Офтальмохирургия. 2014; : 76-80
ВОЗМОЖНОСТИ ФЛЮОРЕСЦЕНТНОЙ АНГИОГРАФИИ В ДИАГНОСТИКЕ И ОПРЕДЕЛЕНИИ ТАКТИКИ ЛЕЧЕНИЯ АКТИВНЫХ СТАДИЙ РЕТИНОПАТИИ НЕДОНОШЕННЫХ
https://doi.org/undefinedАннотация
Цель. Изучить возможности флюоресцентной ангиографии глазного дна (ФАГ) в диагностике и определении тактики лечения активных стадий ретинопатии недоношенных (РН).
Материал и методы. За период с декабря2011 г. по март2013 г. выполнена 71 флюоресцентная ангиография сетчатки 48 недоношенным детям с различными стадиями активной РН. От всех родителей было получено добровольное информированное согласие на проведение данного диагностического исследования. Обследование осуществлялось на ретинальной педиатрической цифровой видеосистеме RetCam-3, оснащенной встроенным блоком для проведения ФАГ.
Результаты. Особенностью ретинальной циркуляции у детей с различными стадиями РН является выраженное отличие васкуляризированной от аваскулярной сетчатки и четко визуализирующаяся граница между ними. Выявлена возможность детальной визуализации ретинальной сосудистой сети, которая не всегда четко видна на цифровых фотографиях. ФАГ позволяет идентифицировать раннюю плоскую неоваскуляризацию при неблагоприятных формах течения РН, которая не определяется при стандартных методах диагностики.
Выводы. ФАГ является важным дополнительным методом исследования детей с РН. Неоценима роль ФАГ в определении тактики ведения и в контроле за эффективностью лечения и регрессом РН.
Список литературы
1. Азнабаев М.Т., Кишкина В.Я., Искандаров Р.Х. Флюоресцентная ангиография глазного дна у детей: Метод. рекомендации. – Уфа, 1990. – 147 с.
2. Сидоренко Е.И., Гусева М.Р., Маркова Е.Ю., Асташева И.Б. Флюоресцентная ангиография в диагностике патологии глазного дна у детей // Вестн. офтальмол. – 2003. – № 2. – С. 15-17.
3. Терещенко А.В., Белый Ю.А., Трифаненкова И.Г. и др. Рабочая классификация ранних стадий ретинопатии недоношенных // Офтальмохирургия. – 2008. – № 1. – С. 32-34.
4. Barteselli G., Chhablani J., Lee S. et al. Safety and efficacy of oral fluorescein angiography in detecting macular edema in comparison with spectral-domain optical coherence tomography // Retina. – 2013. – Vol. 33, № 8. – P. 1574-1583.
5. Blair M., Shapiro M., Hartnett M. Fluorescein angiography to estimate normal peripheral retinal nonperfusion in children // J. AAPOS. – 2012. – Vol. 16, № 3. – P. 234-237.
6. Cantolino S., O’Grady G., Herrera J. et al. Ophthalmoscopic monitoring of oxygen therapy in premature infants. Fluorescein angiography in acute retrolental fibroplasia // Am. J. Ophthalmol. – 1971. – Vol. 72, № 2. – P. 322-331.
7. Croft D., van Hemert J., Wykoff C. et al. Precise montaging and metric quantification of retinal surface area from ultra-widefield fundus photography and fluorescein angiography // Ophthalmic Surg. Lasers Imaging. Retina. – 2014. – Vol. 45, № 4. – P. 312-317.
8. Flynn J., Cassady J., Essner D. et al. Fluorescein angiography in retrolental fibroplasia: experience from 1969-1977 // Ophthalmology. – 1979. – Vol. 86, № 10. – P. 1700-1723.
9. Fung T., Muqit M., Mordant D. et al. Noncontact high-resolution ultra-widefield oral fluorescein angiography in premature infants with retinopathy of prematurity // JAMA Ophthalmol. – 2014. – Vol. 132, № 1. – P. 108-110.
10. Henry C., Hodapp E., Hess D. et al. Fluorescein angiography findings in phacomatosis pigmentovascularis // Ophthalmic Surg. Lasers Imaging Retina. – 2013. – Vol. 44, № 2. – P. 201-203.
11. Jain A., Desai R., Charalel R. et al. Solar retinopathy: comparison of optical coherence tomography (OCT) and fluorescein angiography (FA) // Retina. – 2009. – Vol. 29, № 9. – P. 1340-1345.
12. Kempen J., Sugar E., Jaffe G. et al. Fluorescein angiography versus optical coherence tomography for diagnosis of uveitic macular edema // Ophthalmology. – 2013. – Vol. 120, № 9. – P. 1852-1859.
