Десмопластическая мелкокруглоклеточная опухоль у ребенка

Главная

Статья в Elpub

РУС ENG

Онкопедиатрия. 2016; 3: 42-47

Десмопластическая мелкокруглоклеточная опухоль у ребенка

Петрикова Н. И., Ефременков А. М., Сниткин Н. А., Трунова Р. Б., Бурлуцкая Т. И.

https://doi.org/10.15690/nco.v3i1.1528

Аннотация

Десмопластическая мелкокруглоклеточная опухоль (ДМКО) агрессивная злокачественная опухоль брюшной полости. Она встречается крайне редко и имеет плохой прогноз. В статье представлено клиническое наблюдение ребенка в возрасте 16 лет с поражением ДМКО малого таза, регионарных лимфатических узлов с отдаленными метастазами в легкие, печень, костный мозг. Общепринятых протоколов лечения ДМКО на сегодняшний день не существует. Нами предпринята попытка химиотерапии по протоколам, принятым для лечения других мелкокруглоклеточных опухолей ― ММСЮ-99, VAC в консолидирующем режиме, однако, на фоне терапии отмечено прогрессирование патологического процесса.

Список литературы

1. Benhammane H, Chbani L, Ousadden A, et al. Desmoplastic small round cell tumor of the abdomen: A case report and literature review of therapeutic options. Health. 2012;4(4):207– 211.

2. Harmon RL, Sugarbaker PH. Prognostic indicators in peritoneal carcinomatosis from gastrointestinal cancer. Int Semin Surg Oncol. 2005;2(1):3.

3. Крячок И.А., Степанишина Я.А., Кущевой Е.В. и др. Десмопластическая мелкоклеточная опухоль: трудности и перспективы в диагностике и лечении. Онкология. 2014;16(4): 288– 293.

4. Dufresne A, Cassier P, Couraud L, et al. Desmoplastic small round cell tumor: Current management and recent findings. Hindawi Publishing Corporation. Sarcoma. 2012. Article ID 714986:5.

5. Goldblum JR. Enzinger and Weiss’s Soft Tissue Tumors / JR Goldblum, SW Weiss, AL Folpe. Elsevier Saunders. 2014. P. 1156.

6. Gerald WL, Ladanyi M, De Alava E, et al. Clinical, pathologic, andmolecularspectrumof tumors associated with t(11;22) (p13;q12): desmoplastic small round-cell tumor and its variants. J Clin Oncol. 1998;16(9):3028–3036.

7. Mackinnon AC. Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine. Humana Press. 2012. P. 169–199.

8. Hayes-Jordan A, Green H, Fitzgerald N, et al. Novel treatment for desmoplastic small round cell tumor: Hyperthermic intraperitoneal perfusion. J Pediat Surg. 2010;45(5):1000–6.

9. Hayes-Jordan A, Anderson PM. The diagnosis and management of desmoplastic small round cell tumor: A review. Current Opinion in Oncology. 2011;23(4):385–389.

10. Mrabti H, Kaikani W, Ahbeddou N, et al. Metastatic desmoplastic small round cell tumor controlled by an anthracycline-based regimen: review of the role of chemotherapy. J Gastrointestinal Cancer. 2012;43(1):103–109.

11. Lal DR, Su WT, Wolden SL, et al. Results of multimodal treatment for desmoplastic small round cell tumors. J Pediatr Surg. 2005;40(1):251–255.

12. Kushner BH, LaQuaglia MP, Wollner N, et al. Desmoplastic small round-cell tumor: prolonged progression- free survival with aggressive multimodality therapy. J ClinOncol. 1996;14(5):1526– 31.

13. López-González A, Cantos B, Tejerina E, Provencio M. Activity of trabectidin in desmoplastic small round cell tumor. Med Oncology. 2011;28:644–6.

14. Aguilera D, Hayes-Jordan A, Anderson P, et al. Outpatient and home chemotherapy with novel local control strategies in desmoplastic small round cell tumor. Sarcoma. 2008. Article ID 261589:9.

15. Pinnix CC, Fontanilla HP, Hayes-Jordan A, et al. Whole abdominopelvic intensity-modulated radiation therapy for desmoplastic small round cell tumor after surgery. Int J RadiatOncolBiol Phys. 2012;83(1):317–26.

16. Subbiah V, Murthy R, Anderson PM. [90Y]Yttrium microspheres radioembolotherapy in desmoplastic small round cell tumor hepatic metastases. J Clin Oncol. 2011;29(11):292–294.

17. Italiano A, Kind M, Cioffi A. Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: a case series. Target Oncology. 2013;8(3):211–3.

Oncopediatrics. 2016; 3: 42-47

Desmoplastic Small Round Cell Tumor in the Child

Petrikova N. I., Efremenkov A. M., Snitkitn N. A., Trunova R. B., Burlutskaya T. I.

https://doi.org/10.15690/nco.v3i1.1528

Abstract

Desmoplastic small round cell tumor (DSRCT) is a highly aggressive and malignant tumor that typically occurs in the abdomen. The prognosis for this rare type of soft tissue sarcoma remains extremely poor. The article presents the clinical follow-up of a 16 year-old girl with pelvic cavity-origin DSRCT with multiple-organ metastases: regional lymph node metastases, distant metastasis to the lungs, liver, and bone marrow. Current approved treatment protocols of DSRCT do not exist. We attempted to perform chemotherapy on protocols appropriate for the treatment of other small round cell tumors – VAC consolidation therapy; but the tumor has progressed.

References

1. Benhammane H, Chbani L, Ousadden A, et al. Desmoplastic small round cell tumor of the abdomen: A case report and literature review of therapeutic options. Health. 2012;4(4):207– 211.

2. Harmon RL, Sugarbaker PH. Prognostic indicators in peritoneal carcinomatosis from gastrointestinal cancer. Int Semin Surg Oncol. 2005;2(1):3.

3. Kryachok I.A., Stepanishina Ya.A., Kushchevoi E.V. i dr. Desmoplasticheskaya melkokletochnaya opukhol': trudnosti i perspektivy v diagnostike i lechenii. Onkologiya. 2014;16(4): 288– 293.