova S.D., Medinskiy P.V., Nalbandyan R.T., Sokov S.L., Borisov I.V., Vuyuyu O.Yu.U., Sepeda P.A.M. Purulent and necrotic lesions of the skin and soft tissues. Tactics of localmedical treatment. Gastroenterologiya. Khirurgiya. Intensivnaya terapiya. Consilium Medicum. 2019; 2: 53–62. (in Russian)
4. Amcheslavsky V.G., Bagaev V.G., Saratovsky A.S. et al. The choice of anesthesia to children suffered in an earthquake. 18th World Congress on Disaster & Emergency Medicine. Manchester; 2013: 7–8.
5. Pandit J.J. Intravenous anesthetic agents. AnesthIntens Care dosing in pediatric anesthesia. Pediatr Anesth. 2011; 24(8): 806–812.
6. Weiss M., Vutskits L., Hansen T. G., Engelhardt T. Safe Anesthesia For Every To – The SAFETOTS initiative. Curr. Opin Anaesthesiol. 2015; 28(3): 302–7. https://doi.org/10.1097/aco.0000000000000186
7. McCann M.E., Soriano S.G. Does general anesthesia affect neurodevelopment in infants and children? BMJ. 2019; 367: l6459. https://doi.org/10.1136/bmj.l6459
8. Пыжик Т.Н. Ксенон: место в химии и медицине. Журнал Гродненского государственного медицинского университета. 2009; 3 (27): 9–11. Pyzhik T.N. Xenon: its role in chemistry and medicine. Zhurnal Grodnenskogo Gosudarstvennogo Meditsinskogo Universiteta. 2009; 3(27): 9–11. (in Russian)
9. Буров Н.Е., Потапов В.Н., Макеев Г.Н. Ксенон в анестезиологии: Клинико-эксперим. исслед. М.: Пульс; 2000. Burov N.E., Potapov V.N., Makeev G.N. Xenon in anesthesiology:Clinical and experimental study [Xenon v anesteziologi:Clinico-experimentalnye issledovaniya]. Moscow: Pul’s; 2000. (in Russian)
10. Cullen S.C., Gross E.G. The anesthetic properties of xenon in animals and human beings, with additional observations on krypton. Science. 1951; 113(2942): 580–2. https://doi.org/10.1126/science.113.2942.580
11. Амчеславский В.Г., Багаев В.Г., Арсеньева Е.Н., Лукьянов В.И., Быков М.В., Cабинина Т.С., Пинелис В.Г. Изменение уровня нейромаркеров S 100b и BDNF при анестезиях ксеноном и севофлураном у детей. Медицинский алфавит. Неотложная медицина. 2014; 1(5(221)): 33–6. Amcheslavsky V.G., Bagaev V.G., Arsenieva E.N., Lukyanov V.I., Bykov M.V., Sabinina T.S., Pinelis V.G. Changes in the level of S100b and BDNF neuromarkers during anesthesia with xenon and sevoflurane in children. Medicinskiy alfavit. Neotlozhnaya medicina. 2014; 1(5(221)): 33–6. (in Russian)
12. Багаев В.Г., Амчеславский В.Г., Хмельницкий К.Е., Пинелис В.Г., Арсеньева Е.Н., Васильева И.В., Львова Е.А. Результаты клинического исследования эффективности и безопасности ксенона при общей анестезии у детей. Российский вестник детской хирургии, анестезиологии и реаниматологии. 2012; 4: 70–7. Bagaev V.G., Amcheslavsky V.G., Hmelnitsiy K.E., Pinelis V.G., Arsenieva E.N., Vasileva I.V., L’vova E.A. Results of clinical efficacy and safety studies xenon anesthesia in children. Rossiyskiy vestnik drtskoy khirurgii, anestreziologii I reanimatologii. 2012; 4: 70–7. (in Russian)
13. Лазарев Н.В., Люблина Е.И., Мадорская Р.Я. О наркотическом действии ксенона. Физиологический журнал СССР им. И.М. Сеченова. 1948; 34(1): 131–4. Lazarev N.V., Lublina E.I., Madorskaya R.Ya. About the narcotic effect of xenon. Physiologicheskiy Zhurnalurnal SSSR imeni I.M. Sechenov. 1948; 34(1): 131–4. (in Russian)
14. Бабиков А.С., Рабинович С.А., Наумов С.А., Давыдова Н.С., Костромитина Г.Г., Заводиленко Л.А., Айрапетян С.М. Ксеноновые ингаляции для купирования болевых синдромов в стоматологии. В кн.: Сборник трудов X Всероссийской научно-практической конференции «Образование и практика в стоматологии» по единой тематике «Стоматология и социально-значимые заболевания» 11– 13 февраля 2013, Москва. Санкт-Петербург: Человек; 2013: 26–7. Babikov A.S., Rabinovich S.A., Naumov S.A., Davydova N.S., Kostromitina G.G., Zavodilenko L.A., Hayrapetyan S.M. Xenon inhalations for relief of pain syndromes in dentistry. In: Proceedings of the X All-Russian Scientific and Practical Conference “Education and Practice in Dentistry” on a single topic “Dentistry and socially significant diseases” February 11–13, 2013, Moscow [Sbornik trudov X Vserossiyskoy nauchno-praktichecroy konferentsii “Obrazovanie i praktika v stomatologii” po edinoy tematike” Stomatologiya i socialnoznachimye zabolevaniya, 11–13 Fevralya 2013, Mopskva]. SaintPetersburg: Chelovek; 2013; 26–7. (in Russian)
