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Офтальмохирургия. 2020; : 77-82

Сосудистые осложнения глаза в отдаленные сроки после перенесенной преэклампсии

Коленко О. В., Сорокин Е. Л., Филь А. А., Помыткина Н. В.

https://doi.org/10.25276/0235-4160-2020-1-77-82

Аннотация

В статье приведены основные патогенетические механизмы формирования эндотелиальной дисфункции при осложненной беременности и сосудистой патологии. Представлены возможные последствия перенесенной преэклампсии в послеродовом периоде. Проведенный анализ литературы позволяет утверждать, что преэклампсию следует рассматривать как патологию, грозящую повышенным риском формирования сосудистой патологии глаза, как в краткосрочном, так и в долгосрочном периодах после родов.

Список литературы

1. Адамян Л.В., Артымук Н.В., Башмакова Н.В. и др. Гипертензивные расстройства во время беременности, в родах и послеродовом периоде. Преэклампсия. Эклампсия. Клинические рекомендации (протокол лечения). 2016. [Adamyan LV, Artymuk NV, Bashmakova NV, et al. Hypertensive disorders during pregnancy, in childbirth and the postpartum period. Pre-eclampsia. Eclampsia. Clinical recommendations (protocol of treatment). 2016 (in Russ.).]

2. Сидорова И.С., Никитина Н.А. Особенности патогенеза эндотелиоза при преэклампсии. Акушерство и гинекология. 2015;(1): 72–8. [Sidorova IS, Nikitina NA. Pathogenesis of endotheliosis in preeclampsia. Akusherstvo i ginekologiya. 2015;1: 72– 78 (in Russ.).]

3. Valdiviezo C, Garovic VD. Preeclampsia and hypertensivedisease in pregnancy: their contributions to cardiovascular risk. Clinical Cardiology. 2012;35(3): 160–5. doi.org/10.1002/clc.21965.

4. Evans CS, Gooch L, Flotta D, Lykins D, Powers RW, Landsittel D, Roberts JM, Shroff SG. Cardiovascular system during the postpartum state in women with a history of preeclampsia. Hypertension. 2011;58(1): 57– 62. doi.org/10.1161/hypertensionaha.111.173278.

5. Powe CE, Levine RJ, Karumanchi SA. Preeclampsia, a disease of the maternal endothelium. The role of antiangiogenic factors and implications for later cardiovascular disease. Circulation. 2011;123(24): 2856–69. doi.org/10.1161/circulationaha.109.853127.

6. Ahmed R, Dunford J, Mehran R, Robson S, Kunadian V. Preeclampsia and future cardiovascular risk among women: a review. Journal of the American College of Cardiology. 2014;63(18): 1815–22. doi.org/10.1016/j. jacc.2014.02.529.

7. Hermes W, Van Kesteren F, De Groot CJM. Preeclampsia and cardiovascular risk. Minerva Ginecology. 2012;64(4): 281–92.

8. Leslie MS, Briggs LA. Preeclampsia and the Risk of Future Vascular Disease and Mortality: A Review. Journal of Midwifery and Women’s Health. 2016;61(3): 315–24. doi.org/10.1111/jmwh.12469.

9. Noori M, Donald AE, Angelakopoulou A, Hingorani AD, Williams DJ. Prospective study of placental angiogenic factors and maternal vascular function before and after preeclampsia and gestational hypertension. Circulation. 2010;122(5): 478–87. doi. org/10.1161/circulationaha.109.895458.

10. Grotegut CA. Prevention of preeclampsia. Journal of Clinical Investigation. 2016;126(12): 4396– 8. doi.org/10.1172/jci91300.

11. Phipps E, Prasanna D, Brima W, Jim B. Preeclampsia: updates in pathogenesis, definitions, and guidelines. Clinical Journal of the American Society of Nephrology. 2016;11(6): 1102–13. doi.org/10.2215/ cjn.12081115.

12. Riise HKR, Sulo G, Tell GS, Igland J, Nygard O, Vollset SE, Iversen A-C, Austgulen R, Daltveit AK. Incident coronary heart disease after preeclampsia: role of reduced fetal growth, preterm delivery, and parity. Journal of the American Heart Association. 2017;6(3): e004158 doi.org/10.1161/jaha.116.004158.

13. Мурашко Л.Е., Файзуллин Л.З., Мурашко А.В. Роль эндотелина в патогенезе преэклампсии. Акушерство и гинекология. 2013;11: 4–8. [Murashko LE, Faizullina LZ, Murashko AV. Role of Endothelin in the pathogenesis of preeclampsia. Akusherstvo i ginekologiya. 2013;11: 4–8 (in Russ.).]

