Онкопедиатрия. 2018; 5: 248-256
Хондробластома: этиология, патогенез, методы диагностики и лечения
Самбурова Н. В., Калинин С. А., Жевак Т. Н., Литвицкий П. Ф.
https://doi.org/10.15690/onco.v5i4.1968Аннотация
В статье дана характеристика опухоли из клеток хрящевой ткани — хондробластомы. Анализируются современные сведения об этиологии, ключевых звеньях патогенеза, видах опухоли, общих клинических проявлениях, подходах к диагностике и лечению у детей.
Список литературы
1. Xu H, Nugent D, Monforte HL, et al. Chondroblastoma of bone in the extremities: a multicenter retrospective study. J Bone Joint Surg Am. 2015;97(11):925–931. doi: 10.2106/JBJS.N.00992.
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4. Prashant N, Amber H, Azuhairy A, et al. Spontaneous conventional osteosarcoma transformation of a chondroblastoma first ever case report and literature review. J Orthop Oncol. 2017;3:120. doi: 10.4172/2472-016X.1000120.
5. Punit A, Nadkarni S, Doomra T. Chondroblastoma of diaphysis of radius in a seven year old child. J Orthop Case Rep. 2014;4(3): 32–35. doi: 10.13107/jocr.2250-0685.191.
6. Esmaeili H, Amidfar H, Yavarikia M, Amidfar A. Chondroblastoma of diaphysis of tibia; case report. Am J Med Case Rep. 2016;4(6):215–217.
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16. Sjögren H, Orndal C, Tingby O, et al. Cytogenetic and spectral karyotype of benign and malignant carriage tumours. Int J Oncol. 2004;24(6):1385–1391.
17. Romeo S, Szuhai K, Nishimori I, et al. A balanced t(5;17) (p15;q22-23) in chondroblastoma: frequency of the re-arrangement and analysis of the candidate genes. BMC Cancer. 2009;9:393. doi: 10.1186/1471-2407-9-393.
18. Swarts SJ, Neff JR, Johansson SL, et al. Significance of abnormalities of chromosomes 5 and 8 in chondroblastoma. Clin Orthop Relat Res. 1998;349:189–193. doi.org/10.1097/00003086-199804000-00023.
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22. Papachristou DJ, Goodman MA, Cieply K, et al. Comparison of allelic losses in chondroblastoma and primary chondrosarcoma of bone and correlation with fluorescence in situ hybridization analysis. Hum Pathol. 2006;37(7):890–898. doi: 10.1016/j.humpath.2006.02.014.
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28. Behjati S, Tarpey PS, Presneau N, et al. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genet. 2013;45(12):1479–1482. doi: 10.1038/ng.2814.
29. Amary MF, Berisha F, Mozela R, et al. The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma. Histopathology. 2016;69(1):121–127. doi: 10.1111/his.12945.
30. Cleven AH, Höcker S, Briaire-de Bruijn I, et al. Mutation analysis of H3F3A and H3F3B as a diagnostic tool for giant cell tumor of bone and chondroblastoma. Am J Surg Pathol. 2015;39(11):1576–1583. doi: 10.1097/PAS.0000000000000512.
31. Presneau N, Baumhoer D, Behjati S, et al. Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast-rich mimics. J Pathol Clin Res. 2015;1(2):113–123. doi: 10.1002/cjp2.13.
32. Romeo S, Bovée JV, Jadnanansing NA, et al. Expression of cartilage growth plate signalling molecules in chondroblastoma. J Pathol. 2004;202(1):113–120. doi: 10.1002/path.1501.
33. De Mattos CB, Angsanuntsukh C, Arkader A, Dormans JP. Chondroblastoma and chondromyxoid fibroma. J Am Acad Orthop Surg. 2013;21(4):225–233. doi: 10.5435/JAAOS-21-04-225.
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36. Farfalli GL, Slullitel PA, Muscolo DL, et al. What happens to the articular surface after curettage for epiphyseal chondroblastoma? A report on functional results, arthritis, and arthroplasty. Clin Orthop Relat Res. 2017;475(3):760–766. doi: 10.1007/s11999-016-4715-5.
37. Erickson JK, Rosenthal DI, Zaleske DJ, et al. Primary treatment of chondroblastoma with percutaneous radio-frequency heat ablation: report of three cases. Radiology. 2001;221(2):463–468. doi: 10.1148/radiol.2212010262.
38. Xie C, Jeys L, James SL. Radiofrequency ablation of chondroblastoma: long-term clinical and imaging outcomes. Eur Radiol. 2015;25(4):1127–1134. doi: 10.1007/s00330-014-3506-1.
39. Lin PP, Thenappan A, Deavers MT, et al. Treatment and prognosis of chondroblastoma. Clin Orthop Relat Res. 2005;438:103–109. doi: 10.1097/01.blo.0000179591.72844.c3.
Oncopediatrics. 2018; 5: 248-256
Chondroblastoma: Etiology, Pathogenesis, Methods of Diagnosis and Treatment
Samburova Natalia V., Kalinin Sergey A., Zhevak Tatiana N., Litvitsky Peter F.
https://doi.org/10.15690/onco.v5i4.1968Abstract
The article provides the characteristic of a tumor from cells of cartilaginous tissue — chondroblastoma. Current data on etiology, key links of pathogenesis, types of tumor, General clinical manifestations, approaches to diagnosis and treatment in children are analyzed.
