Альманах клинической медицины. 2017; 45: 352-356
Аденома непигментированного цилиарного эпителия у ребенка 13 лет
https://doi.org/10.18786/2072-0505-2017-45-4-352-356Аннотация
Аденома непигментированного цилиарного эпителия (НПЦЭ) – редкая внутриглазная опухоль, которая часто ошибочно расценивается как меланома сосудистой оболочки глаза либо неопухолевый процесс. В статье дан комплексный клинико-инструментальный и морфологический анализ случая НПЦЭ с ростом в корень радужки и угол передней камеры у ребенка 13 лет. Проведено хирургическое лечение (иридоциклосклерэктомия). Гистологически и иммуногистохимически подтверждена аденома НПЦЭ. Через 6 месяцев после хирургического лечения зрение 1,0, признаков рецидива опухоли не отмечено. Представленное описание расширит представления о клинических проявлениях, данных инструментальной диагностики и морфологической картине аденомы НПЦЭ, что будет полезно в комплексной диагностике различных внутриглазных новообразований.
Список литературы
1. Cursiefen C, Schlötzer-Schrehardt U, Holbach LM, Naumann GO. Adenoma of the nonpigmented ciliary epithelium mimicking a malignant melanoma of the iris. Arch Ophthalmol. 1999;117(1): 113–6. doi: 10.1001/archopht.117.1.113.
2. Serna-Ojeda JC, Ariza-Camacho E, Collado-Solórzano A, Flores-Sánchez BC, Rodríguez- Reyes AA, Fulda-Graue E. Adenoma of the nonpigmented ciliary body and iris epithelium in Mexican mestizo patients. Ocul Oncol Pathol. 2015;1(4): 248–53. doi: 10.1159/000381066.
3. Zimmerman LE. The remarkable polymorphism of tumours of the ciliary epithelium. Trans Aust Coll Ophthalmol. 1970;2:114–25.
4. Kaliki S, Shields CL, Eagle RC Jr, Vemuganti GK, Almeida A, Manjandavida FP, Mulay K, Honavar SG, Shields JA. Ciliary body medulloepithelioma: analysis of 41 cases. Ophthalmology. 2013;120(12): 2552–9. doi: 10.1016/j.ophtha.2013.05.015.
5. Yan J, Liu X, Zhang P, Li Y. Acquired adenoma of the nonpigmented ciliary epithelium: analysis of five cases. Graefes Arch Clin Exp Ophthalmol. 2015;253(4): 637–44. doi: 10.1007/s00417-014-2928-4.
6. Grossniklaus HE, Lim JI. Adenoma of the nonpigmented ciliary epithelium. Retina. 1994;14(5): 452–6.
7. Shields JA, Augsburger JJ, Wallar PH, Shah HG. Adenoma of the nonpigmented epithelium of the ciliary body. Ophthalmology. 1983;90(12): 1528–30. doi: https://doi.org/10.1016/S0161-6420(83)34353-0.
8. Shields JA, Eagle RC Jr, Shields CL, De Potter P. Acquired neoplasms of the nonpigmented ciliary epithelium (adenoma and adenocarcinoma). Ophthalmology. 1996;103(12): 2007–16. doi: https://doi.org/10.1016/S0161-6420(96)30393-X.
9. Shields JA, Eagle RC Jr, Shields CL. Adenoma of nonpigmented ciliary epithelium with smooth muscle differentiation. Arch Ophthalmol. 1999;117(1): 117–9. doi: 10.1001/archopht.117.1.117.
10. Elizalde J, Ubia S, Barraquer RI. Adenoma of the nonpigmented ciliary epithelium. Eur J Ophthalmol. 2006;16(4): 630–3.
11. Shields JA, Eagle RC Jr, Ferguson K, Shields CL. Tumors of the nonpigmented epithelium of the ciliary body: The Lorenz E. Zimmerman Tribute Lecture. Retina. 2015;35(5): 957–65. doi: 10.1097/IAE.0000000000000445.
12. Bušányová B, Babál P, Gerinec A. Adenoma of the ciliary body in 3-year-old boy – a case report. Cesk Slov Oftalmol. 2013;69(1): 37–40.