14. Сухих Г.Т., Вихляева Е.М., Ванько Л.В., Ходжаева З.С., Шуршалина А.В., Холин А.М. Эндотелиальная дисфункция в генезе перинатальной патологии. Акушерство и гинекология. 2008;5: 3–7. [Sukhikh GT, Vikhlyaeva EM, Vanko LV, Khodzhaeva ZS, Shurshalina AV, Kholin AM. Endothelial dysfunction in the genesis of perinatal pathology. Akusherstvo i ginekologiya. 2008;5: 3–7 (In Russ.).]

15. Kotliar KE, Nagel E, Vilser W, Lanzl IM. Functional in vivo assessment of retinal artery microirregularities in glaucoma. Acta Ophthalmologica. 2008;86(4): 424–33. doi.org/10.1111/j.1600-0420.2007.01072.x.

16. Haefliger IO, Flammer J, Beny J-L, Luscher TF. Endothelium-dependent vasoactive modulation in the ophthalmic circulation. Prog. Retin. Eye Res. 2001;20(2): 209–25. doi.org/10.1016/s1350-9462(00)00020-3.

17. Курышева Н.И., Иртегова Е.Ю., Ясаманова А.Н. Роль эндотелиальной дисфункции в прогрессировании глаукомной оптической нейропатии. Российский. офтальмологический журнал. 2015;2: 34– 5. [Kurysheva NI, Irtegova EYu, Yasamanova AN. The role of endothelial dysfunction in glaucomatous optic neuropathy progression. Rossiyskiy. Oftal’mologicheskiy zhurnal. 2015;2: 34–5 (In Russ.).]

18. Астахов Ю.С., Тульцева С.Н., Титаренко А.И. Роль дисфункции эндотелия в патогенезе сосудистых заболеваний органа зрения. Регионарное кровообращение и микроциркуляция. 2016;15(4): 5–16. [Astakhov YuS, Tultseva SN, Titarenko AI. The role of endothelium dysfunction in the pathogenesis of vascular ocular diseases. Regionarnoe krovoobrashchenie i mikrotsirkulyatsiya. 2016;15(4): 5–16 (In Russ.).] doi. org/10.24884/1682-6655-2016-15-4-5-16.

19. Морозов В.И. Гематоофтальмический барьер: структурно-функциональные особенности. Российский офтальмологический журнал. 2017;10(4): 68–72. [Morozov VI. A hematoophthalmic barrier: structural and functional features. Rossiyskiy. Oftal’mologicheskiy zhurnal. 2017;10(4): 68–72 (in Russ.).] doi.org/10.21516/2072-0076-2017-10-4-68-72.

20. Chenkin J, Heslop CL, Atlin CR, Romano M, Jelic T. Bilateral retinal detachments caused by severe preeclampsia diagnosed with point-of-care ultrasound. CJEM. 2016;18(5): 395–8. doi.org/10.1017/cem.2015.76.

21. Lupton SJ, Chiu CL, Hodgson LAB, Tooher J, Lujic S, Ogle R, Wong TY, Hennessy A, Lind JM. Temporal changes in retinal microvascular caliber and blood pressure during pregnancy. Hypertension. 2013;61(4): 880–5. doi.org/10.1161/hypertensionaha.111.00698.

22. Brückmann A, Seeliger C, Lehmann T, Schleuéner E, Schlembach D. Altered retinal flicker response indicates microvascular dysfunction in women with preeclampsia. Hypertension. 2015;66(4): 900–5. doi. org/10.1161/hypertensionaha.115.05734.

23. Oliveira CA, Sa RA, Velarde LG, Silva FC, Netto HC. PP082. Ophthalmic artery doppler for identification of severe preeclampsia in pregnancies complicated by hypertension. Pregnancy Hypertens. 2012;2(3): 284–5. doi.org/10.1016/j.preghy.2012.04.193.

24. Roos NM, Wiegman MJ, Jansonius NM, Zeeman GG. Visual disturbances in (pre)eclampsia. Obstet. Gynecol. Surv. 2012;67(4): 242–50. doi.org/10.1097/ ogx.0b013e318250a457.

