Офтальмохирургия. 2013; : 86-88
ТЕОРЕТИЧЕСКИЕ ПРЕДПОСЫЛКИ К ВЫБОРУ МАТЕРИАЛА ДЛЯ МАТРИЦЫ БИОИНЖЕНЕРНОЙ КОНСТРУКЦИИ ИСКУССТВЕННОЙ РОГОВИЦЫ
https://doi.org/undefinedАннотация
Реферат
Работа посвящена аналитическому обзору биополимерных материалов, используемых в настоящее время для конструирования матриц биоинженерных конструкций тканей. Проанализированы полимерные материалы: альгинат, хитозан, коллаген, спидроин. Показаны положительные и отрицательные их стороны для конструирования матрицы биоинженерной конструкции искусственной роговицы. Наиболее перспективным и отвечающий требованиям для конструирования матриц искусственной роговицы, по нашему мнению, является биосинтетический аналог шелка паутинной нити – спидроин. Спидроин обладает выраженными механическими свойствами, высокой адгезивностью, биоинертностью, биосовместимостью, устойчивостью к условиям внешней среды, абсолютной прозрачностью, что делает его материалом выбора для создания 3D матрицы искусственной роговицы.
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Fyodorov Journal of Ophthalmic Surgery. 2013; : 86-88
THEORETICAL BACKGROUND TO THE CHOICE OF MATERIAL FOR MATRICES OF THE BIOENGINEERING CONSTRUCTION OF THE ARTIFICIAL CORNEA
https://doi.org/undefinedAbstract
The article reviewed biopolymer materials to construct matrices of the bioengineered tissue structures used at present. Polymer materials such as alginate, chitozan, collagen, spidroin were analyzed. There were shown advantages and disadvantages of these materials to construct matrices of the bioengineering construction of the artificial cornea. Spidroin is a recombinant analog of dragline spider silk protein, and in our opinion it is the most promising and adequate to construct matrices of the bioengineering construction of the artificial cornea. Spidroin is the material of choice to construct 3D matrices of the bioengineering construction of the artificial cornea due to its properties such as high adhesive properties, pronounced mechanical properties, a biological inertness, a biocompatibility, a resistance to environmental conditions and an absolute transparency.
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