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Журнал МедиАль. 2018; : 108-110

Изолированная тробэкстракция у пациентов с острым коронарным синдромом

Шарабрин Е. Г., Иванова Я. А., Мухин А. С., Федоров С. А.

Аннотация

Цель исследования - изучить эффект от процедуры изолированной тробаспирации у пациентов с острым инфарктом миокарда с подъемом сегмента ST. При медикаментозной и эндоваскулярной реперфузии миокарда уменьшается риск развития осложнений, что связано с уменьшением нагрузки на инфаркт ответственную артерию. Серьезные осложнения такие, как нарушение мозгового кровообращения и эмбологенный инфаркт отсутствовали у пациентов с острым инфарктом миокарда с подъемом сегмента ST в группе с изолированной тромбаспирацией. Материалы и методы. В исследование включены 35 пациентов с острым инфарктом миокарда, с проведенной изолированной экстренной процедурой тромбэкстракции, и 90 пациентов, которым проведена ургентная ангиопластика без тромбаспирации. Результаты. Изолированная тромбаспирация у пациентов с острым коронарным синдромом эффективна частоту дистальной эмболизации и снижает частоту дислокации тромботических масс. Заключение. При наличии показаний к выполнию изолированной тромбэктракции у пациентов с острым коронарным синдромом данная процедура дает такие же результаты, как стентирование и ангиопластика.
Список литературы

1. Shaw L.J., Berman D.S., Maron D.J., Mancini G.B., Hayes S.W., Hartigan PM. et al. Optimal medical therapy with or without percutantous coronary intervention to reduce ischemic burden: result from the Clinical Outcomes Revascularization and Aggressive Drug Evalution (COURAGE) trial nuclear study. Circulation. 2011; 117 (10): 1283-129.

2. Shaw L.J., Iskandrian A.E. Prognostic value of gated myocardial perfusion SPECT. J. Nucl. Cardiol. 20012; 11(2): 171-85.

3. Tobis J., Azarbal B., Slavin L. Assessment of intermediate sеverity coronary lesion in the cateterisation laboratory. J. Am. Coll. Cardiol. 2007; 49(8): 839-848.

4. Onuma Y. Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST elevation myocardial infarct/ Y. Onuma, L. Thuesen, R.J.Geuns. // trial. Eur. Heart J. -2013.- Vol.34. -C.1050-1060.

5. Bech G.J., De Bruyne B., Pijls N.H., de Muinck E.D., Hoorntje J.C., Escaned J. et al. Fractional flow reserve to determine the appropriateeness if angioplasty in moderate coronary stenosis: a randomized trial. Circulation. 2001; 103(24): 2928-2934.

6. Pijls N.H., van Schaardenburgh P, Manoharan G., Boersma E., Bech J.W., van't Veer M. et al. Percutaneus coronary intervention of functionally nonsignificant stenosis. 5-year follow-up of the DEFER study. J. Am. College of Cardiology. 2007; 49(21): 2105-2111.

7. Iskander S., Iskandrian A.E. Risk assessment using single -photon emission computed tomografic technetium -99m sestamibi imaging. J. Am. College of Cardiology. 1998; 32(1): 57-62.

8. Abizaid A., Mintz G.S., Pichard A.D., Kent K.M., Satler L.F., Walsh C.L. et al. Clinical, intravascular ultrasound, and quantitative angiographic determinants of the coronary flow reserve befom and after percutaneous transluminal coronary angioplasty. Am. J. Carliology. 1998; 82(4):423-842.

9. Abizaid A.S., Mintz G.S., Mehran R., Abizaid A., Lansky A.J., Pichard A.D. et al. Long-term follow-up after percutaneous transluminal coronary angioplasty was not performed based on intravascular ultrasound findings: importance of lumen dimensions. Circulation. 2012; 100 (3):256-261.

10. Toshihiko Nishioka et al., Clinical validation of intravascular ultrasound imaging for assessment of coronary stenosis severity. Cоmparison with stress myocarlial perfusion imaging. JAAC 1999; 33:1870-1878.

11. Ben-Dor I., Torguson R., Gaglia M.A. Jr., Gonzalez M.A., Maluenda G., Bui A.B. et al. Correlation between fractional flow reserve and intravascular ultrasound lumen area in intermediate coronary artery stenosis. Eurointervention. 2011; 7(2):225-233.

12. Pijls N.H., De Bruyne B., Peels K., Van Der Voort PH., Bonnier H.J., Bartunek J. et al. Measurement of fractional flow reserve to assess the functional severity of coronary -artery stenoses. N. Engl. J. Med. 2017; 334 (26):1703-1708.

