Журнал микробиологии, эпидемиологии и иммунобиологии. 2020; 97: 83-90
Современные представления о механизмах взаимодействия биопленки и факторов клеточного иммунитета
https://doi.org/10.36233/0372-9311-2020-97-1-83-90Аннотация
Особенности клеточного иммунного ответа при наличии микробной биопленки достаточно хорошо описаны в литературе. Благодаря многочисленным исследованиям удалось установить ряд закономерностей: зрелые биопленки лучше защищены от иммунных факторов, эффективность противобиопленочных стратегий зависит от видовой принадлежности микроорганизмов, образующих биопленку, и, соответственно, от состава биополимерного матрикса. Так, Pseudomonas aeruginosa может вырабатывать рамнолипиды, а также образовывать альгинат, что оказывает значительное негативное воздействие на функции иммунокомпетентных клеток. Многие из защитных реакций, выработанных иммунной системой и закрепившихся эволюционно, бактерии биопленок стали способны обращать в свою пользу, применяя их для роста и развития микробного консорциума.
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Journal of microbiology, epidemiology and immunobiology. 2020; 97: 83-90
Modern Conceptions about the Mechanisms of Interaction Between Biofilm and Cellular Immunity Factors
https://doi.org/10.36233/0372-9311-2020-97-1-83-90Abstract
Features of the cellular immune response in the presence of a microbial biofilm are well described in the literature. Based on numerous studies, it became possible to establish a number of patterns: mature biofilms are better protected from immune factors, the effectiveness of antibiofilm strategies depends on species of the microorganisms, forming the biofilm, and, accordingly, on the composition of the biopolymer matrix. For example, rhamnolipids and alginate of Pseudomonas aeruginosa exert a significant negative effect on the function of immunocompetent cells. The bacteria of biofilms became able to turn to their advantage many of the protective reactions developed by the immune system and fixed evolutionarily, applying them for the growth and development of the microbial consortium.
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