15. Pauling L. A Molecular theory of general anesthesia. Science. 1961; 134(3471): 15–21.
16. Багаев В.Г., Девайкин Е.В., Амчеславский В.Г., Давыдов М.Ю., Лукьянов В.И. Оценка уровня седации с помощью БИС-мониторинга при анестезии ксеноном у детей. Педиатрия. Журнал им. Г.Н. Сперанского. 2013; 92(4): 124–5. Bagaev V.G., Devaykin E.V., Amcheslavsky V.G., Davidov V.G., Lukyanov V.I. Assessment of sedation level using BIS monitoring during xenon anesthesia in children. Pediatriya. Zhurnal umeni G.N. Speransky. 2013; 92(4): 124–5. (in Russian)
17. Giacalone M., Abramo A., Giunta F., Forfori F. Xenon-related analgesia: a new target for pain treatment. Clin J Pain. 2013 Jul; 29(7): 639–43. https://doi.org/10.1097/AJP.0b013e31826b12f5
18. Marx T., Froeba G., Wagner D., Baeder S., Goertz A., Georgieff M. Effects on haemodynamicsand catecholamine release of xenon anaesthesia compared with total i. v. anaesthesia in the pig. Br J Anaesth. 1997; 78(3): 326–7. https://doi.org/10.1093/bja/78.3.326
19. Genov P.G., Smirnova O.V., Timerbaev V.Kh. Xenon for postoperative analgesia: why not? Article in Russian. Anesteziol Reanimatol. 2011 May–Jun; (3): 74–7.
20. Буров Н.Е., Потапов В.Н., Молчанов И.В., Николаев Л.Л., Коробов А.В. Наркоз ксеноном. Методические рекомендации. М: РМАПО; 2003. Burov N.E., Potapov V.N., Molchanov I.V., Nikolaev L.L., Korobov A.V. Xenon anesthesia. Methodological recommendations [Narkoz xsenonom. Metodologicheskie rekomendscii]. Moscow: RMAPO, 2003. (in Russian)
21. Буров Н.Е., Антонов А.А., патентообладатели. Способ аутоаналгезии ксенон-кислородной смесью. Россия Патент RU 2271815. 21.11.2003 г. Burov N.E., Antonov A.A., authors; Burov N.E., Antonov A.A., assignees. Method of autoanalgesia with mixture xenon-oxygen. Russian Federation patent RU 2271815. 2003 Nov 21. (in Russian)
22. Сабинина Т.С., Багаев В.Г., Амчеславский В.Г., Иванова Т.Ф., Багаева Ю.В., Лукьянов В.И., Аверьянов С.Н., Раушенбах Н.Г., Голубев Б.И. Эффективность ингаляций ксенона в комплексной терапии минно-взрывной травмы у детей. В кн.: Сборник тезисов XXI конгресса педиатров России с международным участием «Актуальные проблемы педиатрии», Москва, 15–17 февраля 2019. М.: 2019; 213. Sabinina T.S., Bagaev V.G., Amcheslavskiy V.G., Ivanova T.F., Bagaeva Yu.V., Lukyanov V.I., Averyanov S.N., Raushenbach N.G., Golubev B.I. The effectiveness of xenon inhalations in the complex therapy of mine-blast trauma in children. In: Collection of abstracts of the XXI Congress of Pediatricians of Russia with international participation “Actual problems of pediatrics”. Moscow, February 15–17, 2019 [Sbornik tezisov XXI kongressa pediatrov Rossii s mezhdunarodnym uchastiem “Aktualnye problem pediatrii”. Moskva, 15–17 fevralya 2019]. Moscow: 2019. (in Russian)
23. Багаева Ю.В., Валиулина С.А., Быстров А.С., Багаев В.Г. Ранняя двигательная реабилитация в условиях терапии ксеноном у детей. В кн.: IV Всероссийский конгресс с международным участием «Медицинская помощь при травмах и неотложных состояниях в мирное и военное время. Новое в организации и технологиях». Сборник тезисов. Санкт-Петербург: Изд-во «Человек и здоровье»; 2019: 23–4. Bagaeva Yu.V., Valiullina S.A., Bystrov A.S., Bagaev V.G. Early motor rehabilitation in the conditions of xenon therapy in children. In: IV All-Russian Congress with international participation “Medical care for injuries and emergencies in peacetime and wartime. New in organization and technology” [IV Vserossiyskiy congress s mezhdunarodnym uchastiem “Medicinskaya pomoshch pri travmakh i neotlozhnykh sostoyanuyakh v mirnoe i voennoe vremya]. Abstracts. Saint-Petersburg: Chelovek & zdorovye, 2019; 23–4. (in Russian)
24. Meiser-Stedman R., Smith P., Glucksman E., Yule W., Dalgleish T. The posttraumatic stress disorder diagnosis in preschool- and elementary school-age children exposed to motor vehicle accidents. American Journal of Psychiatry. 2008; 165(10): 1326–37. https://dopi.org/10.1176/appi.ajp.2008.07081282
25. Scheeringa M.S., Wright M.J., Hunt M.P., Zeanah Ch.H. Factors affecting the diagnosis and prediction of PTSD symptomatology in children and adolescents. American Journal of Psychiatry. 2006; 163(4): 644–51. https://doi.org/10.1176/ajp.2006.163.4.644
26. Павлов И.П. Полное собрание сочинений. Т. 3, кн. 2. Двадцатилетний опыт объективного изучения высшей нервной деятельности животных: главы XXXVI–LXIII (1923–1936 гг.). М.: 1951; 353–79. Pavlov I.P. Complete Works. Vol. 3, book 2. Twenty years of experience in the objective study of higher nervous activity of animals: Chapter XXXVI–LXIII (1923–1936) [Polnoe sobranie sochineniy. Tom3, kniga 2. Dvadtsatiletniy opyt obektivnogo izucheniyz vysshey nervnoy deyatelnosti zhivotnykh: glavy XXXVI–LXIII (1923–1936)]. Moscow: 1951; 353–79. (in Russian)
27. Fanselow M.S., Poulos A.M. The neuroscience of mammalian associative learning. Annu Rev Psychol. 2005; 56: 207–34. https://doi.org/10.1146/annurev.psych.56.091103.070213
