Офтальмохирургия. 2020; : 80-84
Цитокины и факторы роста в патогенезе первичной открытоугольной глаукомы
https://doi.org/10.25276/0235-4160-2020-3-80-84Аннотация
В обзоре представлены данные современной научной литературы, касающиеся роли различных классов цитокинов и факторов роста в патогенезе первичной открытоугольной глаукомы. Информация о значимости в механизмах развития глаукомы биологически активных молекул, участвующих в воспалительных и пролиферативных процессах, является базой для изучения патогенеза патологического процесса и создания новых подходов к лечению.
Список литературы
1. Егоров Е.А., Алексеев В.Н. Патогенез и лечение первичной открытоугольной глаукомы. М.: ГЭОТАР-Медиа; 2017. [Yegorov YeA, Alekseyev VN. Patogenez i lecheniye pervichnoy otkrytougol’noy glaukomy. Moskva: GEOTAR-Media; 2017. (In Russ.)]
2. Бикбов М.М., Бабушкин А.Э., Хуснитдинов И.И., Мурова Л.Х., Матюхина Е.Н. Динамика эпидемиологических показателей глаукомы в Республике Башкортостан за период 2010–2016 гг. РМЖ. Клиническая офтальмология. 2018;4: 163–167. [Bikbov MM, Babushkin A, Khusnitdinov II, Murova LKh, Matyukhina EN. Dynamics of epidemiological indicators of glaucoma in the Republic of Bashkortostan for the period of 2010–2016. RMJ. Clinical ophthalmology. 2018;4: 163–167. (In Russ.)] doi:10.21689/2311-7729-2018-18-4-163-167
3. Юрьева Т.Н., Грищук А.С., Савилов Е.Д., Михалевич И.М., Микова О.И., Новолодский А.И. Основные характеристики заболеваемости глаукомой в Иркутской области и их связь с организационно-методическими мероприятиями офтальмологической. Национальный журнал глаукома. 2014;13(3): 36–42. [Yurieva TN, Grishchuk AS, Savilov ED, Mikhalevich IM, Mikova OI, Novolodskiy AI. Main characteristics of incidence of glaucoma in the Irkutsk region and their relationship with organizational and methodological activities of ophthalmologic service. National Journal glaucoma. 2014;13(3): 36–42. (In Russ.)]
4. Bourne RR, Taylor HR, Flaxman SR, Keeffe J, Leasher J, Naidoo K, Pesudovs K, White RA, Wong TY, Resnikoff S, Jonas JB. Vision Loss Expert Group of the Global Burden of Disease Study. Number of People Blind or Visually Impaired by Glaucoma Worldwide and in World Regions 1990–2010: A Meta-Analysis. PLoS One. 2016;11(10): e0162229. doi:10.1371/journal.pone.0162229
5. Tham YC, Li X, Wong TY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121: 2081–2090. doi 0.1016/j.ophtha.2014.05.013
6. Muratov S, Podbielski DW, Jack SM Preferencebased disease-specific health-related quality of life instrument for glaucoma: a mixed methods study protocol. BMJ Open. 2016;8(6): e012732. doi:10.1136/bmjopen–2016–012732
7. Кулешова О.Н., Лазарева А.К., Айдагулова С.В., Диковская М.А., Ермакова О.В., Дулидова В.В., Глок М.А. Структурные особенности соединительной ткани склеры у повторно оперированных пациентов с первичной открытоугольной псевдоэксфолиативной глаукомой. Бюллетень СО РАМН. 2014;34(3): 56–60. [Kuleshova ON, Lazareva AK, Aidagulova SV, Dikovskaya MA, Ermakova OV, Dulidova VV, Glock MA. Structural features of connective tissue of the sclera in re-operated patients with primary open-angle pseudoexfoliation glaucoma. Bulletin SB RAMS. 2014;34(3): 56–60. (In Russ.)]
8. Трунов А.Н., Бгатова Н.П., Еремина А.В., Дружинин И. Б., Пожидаева А.А., Трунова Л.А., Черных В.В. Новые подходы к оценке выраженности воспалительных нарушений в патогенезе первичной открытоугольной глаукомы. Аллергология и иммунология. 2016;17(2): 107–111. [Trunov AN, Bgatova NP, Eremina AV, Druzhinin IB, Pozhidaeva AA, Trunova LA, Chernykh VV. New approaches to assessing the severity of inflammatory disorders in the pathogenesis of primary open-angle glaucoma. Allergology and immunology. 2016;17(2): 107–111. (In Russ.)]