25. Братко Г.В., Трунов А.Н., Черных В.В. Поздний гестоз беременности и функциональное состояние органа зрения (обзор литературы). Сибирский медицинский журнал. 2010;25(4): 15–18. [Bratko GV, Trunov AN, Chernykh VV. Gestosis of late pregnancy and functional state of the organ of vision. Sibirskiy meditsinskiy zhurnal. 2010;25(4): 15–8 (in Russ.).]

26. Ataş M, Açmaz G, Aksoy H, Demircan S, Ataş F, Gülhan A, Zararsiz G. Evaluation of the macula, retinal nerve fiber layer and choroid in preeclampsia, healthy pregnant and healthy non-pregnant women using spectral-domain optical coherence tomography. Hypertens. Pregnancy. 2014;33(3): 299–310. doi.org/1 0.3109/10641955.2013.877924.

27. Sreckovic SB, Janicijevic-Petrovic MA, Stefanovic IB, Petrovic NT, Sarenac TS, Paunovic SS. Bilateral retinal detachment in a case of preeclampsia. Bosn. J. Basic Med. Sci. 2011;11(2): 129–31. doi.org/10.17305/ bjbms.2011.2598.

28. Radha Bai Prabhu T. Serious visual (ocular) complications in pre-eclampsia and eclampsia. J. Obstet. Gynaecol. India. 2017;67(5): 343–8. doi.org/10.1007/ s13224-017-0975-6.

29. Garg A, Wapner RJ, Ananth CV, Dale E, Tsang SH, Lee W Allikmets R, Bearelly S. Choroidal and retinal thickening in severe preeclampsia. Invest. Ophthalmol. Vis. Sci. 2014;55(9): 5723–9. doi.org/10.1167/iovs.1414143.

30. Mackensen F, Paulus WE, Max R, Ness T. Ocular changes during pregnancy. Dtsch. Arzteblatt Int. 2014;111(33–34): 567–75. doi.org/10.3238/ arztebl.2014.0567.

31. Mihu D, Mihu CM, Talu S, Costin N, Ciuchina S, Malutan A. Ocular changes in preeclampsia. Oftalmologia. 2008;52(2): 16–22.

32. Hariharan N, Shoemaker A, Wagner S. Pathophysiology of hypertension in preeclampsia. Microvasc. Res. 2017;109: 34–7. doi.org/10.1016/j. mvr.2016.10.002.

33. Neudorfer M, Spierer O, Goder M, Newman H, Barak S, Barak A, Asher-Landsberg I. The prevalence of retinal and optical coherence tomography findings in preeclamptic women. Retina Phila. Pa. 2014;34(7): 1376–83. doi.org/10.1097/iae.0000000000000085.

34. Belfort MA, Saade GR, Grunewald C, Dildy GA, Varner MA, Nisell H. Effects of blood pressure on orbital and middle cerebral artery resistances in healthy pregnant women and women with preeclampsia. Am. J. Obstet. Gynecol. 1999;180(3): 601–7. doi.org/10.1016/ s0002-9378(99)70261-9.

35. Коленко О.В., Сорокин Е.Л., Егоров В.В. Изучение закономерностей динамики микроморфометрических показателей макулярной сетчатки у беременных женщин при патологической беременности во взаимосвязи со степенью тяжести гестоза. Кубанский научный медицинский вестник. 2013;2: 48–52. [Kolenko OV, Sorokin EL, Egorov VV. Study of regularities in the dynamics of micromorphometric parameters of the macular retina in pregnant women in pathological pregnancy in correlation with the severity of gestosis. Kubanskiy nauchnyy meditsinskiy vestnik. 2013;2: 48– 52 (in Russ.).]

36. Коленко О.В., Сорокин Е.Л., Егоров В.В., Блощинская И.А., Помыткина Н.В., Коленко Л.Е. Состояние области макулы у женщин при эклампсии и после родов. Офтальмологический журнал. 2015;3: 47– 53. [Kolenko OV, Sorokin EL, Egorov VV, Bloshchinskaya IA, Pomytkina NV, Kolenko LE. The state of the macular area in women with pre-eclampsia and after delivery. Oftal’mologicheskiy zhurnal. 2015;3: 47–53 (in Russ.).]

37. Kim MJ, Kim YN, Jung EJ, Jang HR, Byun JM, Jeong DH. Sung MS, Lee KB, Kim KT. Is massive proteinuria associated with maternal and fetal morbidities in preeclampsia? Obstet. Gynecol. Sci. 2017;60(3): 260–5. doi.org/10.5468/ogs.2017.60.3.260.

