Альманах клинической медицины. 2016; 44: 770-774
Микробиоценоз верхних отделов желудочно-кишечного тракта и его роль в формировании ожирения у детей
https://doi.org/10.18786/2072-0505-2016-44-6-770-774Аннотация
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15. Gronlund MM, Lehtonen OP, Eerola E, Kero P. Fecal microflora in healthy infants born by different methods of delivery: permanent changes in intestinal flora after cesarean delivery. J Pediatr Gastroenterol Nutr. 1999;28(1): 19-25.
16. Kalliomaki M, Collado MC, Salminen S, Isolau-ri E. Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr. 2008;87(3):534-8.
17. Caricilli AM, Saad MJ. The role of gut microbi-ota on insulin resistance. Nutrients. 2013;5(3): 829-51. doi: 10.3390/nu5030829.
18. Galley JD, Bailey M, Kamp Dush C, Schoppe-Sul-livan S, Christian LM. Maternal obesity is associated with alterations in the gut microbiome in toddlers. PLoS One. 2014;9(11):e113026. doi: 10.1371/journal.pone.0113026.
19. Soto A, Martin V, Jimenez E, Mader I, Rodriguez JM, Fernandez L. Lactobacilli and bifidobacteria in human breast milk: influence of an-tibiotherapy and other host and clinical factors. J Pediatr Gastroenterol Nutr. 2014;59(1):78-88. doi: 10.1097/MPG.0000000000000347.
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21. Martin V, Maldonado-Barragan A, Moles L, Rodriguez-Banos M, Campo RD, Fernandez L, Rodriguez JM, Jimenez E. Sharing of bacterial strains between breast milk and infant feces. J Hum Lact. 2012;28(1):36-44. doi: 10.1177/0890334411424729.
22. Angelakis E, Armougom F, Million M, Raoult D. The relationship between gut microbiota and weight gain in humans. Future Microbiol. 2012;7(1):91-109. doi: 10.2217/fmb.11.142.
23. Andersson AF, Lindberg M, Jakobsson H, Back-hed F, Nyren P, Engstrand L. Comparative analysis of human gut microbiota by barcoded py-rosequencing. PLoS One. 2008;3(7):e2836. doi: 10.1371/journal.pone.0002836.
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36. Gen R, Demir M, Ataseven H. Effect of Helico-bacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation. South Med J. 2010;103(3):190-6. doi: 10.1097/SMJ.0b013e3181cf373f.
Almanac of Clinical Medicine. 2016; 44: 770-774
The microbiota of upper parts of gastrointestinal tract and its role in the development of obesity in children
https://doi.org/10.18786/2072-0505-2016-44-6-770-774Abstract
Evaluation of qualitative and quantitative composition of microflora of different habitats of the human body and definition of their role in the development of metabolic disorders are of great interest for investigators worldwide. The gut microbiota is an obligatory contributor to the synthesis, recirculation and metabolism of steroid hormones, lipids, and bile acids. Infectious agents and their biologically active compounds initiate the atherogenesis. Disorders of lipid metabolism are associated with a change in bacterial enterotypes. Microbiotal colonization of gastrointestinal tract starts at birth. Its composition in a newborn depends on a variety of environmental and nutritional factors, maternal health, the course of pregnancy and delivery. Infants born by cesarean section have a higher incidence of obesity, which is thought to be associated with a delay of bifidobacterial colonization of gastrointestinal tract.
Reduction of bifidobacteria counts in the gut in infants below 12 months of age predisposes to obesity in later life. Children born to mothers with obesity have significant differences in the composition of the gut microflora, compared to children born to normal weight mothers. This review presents the data on the association between metabolic disorders, such as obesity and type 2 diabetes, and persistence of Helicobacter pylori infection. Further in-depth research in this area would increase the knowledge on the mechanisms of hormonal and metabolic disorders in childhood and may help to develop algorithms for effective treatment and preventive measures.
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