Журнал микробиологии, эпидемиологии и иммунобиологии. 2022; 99: 362-371
Детерминанты устойчивости Francisella tularensis к стрессовым условиям окружающей среды
https://doi.org/10.36233/0372-9311-219Аннотация
В обзоре обобщены современные данные литературы об основных структурах и антигенах туляремийного микроба, ответственных за адаптацию внутри теплокровного макроорганизма-хозяина (чувствительные животные, человек). Для успешного выживания Francisella tularensis в условиях стресса требуется взаимодействие всех клеточных структур микроба. Несмотря на активные исследования, проводимые в области изучения детерминант и механизмов устойчивости F. tularensis, причина высокой адаптационной способности при низкой изменчивости возбудителя туляремии не установлена. Эти исследования важны для понимания механизмов персистенции и вирулентности F. tularensis, а также для дальнейшей разработки вакцин и диагностических препаратов.
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Journal of microbiology, epidemiology and immunobiology. 2022; 99: 362-371
Determinants of resistance of Francisella tularensis to environmental stress
https://doi.org/10.36233/0372-9311-219Abstract
The review summarizes current literature data on the main structures and components of the tularemia microbe responsible for adaptation to the warm-blooded host macroorganism (susceptible animals, humans). According to scientific data, the successful survival of Francisella tularensis under stress conditions requires the interaction of all cellular structures of the microbe. Despite active research carried out in the field of studying the determinants and mechanisms of F. tularensis resistance, the reason for the high adaptive capacity with low variability of the tularemia pathogen has not been established. These studies are important for understanding the mechanisms of persistence and virulence of F. tularensis, as well as for further development of vaccines and diagnostic tests.
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25. Haurat M.F., Elhenawy W., Feldman M.F. Prokaryotic membrane vesicles: new insights on biogenesis and biological roles. Biol. Chem. 2015; 396(2): 95–109. https://doi.org/10.1515/hsz-2014-0183
26. Yoon H. Bacterial outer membrane vesicles as a delivery system for virulence regulation. J. Microbiol. Biotechnol. 2016; 26(8): 1343–7. https://doi.org/10.4014/jmb.1604.04080
27. McCaig W.D., Koller A., Thanassi D.G. Production of outer membrane vesicles and outer membrane tubes by Francisella novicida. J. Bacteriol. 2013; 195(6): 1120–32. https://doi.org/10.1128/JB.02007-12
28. Sampath V., McCaig W.D., Thanassi D.G. Amino acid deprivation and central carbon metabolism regulate the production of outer membrane vesicles and tubes by Francisella. Mol. Microbiol. 2018; 107(4): 523–41. https://doi.org/10.1111/mmi.13897
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32. Klimentova J., Pavkova I., Horcickova L., Bavlovic J., Kofro nova O., Benada O., et al. Francisella tularensis subsp. holarctica releases differentially loaded outer membrane vesicles under various stress conditions. Front. Microbiol. 2019; 10: 2304. https://doi.org/10.3389/fmicb.2019.02304
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