9. Черных В.В., Бгатова Н.П., Орлов Н.Б., Ермакова О.В., Трунов А.Н. Местный воспалительный процесс как возможное проявление нарушений увеолимфатического оттока внутриглазной жидкости при глаукоме. Часть 2. Национальный журнал глаукома. 2018;17(2): 3–11. [Chernykh VV, Bgatova NP, Orlov NB, Ermakova OV, Trunov AN. Local inflammatory process as a possible manifestation of intraocular fluid uveolymphatic outflow defects in glaucoma. Part 2. National Journal glaucoma. 2018;17(2): 3–11. (In Russ.)] doi:10.25700/NJG.2018.02.01
10. Tektas OY, Lütjen-Drecoll E. Structural changes of the trabecular meshwork in different kinds of glaucoma. Exp Eye Res. 2009;88(4): 769–775. doi:10.1016/j.exer.2008.11.025
11. Sihota R, Goyal A, Kaur J, Gupta V, Nag TC. Scanning electron microscopy of the trabecular meshwork: understanding the pathogenesis of primary angle closure glaucoma. Indian J Ophthalmol. 2012;60(3): 183–188. doi:10.4103/0301-4738.95868
12. Taurone S, Ripandelli G, Pacella E, Bianchi E, Plateroti AM, De Vito S, Plateroti P, Grippaudo FR, Cavallotti C, Artico M. Potential regulatory molecules in the human trabecular meshwork of patients with glaucoma: immunohistochemical profile of a number of inflammatory cytokines. Mol Med Rep. 2015;11(2): 1384–1390. doi:10.3892/mmr.2014.2772
13. Song MM, Lei Y, Wu JH, Sun XH. The progress of studies on aqueous humor dynamics abnormality induced by trabecular meshwork and Schlemm canal endothelial cell senescence and its relation with glaucoma. Zhonghua Yan Ke Za Zhi. 2017;53(11):868–873. doi:10.3760/cma.j.issn.0412-4081.2017.11.014
14. Wang K, Read AT, Sulchek T, Ethier CR. Trabecular meshwork stiffness in glaucoma. Exp Eye Res. 2017;158: 3–12. doi:10.1016/j.exer.2016.07.011
15. Chinnery HR, McMenamin PG, Dando SJ. Macrophage physiology in the eye. Pflugers Arch. 2017;469(3–4): 501–515. doi:10.1007/s00424-017-1947-5
16. Reyes NJ, O’Koren EG, Saban DR. New insights into mononuclear phagocyte biology from the visual system. Nat Rev Immunol. 2017;17(5): 322–332. doi:10.1038/nri.2017.13
17. McMenamin PG, Saban DR., Dando SJ. Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance. Progress in Retinal and Eye Research. 2018. doi:10.1016/j.preteyeres.2018.12.002
18. Черных В.В. Влияние комплексной консервативной терапии на иммунобиохимические показате- ли в слезной жидкости у пациентов с первичной открытоугольной глаукомой. Глаукома. 2005;4(4): 20–24. [Chernykh VV. Influence of complex conservative therapy on immune-biochemical parameters in the tear fluid in patients with primary open-angle glaucoma. Glaucoma. 2005;4 (4): 20–24. (In Russ.)]
19. Еричев В.П., Ганковская Л.В., Ковальчук Л.В., Ганковская О.А., Дугина А.Е. Изменение некоторых иммунологических показателей слезной жидкости при избыточном рубцевании после антиглаукоматозных операций у пациентов с первичной открытоугольной глаукомой. Вестник офтальмологии. 2010;126(3): 25–29. [Erichev VP, Gankovskaya LV, Kovalchuk LV, Gankovskaya OA, Dugina AE. Changes in some immunological parameters of lacrimal fluid in excess scarring after antiglaucoma surgery in patients with primary open-angle glaucoma. Vestnik oftalmologii. 2010;126(3): 25–29. (In Russ.)]
20. Соколов В.А., Леванова О.Н., Никифоров А.А. Матриксные металлопротеиназы-2 и -9 в слез- ной жидкости у больных с первичной открытоугольной глаукомой. Национальный журнал глау- кома. 2013;12(4): 21–29. [Sokolov VA, Levanova ON, Nikiforov AA. Matrix metalloproteinases –2 and –9 in the lacrimal fluid in patients with primary open-angle glaucoma. National Journal of Glaucoma. 2013;12(4): 21–29. (In Russ.)]
21. Хохлова А.С., Кириенко А.В., Филина Н.В., Макелова Е.В. Локальная цитокиновая регуляция на разных стадиях первичной открытоугольной глаукомы. Тихоокеанский медицинский журнал. 2014;4: 46–48. [Khokhlova AS, Kirienko AV, Filina NV, Makelova EV. Local cytokine regulation at different stages of primary open-angle glaucoma. Pacific Medical Journal. 2014;4: 46–48.
22. Чередниченко Л.П., Барычева Л.Ю., Берновская А.А. Определение провоспалительных цитокинов в ранней диагностике первичной открыто-угольной глаукомы. Российский офтальмологический журнал. 2013;6(2): 82–85. [Cherednichenko LP, Barycheva LYu, Bernovskaya AA. Determination of proinflammatory cytokines in early diagnosis of primary openangle glaucoma. Russian Ophthalmological Journal. 2013;6(2): 82–85. (In Russ.)]
