Опухоли головы и шеи. 2022; 12: 12-24
Лимфопролиферативные заболевания с поражением органов головы и шеи
https://doi.org/10.17650/2222-1468-2022-12-2-12-24Аннотация
Введение. Лимфомы - гетерогенная группа опухолей лимфоидной и кроветворной системы. Нередко опухолевый процесс развивается в области головы и шеи, включая покровные ткани, орбиту, полость носа и околоносовые пазухи, полость рта, ротоглотку, слюнные, щитовидную железы, а также лимфатические узлы шеи. при дифференциальной диагностике лимфом головы и шеи возникают сложности, поскольку очень часто процесс сочетается с неопухолевой патологией. Высокая гетерогенность лимфом данной локализации требует структуризации знаний относительно их эпидемиологических и клинических проявлений.
Цель исследования - оптимизация ранней диагностики лимфом области головы и шеи, изучение клинических особенностей лимфопролиферативных заболеваний данной локализации.
Материалы и методы. Проанализированы случаи лимфопролиферативных заболеваний с поражением области головы и шеи. материалом для исследования послужили данные 174 пациентов, госпитализированных в Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава России в период с 1999 по 2020 г.
Результаты. На основании современной клинико-морфологической классификации лимфопролиферативных заболеваний представлены сведения о локализации очагов поражения, характерные признаки экстранодальных очагов и лимфатических узлов шеи, а также методы диагностики лимфом с поражением органов головы и шеи. Заключение. полученные данные способствуют решению проблем диагностики лимфопролиферативных заболеваний с поражением органов головы и шеи и являются основой для успешного прогнозируемого лечения лимфом.
Список литературы
1. Пачес А.И., Таболиновская Т.Д. Злокачественные лимфомы. В кн.: Опухоли слюнных желез. М.: Практическая медицина, 2009. С. 359-364.
2. Гранов А.М., Ильин Н.В. Лимфомы: научно-практ. издание. СПб.: ФГУ «РНЦРХТ», 2010. 272 с.
3. Azarpira N., Ashraf M.J., Khademi B. Non-Hodgkin's lymphoma of the tongue presenting as an ulcerative lesion. Middle East J Cancer 2011;2(3-4):125-8.
4. Cancer: principles and practice of oncology. Ed. by V.T. DeVita, S. Hellman, S.A. Rosenberg. 9th edn. Philadelphia, Pa: Lippincott Williams & Wilkins, 2011. Pp. 729-780.
5. DeVita V.T., Lawrence T.S., Rosenberg's S.A. Cancer Principles & Practice of oncology. 11th ed. Philadelphia, Baltimore, New York, London, Buenos Aires, Hong Rong, Sydney, Tokyo, 2019. Available at: https://www.wolterskluwer.com/en/know/cancer-principles-and-practice-of-oncology.
6. Derringer G.A., Thompson L.D., Frommelt R.A. et al. Malignant lymphoma of the thyroid gland: a clinicopathologic study of 108 cases. Am J Surg Pathol 2000;24(5):623-39. DOI: 10.1097/00000478-20000500000001.
7. Eisenbud L., Sciubba J., Mir R., Sachs S.A. Oral presentations in non-Hodgkin's lymphoma: a review of thirty-one cases. Part II. Fourteen cases arising in bone. Oral Surg Oral Med Oral Pathol 1984;57(3):272-80. DOI: 10.1016/0030-4220(84)90183-x.
8. Dispenza F., Cicero G., Mortellaro G. et al. Primary non-Hodgkins lymphoma of the parotid gland. Braz J Otorhinolaryngol 2011;77(5):639-44. DOI: 10.1590/s1808-86942011000500017.
9. Levine A.M. Acquired immunodeficiency syndrome-related lymphoma: clinical aspects. Review Semin Oncol 2000;27(4):442-53.
10. Corti M., Villafane M., Bistmans A. et al. Primary extranodal non-hodgkin lymphoma of the head and neck in patients with acquired immunodeficiency syndrome: a clinicopathologic study of 24 patients in a single hospital of infectious diseases in Argentina. Int Arch Otorhinolaryngol 2014;18(3):260-5. DOI: 10.1055/s-0034-1373782.
11. Gupta N., Nijhawan R., Srinivasan R. et al. Fine needle aspiration cytology of primary thyroid lymphoma: a report of ten cases. Cytojournal 2005;2:21. DOI: 10.1186/1742-6413-2-21.
12. Paras C.A., Salpin A.P., Veloso J.D. Primary thyroid lymphoma. Philip J Otolaryngol 2012;27:38-40.
13. Bradford P.T., Devesa S.S., Anderson W.F., Toro J.R. Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases. Blood 2009;113(21):5064-73. DOI: 10.1182/blood-2008-10-184168.
