Опухоли головы и шеи. 2018; 8: 26-31
Необходимость и преимущества персонифицированной шейной лимфодиссекции при раке слизистой оболочки полости рта T1-2N0M0. Путь к радикальной операции
https://doi.org/10.17650/2222-1468-2018-8-4-26-31Аннотация
Цель исследования — изучение причин недостаточной эффективности шейной лимфодиссекции и возможностей ее повышения при раке полости рта при отсутствии клинически определяемых метастазов.
Материалы и методы. Выполнен обзор литературы, посвященной оценке эффективности хирургических методов воздействия на регионарные лимфоколлекторы при раке полости рта, а также получены предварительные данные о возможностях биопсии сигнального лимфатического узла.
Заключение. Метод определения сторожевого лимфатического узла с помощью флуоресцентного лимфокартирования и проточной цитометрии позволяет диагностировать сигнальный лимфатический узел и с высокой чувствительностью определить наличие скрытых микрометастазов.
Список литературы
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24. Van den Brekel M.W., Stel H.V., van der Valk P. et al. Micrometastases from squamous cell carcinoma in neck dissection specimens. Eur Arch Otorhinolaryngol 1992;249(6):349-53. PMID: 1384570.
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Head and Neck Tumors (HNT). 2018; 8: 26-31
The necessity and advantages of personified neck lymph node dissection in T1-2N0M0 oral mucosa cancer. A pathway to radical surgery
https://doi.org/10.17650/2222-1468-2018-8-4-26-31Abstract
The study objective is to investigate the causes of insufficient efficiency of neck lymph node dissection and possibilities of its improvement in cancer of the oral mucosa without clinically detectable metastases.
Materials and methods. A review of literature on surgical methods of affecting regional lymph collectors in cancers of the oral cavity was performed, and preliminary data on possibilities of biopsy of the sentinel lymph node were obtained.
Conclusion. Combination of fluorescent lymph node mapping andflow cytometry allows to identify the sentinel lymph node and detect hidden micrometastases with high sensitivity.
References
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9. Ganly I., Patel S., Shah J. Early stage squamous cell cancer of the oral tongue — clinicopathologic features affecting outcome. Cancer 2012;118(1):101—11. DOI: 10.1002/cncr.26229. PMID: 21717431.
10. Ganly I., Goldstein D., Carlson D.L. et al. Long-term regional control and survival in patients with “low-risk” early stage oral tongue cancer managed by partial glossectomy and neck dissection without postoperative radiation tumor thickness in oral tongue cancer. Cancer 2013;119(6):1168—76. DOI: 10.1002/cncr.27872. PMID: 23184439.
11. D’Cruz A.K., Vaish R., Kapre N. et al. Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med 2015;373(6):521—9. DOI: 10.1056/NEJMoa1506007. PMID: 26027881.
12. Huang S.F., Kang C.J., Lin C.Y. et al. Neck treatment of patients with early stage oral tongue cancer: comparison between observation, supraomohyoid dissection, and extended dissection. Cancer 2008;112(5):1066—75. DOI: 10.1002/cncr.23278. PMID: 18246535.
13. Shim S.J., Cha J., Koom W.S. et al. Clinical outcomes for T1—2N0—1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy. Radiat Oncol 2010;5:43. DOI: 10.1186/1748-717X-5-43. PMID: 20504371.
14. So Y.K., Oh D., Choi N. et al. Efficacy of postoperative neck irradiation for regional control in patients with pN0 oral tongue cancer: propensity analysis. Head Neck 2018;40(1):163—9. DOI: 10.1002/hed.24980. PMID: 29083541.
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17. Suarez O. El problema de las metastasis linfaticas y alejadas del cancer de laringe e hipofaringe. Rev Otorrinolaringol (Santiago de Chile) 1963;23:83-99.
18. Robbins K.T., Samant S., Ronen O. Neck dissection. In: Cummings otolaryngology: head & neck surgery. Ed. by P.W. Flint, B.H. Haughey, L.J. Lund et al. 5th edn. Philadelphia: Elsevier Mosby, 2010.
19. Chu W., Strawitz J.G. Results in suprahyoid, modified radical, and standard radical neck dissections for metastatic squamous cell carcinoma: recurrence and survival. Am J Surg 1978;136(4):512—5. PMID: 707733.
20. Byers R.M., Weber R.S., Andrews T. et al. Frequency and therapeutic implications of “skip metastases” in the neck from squamous carcinoma of the oral tongue. Head Neck 1997;19(1):14-9. PMID: 9030939.
21. Rouviere H. Lymphatic system of the head and neck. In: Anatomy of the human lymphatic system. Ed. by M.J. Tobias. Ann Arbor: Edwards Brothers, 1938. Pp. 5-28.
22. Brierley J. The evolving TNM cancer staging system: an essential component of cancer care. CMAJ 2006;174(2):155-6. DOI: 10.1503/cmaj.045113. PMID: 16415456.
23. Van den Brekel M.W., Stel H.V., Castelijns J.A. et al. Cervical lymph node metastasis: assessment of radiologic criteria. Radiology 1990;177(2):379—84. DOI: 10.1148/radiology.177.2.2217772. PMID: 2217772.
24. Van den Brekel M.W., Stel H.V., van der Valk P. et al. Micrometastases from squamous cell carcinoma in neck dissection specimens. Eur Arch Otorhinolaryngol 1992;249(6):349-53. PMID: 1384570.
25. Van den Brekel M.W., van der Waal I., Meijer C.J. et al. The incidence of micrometastases in neck dissection specimens obtained from elective neck dissections. Laryngoscope 1996;106(8):987-91. PMID: 8699914.