MediAl. 2018; : 108-110

Isolated trombextraction in patients with acute coronary syndrome

Sharabrin E. G., Ivanova Ya. A., Mukhin A. S., Fedorov S. A.

Abstract

Purpose of the study - to test the effect and safetythrombus aspiration procedure combining with urgent endovascular angioplastics on embolic artery of patients with acute coronary syndrome and elevated segment ST. In cases of drug and endovascular myocardial reperfusion the risk of complications decreases due to the reduction of load on infarct related artery. No serious complications such as cerebral circulation and myocardial embologenic were detected among patients with acute myocardial infarction with ST segment elevation in the group with formed thrombus aspiration. As for a group with prehospital thrombolysis, there were no deaths in it, indicating the effectiveness of thrombolysis as a preventive measure. Material and methods. We give direct results of 35 patients with acute coronary syndrome after urgent thrombus aspiration and 90 patients after urgent angioplastics without thrombus aspiration. Results. It is proved that complete or the of evacuated thrombotic mass or mostly occlusive substance from embolic artery has positive influence on angiophic results and is capable of dereas cases of distal embolization. Conclusion. After endovascular carring out embolic artery in thrombus aspiration groups we have complete rehabilitation of epicardial blood circulation and myocardial blush grade in comparison with groups without thrombus aspiration.
References

1. Shaw L.J., Berman D.S., Maron D.J., Mancini G.B., Hayes S.W., Hartigan PM. et al. Optimal medical therapy with or without percutantous coronary intervention to reduce ischemic burden: result from the Clinical Outcomes Revascularization and Aggressive Drug Evalution (COURAGE) trial nuclear study. Circulation. 2011; 117 (10): 1283-129.

2. Shaw L.J., Iskandrian A.E. Prognostic value of gated myocardial perfusion SPECT. J. Nucl. Cardiol. 20012; 11(2): 171-85.

3. Tobis J., Azarbal B., Slavin L. Assessment of intermediate severity coronary lesion in the cateterisation laboratory. J. Am. Coll. Cardiol. 2007; 49(8): 839-848.

4. Onuma Y. Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST elevation myocardial infarct/ Y. Onuma, L. Thuesen, R.J.Geuns. // trial. Eur. Heart J. -2013.- Vol.34. -C.1050-1060.

5. Bech G.J., De Bruyne B., Pijls N.H., de Muinck E.D., Hoorntje J.C., Escaned J. et al. Fractional flow reserve to determine the appropriateeness if angioplasty in moderate coronary stenosis: a randomized trial. Circulation. 2001; 103(24): 2928-2934.

6. Pijls N.H., van Schaardenburgh P, Manoharan G., Boersma E., Bech J.W., van't Veer M. et al. Percutaneus coronary intervention of functionally nonsignificant stenosis. 5-year follow-up of the DEFER study. J. Am. College of Cardiology. 2007; 49(21): 2105-2111.

7. Iskander S., Iskandrian A.E. Risk assessment using single -photon emission computed tomografic technetium -99m sestamibi imaging. J. Am. College of Cardiology. 1998; 32(1): 57-62.

8. Abizaid A., Mintz G.S., Pichard A.D., Kent K.M., Satler L.F., Walsh C.L. et al. Clinical, intravascular ultrasound, and quantitative angiographic determinants of the coronary flow reserve befom and after percutaneous transluminal coronary angioplasty. Am. J. Carliology. 1998; 82(4):423-842.

9. Abizaid A.S., Mintz G.S., Mehran R., Abizaid A., Lansky A.J., Pichard A.D. et al. Long-term follow-up after percutaneous transluminal coronary angioplasty was not performed based on intravascular ultrasound findings: importance of lumen dimensions. Circulation. 2012; 100 (3):256-261.

10. Toshihiko Nishioka et al., Clinical validation of intravascular ultrasound imaging for assessment of coronary stenosis severity. Comparison with stress myocarlial perfusion imaging. JAAC 1999; 33:1870-1878.

11. Ben-Dor I., Torguson R., Gaglia M.A. Jr., Gonzalez M.A., Maluenda G., Bui A.B. et al. Correlation between fractional flow reserve and intravascular ultrasound lumen area in intermediate coronary artery stenosis. Eurointervention. 2011; 7(2):225-233.

12. Pijls N.H., De Bruyne B., Peels K., Van Der Voort PH., Bonnier H.J., Bartunek J. et al. Measurement of fractional flow reserve to assess the functional severity of coronary -artery stenoses. N. Engl. J. Med. 2017; 334 (26):1703-1708.