28. Reichelt A.C., Lee J.L.C. Memory reconsolidation in aversive and appetitive settings. Front Behav Neurosci. 2013; 7: 118. https://doi.org/10.3389/fnbeh.2013.00118
29. Котровская Т.И., Бубеев Ю.А., Счастливцева Д.В. Влияние ксенона на посттравматические следы памяти. Авиакосмическая и экологическая медицина. 2019; 53(2): 13–20. https://doi.org/10.21687/0233-528X-2019-53-2-13-20 Kotrovskaya T.I., Bubeev Yu.A., Schastlivtseva D.V. Xenon effect on posttraumatic traces memories. Aviokosmicheskaya i ekologicheskaya medicina. 2019; 53(2): 13–20. https://doi.org/10.21687/0233-528X-2019-53-2-13-20 (in Russian)
30. Przybyslawski J., Sara S.J. Reconsolidation of memory after its reactivation. Beh Brain Res. 1997; 84: 241–6. https://doi.org/10.1016/s0166-4328(96)00153-2
31. Dobrovolsky A., Ichim, T.E., Ma D., Kesari S. Bogin V. Xenon in the treatment of panic disorder: an open label study. J Transl Med. 2017; 15(1): 137. https://doi.org/10.1186/s12967-017-1237-1
32. Бубеев Ю.А., Котровская Т.И., Кальманов А.С. Ксенон-кислородная газовая ингаляция для коррекции негативных последствий стресса. В кн.: Ксенон и инертные газы в медицине. Материалы конференции анестезиологов-реаниматологов медицинских учреждений МО РФ. Москва: ГВКГ им. Н.Н. Бурденко, 2008; 4–9. Bubeev Yu.A., Kotrovskaya T.I., Kalmanov A.S. Xenon-oxygen gas inhalation for correction of negative effects of stress. In: Xenon and inert gases in medicine: Proceedings of the conference of anesthesiologistsresuscitators of medical institutions of the Ministry of Defense of the Russian Federation [Xenon I inertnye gazy v medicine: Materialy konferencii anesteziologo-reanimatologov medicinskikh uchrezdeniy MO RF]. Moscow: GWCG named after N.N. Burdenko, 2008; 4–9. (in Russian)
33. Игошина Т.В. Коррекция связанных со стрессом невротических расстройств методом ингаляции субнаркотических доз ксенона в условиях санатория. Кремлёвская медицина. Клинический вестник. 2013; 4: 37–42. Igoshina T.V. Correction of stress-induced neurotic disorders using inhalation with subnarcotic xenon doses in a sanatorium rehabilitation. Kremlevskaya medicina. Clinicheskiy vestnik. 2013; 4: 37–42. (in Russian)
34. Сабинина Т.С., Багаев В.Г., Алексеев И.Ф. Перспективы применения лечебных свойств ксенона в педиатрии. Педиатрическая фармакология. 2018; 15(5): 390–5. https://doi.org10.15690/pf.v15i5.1961 Sabinina T.S., Bagaev V.G., Alekseev I.F. Prospects for the use of medical properties of xenon in pediatrics. Pediatricheskaya farmakologiya. 2018; 15(5): 390–5. https://doi.org/10.15690/pf.v15i5.1961 (in Russian)
35. Xiang Z., Yuan M., Hassen G.W., Gampel M., Bergold J. Lactate induced excitotoxicity in hippocampal slice cultures. Exp. Neurol. 2004; 186(1): 70–7. https://doi.org/10.1016/j.expneurol.2003.10.015
36. Smith W.S. Pathophysiology of focal cerebral ischemia: a therapeutic perspective. J Vasc Interv Radiol. 2004; 15(1 Pt 2): S3–12. https://doi.org/10.1097/01.rvi.0000108687.75691.0c
37. Schifilliti D., Grasso G., Conti A., Fodale V. Anaesthetic-related neuroprotection: intravenous or inhalational agents? CNS Drugs. 2010; 24(11): 893–907. https://doi.org/10.2165/11584760-000000000-00000
38. Hardingham G.E., Bading H. The Yin and Yang of NMDA receptor signalling. Trends Neurosci. 2003; 26(2): 81–9. https://doi.org/10.1016/S0166-2236(02)00040-1
39. Esencan E., Yuksel S., Tosun Y.B., Robinot A., Solaroglu I., Zhang J.H. Xenon in medical area: emphasis on neuroprotection in hypoxia and anesthesia. Medical Gas Research. 2013; 3(1): 4. https://doi.org/10.1186/2045-9912-3-4
40. Rizvi M., Jawad N., Li Y., Vizcaychipi M.P., Maze M., Ma D. Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells. Exp Biol Med (Maywood). 2010; 235(7): 886–91. https://doi.org/10.1258/ebm.2010.009366
41. Dworschak M. Pharmacologic neuroprotection – is xenon the light at the end of the tunnel? Crit Care Med. 2008; 36(8): 2477–9. https://doi/org/10.1097/CCM.0b013e31818113d2
42. Dingley J., Tooley J., Porter H., Thoresen M. Xenon provides short-term neuroprotection in neonatal rats when administered after hypoxia-ischemia. Stroke. 2006; 37(2): 501–6. https://doi.org/10.1161/01.STR.0000198867.31134.ac
43. Thoresen M., Hobbs C.E., Wood T., Chakkarapani E., Dingley J. Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia. J Cereb Blood Flow Metab. 2009; 29(4): 707–14. https://doi.org/10.1038/jcbfm.2008.163
44. Campos-Pires R., Armstrong S.P., Sebastianietal A., Luh C.,Gruss M., Radyushkin K., Hirnet T., Werner Ch., Engelhard K., Franks N.P., Thal S.C., Dickinson R. Xenon improves neurological outcome and reduces secondary injury following trauma in an in vivo model of traumatic brain injury. Crit Care Med. 2015; 43(1): 149–58. https://doi.org/10.1097/CCM.0000000000000624