References
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2. Chen W, DiFrancesco LM. Chondroblastoma: an update. Arch Pathol Lab Med. 2017;141(6):867– 871. doi: 10.5858/arpa.2016-0281-RS.
3. Konishi E, Nakashima Y, Mano M, et al. Chondroblastoma of extra-craniofacial bones: clinicopathological analyses of 103 cases. Pathol Int. 2017;67(10):495–502. doi: 10.1111/pin.12586.
4. Prashant N, Amber H, Azuhairy A, et al. Spontaneous conventional osteosarcoma transformation of a chondroblastoma first ever case report and literature review. J Orthop Oncol. 2017;3:120. doi: 10.4172/2472-016X.1000120.
5. Punit A, Nadkarni S, Doomra T. Chondroblastoma of diaphysis of radius in a seven year old child. J Orthop Case Rep. 2014;4(3): 32–35. doi: 10.13107/jocr.2250-0685.191.
6. Esmaeili H, Amidfar H, Yavarikia M, Amidfar A. Chondroblastoma of diaphysis of tibia; case report. Am J Med Case Rep. 2016;4(6):215–217.
7. Codman EA. The classic: epiphyseal chondromatous giant cell tumors of the upper end of the humerus. Surg Gynecol Obstet.1931;52:543. Clin Orthop Relat Res. 2006;450:12–16. doi: 10.1097/01.blo.0000229309.90265.
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16. Sjögren H, Orndal C, Tingby O, et al. Cytogenetic and spectral karyotype of benign and malignant carriage tumours. Int J Oncol. 2004;24(6):1385–1391.
17. Romeo S, Szuhai K, Nishimori I, et al. A balanced t(5;17) (p15;q22-23) in chondroblastoma: frequency of the re-arrangement and analysis of the candidate genes. BMC Cancer. 2009;9:393. doi: 10.1186/1471-2407-9-393.
18. Swarts SJ, Neff JR, Johansson SL, et al. Significance of abnormalities of chromosomes 5 and 8 in chondroblastoma. Clin Orthop Relat Res. 1998;349:189–193. doi.org/10.1097/00003086-199804000-00023.
19. Kopnin B.P., Kopnin P.B., Khromova N.V., Agapova L.S. Mnogolikii r53: raznoobrazie form, funktsii, opukhol' supressiruyushchikh i onkogennykh aktivnostei // Klinicheskaya onkogematologiya. — 2008. — T.1. — №1 — S. 2–9.
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21. Strano S, Dell’Orso S, Di Agostino S, et al. Mutant p53: an oncogenic transcription factor. Oncogene. 2007;26(15):2212–2219. doi: 10.1038/sj.onc.1210296.
22. Papachristou DJ, Goodman MA, Cieply K, et al. Comparison of allelic losses in chondroblastoma and primary chondrosarcoma of bone and correlation with fluorescence in situ hybridization analysis. Hum Pathol. 2006;37(7):890–898. doi: 10.1016/j.humpath.2006.02.014.
23. Ostrowski ML, Johnson ME, Truong LD, et al. Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of malignancy. Skeletal Radiol. 1999;28(11):644–650.
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27. Fang D, Gan H, Lee JH, et al. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science. 2016;352(6291):1344–1348. doi: 10.1126/science.aae0065.
28. Behjati S, Tarpey PS, Presneau N, et al. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genet. 2013;45(12):1479–1482. doi: 10.1038/ng.2814.
29. Amary MF, Berisha F, Mozela R, et al. The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma. Histopathology. 2016;69(1):121–127. doi: 10.1111/his.12945.
30. Cleven AH, Höcker S, Briaire-de Bruijn I, et al. Mutation analysis of H3F3A and H3F3B as a diagnostic tool for giant cell tumor of bone and chondroblastoma. Am J Surg Pathol. 2015;39(11):1576–1583. doi: 10.1097/PAS.0000000000000512.
31. Presneau N, Baumhoer D, Behjati S, et al. Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast-rich mimics. J Pathol Clin Res. 2015;1(2):113–123. doi: 10.1002/cjp2.13.
32. Romeo S, Bovée JV, Jadnanansing NA, et al. Expression of cartilage growth plate signalling molecules in chondroblastoma. J Pathol. 2004;202(1):113–120. doi: 10.1002/path.1501.
33. De Mattos CB, Angsanuntsukh C, Arkader A, Dormans JP. Chondroblastoma and chondromyxoid fibroma. J Am Acad Orthop Surg. 2013;21(4):225–233. doi: 10.5435/JAAOS-21-04-225.
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36. Farfalli GL, Slullitel PA, Muscolo DL, et al. What happens to the articular surface after curettage for epiphyseal chondroblastoma? A report on functional results, arthritis, and arthroplasty. Clin Orthop Relat Res. 2017;475(3):760–766. doi: 10.1007/s11999-016-4715-5.
37. Erickson JK, Rosenthal DI, Zaleske DJ, et al. Primary treatment of chondroblastoma with percutaneous radio-frequency heat ablation: report of three cases. Radiology. 2001;221(2):463–468. doi: 10.1148/radiol.2212010262.
38. Xie C, Jeys L, James SL. Radiofrequency ablation of chondroblastoma: long-term clinical and imaging outcomes. Eur Radiol. 2015;25(4):1127–1134. doi: 10.1007/s00330-014-3506-1.
39. Lin PP, Thenappan A, Deavers MT, et al. Treatment and prognosis of chondroblastoma. Clin Orthop Relat Res. 2005;438:103–109. doi: 10.1097/01.blo.0000179591.72844.c3.
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