Журналов:     Статей:        

Альманах клинической медицины. 2014; : 36-41

ЭРУПТИВНАЯ КЕРАТОАКАНТОМА ТИПА ГРЖЕБОВСКИ

Молочков В. А, Кунцевич Ж. С., Бобров М. А., Дибирова С. А.

https://doi.org/10.18786/2072-0505-2014-34-36-41

Аннотация

В статье представлен случай лечения чрезвычайно редкой патологии  – множественной эруптивной кератоакантомы типа Гржебовски у  пациентки 82 лет. Заболевание характеризуется внезапным возникновением сотни или тысячи опухолевых элементов диаметром 2–5 см, в  течение короткого времени распространяющихся по всему кожному покрову. Часто заболевание ассоциируется с  раком внутренних органов. Использованные авторами подходы к диагностике и лечению не только позволили поставить диагноз множественной эруптивной кератоакантомы типа Гржебовски пациентке, в  течение 4 лет страдающей этим заболеванием, но и  продемонстрировали высокую эффективность примененной терапии. Показана эффективность ароматических ретиноидов в лечении множественной эруптивной кератоакантомы типа Гржебовски.

Список литературы

1. Nofal A, Assaf M, Nofal E, Alradi M. Generalized eruptive keratoacanthoma: proposed diagnostic criteria and therapeutic evaluation. J Eur Acad Dermatol Venereol. 2014;28(4):397–404.

2. Winkelmann RK, Brown J. Generalized eruptive keratoacanthoma. Report of cases. Arch Dermatol. 1968;97(6):615–23.

3. Rath S, Cowan BJ, Dolman PJ. Cicatricial ectro-pion in grzybowski type of multiple eruptive keratoacanthomas. Ophthal Plast Reconstr Surg. 2014;30(2):e42–3.

4. Lloyd KM, Madsen DK, Lin PY. Grzybowski’s eruptive keratoacanthoma. J Am Acad Dermatol. 1989;21(5 Pt 1):1023–4.

5. Schwartz RA. The keratoacanthoma: a review. J Surg Oncol. 1979;12:315–17.

6. Sterry W, Steigleder GK, Pullmann H, Bauermeister K. Eruptive keratoacanthoma. Hautarzt. 1981;32(3):119–25.

7. Muir EG, Bell AJ, Barlow KA. Multiple primary carcinomata of the colon, duodenum, and larynx associated with kerato-acanthomata of the face. Br J Surg. 1967;54(3):191–5.

8. Chapman RS, Finn OA. Carcinoma of the larynx in two patients with keratoacanthoma. Br J Dermatol. 1974;90(6):685–8.

9. Kavanagh GM, Marshman G, Hanna MM. A case of Grzybowski’s generalized eruptive keratoacanthomas. Australas J Dermatol. 1995;36(2):83–5.

10. Jaber PW, Cooper PH, Greer KE. Generalized eruptive keratoacanthoma of Grzybowski. J Am Acad Dermatol. 1993;29(2 Pt 2):299–304.

11. Blitstein-Willinger E, Haas N, Nürnberger F, Stüttgen G. Immunological findings during treatment of multiple keratoacanthoma with etretinate. Br J Dermatol. 1986;114(1): 109–16.

12. Consigli JE, González ME, Morsino R, Guidi A, Chappuis JM, Papa M, Maldonado S. Genera-lized eruptive keratoacanthoma (Grzybowski variant). Br J Dermatol. 2000;142(4):800–3.

13. Grine RC, Hendrix JD, Greer KE. Generalized eruptive keratoacanthoma of Grzybowski: response to cyclophosphamide. J Am Acad Dermatol. 1997;36(5 Pt 1):786–7.

14. Anzalone CL, Cohen PR. Generalized eruptive keratoacanthomas of Grzybowski. Int J Dermatol. 2014;53(2):131–6.

15. Oakley A, Ng S. Grzybowski’s generalized eruptive keratoacanthoma: remission with cyclophosphamide. Australas J Dermatol. 2005;46(2):118–23.

16. Молочков ВА, Казанцева ИА, Кунцевич ЖС, Бочкарева ЕВ. Кератоакантома. Дифференциальная диагностика с плоскоклеточным раком кожи. М.: БИНОМ; 2006. 224 с. (Molochkov VA, Kazantseva IA, Kuntsevich ZhS, Bochkareva EV. Keratoacanthoma. Differential diagnosis with squamous cell carcinoma of the skin. Moscow: BINOM; 2006. 224 p. Russian).

17. Молочков ВА, Молочков АВ, Хлебникова АН, Кунцевич ЖС. Эпителиальные опухоли кожи. М.: БИНОМ; 2012. 224 с. (Molochkov VA, Molochkov AV, Khlebnikova AN, Kuntsevich ZhS. Epithelial skin tumors. Moscow: BINOM; 2012. 224 р. Russian).