45. Li Q., Lian C., Zhou R., Li T., Xiang X., Liu B. Pretreatment with xenon protected immature rabbit heart from ischaemia/reperfusion injury by opening of the mitoKATP channel. Heart Lung Circ. 2013; 22(4): 276–83. PMID: 23261327. https://doi.org/10.1016/j.hlc.2012.10.016
46. Mio Y., Shim Y.H., Richards E., Bosnjak Z.J., Pagel P.S., Bienengraeber M. Xenon preconditioning: the role of prosurvival signaling, mitochondrial permeability transition and bioenergetics in rats. Anesth Analg. 2009; 108(3): 858–66. PMID: 19224794. https://doi/org/10.1213/ ane.0b013e318192a520
47. Hausenloy D.J., Lecour S., Yellon D.M. Reperfusion injury salvage kinase and survivor activating factor enhancement prosurvival signaling pathways in ischemic postconditioning: two sides of the same coin. Antioxid Redox Signal. 2011; 14(5): 893–907. PMID: 20615076. https://doi/org/10.1089/ars.2010.3360
48. Goto T., Hanne P., Ishiguro Y., Ichinose F., Niimi Y., Morita S. Cardiovascular effects of xenon and nitrous oxide in patients during fentanyl-midazolam anaesthesia. Anaesthesia. 2004; 59(12): 1178–83. https://doi.org/10.1111/j.1365-2044.2004.03900.x
49. Baumert J.-H., Falter F., Eletr D., Hecker K.E., Reyle-Hahn M., Rossaint R. Xenon anaesthesia may preserve cardiovascular function in patients with heart failure. Acta Anaesthesiol Scand. 2005; 49(6): 743–9. https://doi.org/10.1111/j.1399-6576.2005.00662.x
50. Багаев В.Г., Быков М.В., Амчеславский В.Г. Гемодинамические эффекты при анестезии ксеноном у детей. Педиатрическая фармакология. 2014; 11(3): 42–47. Bagaev V.G., Bykov M.V., Amcheslavsky V.G. Hemodynamic effects of xenon anesthesia in children. Pediatricheskaya Farmakologiya. 2014; 11(3): 42–7. (in Russian)
51. Bronco A., Ingelmo P.M., Aprigliano M., Turella M., Sahillioğlu E., Bucciero M., Somaini M., Fumagalli R. Xenon an aesthesia produces better early postoperative cognitive recovery than sevoflurane anaesthesia. Eur J Anaesthesiol. 2010; 27(10): 912–916. https://doi.org/10.1097/EJA.0b013e32833b652d
52. Буров Н.Е., Арзамасцев Е.В., Кониенко Л.Ю., Кудимова Л.А. Влияние ксенона на репродуктивную функцию. Aнестезиология и реаниматология. 2002; 4: 71–2. Burov N.E., Arzamassev E.V., Kornienko L.Y., Kudimova L.A. The effect of xenon on reproductive function. Anesteziologiya I reanimatologiya. 2002; 4: 71–2. (in Russian)
53. Буров Н.Е., Арзамасцев Е.В., Кониенко Л.Ю., Кудимова Л.А. Исследование тератогенного и эмбриогенного действия ксенона. Aнестезиология и реаниматология. 2002; 4: 69–70. Burov N.E., Arzamassev E.V., Kornienko L.Y., Kudimova L.A. Investigation of teratogenic and embryotoxic effects of xenon. Anesteziologiya I reanimatologiya. 2002; 4: 69–70. (in Russian)
Russian Journal of Pediatric Surgery. 2022; 26: 29-34
Anesthetic and medical properties of xenon in the preparation of children for plastic wound closure
https://doi.org/10.55308/1560-9510-2022-26-1-29-34Abstract
Introduction. The authors present their experience in experimental and clinical studies on the application of Xenon (Xe) in subnarcotic concentrations for pain relief and for the treatment of acute stress disorders. Preparing wounds for plastic closure in children is a long and painful process which requires many anesthesia procedures during dressings. It leads to cognitive disorders, affects memory and learning potentials. Every third child who survived a severe trauma suffers of acute stress disorders: bad sleep, emotional imbalance, anxiety, asociality, inappropriate actions. Xenon is a non-toxic anesthetic. In the concentration of 20–50%, it is not only anesthetizes, but also decreases acute stress disorders, has sedative and anti-stress effects and normalizes sleep.
Objectives. To study literature data on the potentials of gas Xe in subnarcotic concentrations for pain relief and for decreasing acute stress disorders at the stage of preparing a child for plastic closure of a wound defect.
Material and methods. Literature search was done in PubMed, Scopus, eLIBRARY, Cyberleninka in English and Russian using key words: “Xenon”, “Xenon and anesthesia”, “Xenontherapy” “Actions of Xenon”, “Treatment of extensive wounds in children”, “Acute stress disorders”.
Results. The analysis of the data of the conducted studies showed the non-toxicity of Xe, which makes it possible to use it repeatedly for anesthesia in children. The fact that Xe reduces the manifestations of anxiety, depressive and psychosomatic symptoms in patients with acute and chronic stress disorders allows us to count on its positive effects in the treatment of children with extensive wounds of traumatic origin at the stage of preparing them for plastic closure.
Conclusion. The practical absence in the available scientific literature of a study to assess the effectiveness of the use of subnarcotic concentrations of Xe, when dressing extensive wounds at the stage of preparation of the wound process for plastic closure in children with acute stress disorders, justifies the conduct of an appropriate scientific study.
