Альманах клинической медицины. 2015; : 123-128
ИММУНОЛОГИЧЕСКИЕ АСПЕКТЫ ЭНДОМЕТРИОИДНОЙ БОЛЕЗНИ
https://doi.org/10.18786/2072-0505-2015-37-123-128Аннотация
Актуальность. Иммунологические процессы с участием макрофагов, возможно, играют ключевую роль в развитии и прогрессировании наружного генитального эндометриоза.
Цель – исследовать содержание MCP-1, RANTES и С-реактивного белка и выявить корреляционные взаимоотношения с выраженностью эндометриоза.
Материал и методы. Обследованы 72 пациентки – 26 здоровых и 46 с эндометриозом. Пациентки были разделены на группы: 17 с поверхностным эндометриозом, 18 с эндометриомами и 11 с инфильтративным эндометриозом. Всем произведена лапароскопия в 1-ю фазу менструального цикла и определены уровни MCP-1, RANTES и С-реактивного белка методом иммуноферментного анализа в крови и перитонеальной жидкости.
Результаты. Выявлена положительная корреляция сывороточного MCP-1 (p = 0,03) и C-реактивного белка (p = 0,45) c выраженностью эндометриоидной болезни, что может свидетельствовать о дефективной функции перитонеальных макрофагов при распространенных формах эндометриоза.
Заключение. Показатели уровня MCP-1 и C-реактивного белка в периферической крови могут быть использованы в качестве маркера активности эндометриоза.
Список литературы
1. Адамян ЛВ, Кулаков ВИ, Андреева ЕН. Эндометриозы: Руководство для врачей. М.: Медицина; 2006. 411 с. (Adamyan LV, Kulakov VI, Andreeva EN. Endometrioses: a guidebook for physicians. Moscow: Meditsina; 2006. 411 p. Russian).
2. Кудрина ЕА, Станоевич ИВ, Коган ЕА. Комплексная терапия больных наружным генитальным эндометриозом. В: Новые технологии в диагностике и лечении гинекологических заболеваний. Материалы ХХIII международного конгресса с курсом
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5. Rogers PA, D'Hooghe TM, Fazleabas A, Gargett CE, Giudice LC, Montgomery GW, Rombauts L, Salamonsen LA, Zondervan KT. Priori ties for endometriosis research: recommendations from an international consensus workshop. Reprod Sci. 2009;16(4):335–46.
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7. Berkkanoglu M, Arici A. Immunology and endometriosis. Am J Reprod Immunol. 2003;50(1):48–59.
8. Nishida M, Nasu K, Narahara H. Role of chemokines in the pathogenesis of endometriosis. Front Biosci (Schol Ed). 2011;3:1196–204.
9. Olovsson M. Immunological aspects of endometriosis: an update. Am J Reprod Immunol.2011;66 Suppl 1:101–4.
10. Santanam N, Murphy AA, Parthasarathy S. Macrophages, oxidation, and endometriosis. Ann N Y Acad Sci. 2002;955:183–98.
11. Agic A, Xu H, Finas D, Banz C, Diedrich K, Hornung D. Is endometriosis associated with systemic subclinical inflammation? Gynecol Obstet Invest. 2006;62(3):139–47.
12. Wu MY, Ho HN. The role of cytokines in endometriosis. Am J Reprod Immunol. 2003;49(5):285–96.
13. Yadav A, Saini V, Arora S. MCP-1: chemoattractant with a role beyond immunity: a review. Clin Chim Acta. 2010;411(21–22):1570–9.
14. Arici A, Oral E, Attar E, Tazuke SI, Olive DL. Monocytechemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells. Fertil Steril. 1997;67(6):1065–72.
15. Laudański P, Szamatowicz J, Oniszczuk M. Profiling of peritoneal fluid of women with endometriosis by chemokine protein array. Adv Med Sci. 2006;51:148–52.
