Альманах клинической медицины. 2013; : 25-31
ТРАНСЛЯЦИОННАЯ КЛЕТОЧНАЯ ИММУНОТЕРАПИЯ ПРИ АЛЛОТРАНСПЛАНТАЦИИ ТРУПНОЙ ПОЧКИ У УРОЛОГИЧЕСКИХ БОЛЬНЫХ
https://doi.org/10.18786/2072-0505-2013-28-25-31Аннотация
Представлен первый отечественный опыт применения трансляционной клеточной иммунотерапии у реципиентов после аллотрансплантации трупной почки. Приведен анализ клинических, лабораторных и иммунологических данных, а также результаты протокольной биопсии трансплантата на 30-е и 180-е сутки после операции. Выявлены клинико-лабораторные, иммунологические и гистологические преимущества у больных основной группы. Установлены некоторые механизмы, раскрывающие возможности формирования иммунологической толерантности.
Список литературы
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3. Cattaneo D., Baldelli S., Perico N. Pharmacogenetics of immunosuppressants: progress, pitfalls and promises // Am. J. Transplant. 2008. V.8. Р.1374.
4. Cornell L.D., Smith R.N., Colvin R.B. Kidney Transplantation: Mechanisms of Rejection and Acceptance // Ann. Rev. Pathol. Mech. Dis. 2008. V.3. P.189-220.
5. Greinix H.T., Knobler R.M., Worel N. et al. The effect of intensified extracorporeal photochemotherapy on long-term survival in patients with severe acute graft-versus-host disease // Haematologica. 2006. V.91, No.3. P.405-408.
6. Jagasia M.N., Savani B.N., Stricklin G. et al. Classic and overlap chronic graft – versus – host disease is associated with superior outcome after extracorporeal photophere-sis // Biol. Blood Marrow Transplant. 2009. V.15, No.10. P.1288-1295.
7. Jardine M.J., Bhandari S., Wyburn K.R. et al. Photopheresis Therapy for Problematic Renal Allograft Rejection // J. Clin. Apheresis. 2009. V.24. P.161-169.
8. Jiang H., Chess L. Regulation of Immune Responses by T-Cells // N. Engl. J. Med. 2006. V.11, No.354. P.1166-1176.
9. Karczewski M., Glyda M. et al. Role of TH1/TH2 cytokines in kidney allograft rejection // Transplant. Proc. 2008. V.40, No.10. Р.3390-3392.
10. Kenna K.E., Whittaker S., Rhodes L.E. et al. Evidence-based practice of photopheresis 1987 – 2001: a report of a workshop of the British Photodermatology group and the U.K. skin lymphoma group // Brit. J. Dermatol. 2006. V.154. P.7-20.
11. Lamioni A., Carsetti R., Legato A. et al. Induction of regulatory T-cells after prophylactic treatment with photophere-sis in renal transplant recipient // Transplantation. 2007. V.83. P.1393-1396.
12. Meloni F., Cascina A., Miserere S. et al. Peripheral CD4(+) CD25(+) TREG cell counts and the response to extracorpo-real photopheresis in lung transplant recipients // Transplant. Proc. 2007. V.39, No.1. Р.213-217.
13. Mohamed H., Sayegh M.D., Laurence A. et al. The role of T-cell co-stimulatory activation pathways in transplant rejection // Mech. Dis. 2010. P.118-121.
14. Nafar M., Farrokhi F., Vaezi M. et al. Pre-transplant and post-transplant soluble CD30 for prediction and diagnosis of acute kidney allograft rejection // Int. Urol. Nephrol. 2008. V.12. Р.2114-2115.
15. Rummler S., Barz D. Extracorporeal photopheresis – a beneficial treatment for cardiac and lung transplant rejection // Transplant. Int. 2011. V.24. P.5.
16. Sahin G., Akay O.M., Bal C. et al. The effect of calcineurin inhibitors on endothelial and platelet function in renal transplant patients // Clin. Nephrol. 2011. V.76, No.3. P.218-225.