References
1. Mitish V.A., Nalbandyan R.T., Iskhakov O.S., Sidorov S.V., Basargin D.Yu., Bagaev V.G., Kovalenko M.I., Medinskii P.V., Sokov S.L. Osobennosti okazaniya spetsializirovannoi khirurgicheskoi pomoshchi postradavshim pri zemletryasenii v Nepale. Rany i ranevye infektsii. 2016; 3(4): 34–49. Mitish V.A., Nalbandyan R.T., Iskhakov O.S., Sidorov S.V., Basargin D.Yu., Bagaev V.G., Kovalenko M.I., Medinskiy P.V., Sokov S.L. Specifics of rescuing specialized surgical operation for earthquake-stricken in Nepal. Rany I ranevye infekcii. 2016; 3(4): 34–49. (in Russian)
2. Bagaev V.G., Saratovskii A.S., Mitish V.A., Puzhitskii L.B., Medinskii P.A., Zhuravlev N.A., Basargin D.Yu., Vorob'ev D.A. Meditsinskaya pomoshch' postradavshim detyam Gaiti. Anesteziologiya i reanimatologiya. 2011; 1: 27–9. Bagaev V.G., Saratovskiy A.S., Mitish V.A., Puzhitskiy L.B., Medinskiy P.A., Zhuravlev N.A., Basargin D.Yu., Vorobyev D.A. Medical care provision to the victim children of Haiti. Anesthesiologiya I reanimanjlogiya . 2011; 1: 27–9. (in Russian)
3. Blatun L.A., Chekmareva I.A., Mitish V.A., Paskhalova Yu.S., Ushakov A.A., Krutikov M.G., Vishnevskaya G.A., Bobrovnikov A.E., Magomedova S.D., Medinskii P.V., Nalbandyan R.T., Sokov S.L., Borisov I.V., Usu Vuiuyu O.Yu., Mun'os Sepeda P.A. Gnoinonekroticheskie porazheniya kozhi i myagkikh tkanei. Taktika mestnogo medikamentoznogo lecheniya. Gastroenterologiya. Khirurgiya. Intensivnaya terapiya. Consilium Medicum. 2019; 2: 53–62. Blatun L.A., Chekmareva I.A., Mitish V.A., Paskhalova I.S., Ushakov A.A., Krutikov M.G., Vishnevskaya G.A., Bobrovnikov A.E., Magomedova S.D., Medinskiy P.V., Nalbandyan R.T., Sokov S.L., Borisov I.V., Vuyuyu O.Yu.U., Sepeda P.A.M. Purulent and necrotic lesions of the skin and soft tissues. Tactics of localmedical treatment. Gastroenterologiya. Khirurgiya. Intensivnaya terapiya. Consilium Medicum. 2019; 2: 53–62. (in Russian)
4. Amcheslavsky V.G., Bagaev V.G., Saratovsky A.S. et al. The choice of anesthesia to children suffered in an earthquake. 18th World Congress on Disaster & Emergency Medicine. Manchester; 2013: 7–8.
5. Pandit J.J. Intravenous anesthetic agents. AnesthIntens Care dosing in pediatric anesthesia. Pediatr Anesth. 2011; 24(8): 806–812.
6. Weiss M., Vutskits L., Hansen T. G., Engelhardt T. Safe Anesthesia For Every To – The SAFETOTS initiative. Curr. Opin Anaesthesiol. 2015; 28(3): 302–7. https://doi.org/10.1097/aco.0000000000000186
7. McCann M.E., Soriano S.G. Does general anesthesia affect neurodevelopment in infants and children? BMJ. 2019; 367: l6459. https://doi.org/10.1136/bmj.l6459
8. Pyzhik T.N. Ksenon: mesto v khimii i meditsine. Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta. 2009; 3 (27): 9–11. Pyzhik T.N. Xenon: its role in chemistry and medicine. Zhurnal Grodnenskogo Gosudarstvennogo Meditsinskogo Universiteta. 2009; 3(27): 9–11. (in Russian)
9. Burov N.E., Potapov V.N., Makeev G.N. Ksenon v anesteziologii: Kliniko-eksperim. issled. M.: Pul's; 2000. Burov N.E., Potapov V.N., Makeev G.N. Xenon in anesthesiology:Clinical and experimental study [Xenon v anesteziologi:Clinico-experimentalnye issledovaniya]. Moscow: Pul’s; 2000. (in Russian)
10. Cullen S.C., Gross E.G. The anesthetic properties of xenon in animals and human beings, with additional observations on krypton. Science. 1951; 113(2942): 580–2. https://doi.org/10.1126/science.113.2942.580
11. Amcheslavskii V.G., Bagaev V.G., Arsen'eva E.N., Luk'yanov V.I., Bykov M.V., Cabinina T.S., Pinelis V.G. Izmenenie urovnya neiromarkerov S 100b i BDNF pri anesteziyakh ksenonom i sevofluranom u detei. Meditsinskii alfavit. Neotlozhnaya meditsina. 2014; 1(5(221)): 33–6. Amcheslavsky V.G., Bagaev V.G., Arsenieva E.N., Lukyanov V.I., Bykov M.V., Sabinina T.S., Pinelis V.G. Changes in the level of S100b and BDNF neuromarkers during anesthesia with xenon and sevoflurane in children. Medicinskiy alfavit. Neotlozhnaya medicina. 2014; 1(5(221)): 33–6. (in Russian)
12. Bagaev V.G., Amcheslavskii V.G., Khmel'nitskii K.E., Pinelis V.G., Arsen'eva E.N., Vasil'eva I.V., L'vova E.A. Rezul'taty klinicheskogo issledovaniya effektivnosti i bezopasnosti ksenona pri obshchei anestezii u detei. Rossiiskii vestnik detskoi khirurgii, anesteziologii i reanimatologii. 2012; 4: 70–7. Bagaev V.G., Amcheslavsky V.G., Hmelnitsiy K.E., Pinelis V.G., Arsenieva E.N., Vasileva I.V., L’vova E.A. Results of clinical efficacy and safety studies xenon anesthesia in children. Rossiyskiy vestnik drtskoy khirurgii, anestreziologii I reanimatologii. 2012; 4: 70–7. (in Russian)
13. Lazarev N.V., Lyublina E.I., Madorskaya R.Ya. O narkoticheskom deistvii ksenona. Fiziologicheskii zhurnal SSSR im. I.M. Sechenova. 1948; 34(1): 131–4. Lazarev N.V., Lublina E.I., Madorskaya R.Ya. About the narcotic effect of xenon. Physiologicheskiy Zhurnalurnal SSSR imeni I.M. Sechenov. 1948; 34(1): 131–4. (in Russian)
14. Babikov A.S., Rabinovich S.A., Naumov S.A., Davydova N.S., Kostromitina G.G., Zavodilenko L.A., Airapetyan S.M. Ksenonovye ingalyatsii dlya kupirovaniya bolevykh sindromov v stomatologii. V kn.: Sbornik trudov X Vserossiiskoi nauchno-prakticheskoi konferentsii «Obrazovanie i praktika v stomatologii» po edinoi tematike «Stomatologiya i sotsial'no-znachimye zabolevaniya» 11– 13 fevralya 2013, Moskva. Sankt-Peterburg: Chelovek; 2013: 26–7. Babikov A.S., Rabinovich S.A., Naumov S.A., Davydova N.S., Kostromitina G.G., Zavodilenko L.A., Hayrapetyan S.M. Xenon inhalations for relief of pain syndromes in dentistry. In: Proceedings of the X All-Russian Scientific and Practical Conference “Education and Practice in Dentistry” on a single topic “Dentistry and socially significant diseases” February 11–13, 2013, Moscow [Sbornik trudov X Vserossiyskoy nauchno-praktichecroy konferentsii “Obrazovanie i praktika v stomatologii” po edinoy tematike” Stomatologiya i socialnoznachimye zabolevaniya, 11–13 Fevralya 2013, Mopskva]. SaintPetersburg: Chelovek; 2013; 26–7. (in Russian)
