Альманах клинической медицины. 2013; : 79-83
РОЛЬ СИСТЕМЫ HLA В ОТТОРЖЕНИИ ПОЧЕЧНОГО ТРАНСПЛАНТАТА
https://doi.org/10.18786/2072-0505-2013-29-79-83Аннотация
Известно, что количество совпадений по антигенам главного комплекса гистосовместимости имеет прямую связь с длительностью функционирования почечного трансплантата. В статье анализируется роль совпадения по HLA в предсенсибилизации реципиентов почечного трансплантата и в продукции антител de novo, а также уделяется внимание не-HLA-антителам.
Список литературы
1. Абрамов В.Ю., Тарабарко Н.В., Мойсюк Я.Г. и др. Со-вместимость по общим HLA-DR-антигенам эффективно предупреждает раннюю утрату трансплантата почки // Вестн. транспл. искусств. органов. 2006. №5. С.12-17.
2. Бикбов Б.Т., Томилина Н.А. Состояние заместительной терапии больных с хронической почечной недостаточностью в Российской Федерации в 1998-2009 гг. (Отчет по данным Российского регистра заместительной почечной терапии) // Нефрол. диал. 2011. №3. C.150-264.
3. Данович Г.М. Трансплантация почки / пер. с англ. под ред. А.Г. Мойсюка. М.: ГЭОТАР-Медиа, 2013. С.54-138.
4. Сушков А.И., Абрамов В.Ю., Мойсюк Я.Г. Роль предсуществующих и denovoантидонорских антител при трансплантации почки // Вестн. транспл. искусств. органов. 2012. №1. С.84-91.
5. Arnol M., Prather J.C., Mittalhenkle A. et al. Long-term kidney regraft survival from deceased donors: risk factors and outcomes in a single center // Transplantation. 2008. V.86, No.8. P.1084-1089.
6. Burlingham W.J., Muñoz del Rio A., Lorentzen D. et al. HLA-A, -B, and -DR zero-mismatched kidneys shipped to the University of Wisconsin, Madison, 1993-2006: superior graft survival despite longer preservation time // Transplantation. 2010. V.90, No.3. P.312-318.
7. Cecka J.M. Kidney transplantation in the United States // Clin. Transpl. 2008. P.1-18.
8. Cox S.T., Stephens H.A., Fernando R. et al. Major histocompatibility complex class I-related chain A allele mismatching, antibodies, and rejection in renal transplantation // Hum. Immunol. 2011. V.72, No.10. P.827-834.
9. Devos J.M., Gaber A.O., Knight R.J. Donor-specific HLADQ antibodies may contribute to poor graft outcome after renal transplantation // Kidney Int. 2012. V.82, No.5. P.598-604.
10. Devos J.M., Patel S.J., Burns K.M. et al. De novo donor specific antibodies and patient outcomes in renal transplantation // Clin. Transpl. 2011. P.351-358.
11. Doxiadis I.I. Compatibility and kidney transplantation: the way to go // Front Immunol. 2012. V.3. P.111.
12. Doxiadis I.I., Rahmel A., Claas F.H. Towards kidney allocation on basis of HLA-DR compatibility // Clin. Transpl. 2010. P.61-64.
13. Freitas M.C. Kidney transplantation in the US: an analysis of the OPTN/UNOS registry // Clin. Transpl. 2011. P.1-16.
14. Gratwohl A., Döhler B., Stern M., Opelz G. H-Y as a minor his-tocompatibility antigen in kidney transplantation: a retrospective cohort study // Lancet. 2008. V.372, No.9632. P.49-53.
15. Huber L., Lachmann N., Dürr M. et al. Identification and therapeutic management of highly sensitized patients undergoing renal transplantation // Drugs. 2012. V.72, No.10. P.1335-1354.
16. Johnson R.J., Fuggle S.V., O'Neill J. et al. Factors influencing outcome after deceased heart beating donor kidney transplantation in the United Kingdom: an evidence base for a new national kidney allocation policy // Transplantation. 2010. V.89, No.4. P.379-386.
