Альманах клинической медицины. 2016; 44: 363-368
ЭПИЛЕПТИЧЕСКИЙ СТАТУС У ПАЦИЕНТКИ С ЭНЦЕФАЛИТОМ РАСМУССЕНА
https://doi.org/10.18786/2072-0505-2016-44-3-363-368Аннотация
Представлен клинический случай энцефалита Расмуссена у 24-летней женщины во время ее пребывания в стационаре. Клинические проявления сводились к клоническим двигательным расстройствам и фокальной эпилепсии. Проведенная магнитно-резонансная томография головного мозга установила уменьшение левого полушария с признаками воспаления и рубцевания. Электроэнцефалограмма показала электрофизиологические признаки эпилепсии и замедление электрической активности левой гемисферы головного мозга. Биопсия головного мозга не проводилась.
Список литературы
1. Rasmussen T, Olszewski J, Lloyd-Smith D. Focal seizures due to chronic localized encephalitis. Neurology. 1958;8(6):435–45.
2. Piatt JH Jr, Hwang PA, Armstrong DC, Becker LE, Hoffman HJ. Chronic focal encephalitis (Rasmussen syndrome): six cases. Epilepsia. 1988;29(3):268–79. doi: 10.1111/j.1528- 1157.1988.tb03717.x.
3. Andermann E, Oguni H, Guttmann RD, Osterland CK, Antel JP, Eeg-Oloffson O. Genetic aspects of chronic encephalitis. In: Andermann F, editor. Chronic encephalitis and epilepsy. Rasmussen's syndrome. Boston: Butterworth-Heinemann; 1991. p. 167–75.
4. Grenier Y, Antel JP, Osterland CK. Immunologic studies in chronic encephalitis of Rasmussen. In: Andermann F, editor. Chronic encephalitis and epilepsy. Rasmussen's syndrome. Boston: Butterworth-Heinemann; 1991. p. 125–34.
5. Oguni H, Andermann F, Rasmussen TB. The natural history of the syndrome of chronic encephalitis and epilepsy: a study of the MRI series of forty-eight cases. In: Andermann F, editor. Chronic encephalitis and epilepsy. Rasmussen's syndrome. Boston: Butterworth-Heinemann; 1991. p. 7–35.
6. Bien CG, Elger CE, Wiendl H. Advances in pathogenic concepts and therapeutic agents in Rasmussen's encephalitis. Expert Opin Investig Drugs. 2002;11(7):981–9. doi: 10.1517/13543784.11.7.981.
7. Bahi-Buisson N, Nabbout R, Plouin P, Bulteau C, Delalande O, Hertz Pannier L, Dulac O, Chiron C. Recent advances in pathogenic concepts and therapeutic strategies in Rasmussen's encephalitis. Rev Neurol (Paris). 2005;161(4):395–405.
8. McLachlan RS, Girvin JP, Blume WT, Reichman H. Rasmussen's chronic encephalitis in adults. Arch Neurol. 1993;50(3):269–74. doi: 10.1001/archneur.1993.00540030035011.
9. Freeman JM. Rasmussen's syndrome: progressive autoimmune multi-focal encephalopathy. Pediatr Neurol. 2005;32(5):295–9. doi: 10.1016/j.pediatrneurol.2004.12.002.
10. Kinay D, Bebek N, Vanli E, Gurses C, Gokyigit A, Andermann F. Rasmussen's encephalitis and Behcet's disease: autoimmune disorders in first degree relatives. Epileptic Disord. 2008;10(4):319–24. doi: 10.1684/ epd.2008.0228.
11. Bien CG, Widman G, Urbach H, Sassen R, Kuczaty S, Wiestler OD, Schramm J, Elger CE. The natural history of Rasmussen's encephalitis. Brain. 2002;125(Pt 8):1751–9. doi: http://dx.doi. org/10.1093/brain/awf176.
12. Granata T, Gobbi G, Spreafico R, Vigevano F, Capovilla G, Ragona F, Freri E, Chiapparini L, Bernasconi P, Giordano L, Bertani G, Casazza M, Dalla Bernardina B, Fusco L. Rasmussen's encephalitis: early characteristics allow diagnosis. Neurology. 2003;60(3):422–5.
13. Honavar M, Janota I, Polkey CE. Rasmussen's encephalitis in surgery for epilepsy. Dev Med Child Neurol. 1992;34(1):3–14. doi: 10.1111/ j.1469-8749.1992.tb08558.x.
