Хирургия и онкология. 2024; 14: 11-16
Оценка влияния гендерных и возрастных различий на общую выживаемость больных колоректальным раком
https://doi.org/10.17650/2949-5857-2024-14-2-11-16Аннотация
Введение. Исследования последних лет приводят к выводу о значимости пола как важного фактора, влияющего на прогноз выживания больных колоректальным раком (КРР).
Цель исследования – анализ показателей 5-летней общей выживаемости больных КРР разного пола и в различных возрастных группах.
Материалы и методы. В исследование включено 1 593 пациента, из них 720 (45,2 %) мужчин и 873 (54,8 %) женщины. Больных разделили на 3 возрастные группы: до 50 лет, 50–70 лет и старше 70 лет. Проводился подсчет общей выживаемости с последующим сравнением между группами пациентов с учетом пола и стадий заболевания.
Результаты. Анализ результатов лечения с учетом гендерного подхода показал, что прогноз заболевания наиболее благоприятен у женщин. При практически одинаковой 5-летней выживаемости у мужчин и женщин (54,9 и 52,7 % соответственно) этот показатель коррелировал с возрастом пациентов и был достоверно лучше, чем у мужчин в группе больных моложе 50 лет.
Заключение. Выявленные гендерные и возрастные особенности в развитии и течении КРР актуальны для онкологов при выборе диагностических, лечебных и реабилитационных стратегий.
Список литературы
1. Sung H., Ferlay J., Siegel R.L. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71(3):209–49. DOI: 10.3322/caac.21660
2. Available at: http://www.socpolitika.ru/rus/conferences/3985/3989/index.shtml
3. Kim S.E., Paik H.Y., Yoon H. et al. Sex- and gender-specific disparities in colorectal cancer risk. World J Gastroenterol 2015;21(17):5167–75. DOI: 10.3748/wjg.v21.i17.5167
4. Limsu D., Vierkant R.A., Tillmans L.S. et al. Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older women. Gut 2012;61(9):1299–305. DOI: 10.1136/gutjnl-2011-300719
5. Losurdo P., Mastronardi M., de Manzini N., Bortul M. Survival and long-term surgical outcomes after colorectal surgery: are there any gender-related differences? Updates Surg 2022;74(4):1337–43. DOI: 10.1007/s13304-022-01323-4
6. Majek O., Gondos A., Jansen L. et al. Sex differences in colorectal cancer survival: population-based analysis of 164,996 colorectal cancer patients in Germany. PLoS One 2013;8(7):e68077. DOI: 10.1371/journal.pone.0068077
7. Rutegard M., Shore R., Lu Y. et al. Sex differences in the incidence of gastrointestinal adenocarcinoma in Sweden 1970–2006. Eur J Cancer 2010;46(6):1093–100. DOI: 10.1016/j.ejca.2010.01.029
8. Гатауллин Б.И., Хасанов Р.Ш., Савельев А.А., Гатауллин И.Г. Гендерная специфика колоректального рака в Республике Татарстан. Сибирский онкологический журнал 2021;20(1):16–23. DOI: https://doi.org/10.21294/1814-4861-2021-20-1-16-23
9. Eli M., Mollayup A., Muattar J. et al. K-ras genetic mutation and influencing factor analysis for Han and Uygur nationality colorectal cancer patients. Int J Clin Exp Med 2015;8(6):10168–77. eCollection 2015. PMID: 26309716
10. Ferlay J., Soerjomataram I., Dikshit R. et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:E359–86. DOI: 10.1002/ijc.29210
11. Barzi A., Lenz A.M., Labonte M.J., Lenz H.J. Molecular pathways: estrogen pathway in colorectal cancer. Clin Cancer Res 2013;19:5842–8. DOI: 10.1158/1078-0432.CCR-13-0325
12. Maingi J.W., Tang S., Liu S. et al. Targeting estrogen receptors in colorectal cancer. Mol Biol Rep 2020;47(5):4087–91. DOI: 10.1007/s11033-020-05414-6
13. Conti L., Cornò M.D., Gessani S. Revisiting the impact of lifestyle on colorectal cancer risk in a gender perspective. Crit Rev Oncol Hematol 2020;145:102834. DOI: 10.1016/j.critrevonc.2019.102834
Surgery and Oncology. 2024; 14: 11-16
Assessing the impact of gender and age differences on overall survival of patients with colorectal cancer
https://doi.org/10.17650/2949-5857-2024-14-2-11-16Abstract
Introduction. Recent studies have led to the conclusion that gender is an important factor influencing the prognosis of survival of patients with colorectal cancer.
