Альманах клинической медицины. 2018; 46: 374-378
Опухоль из клеток вольфова протока: клиническое наблюдение и обзор литературы
https://doi.org/10.18786/2072-0505-2018-46-4-374-378Аннотация
Опухоль из клеток вольфова протока – редко встречающееся новообразование, развивающееся из остатков мезонефрального протока. В литературе описано не более 100 наблюдений данной опухоли. Авторы приводят собственное наблюдение опухоли из клеток вольфова протока у женщины 43 лет. По результатам лучевых методов исследования у пациентки была заподозрена субсерозная лейомиома матки, однако при оперативном вмешательстве установлено, что образование исходит из стенки маточной трубы. При гистологическом исследовании в стенке маточной трубы без признаков поражения слизистой оболочки определялся рост опухоли, представленной миксоматозно измененной стромой, в которой располагались участки криброзного, солидного и сетчатого строения из относительно мономорфных слабоэозинофильных клеток со слабо полиморфными ядрами и единичными митозами. При иммуногистохимическом исследовании в клетках опухоли отмечалась экспрессия виментина, общего цитокератина, цитокератина 7 и кальретинина. Показано, что окончательная верификация и проведение дифференциального диагноза с другими, в том числе злокачественными, опухолями маточных труб возможны только при помощи иммуногистохимического исследования.
Список литературы
1. Kariminejad MH, Scully RE. Female adnexal tumor of probable Wolffian origin. A distinctive pathologic entity. Cancer. 1973;31(3): 671–7. doi: 10.1002/1097-0142(197303)31:3<671 ::AID-CNCR2820310328>3.0.CO;2-K.
2. Heatley MK. Is female adnexal tumour of probable wolffian origin a benign lesion? A systematic review of the English literature. Pathology. 2009;41(7): 645–8. doi: 10.3109/00313020903273084.
3. Turkcapar AF, Seckin B, Gungor T, Sirvan L, Mollamahmutoğlu L. Diagnosis and management of female adnexal tumor of probable Wolffian origin (FATWO) arising from ovary: a case report. J Turk Ger Gynecol Assoc. 2013;14(1): 56–9. doi: 10.5152/jtgga.2013.14.
4. Hong S, Cui J, Li L, Buscema J, Liggins C, Zheng W. Malignant female adnexal tumor of probable wolffian origin: case report and literature review. Int J Gynecol Pathol. 2018;37(4): 331–7. doi: 10.1097/PGP.0000000000000422.
5. Deshimaru R, Fukunaga T, Sato T, Morinaga S, Takahashi M. A case of metastatic female adnexal tumor of probable Wolffian origin. Gynecol Oncol Rep. 2014;10:22–4. doi: 10.1016/j. gore.2014.07.001.
6. Wakayama A, Matsumoto H, Aoyama H, Saio M, Kumagai A, Ooyama T, Inamine M, Aoki Y. Recurrent female adnexal tumor of probable Wolffian origin treated with debulking surgery, imatinib and paclitaxel/carboplatin combination chemotherapy: A case report. Oncol Lett. 2017;13(5): 3403–8. doi: 10.3892/ol.2017.5874.
7. Tipps AM, Plaxe SC, Weidner N. Endometrioid carcinoma with a low-grade spindle cell component: a tumor resembling an adnexal tumor of probable Wolffian origin. Ann Diagn Pathol. 2011;15(5): 376–81. doi: 10.1016/j.anndiagpath.2010.06.004.
8. Oliva E, Alvarez T, Young RH. Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol. 2005;29(2): 143–56. doi: 10.1097/01. pas.0000149692.21205.9c.
9. Czernobilsky B, Lifschitz-Mercer B, Trejo L, Atlas I. Granulosa cell tumor of the broad ligament: report of a case with emphasis on the differential diagnosis with female adnexal tumor of probable Wolffian origin. Int J Surg Pathol. 2011;19(6): 783–6. doi: 10.1177/1066896909356104.