14. Watson R, Jiang Y, Bermudez I, Houlihan L, Clover L, McKnight K, Cross JH, Hart IK, Roubertie A, Valmier J, Hart Y, Palace J, Beeson D, Vincent A, Lang B. Absence of antibodies to glutamate receptor type 3 (GluR3) in Rasmussen encephalitis. Neurology. 2004;63(1):43–50.
15. Mantegazza R, Bernasconi P, Baggi F, Spreafico R, Ragona F, Antozzi C, Bernardi G, Granata T. Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures. J Neuroimmunol. 2002;131(1–2):179–85. doi: 10.1016/S0165-5728(02)00261-8.
16. Wiendl H, Bien CG, Bernasconi P, Fleckenstein B, Elger CE, Dichgans J, Mantegazza R, Melms A. GluR3 antibodies: prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis. Neurology. 2001;57(8):1511–4.
17. Dulac O, Robain O, Chiron C, Plouin P, Pinel JF, Vigevano F. High-dose steroid treatment of epilepsia partialis continua due to chronic focal encephalitis. In: Andermann F, editor. Chronic encephalitis and epilepsy. Rasmussen's syndrome. Boston: Butterworth-Heinemann; 1991. p. 193–9.
18. Rotenberg A, Depositario-Cabacar D, Bae EH, Harini C, Pascual-Leone A, Takeoka M. Transient suppression of seizures by repetitive transcranial magnetic stimulation in a case of Rasmussen's encephalitis. Epilepsy Behav. 2008;13(1):260–2. doi: 10.1016/j.yebeh.2007.12.022.
19. Andrews PI, McNamara JO, Lewis DV. Clinical and electroencephalographic correlates in Rasmussen's encephalitis. Epilepsia. 1997;38(2):189–94. doi: 10.1111/j. 1528-1157.1997.tb01096.x.
20. Chiapparini L, Granata T, Farina L, Ciceri E, Erbetta A, Ragona F, Freri E, Fusco L, Gobbi G, Capovilla G, Tassi L, Giordano L, Viri M, Dalla Bernardina B, Spreafico R, Savoiardo M. Diagnostic imaging in 13 cases of Rasmussen's encephalitis: can early MRI suggest the diagnosis? Neuroradiology. 2003;45(3):171–83. doi: 10.1007/s00234-002-0923-7.
Almanac of Clinical Medicine. 2016; 44: 363-368
STATUS EPILEPTICUS IN A PATIENT WITH RASMUSSEN’S ENCEPHALITIS
https://doi.org/10.18786/2072-0505-2016-44-3-363-368Abstract
We describe clinical case of Rasmussen's encephalitis in a 24-year-old woman that occurred during her hospital stay. Its clinical manifestations included a clonic movement disorder and partial epilepsy. Brain magnetic resonance imaging study showed shrinkage of her left hemisphere with signs of inflammation and scarring. An electroencephalography showed the electrophysiological characteristics of epilepsy and slowing down of the left hemisphere activity. Brain biopsy was not provided.
References
1. Rasmussen T, Olszewski J, Lloyd-Smith D. Focal seizures due to chronic localized encephalitis. Neurology. 1958;8(6):435–45.
2. Piatt JH Jr, Hwang PA, Armstrong DC, Becker LE, Hoffman HJ. Chronic focal encephalitis (Rasmussen syndrome): six cases. Epilepsia. 1988;29(3):268–79. doi: 10.1111/j.1528- 1157.1988.tb03717.x.
3. Andermann E, Oguni H, Guttmann RD, Osterland CK, Antel JP, Eeg-Oloffson O. Genetic aspects of chronic encephalitis. In: Andermann F, editor. Chronic encephalitis and epilepsy. Rasmussen's syndrome. Boston: Butterworth-Heinemann; 1991. p. 167–75.
4. Grenier Y, Antel JP, Osterland CK. Immunologic studies in chronic encephalitis of Rasmussen. In: Andermann F, editor. Chronic encephalitis and epilepsy. Rasmussen's syndrome. Boston: Butterworth-Heinemann; 1991. p. 125–34.
5. Oguni H, Andermann F, Rasmussen TB. The natural history of the syndrome of chronic encephalitis and epilepsy: a study of the MRI series of forty-eight cases. In: Andermann F, editor. Chronic encephalitis and epilepsy. Rasmussen's syndrome. Boston: Butterworth-Heinemann; 1991. p. 7–35.
