Журнал микробиологии, эпидемиологии и иммунобиологии. 2020; 97: 324-330
Молекулярно-эпидемиологические особенности циркуляции энтеровируса Коксаки А10 в Дальневосточном федеральном округе
https://doi.org/10.36233/0372-9311-2020-97-4-4Аннотация
Актуальность. В Дальневосточном федеральном округе (ДФО) ежегодно наблюдаются подъемы заболеваемости энтеровирусной инфекцией. При этом отмечается широкое разнообразие циркулирующих неполиомиелитных энтеровирусов. Среди них можно выделить те, которые на протяжении ряда лет постоянно идентифицируют у населения ДФО, в том числе вирус Коксаки А10.
Цель. Изучить особенности циркуляции энтеровируса Коксаки А10 на территории ДФО в 2014–2018 гг.
Материалы и методы. Для работы были использованы 117 полных нуклеотидных последовательностей гена VP1 энтеровируса Коксаки А10, которые были выделены в ДФО в 2014–2018 гг.
Результаты. По результатам филогенетического анализа выявлены две генетические линии Коксаки А10, при этом в Сахалинской области в 2017 г. отмечена их одновременная циркуляция. Активная миграция населения способствует широкому распространению Коксаки А10 на сопредельных территориях с формированием эпидемических вариантов.
Заключение. Энтеровирус Коксаки А10 является одним из наиболее актуальных типов неполиомиелитных энтеровирусов для ДФО. Проведенный филогенетический анализ позволил выявить его генетическое разнообразие и предположить как европейское, так и азиатское происхождение полученных штаммов.
Список литературы
1. Pallansch M.A., Roos R. Enteroviruses: Polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses. In: Knipe D.M., Howley P.M., eds. Fields Virology. Philadelphia: Lippincott Williams & Wilkins; 2007: 839-93.
2. EV-A Prototypes. Available at: http://www.picornaviridae.com/enterovirus/prototypes/ev-a_prototypes.htm
3. Tapparel C., Siegrist F., Petty T.J., Kaiser L. Picornavirus and enterovirus diversity with associated human diseases. Infect. Genet. Evol. 2013; 14: 282-93. DOI: http://doi.org/10.1016/j.meegid.2012.10.016
4. Chen M., He S., Yan Q., Xu X., Wu W., Ge S., et al. Severe hand, foot and mouth disease associated with Coxsackievirus A10 infections in Xiamen, China in 2015. J. Clin. Virol. 2017; 93: 20‐4. DOI: http://doi.org/10.1016/j.jcv.2017.05.011
5. Fuschino M.E., Lamson D.M., Rush K., Carbone L.S., Taff M.L., Hua Z., et al. Detection of coxsackievirus A10 in multiple tissues of a fatal infant sepsis case. J. Clin. Virol. 2012; 53(3): 259-61. DOI: http://doi.org/10.1016/j.jcv.2011.12.011
6. Lu Q.B., Zhang X.A., Wo Y., Xu H.M., Li X.J., Wang X.J., et al. Circulation of Coxsackievirus A10 and A6 in hand-foot-mouth disease in China, 2009–2011. PLoS One. 2012; 7(12): e52073. DOI: http://doi.org/10.1371/journal.pone.0052073
7. Blomqvist S., Klemola P., Kaijalainen S., Paananen A., Simonen M.L., Vuorinen T., et al. Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland. J. Clin. Virol. 2010; 48(1): 49-54. DOI: http://doi.org/10.1016/j.jcv.2010.02.002
8. Davia J.L., Bel P.H., Ninet V.Z., Bracho M.A., González-Candelas F., Salazar A., et al. Onychomadesis outbreak in Valencia, Spain associated with hand, foot, and mouth disease caused by enteroviruses. Pediatr. Dermatol. 2011; 28(1): 1-5. DOI: http://doi.org/10.1111/j.1525-1470.2010.01161.x
9. Wu Y., Yeo A., Phoon M.C., Tan E.L., Poh C.L., Quak S.H., et al. The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. Int. J. Infect. Dis. 2010; 14(12): e1076-81. DOI: http://doi.org/10.1016/j.ijid.2010.07.006
10. Mirand A., Henquell C., Archimbaud C., Ughetto S., Antona D., Bailly J.L., et al. Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study. Clin. Microbiol. Infect. 2012; 18(5): E110-8. DOI: http://doi.org/10.1111/j.1469-0691.2012.03789.x
11. Yang Q., Ding J., Cao J., Huang Q., Hong C., Yang B. Epidemiological and etiological characteristics of hand, foot, and mouth disease in Wuhan, China from 2012 to 2013: outbreaks of coxsackieviruses A10. J. Med. Virol. 2015; 87(6): 954-60. DOI: http://doi.org/10.1002/jmv.24151
12. Лукашев А.Н., Голицына Л.Н., Вакуленко Ю.А., Ахмадишина Л.В., Романенкова Н.И., Сапега Е.Ю. и др. Современные возможности и направления развития молекулярно-эпидемиологического мониторинга в надзоре за энтеровирусными инфекциями. Опыт Российской Федерации. Инфекция и иммунитет. 2018; 8(4): 452-64. DOI: http://doi.org/10.15789/2220-7619-2018-4-452-464
Journal of microbiology, epidemiology and immunobiology. 2020; 97: 324-330
Molecular epidemiological features of the Coxsackievirus A10 circulation in the Far Eastern Federal District of Russia
https://doi.org/10.36233/0372-9311-2020-97-4-4Abstract
Background. Increase in incidence rates of enterovirus infections in the Far Eastern Federal District of Russia is observed annually. There is a wide genetic diversity of circulating non-polio enteroviruses. Some of them have been constantly identified for a number of years in the population of the district, including the Coxsackie A10 virus.