23. Benitez-Del-Castillo J, Cantu-Dibildox J, Sanz- González SM, Zanón-Moreno V, Pinazo-Duran MD. Cytokine expression in tears of patients with glaucoma or dry eye disease: A prospective, observational cohort study. Eur J Ophthalmol. 2019;29(4): 437–443. doi:10.1177/1120672118795399
24. Csősz É, Deák E, Tóth N, Traverso CE, Csutak A, Tőzsér J. Comparative analysis of cytokine profiles of glaucomatous tears and aqueous humor reveals potential biomarkers for trabeculectomy complications. FEBS Open Bio. 2019; 9(5): 1020–1028. doi:10.1002/2211-5463.12637
25. Черных В.В., Ермакова О.В., Орлов Н.Б., Обухова О.О., Горбенко О.М., Шваюк А.П., Еремина А.В., Трунов А.Н. Особенности содержания провоспалительных цитокинов в слезной и внутри- глазной жидкостях при первичной открытоугольной глаукоме. Сибирский научный медицинский журнал. 2018;38(5): 5–10. [Chernykh VV, Ermakova OV, Orlov NB, Obukhova OO, Gorbenko OM, Shvayuk AP, Eremina AV, Trunov AN. Features of the content of proinflammatory cytokines in lacrimal and intraocular fluid in patients with primary open-angle glaucoma. Siberian Scientific Medical Journal. 2018;38(5): 5–10. (In Russ.)] doi:10.15372/SSMJ20180501
26. Шпак А.А., Гехт А.Б., Дружкова Т.А., Козлова К.И. Соотношения нейротрофических факторов в слезной жидкости и влаге передней камеры у больных с возрастной катарактой. Офтальмохирур- гия. 2017;1: 16–20. [Shpak AA, Guekht AB, Druzhkova TA, Kozlova KI. The ratio of neurotrophic factors in the lacrimal fluid and aqueous humor in patients with age-related cataract. Fyodorov Journal of Ophthalmic Surgery. 2017;1: 16–20. (In Russ.)] doi:10.25276/0235-4160-2017-1-16-20
27. Chua J, Vania M, Cheung C M, Ang M, Chee SP, Yang H, Li J, Wong TT. Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes. Mol Vis. 2012;18: 431–438.
28. Freedman J, Iserovich P. Pro-inflammatory cytokines in glaucomatous aqueous and encysted Molteno implant blebs and their relationship to pressure. Invest. Ophthalmol Vis Sci. 2013;54(7): 4851–4855. doi:10.1167/iovs.13-12274
29. Takai Y, Tanino M, Obira A. Multiple cytokine analysis of aqueous humor in eyes with primary openangle glaucoma, exfoliation glaucoma, and cataract. Invest. Ophthalmol Vis Sci. 2012;53(1): 241–247. doi:10.1167/iovs.11-8434
30. Engel LA, Muether PS, Fauser S, Hueber A. The effect of previous surgery and topical eye drops for primary open-angle glaucoma on cytokine expression in aqueous humor. Graefes Arch Clin Exp Ophthalmol. 2014;252(5): 791–799. doi:10.1007/s00417-014-2607-5
31. Черных В.В., Коненков В.И., Ермакова О.В., Орлов Н.Б., Обухова О.О., Еремина А.В., Трунов А.Н. Содержание цитокинов и факторов роста во внутриглазной жидкости у пациентов с первичной открытоугольной глаукомой. Бюллетень сибирской медицины. 2019;18(1): 257–265. [Chernykh VV, Konenkov VI, Ermakova OV, Orlov NB, Obukhova OO, Eremina AV, Trunov AN. Сontent of cytokines and growth factors in the intraocular fluid of patients with primary open-angle glaucoma. Bulletin of Siberian Medicine. 2019;18(1): 257–265. (In Russ.)] doi:10.20538/1682-0363-2019-1-257-265.
32. Khalef N, Labib H, Helmy H, El Hamid MA, Moemen L, Fahmy I. Levels of cytokines in the aqueous humor of eyes with primary open angle glaucoma, pseudoexfoliation glaucoma and cataract. Electron Physician. 2017;9(2): 3833–3837. doi:10.19082/3833
33. Pantalon A, Obadă O, Constantinescu D, Feraru C, Chiseliţă D. Inflammatory model in patients with primary open angle glaucoma and diabetes. Int J Ophthalmol. 2019;12(5): 795–801. doi:10.18240/ijo.2019.05.15
34. Kokubun T, Tsuda S, Kunikata H, Yasuda M, Himori N, Kunimatsu-Sanuki S, Maruyama K, Nakazawa T. Characteristic profiles of inflammatory cytokines in the aqueous humor of glaucomatous eyes. Ocul Immunol Inflamm. 2017;16: 1–12. doi:10.1080/09273948.2017.1327605
35. Ten Berge JC, Fazil Z, Van Den Born I, Wolfs RCW, Schreurs MWJ, Dik WA, Rothova A Intraocular cytokine profile and autoimmune reactions in retinitis pigmentosa, age-related macular degeneration, glaucoma and cataract. Acta Ophthalmol. 2019;97(2): 185–192. doi:10.1111/aos.13899
36. Chono I, Miyazaki D, Miyake H, Komatsu N, Ehara F, Nagase D, Kawamoto Y, Shimizu Y, Ideta R, Inoue Y. High interleukin-8 level in aqueous humor is associated with poor prognosis in eyes with open angle glaucoma and neovascular glaucoma. Sci Rep. 2018;8: 14533. doi:10.1038/s41598-018-32725-3.