15. Pauling L. A Molecular theory of general anesthesia. Science. 1961; 134(3471): 15–21.
16. Bagaev V.G., Devaikin E.V., Amcheslavskii V.G., Davydov M.Yu., Luk'yanov V.I. Otsenka urovnya sedatsii s pomoshch'yu BIS-monitoringa pri anestezii ksenonom u detei. Pediatriya. Zhurnal im. G.N. Speranskogo. 2013; 92(4): 124–5. Bagaev V.G., Devaykin E.V., Amcheslavsky V.G., Davidov V.G., Lukyanov V.I. Assessment of sedation level using BIS monitoring during xenon anesthesia in children. Pediatriya. Zhurnal umeni G.N. Speransky. 2013; 92(4): 124–5. (in Russian)
17. Giacalone M., Abramo A., Giunta F., Forfori F. Xenon-related analgesia: a new target for pain treatment. Clin J Pain. 2013 Jul; 29(7): 639–43. https://doi.org/10.1097/AJP.0b013e31826b12f5
18. Marx T., Froeba G., Wagner D., Baeder S., Goertz A., Georgieff M. Effects on haemodynamicsand catecholamine release of xenon anaesthesia compared with total i. v. anaesthesia in the pig. Br J Anaesth. 1997; 78(3): 326–7. https://doi.org/10.1093/bja/78.3.326
19. Genov P.G., Smirnova O.V., Timerbaev V.Kh. Xenon for postoperative analgesia: why not? Article in Russian. Anesteziol Reanimatol. 2011 May–Jun; (3): 74–7.
20. Burov N.E., Potapov V.N., Molchanov I.V., Nikolaev L.L., Korobov A.V. Narkoz ksenonom. Metodicheskie rekomendatsii. M: RMAPO; 2003. Burov N.E., Potapov V.N., Molchanov I.V., Nikolaev L.L., Korobov A.V. Xenon anesthesia. Methodological recommendations [Narkoz xsenonom. Metodologicheskie rekomendscii]. Moscow: RMAPO, 2003. (in Russian)
21. Burov N.E., Antonov A.A., patentoobladateli. Sposob autoanalgezii ksenon-kislorodnoi smes'yu. Rossiya Patent RU 2271815. 21.11.2003 g. Burov N.E., Antonov A.A., authors; Burov N.E., Antonov A.A., assignees. Method of autoanalgesia with mixture xenon-oxygen. Russian Federation patent RU 2271815. 2003 Nov 21. (in Russian)
22. Sabinina T.S., Bagaev V.G., Amcheslavskii V.G., Ivanova T.F., Bagaeva Yu.V., Luk'yanov V.I., Aver'yanov S.N., Raushenbakh N.G., Golubev B.I. Effektivnost' ingalyatsii ksenona v kompleksnoi terapii minno-vzryvnoi travmy u detei. V kn.: Sbornik tezisov XXI kongressa pediatrov Rossii s mezhdunarodnym uchastiem «Aktual'nye problemy pediatrii», Moskva, 15–17 fevralya 2019. M.: 2019; 213. Sabinina T.S., Bagaev V.G., Amcheslavskiy V.G., Ivanova T.F., Bagaeva Yu.V., Lukyanov V.I., Averyanov S.N., Raushenbach N.G., Golubev B.I. The effectiveness of xenon inhalations in the complex therapy of mine-blast trauma in children. In: Collection of abstracts of the XXI Congress of Pediatricians of Russia with international participation “Actual problems of pediatrics”. Moscow, February 15–17, 2019 [Sbornik tezisov XXI kongressa pediatrov Rossii s mezhdunarodnym uchastiem “Aktualnye problem pediatrii”. Moskva, 15–17 fevralya 2019]. Moscow: 2019. (in Russian)
23. Bagaeva Yu.V., Valiulina S.A., Bystrov A.S., Bagaev V.G. Rannyaya dvigatel'naya reabilitatsiya v usloviyakh terapii ksenonom u detei. V kn.: IV Vserossiiskii kongress s mezhdunarodnym uchastiem «Meditsinskaya pomoshch' pri travmakh i neotlozhnykh sostoyaniyakh v mirnoe i voennoe vremya. Novoe v organizatsii i tekhnologiyakh». Sbornik tezisov. Sankt-Peterburg: Izd-vo «Chelovek i zdorov'e»; 2019: 23–4. Bagaeva Yu.V., Valiullina S.A., Bystrov A.S., Bagaev V.G. Early motor rehabilitation in the conditions of xenon therapy in children. In: IV All-Russian Congress with international participation “Medical care for injuries and emergencies in peacetime and wartime. New in organization and technology” [IV Vserossiyskiy congress s mezhdunarodnym uchastiem “Medicinskaya pomoshch pri travmakh i neotlozhnykh sostoyanuyakh v mirnoe i voennoe vremya]. Abstracts. Saint-Petersburg: Chelovek & zdorovye, 2019; 23–4. (in Russian)
24. Meiser-Stedman R., Smith P., Glucksman E., Yule W., Dalgleish T. The posttraumatic stress disorder diagnosis in preschool- and elementary school-age children exposed to motor vehicle accidents. American Journal of Psychiatry. 2008; 165(10): 1326–37. https://dopi.org/10.1176/appi.ajp.2008.07081282
25. Scheeringa M.S., Wright M.J., Hunt M.P., Zeanah Ch.H. Factors affecting the diagnosis and prediction of PTSD symptomatology in children and adolescents. American Journal of Psychiatry. 2006; 163(4): 644–51. https://doi.org/10.1176/ajp.2006.163.4.644