38. Maalej A, Ben Romdhane B, Kaharrat O, Wathek C, Gabsi S. Multifocal choroidal ischemia in preeclampsia: report of two cases. J. Fr. Ophtalmol. 2014;37(3): 183–7. doi.org/10.1016/j.jfo.2013.05.030.

39. Çelik G, Eser A, Gunay M, Yenerel NM. Bilateral vision loss after delivery in two cases: severe preeclampsia and HELLP Syndrome. Turk. J. Ophthalmol. 2015;45(6): 271–3. doi.org/10.4274/tjo.45722.

40. Swende TZ, Abwa T. Reversible blindness in fulminating preeclampsia. Ann. Afr. Med. 2009;8(3): 189–191. doi.org/10.4103/1596-3519.57247.

41. Ferhi F, Khlifi A, Hachani F, Tarmiz K, Benjazia K. Ultrasound assessment of visual loss during severe preeclampsia: a case report. Crit. Ultrasound J. 2018;10(1): 6. doi.org/10.1186/s13089-018-0087-2.

42. Белоцерковцева Л.Д., Зинин В.Н., Фатеева А.В., Федорович О.И., Ларчикова Ю.В., Гораш А.Д. Клинический случай преэклампсии, осложненной двухсторонней отслойкой сетчатки. Вестник СурГУ. Медицина. 2010;3: 92–5. [Belotserkovetskaya LD, Zinin VN, Fateeva AV, Fedorevich OI, Larchikova YuV, Gorash AD. Clinical case of preeclampsia complicated by bilateral retinal detachment. Vestnik SurGU. Meditsina. 2010;3: 92–5 (in Russ.).]

43. Sathish S, Arnold JJ. Bilateral choroidal ischaemia and serous retinal detachment in preeclampsia. Clin. Experiment. Ophthalmol. 2000;28(5): 387–90. doi.org/10.1046/j.1442-9071.2000.00342.x.

44. Androudi S, Ekonomidis P, Kump L, Praidou A, Brazitikos PD. OCT-3 study of serous retinal detachment in a preeclamptic patient. Semin. Ophthalmol. 2007;22(3): 189–91. doi.org/10.1080/08820530701501469.

45. Зуев А.В., Педанова Е.К., Колесник А.В. Билатеральная экссудативная отслойка сетчатки на фоне преэклампсии беременных. Клинический случай. Современные технологии в офтальмологии. 2015;1: 68. [Zuev AV, Pedanova EK, Kolesnik AV. Bilateral exudative retinal detachment on the background of pre-eclampsia of pregnant women. Clinical case. Sovremennye tekhnologii v oftalmologii . 2015;1: 68 (in Russ.).]

46. Fastenberg DM, Fetkenhour CL, Earl C, Shoch DE. Choroidal vascular changes in toxemia of pregnancy. Am. J. Ophthalmol. 1980;89(3): 362–8. doi. org/10.1016/0002-9394(80)90005-7.

47. Auger N, Fraser WD, Paradis G, HealyProfitós J, Hsieh A, Rhéaume M-A. Preeclampsia and long-term risk of maternal retinal disorders. Obstet. Gynecol. 2017;129(1): 42–9. doi.org/10.1097/ aog.0000000000001758.

48. Beharier O, Davidson E, Sergienko R, Szaingurten-Solodkin I, Kessous R, Charach R, et al. Preeclampsia and future risk for maternal ophthalmic complications. Am. J. Perinatol. 2016;33(7): 703–7. doi. org/10.1055/s-0036-1571321.

49. Коленко О.В., Сорокин Е.Л. Изучение возможной причинной связи между формированием острой сосудистой патологии глаза у женщин и перенесенным ОПГ-гестозом. Бюллетень СО РАМН. 2009;4: 85– 7. [Kolenko OV, Sorokin EL. A study of the possible causal relationship between the formation of acute vascular pathology of the eye in women and the transferred OPGgestosis. Byulleten’ SO RAMN. 2009;4: 85–7 (in Russ.).]

50. Bokslag A, Weissenbruch M, Mol BW, de Groot CJM. Preeclampsia; short and long-term consequences for mother and neonate. Early Hum. Dev. 2016;102: 47– 50. doi.org/10.1016/j.earlhumdev.2016.09.007.