17. Solez K., Colvin R.B., Racusen L.S. et al. Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions // Mechan. Dis. 2008. V.10. P.1600-1643.
Almanac of Clinical Medicine. 2013; : 25-31
TRANSLATIONAL CELLULAR IMMUNOTHERAPY FOR CADAVERIC KIDNEY ALLOGRAFT IN UROLOGICAL PATIENTS
https://doi.org/10.18786/2072-0505-2013-28-25-31Abstract
The first domestic experience of translational cellular immunotherapy application in recipients of cadaveric renal allograft is presented. We present the analysis of the clinical, laboratory and immunological data and also the results of transplant protocol biopsy on the 30th and 180th days after transplantation. Clinical, laboratory, immunological, and histological benefits in patients of the main group were revealed. As а result, some mechanisms that explain the possibility to form immunological tolerance were established.
References
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3. Cattaneo D., Baldelli S., Perico N. Pharmacogenetics of immunosuppressants: progress, pitfalls and promises // Am. J. Transplant. 2008. V.8. R.1374.
4. Cornell L.D., Smith R.N., Colvin R.B. Kidney Transplantation: Mechanisms of Rejection and Acceptance // Ann. Rev. Pathol. Mech. Dis. 2008. V.3. P.189-220.
5. Greinix H.T., Knobler R.M., Worel N. et al. The effect of intensified extracorporeal photochemotherapy on long-term survival in patients with severe acute graft-versus-host disease // Haematologica. 2006. V.91, No.3. P.405-408.
6. Jagasia M.N., Savani B.N., Stricklin G. et al. Classic and overlap chronic graft – versus – host disease is associated with superior outcome after extracorporeal photophere-sis // Biol. Blood Marrow Transplant. 2009. V.15, No.10. P.1288-1295.
7. Jardine M.J., Bhandari S., Wyburn K.R. et al. Photopheresis Therapy for Problematic Renal Allograft Rejection // J. Clin. Apheresis. 2009. V.24. P.161-169.
8. Jiang H., Chess L. Regulation of Immune Responses by T-Cells // N. Engl. J. Med. 2006. V.11, No.354. P.1166-1176.
9. Karczewski M., Glyda M. et al. Role of TH1/TH2 cytokines in kidney allograft rejection // Transplant. Proc. 2008. V.40, No.10. R.3390-3392.
10. Kenna K.E., Whittaker S., Rhodes L.E. et al. Evidence-based practice of photopheresis 1987 – 2001: a report of a workshop of the British Photodermatology group and the U.K. skin lymphoma group // Brit. J. Dermatol. 2006. V.154. P.7-20.
11. Lamioni A., Carsetti R., Legato A. et al. Induction of regulatory T-cells after prophylactic treatment with photophere-sis in renal transplant recipient // Transplantation. 2007. V.83. P.1393-1396.
12. Meloni F., Cascina A., Miserere S. et al. Peripheral CD4(+) CD25(+) TREG cell counts and the response to extracorpo-real photopheresis in lung transplant recipients // Transplant. Proc. 2007. V.39, No.1. R.213-217.
13. Mohamed H., Sayegh M.D., Laurence A. et al. The role of T-cell co-stimulatory activation pathways in transplant rejection // Mech. Dis. 2010. P.118-121.
14. Nafar M., Farrokhi F., Vaezi M. et al. Pre-transplant and post-transplant soluble CD30 for prediction and diagnosis of acute kidney allograft rejection // Int. Urol. Nephrol. 2008. V.12. R.2114-2115.
15. Rummler S., Barz D. Extracorporeal photopheresis – a beneficial treatment for cardiac and lung transplant rejection // Transplant. Int. 2011. V.24. P.5.
16. Sahin G., Akay O.M., Bal C. et al. The effect of calcineurin inhibitors on endothelial and platelet function in renal transplant patients // Clin. Nephrol. 2011. V.76, No.3. P.218-225.
17. Solez K., Colvin R.B., Racusen L.S. et al. Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions // Mechan. Dis. 2008. V.10. P.1600-1643.