10. Lesin J, Forko-Ilić J, Plavec A, Planinić P. Management of Wolffian duct tumor recurrence without chemotherapy. Arch Gynecol Obstet. 2009;280(5): 855–7. doi: 10.1007/s00404-0091024-1.
Almanac of Clinical Medicine. 2018; 46: 374-378
Wollfian tumor: a case report and a literature review
https://doi.org/10.18786/2072-0505-2018-46-4-374-378Abstract
Wolffian tumor is a rare neoplasm arising from mesonephric duct remnants. Not more than 100 cases of the disease have been described. The authors present their own clinical observation of the Wolffian tumor in a 43-year old female patient. Radiological examinations resulted in the suspicion of a subserous leiomyoma of the uterus; however, the surgery showed a mass arising from the fallopian tube wall. Histologically, there was a growing tumor within the fallopian tube wall with no mucosal lesions. The tumor consisted of myxomatous stroma with cribriform, solid and reticular areas composed of relatively monomorphic, mildly eosinophilic cells with monotonous nuclei and single mitoses. On immunohistochemistry, the tumor cells expressed vimentin, pan-cytokeratin, cytokeratin 7 and calretinin. This case illustrates that final verification and differential diagnosis of the tumor with other fallopian tube neoplasms, including malignancies, is only possible with an immunohistochemical study.
References
1. Kariminejad MH, Scully RE. Female adnexal tumor of probable Wolffian origin. A distinctive pathologic entity. Cancer. 1973;31(3): 671–7. doi: 10.1002/1097-0142(197303)31:3<671 ::AID-CNCR2820310328>3.0.CO;2-K.
2. Heatley MK. Is female adnexal tumour of probable wolffian origin a benign lesion? A systematic review of the English literature. Pathology. 2009;41(7): 645–8. doi: 10.3109/00313020903273084.
3. Turkcapar AF, Seckin B, Gungor T, Sirvan L, Mollamahmutoğlu L. Diagnosis and management of female adnexal tumor of probable Wolffian origin (FATWO) arising from ovary: a case report. J Turk Ger Gynecol Assoc. 2013;14(1): 56–9. doi: 10.5152/jtgga.2013.14.
4. Hong S, Cui J, Li L, Buscema J, Liggins C, Zheng W. Malignant female adnexal tumor of probable wolffian origin: case report and literature review. Int J Gynecol Pathol. 2018;37(4): 331–7. doi: 10.1097/PGP.0000000000000422.
5. Deshimaru R, Fukunaga T, Sato T, Morinaga S, Takahashi M. A case of metastatic female adnexal tumor of probable Wolffian origin. Gynecol Oncol Rep. 2014;10:22–4. doi: 10.1016/j. gore.2014.07.001.
6. Wakayama A, Matsumoto H, Aoyama H, Saio M, Kumagai A, Ooyama T, Inamine M, Aoki Y. Recurrent female adnexal tumor of probable Wolffian origin treated with debulking surgery, imatinib and paclitaxel/carboplatin combination chemotherapy: A case report. Oncol Lett. 2017;13(5): 3403–8. doi: 10.3892/ol.2017.5874.
7. Tipps AM, Plaxe SC, Weidner N. Endometrioid carcinoma with a low-grade spindle cell component: a tumor resembling an adnexal tumor of probable Wolffian origin. Ann Diagn Pathol. 2011;15(5): 376–81. doi: 10.1016/j.anndiagpath.2010.06.004.
8. Oliva E, Alvarez T, Young RH. Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol. 2005;29(2): 143–56. doi: 10.1097/01. pas.0000149692.21205.9c.
9. Czernobilsky B, Lifschitz-Mercer B, Trejo L, Atlas I. Granulosa cell tumor of the broad ligament: report of a case with emphasis on the differential diagnosis with female adnexal tumor of probable Wolffian origin. Int J Surg Pathol. 2011;19(6): 783–6. doi: 10.1177/1066896909356104.
10. Lesin J, Forko-Ilić J, Plavec A, Planinić P. Management of Wolffian duct tumor recurrence without chemotherapy. Arch Gynecol Obstet. 2009;280(5): 855–7. doi: 10.1007/s00404-0091024-1.