26. Pavlov I.P. Polnoe sobranie sochinenii. T. 3, kn. 2. Dvadtsatiletnii opyt ob\"ektivnogo izucheniya vysshei nervnoi deyatel'nosti zhivotnykh: glavy XXXVI–LXIII (1923–1936 gg.). M.: 1951; 353–79. Pavlov I.P. Complete Works. Vol. 3, book 2. Twenty years of experience in the objective study of higher nervous activity of animals: Chapter XXXVI–LXIII (1923–1936) [Polnoe sobranie sochineniy. Tom3, kniga 2. Dvadtsatiletniy opyt obektivnogo izucheniyz vysshey nervnoy deyatelnosti zhivotnykh: glavy XXXVI–LXIII (1923–1936)]. Moscow: 1951; 353–79. (in Russian)
27. Fanselow M.S., Poulos A.M. The neuroscience of mammalian associative learning. Annu Rev Psychol. 2005; 56: 207–34. https://doi.org/10.1146/annurev.psych.56.091103.070213
28. Reichelt A.C., Lee J.L.C. Memory reconsolidation in aversive and appetitive settings. Front Behav Neurosci. 2013; 7: 118. https://doi.org/10.3389/fnbeh.2013.00118
29. Kotrovskaya T.I., Bubeev Yu.A., Schastlivtseva D.V. Vliyanie ksenona na posttravmaticheskie sledy pamyati. Aviakosmicheskaya i ekologicheskaya meditsina. 2019; 53(2): 13–20. https://doi.org/10.21687/0233-528X-2019-53-2-13-20 Kotrovskaya T.I., Bubeev Yu.A., Schastlivtseva D.V. Xenon effect on posttraumatic traces memories. Aviokosmicheskaya i ekologicheskaya medicina. 2019; 53(2): 13–20. https://doi.org/10.21687/0233-528X-2019-53-2-13-20 (in Russian)
30. Przybyslawski J., Sara S.J. Reconsolidation of memory after its reactivation. Beh Brain Res. 1997; 84: 241–6. https://doi.org/10.1016/s0166-4328(96)00153-2
31. Dobrovolsky A., Ichim, T.E., Ma D., Kesari S. Bogin V. Xenon in the treatment of panic disorder: an open label study. J Transl Med. 2017; 15(1): 137. https://doi.org/10.1186/s12967-017-1237-1
32. Bubeev Yu.A., Kotrovskaya T.I., Kal'manov A.S. Ksenon-kislorodnaya gazovaya ingalyatsiya dlya korrektsii negativnykh posledstvii stressa. V kn.: Ksenon i inertnye gazy v meditsine. Materialy konferentsii anesteziologov-reanimatologov meditsinskikh uchrezhdenii MO RF. Moskva: GVKG im. N.N. Burdenko, 2008; 4–9. Bubeev Yu.A., Kotrovskaya T.I., Kalmanov A.S. Xenon-oxygen gas inhalation for correction of negative effects of stress. In: Xenon and inert gases in medicine: Proceedings of the conference of anesthesiologistsresuscitators of medical institutions of the Ministry of Defense of the Russian Federation [Xenon I inertnye gazy v medicine: Materialy konferencii anesteziologo-reanimatologov medicinskikh uchrezdeniy MO RF]. Moscow: GWCG named after N.N. Burdenko, 2008; 4–9. (in Russian)
33. Igoshina T.V. Korrektsiya svyazannykh so stressom nevroticheskikh rasstroistv metodom ingalyatsii subnarkoticheskikh doz ksenona v usloviyakh sanatoriya. Kremlevskaya meditsina. Klinicheskii vestnik. 2013; 4: 37–42. Igoshina T.V. Correction of stress-induced neurotic disorders using inhalation with subnarcotic xenon doses in a sanatorium rehabilitation. Kremlevskaya medicina. Clinicheskiy vestnik. 2013; 4: 37–42. (in Russian)
34. Sabinina T.S., Bagaev V.G., Alekseev I.F. Perspektivy primeneniya lechebnykh svoistv ksenona v pediatrii. Pediatricheskaya farmakologiya. 2018; 15(5): 390–5. https://doi.org10.15690/pf.v15i5.1961 Sabinina T.S., Bagaev V.G., Alekseev I.F. Prospects for the use of medical properties of xenon in pediatrics. Pediatricheskaya farmakologiya. 2018; 15(5): 390–5. https://doi.org/10.15690/pf.v15i5.1961 (in Russian)
35. Xiang Z., Yuan M., Hassen G.W., Gampel M., Bergold J. Lactate induced excitotoxicity in hippocampal slice cultures. Exp. Neurol. 2004; 186(1): 70–7. https://doi.org/10.1016/j.expneurol.2003.10.015
36. Smith W.S. Pathophysiology of focal cerebral ischemia: a therapeutic perspective. J Vasc Interv Radiol. 2004; 15(1 Pt 2): S3–12. https://doi.org/10.1097/01.rvi.0000108687.75691.0c
37. Schifilliti D., Grasso G., Conti A., Fodale V. Anaesthetic-related neuroprotection: intravenous or inhalational agents? CNS Drugs. 2010; 24(11): 893–907. https://doi.org/10.2165/11584760-000000000-00000
38. Hardingham G.E., Bading H. The Yin and Yang of NMDA receptor signalling. Trends Neurosci. 2003; 26(2): 81–9. https://doi.org/10.1016/S0166-2236(02)00040-1