17. Kanter Berga J., Pallardo Mateu L.M., Beltran Catalan S. et al. Donor-specific HLA antibodies: risk factors and outcomes after kidney transplantation // Transplant. Proc. 2011. V.43, No.6. P.2154-2156.
18. Kim S.J., Gill J.S. H-Y incompatibility predicts short-term outcomes for kidney transplant recipients // J. Am. Soc. Nephrol. 2009. V.20, No.9. P.2025-2033.
19. Lee K.W., Kim S.J., Lee D.S. et al. Effect of panel-reactive antibody positivity on graft rejection before or after kidney transplantation // Transplant. Proc. 2004. V.36, No.7. P.2009-2010.
20. Lefaucheur C., Loupy A., Hill G.S. et al. Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation // J. Am. Soc. Nephrol. 2010. V.21, No.8. P.1398-1406.
21. Lemy A., Andrien M., Wissing K.M. et al. Major histocompatibility complex class 1 chain-related antigen and antibodies: sensitizing events and impact on renal graft outcomes // Transplantation. 2010. V.90, No.2. P.168-174.
22. Li Z., Luo M., Qiu J. et al. Detection of antibodies against major histocompatibility complex class I-related chain A in long-term renal graft recipients // Exp. Clin. Transplant. 2012. V.10, No.3. P.239-242.
23. Lim W.H., Chadban S.J., Clayton P. et al. Human leukocyte antigen mismatches associated with increased risk of rejection, graft failure, and death independent of initial immunosuppression in renal transplant recipients // Clin. Transplant. 2012. V.26, No.4. E428-Е437.
24. Meng H.L., Jin X.B., Li X.T. et al. Impact of human leukocyte antigen matching and recipients' panel reactive antibodies on two-year outcome in presensitized renal allograft recipients // Chin. Med. J. (Engl.). 2009. V.122, No.4. P.420-426.
25. Opelz G. Collaborative Transplant Study. Non-HLA transplantation immunity revealed by lymphocytotoxic antibodies // Lancet. 2005. V.365, No.9470. P.1570-1576.
26. Pabón M.A., Navarro C.E., Martin R. et al. Minor histocompatibility antigens as risk factor for poor prognosis in kidney transplantation // Transplant. Proc. 2011. V.43, No.9. P.3319-3323.
27. Paramesh A.S., Zhang R., Baber J. et al. The effect of HLA mismatch on highly sensitized renal allograft recipients // Clin. Transplant. 2010. V.24, No.6. E247-Е252.
28. Rebellato L.M., Everly M.J., Haisch C.E. et al. A report of the epidemiology of de novo donor-specific anti-HLA antibodies (DSA) in «low-risk» renal transplant recipients // Clin. Transpl. 2011. P.337-340.
29. Sánchez-Fructuoso A.I., Santiago J.L., Pérez-Flores I. et al. De novo anti-HLA antibodies in renal allograft recipients: a cross-section study // Transplant. Proc. 2010. V.42, No.8. P.2874-2876.
30. Sureshkumar K.K., Hussain S.M., Carpenter B.J. et al. Antibody-mediated rejection following renal transplantation // Expert. Opin. Pharmacother. 2007. V.8, No.7. P.913-921.
31. Süsal C., Morath C. Current approaches to the management of highly sensitized kidney transplant patients // Tissue Antigens. 2011. V.77, No.3. P.177-186.
32. Willicombe M., Brookes P., Sergeant R. et al. De Novo DQ Donor-Specific Antibodies Are Associated With a Significant Risk of Antibody-Mediated Rejection and Transplant Glomerulopathy // Transplantation. 2012. V.94, No.2. P.172-177.
33. Wu J., Chen J., Wang Y. et al. Impact of acute rejection episodes on long-term renal allograft survival // Chin. Med. J. (Engl.). 2003. V.116, No.11. P.1741-1745.
34. Zhang M., Lu F.M., Qu L.X. et al. Serum major-histocompatibility-complex class I-related chain A antibody detection for the evaluation of graft dysfunction in renal allograft recipients // Chin. Med. J. (Engl.). 2011. V.124, No.14. P.2127-2131.
