Нозокомиальные респираторные вирусные инфекции: современное состояние проблемы

Главная

Статья в Elpub

РУС ENG

Журнал микробиологии, эпидемиологии и иммунобиологии. 2019; : 50-61

Нозокомиальные респираторные вирусные инфекции: современное состояние проблемы

Акимкин В. Г., Захарова Ю. А., Игонина Е. П., Болгарова Е. В.

https://doi.org/10.36233/0372-9311-2019-5-50-61

Аннотация

Проведен анализ данных зарубежной литературы из поисковой базы данных PubMed за 10-летний период о распространенности нозокомиальных респираторных вирусных инфекций (НРВИ). Установлена необходимость использования при оценке частоты встречаемости стандартного определения случая и лабораторной панели на основе мультиплексной полимеразной цепной реакции. В целом, выявлено преобладание в этиологической структуре риновирусов. Обоснована актуальность внедрения в работу неспецифических противоэпидемических мероприятий в отношении широкого спектра других респираторных патогенов, в числе которых наибольшую актуальность имели респираторно-синцитиальные вирусы, метапневмовирусы, аденовирусы, вирусы гриппа и парагриппа, коронавирусы. К редким видам были отнесены бокавирусы и миммивирусы. Биологическое разнообразие патогенов, вызывающих НРВИ, диктует необходимость активного внедрения в работу лабораторной службы медицинских учреждений методов молекулярной генетики с целью качественной этиологической диагностики, разработки и реализации схем адекватной противовирусной терапии, а также эффективных программ профилактики, реализация которых позволит существенно снизить риск распространения этих инфекций и экономические затраты.

Список литературы

1. Alvarez-Lerma F., Marin-Corral J., Vila C. et al. H1N1 GETGAG/SEMICYUC Study Group. Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit. J. Hosp. Infect. 2017, 95 (2): 200-206. doi:10.1016/j.jhin.2016.12.017.

2. Atmar R.L. Uncommon (ly considered) manifestations of infection with rhinovirus, agent of the common cold. Clin. Infect. Dis. 2005, 41 (2): 266-267. doi: 10.1086/430927.

3. Bearden A., Friedrich T.C., Goldberg T.L. et al. An outbreak of the 2009 influenza a (H1N1) virus in a children’s hospital. Influenza Other Respir Viruses. 2012, 6 (5): 374-379. doi:10.1111/j.1750-2659.2011.00322.x.

4. Berger P., Papazian L., Drancourt M. et al. Ameba-associated microorganisms and diagnosis of nosocomial pneumonia. Emerg. Infect. Dis. 2006, 12 (2): 248-255. doi:10.3201/eid1202.050434.

5. Berkovich S. Acute respiratory illness in the premature nursery associated with respiratory syncytial virus in-fections. Pediatrics. 1964, 34: 753-760.

6. Berner R., Schwoerer F., Schumacher R.F. et al. Community and nosocomially acquired respiratory syncytial virus infection in a German paediatric hospital from 1988 to 1999. Eur. J. Pediatr. 2001, 160 (9): 541-547. doi: 10.1007/s004310100801.

7. Boivin G., De Serres G., Hamelin M.E. et al. An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility. Clin. Infect. Dis. 2007, 44 (9): 1152-1158. doi: 10.1086/513204.

8. Brummitt C.F., Cherrington J.M., Katzenstein D.A. et al. Nosocomial adenovirus infections: molecular epidemiology of an outbreak due to adenovirus 3a. J. Infect. Dis. 1988, 158 (2): 423-432.

9. Calvo C., Garcia-Garcia M.L., Blanco C. et al. Human bocavirus infection in a neonatal intensive care unit. J. Infect. 2008, 57 (3): 269-271. doi:10.1016/j.jinf.2008.06.004.

10. Centers for Disease Control and Prevention (CDC). Outbreaks of human metapneumovirus in two skilled nursing facilities -West Virginia and Idaho, 2011-2012. MMWR Morb. Mortal. Wkly Rep. 2013, 62 (46): 909-913.

11. Chow E.J., Mermel L.A. Hospital-acquired respiratory viral infections: incidence, morbidity, and mortality in pediatric and adult patients. Open Forum Infect. Dis. 2017, 4 (1): ofx006. doi: 10.1093/ofid/ofx006.