13. Appolloni R, Modesti M, Pecorella I, Palladino D, Ciocci L. Uncommon cause of juvenile cataract: adenoma of the nonpigmented ciliary epithelium. J Cataract Refract Surg. 2008;34(11): 1997– 2001. doi: 10.1016/j.jcrs.2008.05.058.
14. Mansoor S, Qureshi A. Ciliary body adenoma of non-pigmented epithelium. J Clin Pathol. 2004;57(9): 997–8. doi: 10.1136/jcp.2004.017871.
15. Biswas J, Neelakantan A, Rao BS. Adenoma of nonpigmented epithelium of the ciliary body presenting as anterior uveitis and glaucoma: a case report. Indian J Ophthalmol. 1995;43(3): 137–40.
16. Bae JH, Kwon JE, Yang WI, Lee SC. Adenoma of the nonpigmented ciliary epithelium presenting with recurrent iridocyclitis: unique expression of glial fibrillary acidic protein. Graefes Arch Clin Exp Ophthalmol. 2011;249(11): 1747–9. doi: 10.1007/s00417-010-1559-7.
17. Papastefanou VP, Cohen VM. Ciliary-body adenoma of the non-pigmented epithelium with rubeosis iridis treated with plaque brachytherapy and bevacizumab. Eye (Lond). 2012;26(10): 1388–90. doi: 10.1038/eye.2012.145.
18. Suzuki J, Goto H, Usui M. Adenoma arising from nonpigmented ciliary epithelium concomitant with neovascularization of the optic disk and cystoid macular edema. Am J Ophthalmol. 2005;139(1): 188–90. doi: 10.1016/j.ajo.2004.06.087.
19. Chen ZQ, Fang XY. Adenoma of nonpigmented epithelium in ciliary body: literature review and case report. J Zhejiang Univ Sci B. 2007;8(9): 612– 5. doi: 10.1631/jzus.2007.B0612.
20. Wei WB, Yang WL, Hu SM, Li B. Local excision of ciliary body tumors: a long-term prospective cohort study in China. Chin Med J (Engl). 2008;121(21): 2152–6.
Almanac of Clinical Medicine. 2017; 45: 352-356
Adenoma of the non-pigmented ciliary epithelium in a 13-year old child
https://doi.org/10.18786/2072-0505-2017-45-4-352-356Abstract
Adenoma of the non-pigmented ciliary epithelium (NPCE) is a rare intraocular tumor which is often misinterpreted as a melanoma of the ciliary body or a non-tumorous process. We present a complex clinical, instrumental and morphological analysis of a case of adenoma of the NPCE growing into the base of the iris and the anterior chamber angle in a 13-year old child. Surgical treatment (iridocyclectomy) was performed. An adenoma of the NPCE was confirmed both histologically and by immunohistochemistry. At 6 months after surgery the patient's visual acuity was 1.0, with no signs of the tumor recurrence. The case can help to better understand clinical manifestation, results of the instrumental diagnostic assessments and the morphological picture of adenoma of NPCE that will be useful in the complex diagnosis of various intraocular tumors.
References
1. Cursiefen C, Schlötzer-Schrehardt U, Holbach LM, Naumann GO. Adenoma of the nonpigmented ciliary epithelium mimicking a malignant melanoma of the iris. Arch Ophthalmol. 1999;117(1): 113–6. doi: 10.1001/archopht.117.1.113.
2. Serna-Ojeda JC, Ariza-Camacho E, Collado-Solórzano A, Flores-Sánchez BC, Rodríguez- Reyes AA, Fulda-Graue E. Adenoma of the nonpigmented ciliary body and iris epithelium in Mexican mestizo patients. Ocul Oncol Pathol. 2015;1(4): 248–53. doi: 10.1159/000381066.
3. Zimmerman LE. The remarkable polymorphism of tumours of the ciliary epithelium. Trans Aust Coll Ophthalmol. 1970;2:114–25.
4. Kaliki S, Shields CL, Eagle RC Jr, Vemuganti GK, Almeida A, Manjandavida FP, Mulay K, Honavar SG, Shields JA. Ciliary body medulloepithelioma: analysis of 41 cases. Ophthalmology. 2013;120(12): 2552–9. doi: 10.1016/j.ophtha.2013.05.015.