6. Bien CG, Elger CE, Wiendl H. Advances in pathogenic concepts and therapeutic agents in Rasmussen's encephalitis. Expert Opin Investig Drugs. 2002;11(7):981–9. doi: 10.1517/13543784.11.7.981.
7. Bahi-Buisson N, Nabbout R, Plouin P, Bulteau C, Delalande O, Hertz Pannier L, Dulac O, Chiron C. Recent advances in pathogenic concepts and therapeutic strategies in Rasmussen's encephalitis. Rev Neurol (Paris). 2005;161(4):395–405.
8. McLachlan RS, Girvin JP, Blume WT, Reichman H. Rasmussen's chronic encephalitis in adults. Arch Neurol. 1993;50(3):269–74. doi: 10.1001/archneur.1993.00540030035011.
9. Freeman JM. Rasmussen's syndrome: progressive autoimmune multi-focal encephalopathy. Pediatr Neurol. 2005;32(5):295–9. doi: 10.1016/j.pediatrneurol.2004.12.002.
10. Kinay D, Bebek N, Vanli E, Gurses C, Gokyigit A, Andermann F. Rasmussen's encephalitis and Behcet's disease: autoimmune disorders in first degree relatives. Epileptic Disord. 2008;10(4):319–24. doi: 10.1684/ epd.2008.0228.
11. Bien CG, Widman G, Urbach H, Sassen R, Kuczaty S, Wiestler OD, Schramm J, Elger CE. The natural history of Rasmussen's encephalitis. Brain. 2002;125(Pt 8):1751–9. doi: http://dx.doi. org/10.1093/brain/awf176.
12. Granata T, Gobbi G, Spreafico R, Vigevano F, Capovilla G, Ragona F, Freri E, Chiapparini L, Bernasconi P, Giordano L, Bertani G, Casazza M, Dalla Bernardina B, Fusco L. Rasmussen's encephalitis: early characteristics allow diagnosis. Neurology. 2003;60(3):422–5.
13. Honavar M, Janota I, Polkey CE. Rasmussen's encephalitis in surgery for epilepsy. Dev Med Child Neurol. 1992;34(1):3–14. doi: 10.1111/ j.1469-8749.1992.tb08558.x.
14. Watson R, Jiang Y, Bermudez I, Houlihan L, Clover L, McKnight K, Cross JH, Hart IK, Roubertie A, Valmier J, Hart Y, Palace J, Beeson D, Vincent A, Lang B. Absence of antibodies to glutamate receptor type 3 (GluR3) in Rasmussen encephalitis. Neurology. 2004;63(1):43–50.
15. Mantegazza R, Bernasconi P, Baggi F, Spreafico R, Ragona F, Antozzi C, Bernardi G, Granata T. Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures. J Neuroimmunol. 2002;131(1–2):179–85. doi: 10.1016/S0165-5728(02)00261-8.
16. Wiendl H, Bien CG, Bernasconi P, Fleckenstein B, Elger CE, Dichgans J, Mantegazza R, Melms A. GluR3 antibodies: prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis. Neurology. 2001;57(8):1511–4.
17. Dulac O, Robain O, Chiron C, Plouin P, Pinel JF, Vigevano F. High-dose steroid treatment of epilepsia partialis continua due to chronic focal encephalitis. In: Andermann F, editor. Chronic encephalitis and epilepsy. Rasmussen's syndrome. Boston: Butterworth-Heinemann; 1991. p. 193–9.
18. Rotenberg A, Depositario-Cabacar D, Bae EH, Harini C, Pascual-Leone A, Takeoka M. Transient suppression of seizures by repetitive transcranial magnetic stimulation in a case of Rasmussen's encephalitis. Epilepsy Behav. 2008;13(1):260–2. doi: 10.1016/j.yebeh.2007.12.022.
19. Andrews PI, McNamara JO, Lewis DV. Clinical and electroencephalographic correlates in Rasmussen's encephalitis. Epilepsia. 1997;38(2):189–94. doi: 10.1111/j. 1528-1157.1997.tb01096.x.
20. Chiapparini L, Granata T, Farina L, Ciceri E, Erbetta A, Ragona F, Freri E, Fusco L, Gobbi G, Capovilla G, Tassi L, Giordano L, Viri M, Dalla Bernardina B, Spreafico R, Savoiardo M. Diagnostic imaging in 13 cases of Rasmussen's encephalitis: can early MRI suggest the diagnosis? Neuroradiology. 2003;45(3):171–83. doi: 10.1007/s00234-002-0923-7.