12. Chowell G., Abdirizak F., Lee S. et al. Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study. BMC Med. 2015, 13:210. doi:10.1186/s12916-015-0450-0.

13. Class II Special Controls Guidance Document: Respiratory Viral Panel Multiplex Nucleic Acid Assay — Guidance for Industry and FDA Staff. URL: http://www.fda.gov/RegulatoryInformation/Guidances/.

14. Cunney R.J., Bialachowski A., Thornley D. et al. An outbreak of influenza A in a neonatal intensive care unit. Infect. Control Hosp. Epidemiol. 2000, 21 (7): 449-454.

15. de Groot R.J., Baker S.C., Baric R.S. et al. Middle East respiratory syndrome coronavirus (MERSCoV): announcement of the Coronavirus Study Group. J. Virol. 2013, 87 (14): 7790-7792. doi: 10.1128/JVI.01244-13.

16. Durigon G.S., Oliveira D.B., Vollet S.B. et al. Hospital-acquired human bocavirus in infants. J. Hosp. Infect. 2010, 76 (2): 171-173. doi:10.1016/j.jhin.2010.04.028.

17. Godoy C., Peremiquel-Trillas P., Andres C. et al. A molecular epidemiological study of human parainfluenza virus type 3 at a tertiary university hospital during 2013-2015 in Catalonia, Spain. Diagn. Microbiol. Infect. Dis. 2016, 86 (2): 153-159. doi:10.1016/j.diagmicrobio.2016.07.023.

18. Greninger A.L., Zerr D.M., Qin X. et al. Rapid metagenomic next-generation sequencing during an investigation of hospital-acquired human parainfluenza virus 3 infections. J. Clin. Microbiol. 2016, 55 (1): 177-182. doi: 10.1128/JCM.01881-16.

19. Harvala H., Gaunt E., McIntyre C. et al. Epidemiology and clinical characteristics of parainfluenza virus 3 outbreak in a haemato-oncology unit. J. Infect. 2012, 65 (3): 246-254. doi: 10.1016/j.jinf.2012.04.011.

20. Hicks L.A., Shepard C.W., Britz P.H. et al. Two outbreaks of severe respiratory disease in nursing homes associated with rhinovirus. J. Am. Geriatr. Soc. 2006, 54 (2): 284-289. doi: 10.1111/j.1532-5415.2005.00529.x.

21. Hohenthal U., Nikoskelainen J., Vainionpaa R. et al. Parainfluenza virus type 3 infections in a hematology unit. Bone Marrow Transplant. 2001, 27 (3): 295-300.

22. Home — PubMed — NCBI. URL: http://www.ncbi.nlm.nih.gov/pubmed/ (дата обращения 03.06.2018).

23. Kakiuchi S., Tsuji M., Nishimura H. et al. Human parainfluenza virus type 3 infections in patients with hematopoietic stem cell transplants: the mode of nosocomial infections and prognosis. Jpn J. Infect. Dis. 2018, 71 (2): 109-115. doi:10.7883/yoken.JJID.2017.424.

24. Kapikian A.Z., Bell J.A., Mastrota F.M. et al. An outbreak of febrile illness and pneumonia associated with respiratory syncytial virus infection. Am. J. Hyg. 1961, 74: 234-248.

25. Kapoor A., Simmonds P., Slikas E., Li L. et al. Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infections. J. Infect. Dis. 2010, 201 (11): 1633-1643. doi:10.1086/652416.

26. Karron R.A., O’Brien K.L., Froehlich J.L., Brown V.A. Molecular epidemiology of a parainfluenza type 3 virus outbreak on a pediatric ward. J. Infect. Dis. 1993, 167 (6): 1441-1445.

27. Kim T., Jin C.E., Sung H. et al. Molecular epidemiology and environmental contamination during an outbreak of parainfluenza virus 3 in a haematology ward. J. Hosp. Infect. 2017, 97 (4): 403-413. doi:10.1016/j.jhin.2017.09.003.

28. La Rosa G., Fratini M., Della Libera S. et al. Viral infections acquired indoors through airborne, droplet or contact transmission. Ann. Ist. Super. Sanita. 2013, 49 (2): 124-132. doi: 10.4415/ANN_13_02_03.