35. Zou Y., Stastny P. Antibodies against major histocompatibility complex class I-related chain A in transplant recipients // Chin. Med. J. (Engl.). 2011. V.124, No.5. P.764-770.
36. Zou Y., Stastny P., Süsal C. et al. Antibodies against MICA antigens and kidney-transplant rejection // N. Engl. J. Med. 2007. V.357, No.13. P.1293-1300.
Almanac of Clinical Medicine. 2013; : 79-83
ROLE OF HLA IN RENAL TRANSPLANT REJECTION
https://doi.org/10.18786/2072-0505-2013-29-79-83Abstract
It is known that the number of matches of the major histocompatibility complex antigens has a direct relationship with the duration of a renal transplant functioning. The lecture examines the role of HLA matching in presensitization of renal transplant recipients and de novo production of antibodies. Attention is also paid to non-HLA antibodies.
References
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4. Sushkov A.I., Abramov V.Yu., Moisyuk Ya.G. Rol' predsushchestvuyushchikh i denovoantidonorskikh antitel pri transplantatsii pochki // Vestn. transpl. iskusstv. organov. 2012. №1. S.84-91.
5. Arnol M., Prather J.C., Mittalhenkle A. et al. Long-term kidney regraft survival from deceased donors: risk factors and outcomes in a single center // Transplantation. 2008. V.86, No.8. P.1084-1089.
6. Burlingham W.J., Muñoz del Rio A., Lorentzen D. et al. HLA-A, -B, and -DR zero-mismatched kidneys shipped to the University of Wisconsin, Madison, 1993-2006: superior graft survival despite longer preservation time // Transplantation. 2010. V.90, No.3. P.312-318.
7. Cecka J.M. Kidney transplantation in the United States // Clin. Transpl. 2008. P.1-18.
8. Cox S.T., Stephens H.A., Fernando R. et al. Major histocompatibility complex class I-related chain A allele mismatching, antibodies, and rejection in renal transplantation // Hum. Immunol. 2011. V.72, No.10. P.827-834.
9. Devos J.M., Gaber A.O., Knight R.J. Donor-specific HLADQ antibodies may contribute to poor graft outcome after renal transplantation // Kidney Int. 2012. V.82, No.5. P.598-604.
10. Devos J.M., Patel S.J., Burns K.M. et al. De novo donor specific antibodies and patient outcomes in renal transplantation // Clin. Transpl. 2011. P.351-358.
11. Doxiadis I.I. Compatibility and kidney transplantation: the way to go // Front Immunol. 2012. V.3. P.111.
12. Doxiadis I.I., Rahmel A., Claas F.H. Towards kidney allocation on basis of HLA-DR compatibility // Clin. Transpl. 2010. P.61-64.
13. Freitas M.C. Kidney transplantation in the US: an analysis of the OPTN/UNOS registry // Clin. Transpl. 2011. P.1-16.
14. Gratwohl A., Döhler B., Stern M., Opelz G. H-Y as a minor his-tocompatibility antigen in kidney transplantation: a retrospective cohort study // Lancet. 2008. V.372, No.9632. P.49-53.
15. Huber L., Lachmann N., Dürr M. et al. Identification and therapeutic management of highly sensitized patients undergoing renal transplantation // Drugs. 2012. V.72, No.10. P.1335-1354.
16. Johnson R.J., Fuggle S.V., O'Neill J. et al. Factors influencing outcome after deceased heart beating donor kidney transplantation in the United Kingdom: an evidence base for a new national kidney allocation policy // Transplantation. 2010. V.89, No.4. P.379-386.
17. Kanter Berga J., Pallardo Mateu L.M., Beltran Catalan S. et al. Donor-specific HLA antibodies: risk factors and outcomes after kidney transplantation // Transplant. Proc. 2011. V.43, No.6. P.2154-2156.
18. Kim S.J., Gill J.S. H-Y incompatibility predicts short-term outcomes for kidney transplant recipients // J. Am. Soc. Nephrol. 2009. V.20, No.9. P.2025-2033.
