Однонуклеотидные полиморфизмы членов суперсемейства интерлейкина-1: ассоциация с вирусными гепатитами В и С

Статья в Elpub

Журнал микробиологии, эпидемиологии и иммунобиологии. 2021; 98: 198-212

Однонуклеотидные полиморфизмы членов суперсемейства интерлейкина-1: ассоциация с вирусными гепатитами В и С

Власенко Н. В., Чурилова Н. С., Панасюк Я. В., Клушкина В. В., Дубоделов Д. В., Кудрявцева Е. Н., Семененко Т. А., Кузин С. Н., Акимкин В. Г.

https://doi.org/10.36233/0372-9311-121

Аннотация

В обзоре представлена информация об однонуклеотидных полиморфизмах (single nucleotide polymorphism, SNP) в генах некоторых интерлейкинов (IL), входящих в суперсемейство IL-1, и их связи с различными заболеваниями человека как инфекционной, так и неинфекционной природы. Кратко изложена история обнаружения SNP и развитие научного поиска по данной проблеме до сегодняшнего времени. Описаны некоторые механизмы взаимодействия инфекционных агентов и иммунной системы человека с учётом SNP отдельных цитокинов суперсемейства IL-1. Приведены данные о связи ряда SNP в генах, кодирующих другие факторы иммунной системы, ассоциированные с особенностями течения вирусных гепатитов В и С. Обсуждается значение определения SNP-пропорции провоспалительных цитокинов и их антагонистов суперсемейства IL-1 среди здорового населения и соотношения отдельных SNP у определённых групп пациентов как параметра мониторинга систем эпидемиологического надзора за инфекционными заболеваниями.

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Journal of microbiology, epidemiology and immunobiology. 2021; 98: 198-212

Single nucleotide polymorphisms of the interleukin-1 superfamily members: аssociation with viral hepatitis B and C

Vlasenko N. V., Churilova N. S., Panasyuk Ya. V., Klushkina V. V., Dubodelov D. V., Kudryavtseva E. N., Semenenko T. A., Kuzin S. N., Akimkin N. G.

https://doi.org/10.36233/0372-9311-121

Abstract

The review provides information on single nucleotide polymorphisms (SNPs) in genes encoding some interleukins belonging to the interleukin-1 (IL-1) superfamily and on their association with different infectious and non-infectious human diseases. It also briefs on the history of SNP discovery and the progress in the related scientific studies till the present time. It gives an insight into some mechanisms of interaction between infectious agents and the human immune system, involving SNPs in some cytokines of the IL-1 superfamily. The review provides data on relationships of SNPs in genes encoding other factors of the immune system, which are associated with the specific characteristics of natural history of chronic hepatitis B and C. It explores the significance of assessment of the SNP-proportion in proinflammatory cytokines and their antagonists of the IL-1 superfamily among the healthy population as well as the ratio of individual SNPs in specific groups of patients as a monitoring parameter for epidemiological surveillance of infectious diseases.

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