Aim. To analyze 5-year overall survival rates in patients with colorectal cancer of different sexes and in different age groups.
Materials and methods. The study included 1593 patients, of whom 720 were men (45.2 %) and 873 women (54.8 %). Patients were divided into 3 age groups: under 50 years, 50–70 years and over 70. Overall survival rates were calculated, followed by comparison between groups of patients, taking into account gender and stage of the disease.
Results. Analysis of treatment results taking into account a gender approach showed that the prognosis of the disease was most favorable in women. With approximately the same 5-year survival rate in men and women (54.9 and 52.7 %), this indicator correlated with the age of the patients and was significantly better than in men in the group of patients under 50 years of age.
Conclusion. The identified gender and age characteristics in the development and course of colorectal cancer are relevant for oncologists when choosing diagnostic, treatment and rehabilitation strategies.
References
1. Sung H., Ferlay J., Siegel R.L. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71(3):209–49. DOI: 10.3322/caac.21660
2. Available at: http://www.socpolitika.ru/rus/conferences/3985/3989/index.shtml
3. Kim S.E., Paik H.Y., Yoon H. et al. Sex- and gender-specific disparities in colorectal cancer risk. World J Gastroenterol 2015;21(17):5167–75. DOI: 10.3748/wjg.v21.i17.5167
4. Limsu D., Vierkant R.A., Tillmans L.S. et al. Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older women. Gut 2012;61(9):1299–305. DOI: 10.1136/gutjnl-2011-300719
5. Losurdo P., Mastronardi M., de Manzini N., Bortul M. Survival and long-term surgical outcomes after colorectal surgery: are there any gender-related differences? Updates Surg 2022;74(4):1337–43. DOI: 10.1007/s13304-022-01323-4
6. Majek O., Gondos A., Jansen L. et al. Sex differences in colorectal cancer survival: population-based analysis of 164,996 colorectal cancer patients in Germany. PLoS One 2013;8(7):e68077. DOI: 10.1371/journal.pone.0068077
7. Rutegard M., Shore R., Lu Y. et al. Sex differences in the incidence of gastrointestinal adenocarcinoma in Sweden 1970–2006. Eur J Cancer 2010;46(6):1093–100. DOI: 10.1016/j.ejca.2010.01.029
8. Gataullin B.I., Khasanov R.Sh., Savel'ev A.A., Gataullin I.G. Gendernaya spetsifika kolorektal'nogo raka v Respublike Tatarstan. Sibirskii onkologicheskii zhurnal 2021;20(1):16–23. DOI: https://doi.org/10.21294/1814-4861-2021-20-1-16-23
9. Eli M., Mollayup A., Muattar J. et al. K-ras genetic mutation and influencing factor analysis for Han and Uygur nationality colorectal cancer patients. Int J Clin Exp Med 2015;8(6):10168–77. eCollection 2015. PMID: 26309716
10. Ferlay J., Soerjomataram I., Dikshit R. et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:E359–86. DOI: 10.1002/ijc.29210
11. Barzi A., Lenz A.M., Labonte M.J., Lenz H.J. Molecular pathways: estrogen pathway in colorectal cancer. Clin Cancer Res 2013;19:5842–8. DOI: 10.1158/1078-0432.CCR-13-0325
12. Maingi J.W., Tang S., Liu S. et al. Targeting estrogen receptors in colorectal cancer. Mol Biol Rep 2020;47(5):4087–91. DOI: 10.1007/s11033-020-05414-6
13. Conti L., Cornò M.D., Gessani S. Revisiting the impact of lifestyle on colorectal cancer risk in a gender perspective. Crit Rev Oncol Hematol 2020;145:102834. DOI: 10.1016/j.critrevonc.2019.102834