5. Yan J, Liu X, Zhang P, Li Y. Acquired adenoma of the nonpigmented ciliary epithelium: analysis of five cases. Graefes Arch Clin Exp Ophthalmol. 2015;253(4): 637–44. doi: 10.1007/s00417-014-2928-4.
6. Grossniklaus HE, Lim JI. Adenoma of the nonpigmented ciliary epithelium. Retina. 1994;14(5): 452–6.
7. Shields JA, Augsburger JJ, Wallar PH, Shah HG. Adenoma of the nonpigmented epithelium of the ciliary body. Ophthalmology. 1983;90(12): 1528–30. doi: https://doi.org/10.1016/S0161-6420(83)34353-0.
8. Shields JA, Eagle RC Jr, Shields CL, De Potter P. Acquired neoplasms of the nonpigmented ciliary epithelium (adenoma and adenocarcinoma). Ophthalmology. 1996;103(12): 2007–16. doi: https://doi.org/10.1016/S0161-6420(96)30393-X.
9. Shields JA, Eagle RC Jr, Shields CL. Adenoma of nonpigmented ciliary epithelium with smooth muscle differentiation. Arch Ophthalmol. 1999;117(1): 117–9. doi: 10.1001/archopht.117.1.117.
10. Elizalde J, Ubia S, Barraquer RI. Adenoma of the nonpigmented ciliary epithelium. Eur J Ophthalmol. 2006;16(4): 630–3.
11. Shields JA, Eagle RC Jr, Ferguson K, Shields CL. Tumors of the nonpigmented epithelium of the ciliary body: The Lorenz E. Zimmerman Tribute Lecture. Retina. 2015;35(5): 957–65. doi: 10.1097/IAE.0000000000000445.
12. Bušányová B, Babál P, Gerinec A. Adenoma of the ciliary body in 3-year-old boy – a case report. Cesk Slov Oftalmol. 2013;69(1): 37–40.
13. Appolloni R, Modesti M, Pecorella I, Palladino D, Ciocci L. Uncommon cause of juvenile cataract: adenoma of the nonpigmented ciliary epithelium. J Cataract Refract Surg. 2008;34(11): 1997– 2001. doi: 10.1016/j.jcrs.2008.05.058.
14. Mansoor S, Qureshi A. Ciliary body adenoma of non-pigmented epithelium. J Clin Pathol. 2004;57(9): 997–8. doi: 10.1136/jcp.2004.017871.
15. Biswas J, Neelakantan A, Rao BS. Adenoma of nonpigmented epithelium of the ciliary body presenting as anterior uveitis and glaucoma: a case report. Indian J Ophthalmol. 1995;43(3): 137–40.
16. Bae JH, Kwon JE, Yang WI, Lee SC. Adenoma of the nonpigmented ciliary epithelium presenting with recurrent iridocyclitis: unique expression of glial fibrillary acidic protein. Graefes Arch Clin Exp Ophthalmol. 2011;249(11): 1747–9. doi: 10.1007/s00417-010-1559-7.
17. Papastefanou VP, Cohen VM. Ciliary-body adenoma of the non-pigmented epithelium with rubeosis iridis treated with plaque brachytherapy and bevacizumab. Eye (Lond). 2012;26(10): 1388–90. doi: 10.1038/eye.2012.145.
18. Suzuki J, Goto H, Usui M. Adenoma arising from nonpigmented ciliary epithelium concomitant with neovascularization of the optic disk and cystoid macular edema. Am J Ophthalmol. 2005;139(1): 188–90. doi: 10.1016/j.ajo.2004.06.087.
19. Chen ZQ, Fang XY. Adenoma of nonpigmented epithelium in ciliary body: literature review and case report. J Zhejiang Univ Sci B. 2007;8(9): 612– 5. doi: 10.1631/jzus.2007.B0612.
20. Wei WB, Yang WL, Hu SM, Li B. Local excision of ciliary body tumors: a long-term prospective cohort study in China. Chin Med J (Engl). 2008;121(21): 2152–6.