Almanac of Clinical Medicine. 2014; : 36-41

ERUPTIVE KERATOACANTHOMA OF GRZYBOWSKI

Molochkov V. A., Kuntsevich Zh. S., Bobrov M. A., Dibirova S. A.

https://doi.org/10.18786/2072-0505-2014-34-36-41

Abstract

The article presents a case of a very rare disorder – generalized eruptive keratoacanthoma of Grzybowski in a woman aged 82 years old. The disease is characterized by sudden emergence of hundreds or thousands of neoplasms (2–5 cm in diameters) rapidly spreading throughout the body skin. It is frequently associated with internistic cancer. In this case, generalized eruptive keratoacanthoma of Grzybowski was diagnosed 4 years after the disease onset. The authors emphasize the role of proper diagnosis and treatment of this pathology. Aromatic retinoids were highly effective in the therapy of generalized eruptive keratoacanthoma of Grzybowski.
References

1. Nofal A, Assaf M, Nofal E, Alradi M. Generalized eruptive keratoacanthoma: proposed diagnostic criteria and therapeutic evaluation. J Eur Acad Dermatol Venereol. 2014;28(4):397–404.

2. Winkelmann RK, Brown J. Generalized eruptive keratoacanthoma. Report of cases. Arch Dermatol. 1968;97(6):615–23.

3. Rath S, Cowan BJ, Dolman PJ. Cicatricial ectro-pion in grzybowski type of multiple eruptive keratoacanthomas. Ophthal Plast Reconstr Surg. 2014;30(2):e42–3.

4. Lloyd KM, Madsen DK, Lin PY. Grzybowski’s eruptive keratoacanthoma. J Am Acad Dermatol. 1989;21(5 Pt 1):1023–4.

5. Schwartz RA. The keratoacanthoma: a review. J Surg Oncol. 1979;12:315–17.

6. Sterry W, Steigleder GK, Pullmann H, Bauermeister K. Eruptive keratoacanthoma. Hautarzt. 1981;32(3):119–25.

7. Muir EG, Bell AJ, Barlow KA. Multiple primary carcinomata of the colon, duodenum, and larynx associated with kerato-acanthomata of the face. Br J Surg. 1967;54(3):191–5.

8. Chapman RS, Finn OA. Carcinoma of the larynx in two patients with keratoacanthoma. Br J Dermatol. 1974;90(6):685–8.

9. Kavanagh GM, Marshman G, Hanna MM. A case of Grzybowski’s generalized eruptive keratoacanthomas. Australas J Dermatol. 1995;36(2):83–5.

10. Jaber PW, Cooper PH, Greer KE. Generalized eruptive keratoacanthoma of Grzybowski. J Am Acad Dermatol. 1993;29(2 Pt 2):299–304.

11. Blitstein-Willinger E, Haas N, Nürnberger F, Stüttgen G. Immunological findings during treatment of multiple keratoacanthoma with etretinate. Br J Dermatol. 1986;114(1): 109–16.

12. Consigli JE, González ME, Morsino R, Guidi A, Chappuis JM, Papa M, Maldonado S. Genera-lized eruptive keratoacanthoma (Grzybowski variant). Br J Dermatol. 2000;142(4):800–3.

13. Grine RC, Hendrix JD, Greer KE. Generalized eruptive keratoacanthoma of Grzybowski: response to cyclophosphamide. J Am Acad Dermatol. 1997;36(5 Pt 1):786–7.

14. Anzalone CL, Cohen PR. Generalized eruptive keratoacanthomas of Grzybowski. Int J Dermatol. 2014;53(2):131–6.

15. Oakley A, Ng S. Grzybowski’s generalized eruptive keratoacanthoma: remission with cyclophosphamide. Australas J Dermatol. 2005;46(2):118–23.

16. Molochkov VA, Kazantseva IA, Kuntsevich ZhS, Bochkareva EV. Keratoakantoma. Differentsial'naya diagnostika s ploskokletochnym rakom kozhi. M.: BINOM; 2006. 224 s. (Molochkov VA, Kazantseva IA, Kuntsevich ZhS, Bochkareva EV. Keratoacanthoma. Differential diagnosis with squamous cell carcinoma of the skin. Moscow: BINOM; 2006. 224 p. Russian).

17. Molochkov VA, Molochkov AV, Khlebnikova AN, Kuntsevich ZhS. Epitelial'nye opukholi kozhi. M.: BINOM; 2012. 224 s. (Molochkov VA, Molochkov AV, Khlebnikova AN, Kuntsevich ZhS. Epithelial skin tumors. Moscow: BINOM; 2012. 224 r. Russian).