13. Kozak I., El-Emam S., Cheng L. et al. Fluorescein angiography versus optical coherence tomography-guided planning for macular laser photocoagulation in diabetic macular edema // Retina. – 2014. – Vol. 3, № 48. – P. 1600-1605.
14. Lee C., Lee A., Sim D. et al. Reevaluating the Definition of Intraretinal Microvascular Abnormalities and Neovascularization Elsewhere in Diabetic Retinopathy using Optical Coherence Tomography and Fluorescein Angiography // Am. J. Ophthalmol. – 2014. – № 2. – Pii: S0002-9394(14)00631-X. doi: 10.1016/j. ajo. 2014.09.041.
15. Lepore D., Quinn G., Molle F. et al. Romagnoli C. Intravitreal Bevacizumab versus Laser Treatment in Type 1 Retinopathy of Prematurity: Report on Fluorescein Angiographic Findings // Ophthalmology. – 2014. – № 4. – Pii: S01616420(14)00435-7. doi: 10.1016/j.ophtha.2014.05.015.
16. Lin P., Hahn P., Fekrat S. et al. Peripheral retinal vascular leakage demonstrated by ultra-widefield fluorescein angiography in preeclampsia with HELLP syndrome // Retina. – 2012. – Vol. 32, № 8. – P. 1689-1690.
17. Parvin P., Pournaras J., Nguyen C. et al. Simultaneous anterior and posterior segment fluorescein angiography for ischemic central retinal vein occlusion // Klin. Monbl. Augenheilkd. – 2011. – Vol. 228, № 4. – P. 381-382.
18. Schneider E., Mruthyunjaya P., Talwar N. et al. Reduced fluorescein angiography and fundus photography use in the management of neovascular macular degeneration and macular edema during the past decade // Invest. Ophthalmol. Vis. Sci. – 2014. – Vol. 55, № 1. – P. 542-549.
19. Serlin Y., Tal G., Chassidim Y. et al. Novel fluorescein angiography-based computer-aided algorithm for assessment of retinal vessel permeability // PLoS One. – 2013. – Vol. 8, № 4. – e61599. doi:10.1371/journal.pone.0061599.
20. Yang H., Joe S., Kim J. et al. Delayed choroidal and retinal blood flow in polycythaemia vera patients with transient ocular blindness: a preliminary study with fluorescein angiography // Br. J. Haematol. – 2013. – Vol. 161, № 5. – P. 745-747.
Fyodorov Journal of Ophthalmic Surgery. 2014; : 76-80
FLUORESCEIN ANGIOGRAPHY OPPORTUNITIES IN THE DIAGNOSIS AND TREATMENT TACTICS FOR RETINOPATHY OF PREMATURITY IN CASE OF ACTIVE STAGES
https://doi.org/undefinedAbstract
Purpose. To study possibilities of fluorescein angiography (FA) in the diagnosis and treatment tactics for retinopathy of prematurity (ROP) in case of active stages.
Material and methods. Between December 2011 and March 2013 there were performed 71 fluorescent angiographies in 48 premature children with different stages of active ROP. Voluntary informed consents for the diagnostic examination were received from all the parents. The examination was carried out by the retinal pediatric digital video system «RetCam-3» equipped with a built unit for the FA.
Results. The peculiarity of the retinal circulation in children with different ROP stages is a pronounced difference between vascularized and avascular retina and a clearly visualized boundary between them. It is revealed a possibility of detailed visualization of the retinal vasculature, which is not always clearly visible on the digital images. The FA allows to identify an early flat neovascularization in unfavorable forms of ROP course, which is not defined in the standard diagnostic methods.
Conclusion. The FA is important additional method for children with ROP examination. The FA role in the ROP management and the control of treatment efficiency and ROP regression is invaluable.
References
1. Aznabaev M.T., Kishkina V.Ya., Iskandarov R.Kh. Flyuorestsentnaya angiografiya glaznogo dna u detei: Metod. rekomendatsii. – Ufa, 1990. – 147 s.
2. Sidorenko E.I., Guseva M.R., Markova E.Yu., Astasheva I.B. Flyuorestsentnaya angiografiya v diagnostike patologii glaznogo dna u detei // Vestn. oftal'mol. – 2003. – № 2. – S. 15-17.
3. Tereshchenko A.V., Belyi Yu.A., Trifanenkova I.G. i dr. Rabochaya klassifikatsiya rannikh stadii retinopatii nedonoshennykh // Oftal'mokhirurgiya. – 2008. – № 1. – S. 32-34.