29. Lau S.K., To W.K., Tse P.W. et al. Human parainfluenza virus 4 outbreak and the role of diagnostic tests. J. Clin. Microbiol. 2005, 43 (9): 4515-4521.

30. Lee A.V., Bibby D.F., Oakervee H. et al. Nosocomial transmission of parainfluenza 3 virus in hematological patients characterized by molecular epidemiology. Transpl. Infect. Dis. 2011, 13 (4): 433-437. doi: 10.1111/j.1399-3062.2011.00603.x.

31. Lessa F.C., Gould P.L., Pascoe N. et al. Health care transmission of a newly emergent adenovirus serotype in health care personnel at a military hospital in Texas, 2007. J. Infect. Dis. 2009, 200 (11): 1759-1765. doi:10.1086/647987.

32. Liao R.S., Appelgate D.M., Pelz R.K. An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility for the elderly in Oregon. J. Clin. Virol. 2012, 53 (2): 171-173. doi: 10.1016/j.jcv.2011.10.010.

33. Lindsley W.G., Blachere F.M., Davis K.A. et al. Distribution of airborne influenza virus and respiratory syncytial virus in an urgent care medical clinic. Clin. Infect. Dis. 2010, 50 (5): 693-698. doi: 10.1086/650457.

34. Liu S., Chan T.C., Chu Y.T. et al. Comparative epidemiology of human infections with Middle East respiratory syndrome and Severe Acute Respiratory Syndrome Coronaviruses among healthcare personnel. PLoS One. 2016, 11 (3): e0149988. doi: 10.1371/journal.pone.0149988.

35. Louie J.K., Schnurr D.P., Pan C.Y. et al. A summer outbreak of human metapneumovirus infection in a long-term-care facility. J. Infect. Dis. 2007, 196 (5): 705-708.

36. Louie J.K., Yagi S., Nelson F.A. et al. Rhinovirus outbreak in a long-term care facility for elderly persons associated with unusually high mortality. Clin. Infect. Dis. 2005, 41 (2): 262-265. doi: 10.1086/430915.

37. Macartney K.K., Gorelick M.H., Manning M.L. et al. Nosocomial respiratory syncytial virus infections: the cost-effectiveness and cost-benefit of infection control. Pediatrics 2000, 106 (3): 520-526. doi: 10.1542/peds.106.3.520.

38. Macesic N., Kotsimbos T.C., Kelly P., Cheng A.C. Hospital-acquired influenza in an Australian sentinel surveillance system. Med. J. Aust. 2013, 198 (7): 370-372.

39. Maeng S.H., Yoo H.S., Choi S.H. et al. Impact of parainfluenza virus infection in pediatric cancer patients. Pediatr. Blood Cancer. 2012, 59 (4): 708-710. doi: 10.1002/pbc.23390.

40. Maille L., Beby-Defaux A., Bourgoin A. et al. Nosocomial infections due to rotavirus and respiratory syncytial virus in pediatric wards: a 2-year study. Ann. Biol. Clin. (Paris). 2000, 58 (5): 601-606.

41. Matsuda S., Nakamura M., Hirano E. et al. Characteristics of human metapneumovirus infection prevailing in hospital wards housing patients with severe disabilities. Jpn J. Infect. Dis. 2013, 66 (3): 195-200.

42. Meibalane R., Sedmak G.V., Sasidharan P. et al. Outbreak of influenza in a neonatal intensive care unit. J. Pediatr. 1977, 91 (6): 974-976.

43. Meissner H.C., Murray S.A., Kiernan M.A. et al. A simultaneous outbreak of respiratory syncytial virus and parainfluenza virus type 3 in a newborn nursery. J. Pediatr. 1984, 104 (5): 680-684.

44. Moisiuk S.E., Robson D., Klass L. et al. Outbreak of parainfluenza virus type 3 in an intermediate care neonatal nursery. Pediatr. Infect. Dis. J. 1998, 17 (1): 49-53.

45. Munoz F.M., Campbell J.R., Atmar R.L. et al. Influenza A virus outbreak in a neonatal intensive care unit. Pediatr. Infect. Dis. J. 1999, 18 (9): 811-815.

46. Neu N., Plaskett T., Hutcheon G. et al. Epidemiology of human metapneumovirus in a pediatric longterm care facility. Infect. Control Hosp. Epidemiol. 2012, 33 (6): 545-550. doi: 10.1086/665727.