Fyodorov Journal of Ophthalmic Surgery. 2020; : 77-82

Vascular complications of the eye in the late postpartum period of postponed preeclampsia

Кolenko O. V., Sorokin E. L., Fil A. A., Pomytkina N. V.

https://doi.org/10.25276/0235-4160-2020-1-77-82

Abstract

The article presents the main pathogenetic mechanisms of endothelial dysfunction formation in complicated pregnancy and vascular pathology. The possible consequences of postponed preeclampsia are described. The performed analysis of the literature allows to approve that preeclampsia should be considered as a pathology threatening an increased risk of the vascular eye pathology formation, both in the short and in the long-term periods after childbirth.

References

1. Adamyan L.V., Artymuk N.V., Bashmakova N.V. i dr. Gipertenzivnye rasstroistva vo vremya beremennosti, v rodakh i poslerodovom periode. Preeklampsiya. Eklampsiya. Klinicheskie rekomendatsii (protokol lecheniya). 2016. [Adamyan LV, Artymuk NV, Bashmakova NV, et al. Hypertensive disorders during pregnancy, in childbirth and the postpartum period. Pre-eclampsia. Eclampsia. Clinical recommendations (protocol of treatment). 2016 (in Russ.).]

2. Sidorova I.S., Nikitina N.A. Osobennosti patogeneza endotelioza pri preeklampsii. Akusherstvo i ginekologiya. 2015;(1): 72–8. [Sidorova IS, Nikitina NA. Pathogenesis of endotheliosis in preeclampsia. Akusherstvo i ginekologiya. 2015;1: 72– 78 (in Russ.).]

3. Valdiviezo C, Garovic VD. Preeclampsia and hypertensivedisease in pregnancy: their contributions to cardiovascular risk. Clinical Cardiology. 2012;35(3): 160–5. doi.org/10.1002/clc.21965.

4. Evans CS, Gooch L, Flotta D, Lykins D, Powers RW, Landsittel D, Roberts JM, Shroff SG. Cardiovascular system during the postpartum state in women with a history of preeclampsia. Hypertension. 2011;58(1): 57– 62. doi.org/10.1161/hypertensionaha.111.173278.

5. Powe CE, Levine RJ, Karumanchi SA. Preeclampsia, a disease of the maternal endothelium. The role of antiangiogenic factors and implications for later cardiovascular disease. Circulation. 2011;123(24): 2856–69. doi.org/10.1161/circulationaha.109.853127.

6. Ahmed R, Dunford J, Mehran R, Robson S, Kunadian V. Preeclampsia and future cardiovascular risk among women: a review. Journal of the American College of Cardiology. 2014;63(18): 1815–22. doi.org/10.1016/j. jacc.2014.02.529.

7. Hermes W, Van Kesteren F, De Groot CJM. Preeclampsia and cardiovascular risk. Minerva Ginecology. 2012;64(4): 281–92.

8. Leslie MS, Briggs LA. Preeclampsia and the Risk of Future Vascular Disease and Mortality: A Review. Journal of Midwifery and Women’s Health. 2016;61(3): 315–24. doi.org/10.1111/jmwh.12469.

9. Noori M, Donald AE, Angelakopoulou A, Hingorani AD, Williams DJ. Prospective study of placental angiogenic factors and maternal vascular function before and after preeclampsia and gestational hypertension. Circulation. 2010;122(5): 478–87. doi. org/10.1161/circulationaha.109.895458.

10. Grotegut CA. Prevention of preeclampsia. Journal of Clinical Investigation. 2016;126(12): 4396– 8. doi.org/10.1172/jci91300.

11. Phipps E, Prasanna D, Brima W, Jim B. Preeclampsia: updates in pathogenesis, definitions, and guidelines. Clinical Journal of the American Society of Nephrology. 2016;11(6): 1102–13. doi.org/10.2215/ cjn.12081115.

12. Riise HKR, Sulo G, Tell GS, Igland J, Nygard O, Vollset SE, Iversen A-C, Austgulen R, Daltveit AK. Incident coronary heart disease after preeclampsia: role of reduced fetal growth, preterm delivery, and parity. Journal of the American Heart Association. 2017;6(3): e004158 doi.org/10.1161/jaha.116.004158.

13. Murashko L.E., Faizullin L.Z., Murashko A.V. Rol' endotelina v patogeneze preeklampsii. Akusherstvo i ginekologiya. 2013;11: 4–8. [Murashko LE, Faizullina LZ, Murashko AV. Role of Endothelin in the pathogenesis of preeclampsia. Akusherstvo i ginekologiya. 2013;11: 4–8 (in Russ.).]