37. Peng H, Sarwar Z, Yang XP, Peterson EL, Xu J, Janic B, Rhaleb N, Carretero OA, Rhaleb NE. Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction. Hypertension. 2015;66(3): 582–589. doi:10.1161/HYPERTENSIONAHA.115.05627
38. Huang P, Zhang SS, Zhang C. Erratum: The two sides of cytokine signaling and glaucomatous optic neuropathy. J Ocul Biol Dis Infor. 2009;2(3): 98–103. doi:10.1007/s12177-009-9034-6
39. Wong M, Huang P, Li W, Li Y, Zhang SS, Zhang C. T-helper1/T-helper2 cytokine imbalance in the iris of patients with glaucoma. PLoS One. 2015;10(3): e0122184. doi:10.1371/journal.pone.0122184
40. Tong Y, Zhou YL, Zheng Y, Biswal M, Zhao PQ, Wang ZY. Analyzing cytokines as biomarkers to evaluate severity of glaucoma. Int J Ophthalmol. 2017;10(6): 925–930. doi:10.18240/ijo.2017.06.15
41. Huang HY, Luther SA. Expression and function of interleukin-7 in secondary and tertiary lymphoid organs. Seminars in Immunology. 2012;24(3): 175–189. doi:10.1016/j.smim.2012.02
42. Vonarbourg C, Diefenbach A. Multifaceted roles of interleukin-7 signaling for the development and function of innate lymphoid cells. Seminars in Immunology. 2012;24(3): 165–174. doi:10.1016/j.smim.2012.03.002
43. Iolyeva M, Aebischer D, Proulx ST, Willrodt AH, Ecoiffier T, Häner S, Bouchaud G, Krieg C, Onder L, Ludewig B, Santambrogio L, Boyman O, Chen L, Finke D, Halin C. Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage. Blood. 2013;122(13): 2271–2281. doi:10.1182/blood-2013-01-478073
44. Черных В.B., Бгатова Н.П. Лимфатические структуры глаза и увеолимфатический (метаболический) путь оттока внутриглазной жидкости. Часть 1. Национальный журнал глаукома. 2018;17(1): 3–13. [Chernykh VV, Bgatova NP. Lymphatic structures of the eye and uveolymphatic (metabolic) pathway of intraocular fluid outflow. Part 1. doi:10.25700/NJG.2018.01.01
45. Yücel YH, Johnston MG, Ly T, Patel M, Drake B, Gümüş E, Fraenkl S, Moore S, Tobbia D, Armstrong D, Horvath E, Gupta N Identification of lymphatics in the ciliary body of the human eye: a novel «uveolymphatic» outflow pathway. Exp Eye Res. 2009;89(5): 809–810. doi:10.1016/j.exer.2009.08.01019
46. Kim M, Johnston MG, Gupta N, Moore S, Yücel YH. A model to measure lymphatic drainage from the eye. Exp Eye Res. 2011;93(5): 586–591. doi:10.1016/j.exer.2011.07.006
47. Ikushima H, Miyazono K. Biology of transforming growth factor-β signaling. Current Pharmaceutical Biotechnology. 2011;12(12): 2099–2107. doi:10.2174/138920111798808419
48. Poniatowski L, Wojdasiewicz P, Gasik R, Szukiewicz D. Transforming growth factor Beta family: insight into the role of growth factors in regulation of fracture healing biology and potential clinical applications. Mediators Inflamm. 2015;2015: 137823. doi:10.1155/2015/137823
49. Черных В.В., Коненков В.И., Орлов Н.Б., Ермакова О.В., Ходжаев Н.С., Трунов А.Н. Особенности содержания трансформирующих факторов ростабета 1,2,3 (TGF-β1, TGF-β2, TGF-β3) во внутриглазной жидкости при первичной открытоугольной глаукоме. Офтальмохирургия. 2019;2: 13–17. [Chernykh VV, Konenkov VI, Orlov NB, Ermakova OV, Khodzhaev NS, Trunov AN. Features of the content of transforming growth factors-beta 1,2,3 (TGF-β1, TGF-β2, TGF-β3) in intraocular fluid in primary open-angle glaucoma. Fyodorov Journal of Ophthalmic Surgery. 2019;2: 13–17. (In Russ.)] doi:10.25276/0235-4160-2019-2-13-17
50. Junglas B, Kuespert S, Seleem AA, Struller T, Ullmann S, Bösl M, Bosserhoff A, Köstler J, Wagner R, Tamm ER, Fuchshofer R. Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork. Am J Pathol. 2012;180(6): 2386‑–2403. doi:10.1016/j.ajpath.2012.02.030
51. Wordinger RJ, Sharma T, Clark A. The role of TGF-β2 and bone morphogenetic proteins in the trabecular meshwork and glaucoma. J Ocul Pharmacol Ther. 2014;30(2-3): 154–162. doi:10.1089/jop.2013.0220
52. Agarwal P, Daher AM, Agarwal R. Aqueous humor TGF-β2 levels in patients with open-angle glaucoma: A meta-analysis. Mol Vis. 2015;21: 612–620.
53. Braunger BM, Fuchshofer R, Tamm ER. The aqueous humor outflow pathways in glaucoma: A unifying concept of disease mechanisms and causative treatment. Eur J Pharm Biopharm. 2015;95: 173–181. doi:10.1016/j.ejpb.2015.04.029
54. Murphy-Ullrich JE, Downs JC. The Thrombospondin1-TGF-β Pathway and Glaucoma. J Ocul Pharmacol Ther. 2015;31(7): 371–375. doi:10.1089/jop.2015.0016
55. Gajda-Derylo B, Stahnke T, Struckmann S, Warsow G, Birke K, Birke MT, Hohberger B, Rejdak R, Fuellen G, Jünemann AG. Comparison of cytokine/ chemokine levels in aqueous humor of primary openangle glaucoma patients with positive or negative outcome following trabeculectomy. Biosci Rep. 2019;39: 5. doi:10.1042/BSR20181894
Fyodorov Journal of Ophthalmic Surgery. 2020; : 80-84
Cytokines and growth factors in the pathogenesis of primary open-angle glaucoma
https://doi.org/10.25276/0235-4160-2020-3-80-84Abstract
The review presents data from contemporary scientific literature regarding the role of the various classes of cytokines and growth factors in the pathogenesis of in the pathogenesis of primary openangle glaucoma. Information of the role in the mechanisms of glaucoma development of biologically active molecules, involved in the inflammatory and proliferative processes, is a basis for studying the pathogenesis of the pathological process and creating new approaches to treatment. glaucoma; inflammation; cytokines; growth factors
References
1. Egorov E.A., Alekseev V.N. Patogenez i lechenie pervichnoi otkrytougol'noi glaukomy. M.: GEOTAR-Media; 2017. [Yegorov YeA, Alekseyev VN. Patogenez i lecheniye pervichnoy otkrytougol’noy glaukomy. Moskva: GEOTAR-Media; 2017. (In Russ.)]
