Российские нанотехнологии. 2019; 14: 46-58
Биоразлагаемые композиции ультратонких волокон поли-3-гидроксибутирата с комплексами MnCl–тетрафенилпорфирин. Динамика, структура и свойства
https://doi.org/10.21517/1992-7223-2019-3-4-46-58Аннотация
Проведены комплексные исследования надмолекулярной структуры нетканых материалов на основе ультратонких волокон поли(3-гидроксибутирата), содержащих комплекс марганец–хлор тетрафенилпорфирин. Ультратонкие волокна получали методом электроформования. Концентрация комплекса в волокнах составляла 0–5%. Исследования проводили с помощью рентгеноструктурного анализа, зондового метода электронного парамагнитного резонанса, дифференциальной сканирующей калориметрии и сканирующей электронной микроскопии. Показано, что с ростом концентрации комплекса изменяется морфология полимерных волокон, наблюдается заметный рост степени кристалличности и замедляется молекулярная подвижность в плотных аморфных областях волокон поли(3-гидроксибутирата). Температурное воздействие (при 140°С) приводит к резкому возрастанию степени кристалличности и молекулярной подвижности в аморфных областях волокон. Экспозиция волокон в воде (при 70°С) приводит к значительному снижению энтальпии плавления и повышению молекулярной подвижности цепей в аморфных областях полимера. Полученные волокнистые материалы обладают высокими антибактериальными свойствами и должны найти непосредственное приложение при создании терапевтических систем антисептического и противоопухолевого действия.
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Title in english. 2019; 14: 46-58
Poly-3-hydroxybutirate with MnCl-tetrafenylporphyrin complexes. Dynamics, structure and properties
https://doi.org/10.21517/1992-7223-2019-3-4-46-58Abstract
Comprehensive studies combining X-ray structural analysis, structural dynamic measurements with an EPR probe method, thermophysical measurements (DSC), and scanning electron microscopy have been carried out. The specificity of the crystalline and amorphous structure of ultra-thin poly (3-hydroxybutyrate) fibers containing a low concentration of manganese complex with chlorotetraphenyl porphyrin (MnCl-TFP) (0-5%), obtained by electroforming, is considered. It was shown that when PHB of MnCl-TTP complexes are added to PHB fibers, the morphology of the fibers changes, crystallinity increases, and the molecular mobility in the dense amorphous regions of the polymer slows down. The temperature effect on the fibers (annealing at 1400) leads to a sharp increase in crystallinity and molecular mobility in the amorphous regions of poly (3-hydroxybutyrate). Exposure of fibers in an aqueous medium at 700 leads to a sharp decrease in the enthalpy of melting and to an increase in the molecular mobility of the chains in the amorphous regions. The obtained fibrous materials have bactericidal properties and must be directly applied in the creation of therapeutic systems with antibacterial and antitumor action.
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