16. Zeyneloglu HB, Senturk LM, Seli E, Oral E, Olive DL, Arici A. The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation. Hum Reprod. 1998;13(5):1194–9.
17. Lermann J, Mueller A, Korber F, Oppelt P, Beckmann MW, Dittrich R, Renner SP. Evaluation of high-sensitivity C-reactive protein in comparison with C-reactive protein as biochemical serum markers in women with endometriosis. Fertil Steril. 2010;93(7):2125–9.
18. Kianpour M, Nematbakhsh M, Ahmadi SM. C-reactive protein of serum and peritoneal fluid in endometriosis. Iran J Nurs Midwifery Res. 2012;17(2 Suppl 1):S115–9.
19. Chapron C, Fauconnier A, Dubuisson JB, Barakat H, Vieira M, Breart G. Deep infiltrating endometriosis: relation between severity of dysmenorrhoea and extent of disease. Hum Reprod. 2003;18(4):760–6.
20. Adamson GD, Pasta DJ. Surgical treatment of endometriosis-associated infertility: metaanalysis compared with survival analysis. Am J Obstet Gynecol. 1994;171(6):1488–504.
21. Oral E, Olive DL, Arici A. The peritoneal environment in endometriosis. Hum Reprod Update. 1996;2(5):385–98.
22. Halme J, Becker S, Wing R. Accentuated cyclic activation of peritoneal macrophages in patients with endometriosis. Am J Obstet Gynecol. 1984;1;148(1):85–90.
23. Bersinger NA, von Roten S, Wunder DM, Raio L, Dreher E, Mueller MD. PAPP-A and osteoprotegerin, together with interleukin-8 and RANTES, are elevated in the peritoneal fluid of women with endometriosis. Am J Obstet Gynecol. 2006;195(1):103–8.
Almanac of Clinical Medicine. 2015; : 123-128
IMMUNOLOGICAL ASPECTS OF ENDOMETRIAL DISEASE
https://doi.org/10.18786/2072-0505-2015-37-123-128Abstract
Background: Immunological processes involving peritoneal macrophages could play a critical role in pathophysiology of external genital endometriosis.
Aim: To assess levels of MCP-1, RANTES, and C-reactive protein and to identify their correlations with endometriosis.
Materials and methods: Seventy two patients were evaluated: 26 healthy controls and 46 with endometriosis. Patients were divided into groups as follows: 17 with superficial endometriosis, 18 with endometriomas and 11 with deep infiltrative endometriosis. All patients underwent a laparoscopy during the proliferative phase of the cycle; levels of peritoneal and serum MCP-1, RANTES and C-reactive protein were measured using standard ELISA assays.
Results: There were positive correlations between serum MCP-1 (p = 0.03) and C-reactive protein(p = 0.045) and severity of endometriosis, that could indicate malfunctioning of peritoneal macrophages in advanced stages of endometriosis. Conclusion: MCP-1 and C-reactive protein levels in peripheral blood can be used as markers of endometriosis activity.
References
1. Adamyan LV, Kulakov VI, Andreeva EN. Endometriozy: Rukovodstvo dlya vrachei. M.: Meditsina; 2006. 411 s. (Adamyan LV, Kulakov VI, Andreeva EN. Endometrioses: a guidebook for physicians. Moscow: Meditsina; 2006. 411 p. Russian).
2. Kudrina EA, Stanoevich IV, Kogan EA. Kompleksnaya terapiya bol'nykh naruzhnym genital'nym endometriozom. V: Novye tekhnologii v diagnostike i lechenii ginekologicheskikh zabolevanii. Materialy KhKhIII mezhdunarodnogo kongressa s kursom
3. endoskopii. Moskva, 7–10 iyunya 2010 g. M.; 2010. s.159. (Kudrina EA, Stanoevich IV, Kogan EA. Complex therapy of patients with external genital endometriosis. In: New technologies in diagnostics and treatment of gynecological disorders. Abstracts of KhKhIII International Congress witha Course on Endoscopy. 2010 Jun 7–10; Moscow, Russia. Moscow; 2010. p. 159. Russian).