2. Bikbov M.M., Babushkin A.E., Khusnitdinov I.I., Murova L.Kh., Matyukhina E.N. Dinamika epidemiologicheskikh pokazatelei glaukomy v Respublike Bashkortostan za period 2010–2016 gg. RMZh. Klinicheskaya oftal'mologiya. 2018;4: 163–167. [Bikbov MM, Babushkin A, Khusnitdinov II, Murova LKh, Matyukhina EN. Dynamics of epidemiological indicators of glaucoma in the Republic of Bashkortostan for the period of 2010–2016. RMJ. Clinical ophthalmology. 2018;4: 163–167. (In Russ.)] doi:10.21689/2311-7729-2018-18-4-163-167
3. Yur'eva T.N., Grishchuk A.S., Savilov E.D., Mikhalevich I.M., Mikova O.I., Novolodskii A.I. Osnovnye kharakteristiki zabolevaemosti glaukomoi v Irkutskoi oblasti i ikh svyaz' s organizatsionno-metodicheskimi meropriyatiyami oftal'mologicheskoi. Natsional'nyi zhurnal glaukoma. 2014;13(3): 36–42. [Yurieva TN, Grishchuk AS, Savilov ED, Mikhalevich IM, Mikova OI, Novolodskiy AI. Main characteristics of incidence of glaucoma in the Irkutsk region and their relationship with organizational and methodological activities of ophthalmologic service. National Journal glaucoma. 2014;13(3): 36–42. (In Russ.)]
4. Bourne RR, Taylor HR, Flaxman SR, Keeffe J, Leasher J, Naidoo K, Pesudovs K, White RA, Wong TY, Resnikoff S, Jonas JB. Vision Loss Expert Group of the Global Burden of Disease Study. Number of People Blind or Visually Impaired by Glaucoma Worldwide and in World Regions 1990–2010: A Meta-Analysis. PLoS One. 2016;11(10): e0162229. doi:10.1371/journal.pone.0162229
5. Tham YC, Li X, Wong TY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121: 2081–2090. doi 0.1016/j.ophtha.2014.05.013
6. Muratov S, Podbielski DW, Jack SM Preferencebased disease-specific health-related quality of life instrument for glaucoma: a mixed methods study protocol. BMJ Open. 2016;8(6): e012732. doi:10.1136/bmjopen–2016–012732
7. Kuleshova O.N., Lazareva A.K., Aidagulova S.V., Dikovskaya M.A., Ermakova O.V., Dulidova V.V., Glok M.A. Strukturnye osobennosti soedinitel'noi tkani sklery u povtorno operirovannykh patsientov s pervichnoi otkrytougol'noi psevdoeksfoliativnoi glaukomoi. Byulleten' SO RAMN. 2014;34(3): 56–60. [Kuleshova ON, Lazareva AK, Aidagulova SV, Dikovskaya MA, Ermakova OV, Dulidova VV, Glock MA. Structural features of connective tissue of the sclera in re-operated patients with primary open-angle pseudoexfoliation glaucoma. Bulletin SB RAMS. 2014;34(3): 56–60. (In Russ.)]
8. Trunov A.N., Bgatova N.P., Eremina A.V., Druzhinin I. B., Pozhidaeva A.A., Trunova L.A., Chernykh V.V. Novye podkhody k otsenke vyrazhennosti vospalitel'nykh narushenii v patogeneze pervichnoi otkrytougol'noi glaukomy. Allergologiya i immunologiya. 2016;17(2): 107–111. [Trunov AN, Bgatova NP, Eremina AV, Druzhinin IB, Pozhidaeva AA, Trunova LA, Chernykh VV. New approaches to assessing the severity of inflammatory disorders in the pathogenesis of primary open-angle glaucoma. Allergology and immunology. 2016;17(2): 107–111. (In Russ.)]