14. Sukhikh G.T., Vikhlyaeva E.M., Van'ko L.V., Khodzhaeva Z.S., Shurshalina A.V., Kholin A.M. Endotelial'naya disfunktsiya v geneze perinatal'noi patologii. Akusherstvo i ginekologiya. 2008;5: 3–7. [Sukhikh GT, Vikhlyaeva EM, Vanko LV, Khodzhaeva ZS, Shurshalina AV, Kholin AM. Endothelial dysfunction in the genesis of perinatal pathology. Akusherstvo i ginekologiya. 2008;5: 3–7 (In Russ.).]

15. Kotliar KE, Nagel E, Vilser W, Lanzl IM. Functional in vivo assessment of retinal artery microirregularities in glaucoma. Acta Ophthalmologica. 2008;86(4): 424–33. doi.org/10.1111/j.1600-0420.2007.01072.x.

16. Haefliger IO, Flammer J, Beny J-L, Luscher TF. Endothelium-dependent vasoactive modulation in the ophthalmic circulation. Prog. Retin. Eye Res. 2001;20(2): 209–25. doi.org/10.1016/s1350-9462(00)00020-3.

17. Kurysheva N.I., Irtegova E.Yu., Yasamanova A.N. Rol' endotelial'noi disfunktsii v progressirovanii glaukomnoi opticheskoi neiropatii. Rossiiskii. oftal'mologicheskii zhurnal. 2015;2: 34– 5. [Kurysheva NI, Irtegova EYu, Yasamanova AN. The role of endothelial dysfunction in glaucomatous optic neuropathy progression. Rossiyskiy. Oftal’mologicheskiy zhurnal. 2015;2: 34–5 (In Russ.).]

18. Astakhov Yu.S., Tul'tseva S.N., Titarenko A.I. Rol' disfunktsii endoteliya v patogeneze sosudistykh zabolevanii organa zreniya. Regionarnoe krovoobrashchenie i mikrotsirkulyatsiya. 2016;15(4): 5–16. [Astakhov YuS, Tultseva SN, Titarenko AI. The role of endothelium dysfunction in the pathogenesis of vascular ocular diseases. Regionarnoe krovoobrashchenie i mikrotsirkulyatsiya. 2016;15(4): 5–16 (In Russ.).] doi. org/10.24884/1682-6655-2016-15-4-5-16.

19. Morozov V.I. Gematooftal'micheskii bar'er: strukturno-funktsional'nye osobennosti. Rossiiskii oftal'mologicheskii zhurnal. 2017;10(4): 68–72. [Morozov VI. A hematoophthalmic barrier: structural and functional features. Rossiyskiy. Oftal’mologicheskiy zhurnal. 2017;10(4): 68–72 (in Russ.).] doi.org/10.21516/2072-0076-2017-10-4-68-72.

20. Chenkin J, Heslop CL, Atlin CR, Romano M, Jelic T. Bilateral retinal detachments caused by severe preeclampsia diagnosed with point-of-care ultrasound. CJEM. 2016;18(5): 395–8. doi.org/10.1017/cem.2015.76.

21. Lupton SJ, Chiu CL, Hodgson LAB, Tooher J, Lujic S, Ogle R, Wong TY, Hennessy A, Lind JM. Temporal changes in retinal microvascular caliber and blood pressure during pregnancy. Hypertension. 2013;61(4): 880–5. doi.org/10.1161/hypertensionaha.111.00698.

22. Brückmann A, Seeliger C, Lehmann T, Schleuéner E, Schlembach D. Altered retinal flicker response indicates microvascular dysfunction in women with preeclampsia. Hypertension. 2015;66(4): 900–5. doi. org/10.1161/hypertensionaha.115.05734.

23. Oliveira CA, Sa RA, Velarde LG, Silva FC, Netto HC. PP082. Ophthalmic artery doppler for identification of severe preeclampsia in pregnancies complicated by hypertension. Pregnancy Hypertens. 2012;2(3): 284–5. doi.org/10.1016/j.preghy.2012.04.193.

24. Roos NM, Wiegman MJ, Jansonius NM, Zeeman GG. Visual disturbances in (pre)eclampsia. Obstet. Gynecol. Surv. 2012;67(4): 242–50. doi.org/10.1097/ ogx.0b013e318250a457.

25. Bratko G.V., Trunov A.N., Chernykh V.V. Pozdnii gestoz beremennosti i funktsional'noe sostoyanie organa zreniya (obzor literatury). Sibirskii meditsinskii zhurnal. 2010;25(4): 15–18. [Bratko GV, Trunov AN, Chernykh VV. Gestosis of late pregnancy and functional state of the organ of vision. Sibirskiy meditsinskiy zhurnal. 2010;25(4): 15–8 (in Russ.).]