4. Ozkan S, Murk W, Arici A. Endometriosis and infertility: epidemiology and evidence-based treatments. Ann N Y Acad Sci. 2008;1127:92–100.
5. Rogers PA, D'Hooghe TM, Fazleabas A, Gargett CE, Giudice LC, Montgomery GW, Rombauts L, Salamonsen LA, Zondervan KT. Priori ties for endometriosis research: recommendations from an international consensus workshop. Reprod Sci. 2009;16(4):335–46.
6. Sampson JA. Peritoneal endometriosis is due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol. 1927;14:422–69.
7. Berkkanoglu M, Arici A. Immunology and endometriosis. Am J Reprod Immunol. 2003;50(1):48–59.
8. Nishida M, Nasu K, Narahara H. Role of chemokines in the pathogenesis of endometriosis. Front Biosci (Schol Ed). 2011;3:1196–204.
9. Olovsson M. Immunological aspects of endometriosis: an update. Am J Reprod Immunol.2011;66 Suppl 1:101–4.
10. Santanam N, Murphy AA, Parthasarathy S. Macrophages, oxidation, and endometriosis. Ann N Y Acad Sci. 2002;955:183–98.
11. Agic A, Xu H, Finas D, Banz C, Diedrich K, Hornung D. Is endometriosis associated with systemic subclinical inflammation? Gynecol Obstet Invest. 2006;62(3):139–47.
12. Wu MY, Ho HN. The role of cytokines in endometriosis. Am J Reprod Immunol. 2003;49(5):285–96.
13. Yadav A, Saini V, Arora S. MCP-1: chemoattractant with a role beyond immunity: a review. Clin Chim Acta. 2010;411(21–22):1570–9.
14. Arici A, Oral E, Attar E, Tazuke SI, Olive DL. Monocytechemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells. Fertil Steril. 1997;67(6):1065–72.
15. Laudański P, Szamatowicz J, Oniszczuk M. Profiling of peritoneal fluid of women with endometriosis by chemokine protein array. Adv Med Sci. 2006;51:148–52.
16. Zeyneloglu HB, Senturk LM, Seli E, Oral E, Olive DL, Arici A. The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation. Hum Reprod. 1998;13(5):1194–9.
17. Lermann J, Mueller A, Korber F, Oppelt P, Beckmann MW, Dittrich R, Renner SP. Evaluation of high-sensitivity C-reactive protein in comparison with C-reactive protein as biochemical serum markers in women with endometriosis. Fertil Steril. 2010;93(7):2125–9.
18. Kianpour M, Nematbakhsh M, Ahmadi SM. C-reactive protein of serum and peritoneal fluid in endometriosis. Iran J Nurs Midwifery Res. 2012;17(2 Suppl 1):S115–9.
19. Chapron C, Fauconnier A, Dubuisson JB, Barakat H, Vieira M, Breart G. Deep infiltrating endometriosis: relation between severity of dysmenorrhoea and extent of disease. Hum Reprod. 2003;18(4):760–6.
20. Adamson GD, Pasta DJ. Surgical treatment of endometriosis-associated infertility: metaanalysis compared with survival analysis. Am J Obstet Gynecol. 1994;171(6):1488–504.
21. Oral E, Olive DL, Arici A. The peritoneal environment in endometriosis. Hum Reprod Update. 1996;2(5):385–98.
22. Halme J, Becker S, Wing R. Accentuated cyclic activation of peritoneal macrophages in patients with endometriosis. Am J Obstet Gynecol. 1984;1;148(1):85–90.
23. Bersinger NA, von Roten S, Wunder DM, Raio L, Dreher E, Mueller MD. PAPP-A and osteoprotegerin, together with interleukin-8 and RANTES, are elevated in the peritoneal fluid of women with endometriosis. Am J Obstet Gynecol. 2006;195(1):103–8.