9. Chernykh V.V., Bgatova N.P., Orlov N.B., Ermakova O.V., Trunov A.N. Mestnyi vospalitel'nyi protsess kak vozmozhnoe proyavlenie narushenii uveolimfaticheskogo ottoka vnutriglaznoi zhidkosti pri glaukome. Chast' 2. Natsional'nyi zhurnal glaukoma. 2018;17(2): 3–11. [Chernykh VV, Bgatova NP, Orlov NB, Ermakova OV, Trunov AN. Local inflammatory process as a possible manifestation of intraocular fluid uveolymphatic outflow defects in glaucoma. Part 2. National Journal glaucoma. 2018;17(2): 3–11. (In Russ.)] doi:10.25700/NJG.2018.02.01
10. Tektas OY, Lütjen-Drecoll E. Structural changes of the trabecular meshwork in different kinds of glaucoma. Exp Eye Res. 2009;88(4): 769–775. doi:10.1016/j.exer.2008.11.025
11. Sihota R, Goyal A, Kaur J, Gupta V, Nag TC. Scanning electron microscopy of the trabecular meshwork: understanding the pathogenesis of primary angle closure glaucoma. Indian J Ophthalmol. 2012;60(3): 183–188. doi:10.4103/0301-4738.95868
12. Taurone S, Ripandelli G, Pacella E, Bianchi E, Plateroti AM, De Vito S, Plateroti P, Grippaudo FR, Cavallotti C, Artico M. Potential regulatory molecules in the human trabecular meshwork of patients with glaucoma: immunohistochemical profile of a number of inflammatory cytokines. Mol Med Rep. 2015;11(2): 1384–1390. doi:10.3892/mmr.2014.2772
13. Song MM, Lei Y, Wu JH, Sun XH. The progress of studies on aqueous humor dynamics abnormality induced by trabecular meshwork and Schlemm canal endothelial cell senescence and its relation with glaucoma. Zhonghua Yan Ke Za Zhi. 2017;53(11):868–873. doi:10.3760/cma.j.issn.0412-4081.2017.11.014
14. Wang K, Read AT, Sulchek T, Ethier CR. Trabecular meshwork stiffness in glaucoma. Exp Eye Res. 2017;158: 3–12. doi:10.1016/j.exer.2016.07.011
15. Chinnery HR, McMenamin PG, Dando SJ. Macrophage physiology in the eye. Pflugers Arch. 2017;469(3–4): 501–515. doi:10.1007/s00424-017-1947-5
16. Reyes NJ, O’Koren EG, Saban DR. New insights into mononuclear phagocyte biology from the visual system. Nat Rev Immunol. 2017;17(5): 322–332. doi:10.1038/nri.2017.13
17. McMenamin PG, Saban DR., Dando SJ. Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance. Progress in Retinal and Eye Research. 2018. doi:10.1016/j.preteyeres.2018.12.002
18. Chernykh V.V. Vliyanie kompleksnoi konservativnoi terapii na immunobiokhimicheskie pokazate- li v sleznoi zhidkosti u patsientov s pervichnoi otkrytougol'noi glaukomoi. Glaukoma. 2005;4(4): 20–24. [Chernykh VV. Influence of complex conservative therapy on immune-biochemical parameters in the tear fluid in patients with primary open-angle glaucoma. Glaucoma. 2005;4 (4): 20–24. (In Russ.)]
19. Erichev V.P., Gankovskaya L.V., Koval'chuk L.V., Gankovskaya O.A., Dugina A.E. Izmenenie nekotorykh immunologicheskikh pokazatelei sleznoi zhidkosti pri izbytochnom rubtsevanii posle antiglaukomatoznykh operatsii u patsientov s pervichnoi otkrytougol'noi glaukomoi. Vestnik oftal'mologii. 2010;126(3): 25–29. [Erichev VP, Gankovskaya LV, Kovalchuk LV, Gankovskaya OA, Dugina AE. Changes in some immunological parameters of lacrimal fluid in excess scarring after antiglaucoma surgery in patients with primary open-angle glaucoma. Vestnik oftalmologii. 2010;126(3): 25–29. (In Russ.)]
20. Sokolov V.A., Levanova O.N., Nikiforov A.A. Matriksnye metalloproteinazy-2 i -9 v slez- noi zhidkosti u bol'nykh s pervichnoi otkrytougol'noi glaukomoi. Natsional'nyi zhurnal glau- koma. 2013;12(4): 21–29. [Sokolov VA, Levanova ON, Nikiforov AA. Matrix metalloproteinases –2 and –9 in the lacrimal fluid in patients with primary open-angle glaucoma. National Journal of Glaucoma. 2013;12(4): 21–29. (In Russ.)]
21. Khokhlova A.S., Kirienko A.V., Filina N.V., Makelova E.V. Lokal'naya tsitokinovaya regulyatsiya na raznykh stadiyakh pervichnoi otkrytougol'noi glaukomy. Tikhookeanskii meditsinskii zhurnal. 2014;4: 46–48. [Khokhlova AS, Kirienko AV, Filina NV, Makelova EV. Local cytokine regulation at different stages of primary open-angle glaucoma. Pacific Medical Journal. 2014;4: 46–48.
22. Cherednichenko L.P., Barycheva L.Yu., Bernovskaya A.A. Opredelenie provospalitel'nykh tsitokinov v rannei diagnostike pervichnoi otkryto-ugol'noi glaukomy. Rossiiskii oftal'mologicheskii zhurnal. 2013;6(2): 82–85. [Cherednichenko LP, Barycheva LYu, Bernovskaya AA. Determination of proinflammatory cytokines in early diagnosis of primary openangle glaucoma. Russian Ophthalmological Journal. 2013;6(2): 82–85. (In Russ.)]