Purpose. To study the features of the Coxsackievirus A10 circulation in the Far Eastern Federal District of Russia in 2014–2018.
Methods. For this work, 117 Coxsackievirus A10 complete sequences of the VP1 gene were used, which were isolated in the Far Eastern Federal District of Russia in 2014–2018.
Results. Phylogenetic analysis revealed two Coxsackievirus A10 lineages in the Far Eastern Federal District of Russia in 2014-2018, while their simultaneous circulation was noted in the Sakhalin region in 2017. Active population migration contributes to the widespread distribution of Coxsackievirus A10 in border areas with the formation of epidemic variants.
Conclusion. Coxsackievirus A10 is one of the most relevant types of non-polio enteroviruses for the Far Eastern Federal District of Russia. Phylogenetic analysis revealed its genetic diversity and suggested both European and Asian origin of the obtained strains.
References
1. Pallansch M.A., Roos R. Enteroviruses: Polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses. In: Knipe D.M., Howley P.M., eds. Fields Virology. Philadelphia: Lippincott Williams & Wilkins; 2007: 839-93.
2. EV-A Prototypes. Available at: http://www.picornaviridae.com/enterovirus/prototypes/ev-a_prototypes.htm
3. Tapparel C., Siegrist F., Petty T.J., Kaiser L. Picornavirus and enterovirus diversity with associated human diseases. Infect. Genet. Evol. 2013; 14: 282-93. DOI: http://doi.org/10.1016/j.meegid.2012.10.016
4. Chen M., He S., Yan Q., Xu X., Wu W., Ge S., et al. Severe hand, foot and mouth disease associated with Coxsackievirus A10 infections in Xiamen, China in 2015. J. Clin. Virol. 2017; 93: 20‐4. DOI: http://doi.org/10.1016/j.jcv.2017.05.011
5. Fuschino M.E., Lamson D.M., Rush K., Carbone L.S., Taff M.L., Hua Z., et al. Detection of coxsackievirus A10 in multiple tissues of a fatal infant sepsis case. J. Clin. Virol. 2012; 53(3): 259-61. DOI: http://doi.org/10.1016/j.jcv.2011.12.011
6. Lu Q.B., Zhang X.A., Wo Y., Xu H.M., Li X.J., Wang X.J., et al. Circulation of Coxsackievirus A10 and A6 in hand-foot-mouth disease in China, 2009–2011. PLoS One. 2012; 7(12): e52073. DOI: http://doi.org/10.1371/journal.pone.0052073
7. Blomqvist S., Klemola P., Kaijalainen S., Paananen A., Simonen M.L., Vuorinen T., et al. Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland. J. Clin. Virol. 2010; 48(1): 49-54. DOI: http://doi.org/10.1016/j.jcv.2010.02.002
8. Davia J.L., Bel P.H., Ninet V.Z., Bracho M.A., González-Candelas F., Salazar A., et al. Onychomadesis outbreak in Valencia, Spain associated with hand, foot, and mouth disease caused by enteroviruses. Pediatr. Dermatol. 2011; 28(1): 1-5. DOI: http://doi.org/10.1111/j.1525-1470.2010.01161.x
9. Wu Y., Yeo A., Phoon M.C., Tan E.L., Poh C.L., Quak S.H., et al. The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. Int. J. Infect. Dis. 2010; 14(12): e1076-81. DOI: http://doi.org/10.1016/j.ijid.2010.07.006
10. Mirand A., Henquell C., Archimbaud C., Ughetto S., Antona D., Bailly J.L., et al. Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study. Clin. Microbiol. Infect. 2012; 18(5): E110-8. DOI: http://doi.org/10.1111/j.1469-0691.2012.03789.x
11. Yang Q., Ding J., Cao J., Huang Q., Hong C., Yang B. Epidemiological and etiological characteristics of hand, foot, and mouth disease in Wuhan, China from 2012 to 2013: outbreaks of coxsackieviruses A10. J. Med. Virol. 2015; 87(6): 954-60. DOI: http://doi.org/10.1002/jmv.24151
12. Lukashev A.N., Golitsyna L.N., Vakulenko Yu.A., Akhmadishina L.V., Romanenkova N.I., Sapega E.Yu. i dr. Sovremennye vozmozhnosti i napravleniya razvitiya molekulyarno-epidemiologicheskogo monitoringa v nadzore za enterovirusnymi infektsiyami. Opyt Rossiiskoi Federatsii. Infektsiya i immunitet. 2018; 8(4): 452-64. DOI: http://doi.org/10.15789/2220-7619-2018-4-452-464