26. Ataş M, Açmaz G, Aksoy H, Demircan S, Ataş F, Gülhan A, Zararsiz G. Evaluation of the macula, retinal nerve fiber layer and choroid in preeclampsia, healthy pregnant and healthy non-pregnant women using spectral-domain optical coherence tomography. Hypertens. Pregnancy. 2014;33(3): 299–310. doi.org/1 0.3109/10641955.2013.877924.

27. Sreckovic SB, Janicijevic-Petrovic MA, Stefanovic IB, Petrovic NT, Sarenac TS, Paunovic SS. Bilateral retinal detachment in a case of preeclampsia. Bosn. J. Basic Med. Sci. 2011;11(2): 129–31. doi.org/10.17305/ bjbms.2011.2598.

28. Radha Bai Prabhu T. Serious visual (ocular) complications in pre-eclampsia and eclampsia. J. Obstet. Gynaecol. India. 2017;67(5): 343–8. doi.org/10.1007/ s13224-017-0975-6.

29. Garg A, Wapner RJ, Ananth CV, Dale E, Tsang SH, Lee W Allikmets R, Bearelly S. Choroidal and retinal thickening in severe preeclampsia. Invest. Ophthalmol. Vis. Sci. 2014;55(9): 5723–9. doi.org/10.1167/iovs.1414143.

30. Mackensen F, Paulus WE, Max R, Ness T. Ocular changes during pregnancy. Dtsch. Arzteblatt Int. 2014;111(33–34): 567–75. doi.org/10.3238/ arztebl.2014.0567.

31. Mihu D, Mihu CM, Talu S, Costin N, Ciuchina S, Malutan A. Ocular changes in preeclampsia. Oftalmologia. 2008;52(2): 16–22.

32. Hariharan N, Shoemaker A, Wagner S. Pathophysiology of hypertension in preeclampsia. Microvasc. Res. 2017;109: 34–7. doi.org/10.1016/j. mvr.2016.10.002.

33. Neudorfer M, Spierer O, Goder M, Newman H, Barak S, Barak A, Asher-Landsberg I. The prevalence of retinal and optical coherence tomography findings in preeclamptic women. Retina Phila. Pa. 2014;34(7): 1376–83. doi.org/10.1097/iae.0000000000000085.

34. Belfort MA, Saade GR, Grunewald C, Dildy GA, Varner MA, Nisell H. Effects of blood pressure on orbital and middle cerebral artery resistances in healthy pregnant women and women with preeclampsia. Am. J. Obstet. Gynecol. 1999;180(3): 601–7. doi.org/10.1016/ s0002-9378(99)70261-9.

35. Kolenko O.V., Sorokin E.L., Egorov V.V. Izuchenie zakonomernostei dinamiki mikromorfometricheskikh pokazatelei makulyarnoi setchatki u beremennykh zhenshchin pri patologicheskoi beremennosti vo vzaimosvyazi so stepen'yu tyazhesti gestoza. Kubanskii nauchnyi meditsinskii vestnik. 2013;2: 48–52. [Kolenko OV, Sorokin EL, Egorov VV. Study of regularities in the dynamics of micromorphometric parameters of the macular retina in pregnant women in pathological pregnancy in correlation with the severity of gestosis. Kubanskiy nauchnyy meditsinskiy vestnik. 2013;2: 48– 52 (in Russ.).]

36. Kolenko O.V., Sorokin E.L., Egorov V.V., Bloshchinskaya I.A., Pomytkina N.V., Kolenko L.E. Sostoyanie oblasti makuly u zhenshchin pri eklampsii i posle rodov. Oftal'mologicheskii zhurnal. 2015;3: 47– 53. [Kolenko OV, Sorokin EL, Egorov VV, Bloshchinskaya IA, Pomytkina NV, Kolenko LE. The state of the macular area in women with pre-eclampsia and after delivery. Oftal’mologicheskiy zhurnal. 2015;3: 47–53 (in Russ.).]

37. Kim MJ, Kim YN, Jung EJ, Jang HR, Byun JM, Jeong DH. Sung MS, Lee KB, Kim KT. Is massive proteinuria associated with maternal and fetal morbidities in preeclampsia? Obstet. Gynecol. Sci. 2017;60(3): 260–5. doi.org/10.5468/ogs.2017.60.3.260.