14. Kini R., Saha A., Naik V. Diffuse large B-cell lymphoma of mandible: a case report. Case Reports Med Oral Patol Oral Cir Bucal 2009;14(9):e421-4.
15. Samanta M., Ratha B., Mallik A.K., Mishra M. Disseminated non-Hodgkin's lymphoma presenting as unilateral parotid gland enlargement with facial nerve palsy. Med J DY Patil Univ 2014;7:683-5.
16. Castellano S., Carbone M., Carrozzo M. et al. Onset of oral extranodal large B-cell non-Hodgkin's lymphoma in a patient with polycythemia vera: a rare presentation. Case Reports Oral Oncol 2002;38(6):624-6. DOI: 10.1016/s1368-8375(01)00099-9.
17. Sikorowa L., Meyzowa J.W. Mucoepidermoid tumor. In: Salivary Gland Tumors. New York - Oxford. P. 130-146.
18. Bondi R., Carcangiu M.L., Santucci M. Il tumore mucoepidermoide delle ghiandole salivari Mucoepidermoid tumor of the salivary glands. Arch De Vecchi Anat Patol 1977;62(1):117-26.
19. Thieblemont C., Mayer A., Dumontet C. et al. Primary thyroid lymphoma is a heterogeneous disease J Clin Endocrinol Metab 2002;87(1):105-11. DOI: 10.1210/jcem.87.1.8156.
20. Thieblemont С., Bastion Y., Berger F. et al. Mucosa-associated lymphoid tissue gastrointestinal and nongastrointestinal lymphoma behavior: analysis of 108 patients. J Clin Oncol 1997;15(4):1624-30. DOI: 10.1200/JCO.1997.15.4.1624.
21. Knowles' Neoplastic Hematopathology. Ed. by A. Orazi, K. Foucar, D.M. Knowles, L.M. Weiss. 3rd edn. Philadelphia: Lippincott Williams & Wilkins, 2013. Pp. 354-384.
22. Longo F., De Maria G., Esposito P., Califano L. Primary non-Hodgkin's lymphoma of the mandible. Report of a case. Int J Oral Maxillofac Surg 2004;33(8):801-3. DOI: 10.1016/j.ijom.2003.12.003.
Head and Neck Tumors (HNT). 2022; 12: 12-24
Lymphoproliferative disorders affecting organs of the head and neck
https://doi.org/10.17650/2222-1468-2022-12-2-12-24Abstract
Introduction. Lymphomas are a heterogenic group of tumors of the lymphatic and hematopoietic systems, and in many cases tumor process develops in the area of the head and neck including skin and mucosa, orbit, nasal cavity and paranasal sinuses, oral cavity, oropharynx, salivary glands, thyroid, and cervical lymph nodes. Differential diagnosis of lymphomas of the head and neck is complicated because it can be accompanied by another non-tumor pathology. High heterogeneity of lymphomas of the head and neck requires structurization of knowledge on their epidemiological and clinical manifestations.
The study objective is to optimize early diagnosis as it allows to significantly increase cancer alertness in local practitioners, oncologists, diagnosis specialists and, in turn, to decrease verification frequency in generalized disease processes. Study of clinical characteristics of lymphoproliferative disorders of the head and neck leads to increased quality of differential diagnosis.
Materials and methods. A study of lymphoproliferative disorders affecting head and neck was performed. Study material consisted of data on 174 patients hospitalized at the N.N. Blokhin National medical Research Center of Oncology between 1999 and 2020.
Results. Based on the current clinical and morphological classification of lymphoproliferative disorders, data on location of lesions, characteristic signs of extranodal lesions and cervical lymph nodes involvement, as well as methods of diagnosis of lymphomas of the head and neck, are presented.
Conclusion. The obtained data helps solve problems of diagnosis of lymphoproliferative disorders affecting the head and neck and serve as a basis for successful, predictable treatment of lymphomas.
References
1. Paches A.I., Tabolinovskaya T.D. Zlokachestvennye limfomy. V kn.: Opukholi slyunnykh zhelez. M.: Prakticheskaya meditsina, 2009. S. 359-364.
2. Granov A.M., Il'in N.V. Limfomy: nauchno-prakt. izdanie. SPb.: FGU «RNTsRKhT», 2010. 272 s.
3. Azarpira N., Ashraf M.J., Khademi B. Non-Hodgkin's lymphoma of the tongue presenting as an ulcerative lesion. Middle East J Cancer 2011;2(3-4):125-8.