23. Benitez-Del-Castillo J, Cantu-Dibildox J, Sanz- González SM, Zanón-Moreno V, Pinazo-Duran MD. Cytokine expression in tears of patients with glaucoma or dry eye disease: A prospective, observational cohort study. Eur J Ophthalmol. 2019;29(4): 437–443. doi:10.1177/1120672118795399
24. Csősz É, Deák E, Tóth N, Traverso CE, Csutak A, Tőzsér J. Comparative analysis of cytokine profiles of glaucomatous tears and aqueous humor reveals potential biomarkers for trabeculectomy complications. FEBS Open Bio. 2019; 9(5): 1020–1028. doi:10.1002/2211-5463.12637
25. Chernykh V.V., Ermakova O.V., Orlov N.B., Obukhova O.O., Gorbenko O.M., Shvayuk A.P., Eremina A.V., Trunov A.N. Osobennosti soderzhaniya provospalitel'nykh tsitokinov v sleznoi i vnutri- glaznoi zhidkostyakh pri pervichnoi otkrytougol'noi glaukome. Sibirskii nauchnyi meditsinskii zhurnal. 2018;38(5): 5–10. [Chernykh VV, Ermakova OV, Orlov NB, Obukhova OO, Gorbenko OM, Shvayuk AP, Eremina AV, Trunov AN. Features of the content of proinflammatory cytokines in lacrimal and intraocular fluid in patients with primary open-angle glaucoma. Siberian Scientific Medical Journal. 2018;38(5): 5–10. (In Russ.)] doi:10.15372/SSMJ20180501
26. Shpak A.A., Gekht A.B., Druzhkova T.A., Kozlova K.I. Sootnosheniya neirotroficheskikh faktorov v sleznoi zhidkosti i vlage perednei kamery u bol'nykh s vozrastnoi kataraktoi. Oftal'mokhirur- giya. 2017;1: 16–20. [Shpak AA, Guekht AB, Druzhkova TA, Kozlova KI. The ratio of neurotrophic factors in the lacrimal fluid and aqueous humor in patients with age-related cataract. Fyodorov Journal of Ophthalmic Surgery. 2017;1: 16–20. (In Russ.)] doi:10.25276/0235-4160-2017-1-16-20
27. Chua J, Vania M, Cheung C M, Ang M, Chee SP, Yang H, Li J, Wong TT. Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes. Mol Vis. 2012;18: 431–438.
28. Freedman J, Iserovich P. Pro-inflammatory cytokines in glaucomatous aqueous and encysted Molteno implant blebs and their relationship to pressure. Invest. Ophthalmol Vis Sci. 2013;54(7): 4851–4855. doi:10.1167/iovs.13-12274
29. Takai Y, Tanino M, Obira A. Multiple cytokine analysis of aqueous humor in eyes with primary openangle glaucoma, exfoliation glaucoma, and cataract. Invest. Ophthalmol Vis Sci. 2012;53(1): 241–247. doi:10.1167/iovs.11-8434
30. Engel LA, Muether PS, Fauser S, Hueber A. The effect of previous surgery and topical eye drops for primary open-angle glaucoma on cytokine expression in aqueous humor. Graefes Arch Clin Exp Ophthalmol. 2014;252(5): 791–799. doi:10.1007/s00417-014-2607-5
31. Chernykh V.V., Konenkov V.I., Ermakova O.V., Orlov N.B., Obukhova O.O., Eremina A.V., Trunov A.N. Soderzhanie tsitokinov i faktorov rosta vo vnutriglaznoi zhidkosti u patsientov s pervichnoi otkrytougol'noi glaukomoi. Byulleten' sibirskoi meditsiny. 2019;18(1): 257–265. [Chernykh VV, Konenkov VI, Ermakova OV, Orlov NB, Obukhova OO, Eremina AV, Trunov AN. Sontent of cytokines and growth factors in the intraocular fluid of patients with primary open-angle glaucoma. Bulletin of Siberian Medicine. 2019;18(1): 257–265. (In Russ.)] doi:10.20538/1682-0363-2019-1-257-265.
32. Khalef N, Labib H, Helmy H, El Hamid MA, Moemen L, Fahmy I. Levels of cytokines in the aqueous humor of eyes with primary open angle glaucoma, pseudoexfoliation glaucoma and cataract. Electron Physician. 2017;9(2): 3833–3837. doi:10.19082/3833
33. Pantalon A, Obadă O, Constantinescu D, Feraru C, Chiseliţă D. Inflammatory model in patients with primary open angle glaucoma and diabetes. Int J Ophthalmol. 2019;12(5): 795–801. doi:10.18240/ijo.2019.05.15
34. Kokubun T, Tsuda S, Kunikata H, Yasuda M, Himori N, Kunimatsu-Sanuki S, Maruyama K, Nakazawa T. Characteristic profiles of inflammatory cytokines in the aqueous humor of glaucomatous eyes. Ocul Immunol Inflamm. 2017;16: 1–12. doi:10.1080/09273948.2017.1327605
35. Ten Berge JC, Fazil Z, Van Den Born I, Wolfs RCW, Schreurs MWJ, Dik WA, Rothova A Intraocular cytokine profile and autoimmune reactions in retinitis pigmentosa, age-related macular degeneration, glaucoma and cataract. Acta Ophthalmol. 2019;97(2): 185–192. doi:10.1111/aos.13899
36. Chono I, Miyazaki D, Miyake H, Komatsu N, Ehara F, Nagase D, Kawamoto Y, Shimizu Y, Ideta R, Inoue Y. High interleukin-8 level in aqueous humor is associated with poor prognosis in eyes with open angle glaucoma and neovascular glaucoma. Sci Rep. 2018;8: 14533. doi:10.1038/s41598-018-32725-3.