38. Maalej A, Ben Romdhane B, Kaharrat O, Wathek C, Gabsi S. Multifocal choroidal ischemia in preeclampsia: report of two cases. J. Fr. Ophtalmol. 2014;37(3): 183–7. doi.org/10.1016/j.jfo.2013.05.030.

39. Çelik G, Eser A, Gunay M, Yenerel NM. Bilateral vision loss after delivery in two cases: severe preeclampsia and HELLP Syndrome. Turk. J. Ophthalmol. 2015;45(6): 271–3. doi.org/10.4274/tjo.45722.

40. Swende TZ, Abwa T. Reversible blindness in fulminating preeclampsia. Ann. Afr. Med. 2009;8(3): 189–191. doi.org/10.4103/1596-3519.57247.

41. Ferhi F, Khlifi A, Hachani F, Tarmiz K, Benjazia K. Ultrasound assessment of visual loss during severe preeclampsia: a case report. Crit. Ultrasound J. 2018;10(1): 6. doi.org/10.1186/s13089-018-0087-2.

42. Belotserkovtseva L.D., Zinin V.N., Fateeva A.V., Fedorovich O.I., Larchikova Yu.V., Gorash A.D. Klinicheskii sluchai preeklampsii, oslozhnennoi dvukhstoronnei otsloikoi setchatki. Vestnik SurGU. Meditsina. 2010;3: 92–5. [Belotserkovetskaya LD, Zinin VN, Fateeva AV, Fedorevich OI, Larchikova YuV, Gorash AD. Clinical case of preeclampsia complicated by bilateral retinal detachment. Vestnik SurGU. Meditsina. 2010;3: 92–5 (in Russ.).]

43. Sathish S, Arnold JJ. Bilateral choroidal ischaemia and serous retinal detachment in preeclampsia. Clin. Experiment. Ophthalmol. 2000;28(5): 387–90. doi.org/10.1046/j.1442-9071.2000.00342.x.

44. Androudi S, Ekonomidis P, Kump L, Praidou A, Brazitikos PD. OCT-3 study of serous retinal detachment in a preeclamptic patient. Semin. Ophthalmol. 2007;22(3): 189–91. doi.org/10.1080/08820530701501469.

45. Zuev A.V., Pedanova E.K., Kolesnik A.V. Bilateral'naya ekssudativnaya otsloika setchatki na fone preeklampsii beremennykh. Klinicheskii sluchai. Sovremennye tekhnologii v oftal'mologii. 2015;1: 68. [Zuev AV, Pedanova EK, Kolesnik AV. Bilateral exudative retinal detachment on the background of pre-eclampsia of pregnant women. Clinical case. Sovremennye tekhnologii v oftalmologii . 2015;1: 68 (in Russ.).]

46. Fastenberg DM, Fetkenhour CL, Earl C, Shoch DE. Choroidal vascular changes in toxemia of pregnancy. Am. J. Ophthalmol. 1980;89(3): 362–8. doi. org/10.1016/0002-9394(80)90005-7.

47. Auger N, Fraser WD, Paradis G, HealyProfitós J, Hsieh A, Rhéaume M-A. Preeclampsia and long-term risk of maternal retinal disorders. Obstet. Gynecol. 2017;129(1): 42–9. doi.org/10.1097/ aog.0000000000001758.

48. Beharier O, Davidson E, Sergienko R, Szaingurten-Solodkin I, Kessous R, Charach R, et al. Preeclampsia and future risk for maternal ophthalmic complications. Am. J. Perinatol. 2016;33(7): 703–7. doi. org/10.1055/s-0036-1571321.

49. Kolenko O.V., Sorokin E.L. Izuchenie vozmozhnoi prichinnoi svyazi mezhdu formirovaniem ostroi sosudistoi patologii glaza u zhenshchin i perenesennym OPG-gestozom. Byulleten' SO RAMN. 2009;4: 85– 7. [Kolenko OV, Sorokin EL. A study of the possible causal relationship between the formation of acute vascular pathology of the eye in women and the transferred OPGgestosis. Byulleten’ SO RAMN. 2009;4: 85–7 (in Russ.).]

50. Bokslag A, Weissenbruch M, Mol BW, de Groot CJM. Preeclampsia; short and long-term consequences for mother and neonate. Early Hum. Dev. 2016;102: 47– 50. doi.org/10.1016/j.earlhumdev.2016.09.007.