Журнал микробиологии, эпидемиологии и иммунобиологии. 2021; 98: 331-338
Нарушения кишечной микробиоты при расстройствах аутистического спектра: новые горизонты в поиске патогенетических подходов к терапии. Часть 3. Потенциальные стратегии влияния на ось кишечник–мозг для коррекции симптомов расстройств аутистического спектра
https://doi.org/10.36233/0372-9311-84Аннотация
Третья часть обзора литературы, посвящённого роли нарушений кишечной микробиоты в патогенезе расстройств аутистического спектра (РАС), содержит анализ опубликованной литературы о возможных интервенционных подходах в отношении кишечной микробиоты при РАС и оценку эффективности различных типов вмешательств, которые изучались в эксперименте и клинической практике. Приведены имеющиеся к настоящему времени данные о возможности коррекции кишечной микробиоты при РАС с помощью диеты, приёма пре- и пробиотиков, антибиотикотерапии, а также об эффективности трансплантации кишечной микробиоты. Анализ опубликованных данных свидетельствует о том, что дальнейшая разработка подходов к коррекции дисбиоза кишечника при РАС может дать безопасные и, вероятно, эффективные в отношении поведенческих симптомов подходы, но это требует дальнейших рандомизированных контролируемых исследований для подтверждения эффективности и безопасности с позиции доказательной медицины, поскольку имеющиеся к настоящему времени исследования являются малочисленными и раз- розненными, в связи с чем их можно считать предварительными.
Список литературы
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Journal of microbiology, epidemiology and immunobiology. 2021; 98: 331-338
Disturbances of intestinal microbiota in autism spectrum disorders: new horizons in search for pathogenetic approaches to therapy. Рart 3. Рotential strategies of influence on gut-brain axis for correction of symptoms of autism spectrum disorders
https://doi.org/10.36233/0372-9311-84Abstract
The third part of the literature review on the role of intestinal microbiota disturbances in the pathogenesis of autism spectrum disorders (ASD) is devoted to the analysis of published literature on possible interventional approaches for intestinal microbiota in ASD and the evaluation of the effectiveness of various types of interventions that have been studied in experiment and in clinical practice. Presented are available data on the possibility of correcting the intestinal microbiota in ASD with diet, taking pre- and probiotics, antibiotic therapy, as well as the effectiveness of transplantation of intestinal microbiota. An analysis of published data suggests that further development of approaches for correcting intestinal dysbiosis in ASD may provide safe and probably effective strategy for behavioral symptoms, but this requires further randomized controlled trials to confirm efficacy and safety from the perspective of evidence-based medicine, since available to date studies are small and scattered, and therefore they can only be considered preliminary.
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