47. Nichols W.G., Erdman D.D., Han A. et al. Prolonged outbreak of human parainfluenza virus 3 infection in a stem cell transplant outpatient department: insights from molecular epidemiologic analysis. Biol. Blood Marrow Transplant. 2004, 10 (1): 58-64.

48. Palomino M.A., Larranaga C., Avendano L.F. Hospital-acquired adenovirus 7h infantile respiratory infection in Chile. Pediatr. Infect. Dis. J. 2000, 19 (6): 527-531.

49. Park H.Y., Lee E.J., Ryu Y.W. et al. Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea, May to June 2015. Euro. Surveill. 2015, 20 (25): 1-6.

50. Qiu S., Li P., Liu H. et al. Whole-genome sequencing for tracing the transmission link between two ARD outbreaks caused by a novel HAdV serotype 7 variant, China. Sci. Rep. 2015, 5: 13617. doi: 10.1038/srep13617.

51. Sanchez M.P., Erdman D.D., Torok T.J. et al. Outbreak of adenovirus 35 pneumonia among adult residents and staff of a chronic care psychiatric facility. J. Infect. Dis. 1997, 176 (3): 760-763.

52. Sidler J.A., Haberthur C., Dumoulin A. et al. A retrospective analysis of nosocomial viral gastrointestinal and respiratory tract infections. Pediatr. Infect. Dis. J. 2012, 31: 1233-1238.

53. Valenti W.M., Menegus M.A., Hall C.B. et al. Nosocomial viral infections: I. Epidemiology and significance. Infect. Control. 1980, 1 (1): 33-37.

54. Valley-Omar Z., Nindo F., Mudau M. et al. Phylogenetic exploration of nosocomial transmission chains of 2009 Influenza A/H1N1 among children admitted at Red Cross War Memorial Children’s Hospital, Cape Town, South Africa in 2011. PLoS One. 2015, 10 (11): e0141744. doi:10.1371/journal.pone.0141744.

55. Vincent A., La Scola B., Forel J.M. et al. Clinical significance of a positive serology for mimivirus in patients presenting a suspicion of ventilator-associated pneumonia. Crit. Care Med. 2009, 37 (1):111- 118. doi:10.1097/CCM.0b013e318192fa8b.

56. Voirin N., Barret B., Metzger M.H., Vanhems P. Hospital-acquired influenza: a synthesis using the Outbreak Reports and Intervention Studies of Nosocomial Infection (ORION) statement. J. Hosp. Infect. 2009, 71 (1): 1-14. doi: 10.1016/j.jhin.2008.08.013.

57. von Linstow M.L., Hogh M., Hogh B. Clinical and epidemiologic characteristics of human bocavirus in Danish infants: results from a prospective birth cohort study. Pediatr. Infect. Dis. J. 2008, 27 (10): 897-902. doi:10.1097/INF.0b013e3181757b16.

58. Wald T.G., Shult P., Krause P. et al. A rhinovirus outbreak among residents of a long-term care facility. Ann. Intern. Med. 1995, 123 (8): 588-593.

Journal of microbiology, epidemiology and immunobiology. 2019; : 50-61

Nosocomial respiratory viral infections: state of the problems

Akimkin V. G., Zakharova Yu. A., Igonina E. P., Bolgarova E. V.

https://doi.org/10.36233/0372-9311-2019-5-50-61

Abstract

We scanned the PubMed search database for literature on the incidence of nosocomial respiratory viral infections (NRVI) published over a ten-year period. Necessity to apply the standard case definition and the laboratory panel based on the multiplex polymerase chain reaction in frequency assessment was established. In general, predominance of rhinoviruses in the etiological structure was detected. Rationale was given for introduction of nonspecific epidemic prevention activities against a broad spectrum of other respiratory pathogens including high-priority respiratory syncytial viruses, metapneumoviruses, adenoviruses, influenza and parainfluenza viruses and coronaviruses. Bocaviruses and mimiviruses were designated as rare species. The biological diversity of the pathogens causing NRVI calls for active promotion of molecular genetics techniques in the work of the laboratory services of health facilities to perform quality etiological diagnosis, design relevant antiviral therapy regimens and effective prevention programs whose implementation will lead to significant reduction in the spread risk of these infections and the treatment costs.

References