КЛИНИЧЕСКАЯ ХАРАКТЕРИСТИКА И ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА КЛАССИЧЕСКИХ ПАРАНЕОПЛАСТИЧЕСКИХ НЕВРОЛОГИЧЕСКИХ СИНДРОМОВ ПРИ ЛИМФОМАХ

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Онкопедиатрия. 2017; 4: 183-191

КЛИНИЧЕСКАЯ ХАРАКТЕРИСТИКА И ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА КЛАССИЧЕСКИХ ПАРАНЕОПЛАСТИЧЕСКИХ НЕВРОЛОГИЧЕСКИХ СИНДРОМОВ ПРИ ЛИМФОМАХ

Валиев Т. Т., Гусева Н. А., Соложенцева К. Д.

https://doi.org/10.15690/onco.v4i3.1749

Аннотация

Клиническая гетерогенность лимфом обусловлена не только локализацией и морфоиммунологическим вариантом опухоли, но и в ряде случаев развитием паранеопластических неврологических синдромов. По мере развития иммуноонкологии были выявлены антинейрональные антитела, которые определяются при злокачественных новообразованиях и объясняют патогенетические механизмы развития паранеопластических неврологических синдромов. В настоящем литературном обзоре сообщается о клинико-лабораторных особенностях классических паранеопластических неврологических синдромов при лимфомах, а также охарактеризованы антинейрональные антитела, определяемые при них.

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Oncopediatrics. 2017; 4: 183-191

CLINICAL PROFILE AND DIFFERENTIAL DIAGNOSIS OF CLASSICAL PARANEOPLASTIC NEUROLOGIC SYNDROMES IN LYMPHOMAS

Valiev T. T., Guseva N. A., Solozhentseva K. D.

https://doi.org/10.15690/onco.v4i3.1749

Abstract

Clinical heterogeneity of lymphomas is associated with both tumor localization and its morphological and immunological variants, moreover, in some cases with paraneoplastic neurological syndromes (PNS). As the immuno-oncology advances, the antineuronal antibodies were investigated. They are revealed in case of malignant neoplasms and explain the pathological mechanisms of PNS development. The presented literature review provides data on main clinical and laboratory characteristics of classical PNS associated with lymphomas and characterizes the antineuronal antibodies determined in patients with PNS.

References