37. Peng H, Sarwar Z, Yang XP, Peterson EL, Xu J, Janic B, Rhaleb N, Carretero OA, Rhaleb NE. Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction. Hypertension. 2015;66(3): 582–589. doi:10.1161/HYPERTENSIONAHA.115.05627
38. Huang P, Zhang SS, Zhang C. Erratum: The two sides of cytokine signaling and glaucomatous optic neuropathy. J Ocul Biol Dis Infor. 2009;2(3): 98–103. doi:10.1007/s12177-009-9034-6
39. Wong M, Huang P, Li W, Li Y, Zhang SS, Zhang C. T-helper1/T-helper2 cytokine imbalance in the iris of patients with glaucoma. PLoS One. 2015;10(3): e0122184. doi:10.1371/journal.pone.0122184
40. Tong Y, Zhou YL, Zheng Y, Biswal M, Zhao PQ, Wang ZY. Analyzing cytokines as biomarkers to evaluate severity of glaucoma. Int J Ophthalmol. 2017;10(6): 925–930. doi:10.18240/ijo.2017.06.15
41. Huang HY, Luther SA. Expression and function of interleukin-7 in secondary and tertiary lymphoid organs. Seminars in Immunology. 2012;24(3): 175–189. doi:10.1016/j.smim.2012.02
42. Vonarbourg C, Diefenbach A. Multifaceted roles of interleukin-7 signaling for the development and function of innate lymphoid cells. Seminars in Immunology. 2012;24(3): 165–174. doi:10.1016/j.smim.2012.03.002
43. Iolyeva M, Aebischer D, Proulx ST, Willrodt AH, Ecoiffier T, Häner S, Bouchaud G, Krieg C, Onder L, Ludewig B, Santambrogio L, Boyman O, Chen L, Finke D, Halin C. Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage. Blood. 2013;122(13): 2271–2281. doi:10.1182/blood-2013-01-478073
44. Chernykh V.B., Bgatova N.P. Limfaticheskie struktury glaza i uveolimfaticheskii (metabolicheskii) put' ottoka vnutriglaznoi zhidkosti. Chast' 1. Natsional'nyi zhurnal glaukoma. 2018;17(1): 3–13. [Chernykh VV, Bgatova NP. Lymphatic structures of the eye and uveolymphatic (metabolic) pathway of intraocular fluid outflow. Part 1. doi:10.25700/NJG.2018.01.01
45. Yücel YH, Johnston MG, Ly T, Patel M, Drake B, Gümüş E, Fraenkl S, Moore S, Tobbia D, Armstrong D, Horvath E, Gupta N Identification of lymphatics in the ciliary body of the human eye: a novel «uveolymphatic» outflow pathway. Exp Eye Res. 2009;89(5): 809–810. doi:10.1016/j.exer.2009.08.01019
46. Kim M, Johnston MG, Gupta N, Moore S, Yücel YH. A model to measure lymphatic drainage from the eye. Exp Eye Res. 2011;93(5): 586–591. doi:10.1016/j.exer.2011.07.006
47. Ikushima H, Miyazono K. Biology of transforming growth factor-β signaling. Current Pharmaceutical Biotechnology. 2011;12(12): 2099–2107. doi:10.2174/138920111798808419
48. Poniatowski L, Wojdasiewicz P, Gasik R, Szukiewicz D. Transforming growth factor Beta family: insight into the role of growth factors in regulation of fracture healing biology and potential clinical applications. Mediators Inflamm. 2015;2015: 137823. doi:10.1155/2015/137823
49. Chernykh V.V., Konenkov V.I., Orlov N.B., Ermakova O.V., Khodzhaev N.S., Trunov A.N. Osobennosti soderzhaniya transformiruyushchikh faktorov rostabeta 1,2,3 (TGF-β1, TGF-β2, TGF-β3) vo vnutriglaznoi zhidkosti pri pervichnoi otkrytougol'noi glaukome. Oftal'mokhirurgiya. 2019;2: 13–17. [Chernykh VV, Konenkov VI, Orlov NB, Ermakova OV, Khodzhaev NS, Trunov AN. Features of the content of transforming growth factors-beta 1,2,3 (TGF-β1, TGF-β2, TGF-β3) in intraocular fluid in primary open-angle glaucoma. Fyodorov Journal of Ophthalmic Surgery. 2019;2: 13–17. (In Russ.)] doi:10.25276/0235-4160-2019-2-13-17
50. Junglas B, Kuespert S, Seleem AA, Struller T, Ullmann S, Bösl M, Bosserhoff A, Köstler J, Wagner R, Tamm ER, Fuchshofer R. Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork. Am J Pathol. 2012;180(6): 2386‑–2403. doi:10.1016/j.ajpath.2012.02.030
51. Wordinger RJ, Sharma T, Clark A. The role of TGF-β2 and bone morphogenetic proteins in the trabecular meshwork and glaucoma. J Ocul Pharmacol Ther. 2014;30(2-3): 154–162. doi:10.1089/jop.2013.0220
52. Agarwal P, Daher AM, Agarwal R. Aqueous humor TGF-β2 levels in patients with open-angle glaucoma: A meta-analysis. Mol Vis. 2015;21: 612–620.
53. Braunger BM, Fuchshofer R, Tamm ER. The aqueous humor outflow pathways in glaucoma: A unifying concept of disease mechanisms and causative treatment. Eur J Pharm Biopharm. 2015;95: 173–181. doi:10.1016/j.ejpb.2015.04.029
54. Murphy-Ullrich JE, Downs JC. The Thrombospondin1-TGF-β Pathway and Glaucoma. J Ocul Pharmacol Ther. 2015;31(7): 371–375. doi:10.1089/jop.2015.0016
55. Gajda-Derylo B, Stahnke T, Struckmann S, Warsow G, Birke K, Birke MT, Hohberger B, Rejdak R, Fuellen G, Jünemann AG. Comparison of cytokine/ chemokine levels in aqueous humor of primary openangle glaucoma patients with positive or negative outcome following trabeculectomy. Biosci Rep. 2019;39: 5. doi:10.1042/BSR20181894