4. Barteselli G., Chhablani J., Lee S. et al. Safety and efficacy of oral fluorescein angiography in detecting macular edema in comparison with spectral-domain optical coherence tomography // Retina. – 2013. – Vol. 33, № 8. – P. 1574-1583.
5. Blair M., Shapiro M., Hartnett M. Fluorescein angiography to estimate normal peripheral retinal nonperfusion in children // J. AAPOS. – 2012. – Vol. 16, № 3. – P. 234-237.
6. Cantolino S., O’Grady G., Herrera J. et al. Ophthalmoscopic monitoring of oxygen therapy in premature infants. Fluorescein angiography in acute retrolental fibroplasia // Am. J. Ophthalmol. – 1971. – Vol. 72, № 2. – P. 322-331.
7. Croft D., van Hemert J., Wykoff C. et al. Precise montaging and metric quantification of retinal surface area from ultra-widefield fundus photography and fluorescein angiography // Ophthalmic Surg. Lasers Imaging. Retina. – 2014. – Vol. 45, № 4. – P. 312-317.
8. Flynn J., Cassady J., Essner D. et al. Fluorescein angiography in retrolental fibroplasia: experience from 1969-1977 // Ophthalmology. – 1979. – Vol. 86, № 10. – P. 1700-1723.
9. Fung T., Muqit M., Mordant D. et al. Noncontact high-resolution ultra-widefield oral fluorescein angiography in premature infants with retinopathy of prematurity // JAMA Ophthalmol. – 2014. – Vol. 132, № 1. – P. 108-110.
10. Henry C., Hodapp E., Hess D. et al. Fluorescein angiography findings in phacomatosis pigmentovascularis // Ophthalmic Surg. Lasers Imaging Retina. – 2013. – Vol. 44, № 2. – P. 201-203.
11. Jain A., Desai R., Charalel R. et al. Solar retinopathy: comparison of optical coherence tomography (OCT) and fluorescein angiography (FA) // Retina. – 2009. – Vol. 29, № 9. – P. 1340-1345.
12. Kempen J., Sugar E., Jaffe G. et al. Fluorescein angiography versus optical coherence tomography for diagnosis of uveitic macular edema // Ophthalmology. – 2013. – Vol. 120, № 9. – P. 1852-1859.
13. Kozak I., El-Emam S., Cheng L. et al. Fluorescein angiography versus optical coherence tomography-guided planning for macular laser photocoagulation in diabetic macular edema // Retina. – 2014. – Vol. 3, № 48. – P. 1600-1605.
14. Lee C., Lee A., Sim D. et al. Reevaluating the Definition of Intraretinal Microvascular Abnormalities and Neovascularization Elsewhere in Diabetic Retinopathy using Optical Coherence Tomography and Fluorescein Angiography // Am. J. Ophthalmol. – 2014. – № 2. – Pii: S0002-9394(14)00631-X. doi: 10.1016/j. ajo. 2014.09.041.
15. Lepore D., Quinn G., Molle F. et al. Romagnoli C. Intravitreal Bevacizumab versus Laser Treatment in Type 1 Retinopathy of Prematurity: Report on Fluorescein Angiographic Findings // Ophthalmology. – 2014. – № 4. – Pii: S01616420(14)00435-7. doi: 10.1016/j.ophtha.2014.05.015.
16. Lin P., Hahn P., Fekrat S. et al. Peripheral retinal vascular leakage demonstrated by ultra-widefield fluorescein angiography in preeclampsia with HELLP syndrome // Retina. – 2012. – Vol. 32, № 8. – P. 1689-1690.
17. Parvin P., Pournaras J., Nguyen C. et al. Simultaneous anterior and posterior segment fluorescein angiography for ischemic central retinal vein occlusion // Klin. Monbl. Augenheilkd. – 2011. – Vol. 228, № 4. – P. 381-382.
18. Schneider E., Mruthyunjaya P., Talwar N. et al. Reduced fluorescein angiography and fundus photography use in the management of neovascular macular degeneration and macular edema during the past decade // Invest. Ophthalmol. Vis. Sci. – 2014. – Vol. 55, № 1. – P. 542-549.
19. Serlin Y., Tal G., Chassidim Y. et al. Novel fluorescein angiography-based computer-aided algorithm for assessment of retinal vessel permeability // PLoS One. – 2013. – Vol. 8, № 4. – e61599. doi:10.1371/journal.pone.0061599.
20. Yang H., Joe S., Kim J. et al. Delayed choroidal and retinal blood flow in polycythaemia vera patients with transient ocular blindness: a preliminary study with fluorescein angiography // Br. J. Haematol. – 2013. – Vol. 161, № 5. – P. 745-747.