4. Cancer: principles and practice of oncology. Ed. by V.T. DeVita, S. Hellman, S.A. Rosenberg. 9th edn. Philadelphia, Pa: Lippincott Williams & Wilkins, 2011. Pp. 729-780.
5. DeVita V.T., Lawrence T.S., Rosenberg's S.A. Cancer Principles & Practice of oncology. 11th ed. Philadelphia, Baltimore, New York, London, Buenos Aires, Hong Rong, Sydney, Tokyo, 2019. Available at: https://www.wolterskluwer.com/en/know/cancer-principles-and-practice-of-oncology.
6. Derringer G.A., Thompson L.D., Frommelt R.A. et al. Malignant lymphoma of the thyroid gland: a clinicopathologic study of 108 cases. Am J Surg Pathol 2000;24(5):623-39. DOI: 10.1097/00000478-20000500000001.
7. Eisenbud L., Sciubba J., Mir R., Sachs S.A. Oral presentations in non-Hodgkin's lymphoma: a review of thirty-one cases. Part II. Fourteen cases arising in bone. Oral Surg Oral Med Oral Pathol 1984;57(3):272-80. DOI: 10.1016/0030-4220(84)90183-x.
8. Dispenza F., Cicero G., Mortellaro G. et al. Primary non-Hodgkins lymphoma of the parotid gland. Braz J Otorhinolaryngol 2011;77(5):639-44. DOI: 10.1590/s1808-86942011000500017.
9. Levine A.M. Acquired immunodeficiency syndrome-related lymphoma: clinical aspects. Review Semin Oncol 2000;27(4):442-53.
10. Corti M., Villafane M., Bistmans A. et al. Primary extranodal non-hodgkin lymphoma of the head and neck in patients with acquired immunodeficiency syndrome: a clinicopathologic study of 24 patients in a single hospital of infectious diseases in Argentina. Int Arch Otorhinolaryngol 2014;18(3):260-5. DOI: 10.1055/s-0034-1373782.
11. Gupta N., Nijhawan R., Srinivasan R. et al. Fine needle aspiration cytology of primary thyroid lymphoma: a report of ten cases. Cytojournal 2005;2:21. DOI: 10.1186/1742-6413-2-21.
12. Paras C.A., Salpin A.P., Veloso J.D. Primary thyroid lymphoma. Philip J Otolaryngol 2012;27:38-40.
13. Bradford P.T., Devesa S.S., Anderson W.F., Toro J.R. Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases. Blood 2009;113(21):5064-73. DOI: 10.1182/blood-2008-10-184168.
14. Kini R., Saha A., Naik V. Diffuse large B-cell lymphoma of mandible: a case report. Case Reports Med Oral Patol Oral Cir Bucal 2009;14(9):e421-4.
15. Samanta M., Ratha B., Mallik A.K., Mishra M. Disseminated non-Hodgkin's lymphoma presenting as unilateral parotid gland enlargement with facial nerve palsy. Med J DY Patil Univ 2014;7:683-5.
16. Castellano S., Carbone M., Carrozzo M. et al. Onset of oral extranodal large B-cell non-Hodgkin's lymphoma in a patient with polycythemia vera: a rare presentation. Case Reports Oral Oncol 2002;38(6):624-6. DOI: 10.1016/s1368-8375(01)00099-9.
17. Sikorowa L., Meyzowa J.W. Mucoepidermoid tumor. In: Salivary Gland Tumors. New York - Oxford. P. 130-146.
18. Bondi R., Carcangiu M.L., Santucci M. Il tumore mucoepidermoide delle ghiandole salivari Mucoepidermoid tumor of the salivary glands. Arch De Vecchi Anat Patol 1977;62(1):117-26.
19. Thieblemont C., Mayer A., Dumontet C. et al. Primary thyroid lymphoma is a heterogeneous disease J Clin Endocrinol Metab 2002;87(1):105-11. DOI: 10.1210/jcem.87.1.8156.
20. Thieblemont S., Bastion Y., Berger F. et al. Mucosa-associated lymphoid tissue gastrointestinal and nongastrointestinal lymphoma behavior: analysis of 108 patients. J Clin Oncol 1997;15(4):1624-30. DOI: 10.1200/JCO.1997.15.4.1624.
21. Knowles' Neoplastic Hematopathology. Ed. by A. Orazi, K. Foucar, D.M. Knowles, L.M. Weiss. 3rd edn. Philadelphia: Lippincott Williams & Wilkins, 2013. Pp. 354-384.
22. Longo F., De Maria G., Esposito P., Califano L. Primary non-Hodgkin's lymphoma of the mandible. Report of a case. Int J Oral Maxillofac Surg 2004;33(8):801-3. DOI: 10.1016/j.ijom.2003.12.003.