19. Lee K.W., Kim S.J., Lee D.S. et al. Effect of panel-reactive antibody positivity on graft rejection before or after kidney transplantation // Transplant. Proc. 2004. V.36, No.7. P.2009-2010.
20. Lefaucheur C., Loupy A., Hill G.S. et al. Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation // J. Am. Soc. Nephrol. 2010. V.21, No.8. P.1398-1406.
21. Lemy A., Andrien M., Wissing K.M. et al. Major histocompatibility complex class 1 chain-related antigen and antibodies: sensitizing events and impact on renal graft outcomes // Transplantation. 2010. V.90, No.2. P.168-174.
22. Li Z., Luo M., Qiu J. et al. Detection of antibodies against major histocompatibility complex class I-related chain A in long-term renal graft recipients // Exp. Clin. Transplant. 2012. V.10, No.3. P.239-242.
23. Lim W.H., Chadban S.J., Clayton P. et al. Human leukocyte antigen mismatches associated with increased risk of rejection, graft failure, and death independent of initial immunosuppression in renal transplant recipients // Clin. Transplant. 2012. V.26, No.4. E428-E437.
24. Meng H.L., Jin X.B., Li X.T. et al. Impact of human leukocyte antigen matching and recipients' panel reactive antibodies on two-year outcome in presensitized renal allograft recipients // Chin. Med. J. (Engl.). 2009. V.122, No.4. P.420-426.
25. Opelz G. Collaborative Transplant Study. Non-HLA transplantation immunity revealed by lymphocytotoxic antibodies // Lancet. 2005. V.365, No.9470. P.1570-1576.
26. Pabón M.A., Navarro C.E., Martin R. et al. Minor histocompatibility antigens as risk factor for poor prognosis in kidney transplantation // Transplant. Proc. 2011. V.43, No.9. P.3319-3323.
27. Paramesh A.S., Zhang R., Baber J. et al. The effect of HLA mismatch on highly sensitized renal allograft recipients // Clin. Transplant. 2010. V.24, No.6. E247-E252.
28. Rebellato L.M., Everly M.J., Haisch C.E. et al. A report of the epidemiology of de novo donor-specific anti-HLA antibodies (DSA) in «low-risk» renal transplant recipients // Clin. Transpl. 2011. P.337-340.
29. Sánchez-Fructuoso A.I., Santiago J.L., Pérez-Flores I. et al. De novo anti-HLA antibodies in renal allograft recipients: a cross-section study // Transplant. Proc. 2010. V.42, No.8. P.2874-2876.
30. Sureshkumar K.K., Hussain S.M., Carpenter B.J. et al. Antibody-mediated rejection following renal transplantation // Expert. Opin. Pharmacother. 2007. V.8, No.7. P.913-921.
31. Süsal C., Morath C. Current approaches to the management of highly sensitized kidney transplant patients // Tissue Antigens. 2011. V.77, No.3. P.177-186.
32. Willicombe M., Brookes P., Sergeant R. et al. De Novo DQ Donor-Specific Antibodies Are Associated With a Significant Risk of Antibody-Mediated Rejection and Transplant Glomerulopathy // Transplantation. 2012. V.94, No.2. P.172-177.
33. Wu J., Chen J., Wang Y. et al. Impact of acute rejection episodes on long-term renal allograft survival // Chin. Med. J. (Engl.). 2003. V.116, No.11. P.1741-1745.
34. Zhang M., Lu F.M., Qu L.X. et al. Serum major-histocompatibility-complex class I-related chain A antibody detection for the evaluation of graft dysfunction in renal allograft recipients // Chin. Med. J. (Engl.). 2011. V.124, No.14. P.2127-2131.
35. Zou Y., Stastny P. Antibodies against major histocompatibility complex class I-related chain A in transplant recipients // Chin. Med. J. (Engl.). 2011. V.124, No.5. P.764-770.
36. Zou Y., Stastny P., Süsal C. et al. Antibodies against MICA antigens and kidney-transplant rejection // N. Engl. J. Med. 2007. V.357, No.13. P.1293-1300.