39. Esencan E., Yuksel S., Tosun Y.B., Robinot A., Solaroglu I., Zhang J.H. Xenon in medical area: emphasis on neuroprotection in hypoxia and anesthesia. Medical Gas Research. 2013; 3(1): 4. https://doi.org/10.1186/2045-9912-3-4
40. Rizvi M., Jawad N., Li Y., Vizcaychipi M.P., Maze M., Ma D. Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells. Exp Biol Med (Maywood). 2010; 235(7): 886–91. https://doi.org/10.1258/ebm.2010.009366
41. Dworschak M. Pharmacologic neuroprotection – is xenon the light at the end of the tunnel? Crit Care Med. 2008; 36(8): 2477–9. https://doi/org/10.1097/CCM.0b013e31818113d2
42. Dingley J., Tooley J., Porter H., Thoresen M. Xenon provides short-term neuroprotection in neonatal rats when administered after hypoxia-ischemia. Stroke. 2006; 37(2): 501–6. https://doi.org/10.1161/01.STR.0000198867.31134.ac
43. Thoresen M., Hobbs C.E., Wood T., Chakkarapani E., Dingley J. Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia. J Cereb Blood Flow Metab. 2009; 29(4): 707–14. https://doi.org/10.1038/jcbfm.2008.163
44. Campos-Pires R., Armstrong S.P., Sebastianietal A., Luh C.,Gruss M., Radyushkin K., Hirnet T., Werner Ch., Engelhard K., Franks N.P., Thal S.C., Dickinson R. Xenon improves neurological outcome and reduces secondary injury following trauma in an in vivo model of traumatic brain injury. Crit Care Med. 2015; 43(1): 149–58. https://doi.org/10.1097/CCM.0000000000000624
45. Li Q., Lian C., Zhou R., Li T., Xiang X., Liu B. Pretreatment with xenon protected immature rabbit heart from ischaemia/reperfusion injury by opening of the mitoKATP channel. Heart Lung Circ. 2013; 22(4): 276–83. PMID: 23261327. https://doi.org/10.1016/j.hlc.2012.10.016
46. Mio Y., Shim Y.H., Richards E., Bosnjak Z.J., Pagel P.S., Bienengraeber M. Xenon preconditioning: the role of prosurvival signaling, mitochondrial permeability transition and bioenergetics in rats. Anesth Analg. 2009; 108(3): 858–66. PMID: 19224794. https://doi/org/10.1213/ ane.0b013e318192a520
47. Hausenloy D.J., Lecour S., Yellon D.M. Reperfusion injury salvage kinase and survivor activating factor enhancement prosurvival signaling pathways in ischemic postconditioning: two sides of the same coin. Antioxid Redox Signal. 2011; 14(5): 893–907. PMID: 20615076. https://doi/org/10.1089/ars.2010.3360
48. Goto T., Hanne P., Ishiguro Y., Ichinose F., Niimi Y., Morita S. Cardiovascular effects of xenon and nitrous oxide in patients during fentanyl-midazolam anaesthesia. Anaesthesia. 2004; 59(12): 1178–83. https://doi.org/10.1111/j.1365-2044.2004.03900.x
49. Baumert J.-H., Falter F., Eletr D., Hecker K.E., Reyle-Hahn M., Rossaint R. Xenon anaesthesia may preserve cardiovascular function in patients with heart failure. Acta Anaesthesiol Scand. 2005; 49(6): 743–9. https://doi.org/10.1111/j.1399-6576.2005.00662.x
50. Bagaev V.G., Bykov M.V., Amcheslavskii V.G. Gemodinamicheskie effekty pri anestezii ksenonom u detei. Pediatricheskaya farmakologiya. 2014; 11(3): 42–47. Bagaev V.G., Bykov M.V., Amcheslavsky V.G. Hemodynamic effects of xenon anesthesia in children. Pediatricheskaya Farmakologiya. 2014; 11(3): 42–7. (in Russian)
51. Bronco A., Ingelmo P.M., Aprigliano M., Turella M., Sahillioğlu E., Bucciero M., Somaini M., Fumagalli R. Xenon an aesthesia produces better early postoperative cognitive recovery than sevoflurane anaesthesia. Eur J Anaesthesiol. 2010; 27(10): 912–916. https://doi.org/10.1097/EJA.0b013e32833b652d
52. Burov N.E., Arzamastsev E.V., Konienko L.Yu., Kudimova L.A. Vliyanie ksenona na reproduktivnuyu funktsiyu. Anesteziologiya i reanimatologiya. 2002; 4: 71–2. Burov N.E., Arzamassev E.V., Kornienko L.Y., Kudimova L.A. The effect of xenon on reproductive function. Anesteziologiya I reanimatologiya. 2002; 4: 71–2. (in Russian)
53. Burov N.E., Arzamastsev E.V., Konienko L.Yu., Kudimova L.A. Issledovanie teratogennogo i embriogennogo deistviya ksenona. Anesteziologiya i reanimatologiya. 2002; 4: 69–70. Burov N.E., Arzamassev E.V., Kornienko L.Y., Kudimova L.A. Investigation of teratogenic and embryotoxic effects of xenon. Anesteziologiya I reanimatologiya. 2002; 4: 69–70. (in Russian)
