Валеология: Здоровье, Болезнь, Выздоровление. 2019; : 109-113
КЛИНИКО-МЕТАБОЛИЧЕСКИЕ ИЗМЕНЕНИЯ В ЗАВИСИМОСТИ ОТ ПОЛИМОРФИЗМА ГЕНА АНГИОТЕНЗИНПРЕВРАЩАЮЩЕГО ФЕРМЕНТА
Аннотация
В данной статье говорится о важности изучения роли полиморфизма генов АПФ и клинико-метаболических изменений. Наименее исследованными на сегодняшний день остаются генетические механизмы предрасположенности к метаболическому синдрому. Сложность их изучения заключается в большом количестве генов, которые могут участвовать в формировании наследственной предрасположенности как самостоятельно, так и путем взаимодействия друг с другом.
Список литературы
1. Котловский М. Ю. Полиморфизм гена ангиотензин-превращающего фермента у людей с гипертонической болезнью и хронической формой ИБС / М. Ю. Котловский [и др.] // Фундаментальные исследования. – 2011. – № 11-1. – С. 49-52.
2. Celentano A. I., Mancini F. P. et. al. Cardiovascular risk factors, angiotensin-converting enzyme gene I/D polymorphism, and left ventricular mass in systemic hypertension // Am J Cardiol.- 1999. -№ 83 (8). - Р. 1196-200.
3. Moleda P. I. , Majkowska L. et. al. I/D polymorphism of angiotensin I converting enzyme gene and arterial hypertension in patients with type 2 diabetes mellitus // Pol Merkur Lekarski. - 2007. -№ 22(129). - Р. 169-72.
4. Dursunoğlu D. I., Tanriverdi H. et. al. Do left ventricular mass, diameters and long-axis systolic function differ according to angiotensin converting enzyme genotypes? // Anadolu Kardiyol Derg. - 2005. -№5 (3). - Р. 172-7.
5. Mittal G., Gupta V., Haque S. F., Khan A. S. Effect of angiotensin converting enzyme gene I/D polymorphism in patients with metabolic syndrome in North Indian population // Chin Med J (Engl). – 2011. - №124 (1). – Р. 45-8.
6. Lee Y. J., Tsai J. C. ACE gene insertion/deletion polymorphism associated with 1998 World Health Organization definition ofmetabolic syndrome in Chinese type 2 diabetic patients // Diabetes Care. – 2002. - №25 (6). – Р. 1002-8.
7. Feng Y., Niu T., Xu X., Chen C., Li Q., et al. Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes // Diabetes. - 2002. -№51 (6). – Р. 1986-8.
8. Sinorita H., Madiyan M., Pramono R. B., et al. ACE gene insertion / deletion polymorphism among patients with type 2 diabetes, and its relationship withmetabolic syndrome at Sardjito Hospital Yogyakarta, Indonesia // Acta Med Indones. – 2010. -№ 42 (1). – Р. 12-6.
9. Lahiri D. K., Bye S., Nunberg J. I., et al. A non-organic and non-enzymatic extraction method gives higher yields of genomic DNA from whole-blood samples than do nine other methods used // J. Biochem. Biophys. Meth. – 1992. - № 25. – Р. 193–205.
10. Rigat B., Hubert C., Corvol P., Soubrier F. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene // Nucleic Acid Res. - 1992. 20; 1433. 15.
11. Odawara M., Matsunuma A., Yamashita K. Mistyping frequency of the angiotensin-converting enzyme gene polymorphism and an improved method for its avoidance // Hum Genet – 1997. - №100. – Р.163–166.
12. Muhlbauer S., Wolfarth B. GenetischePolymorphismen und linksventrikulare Masse beihochtrainiertenAusdauerathleten // Jahrang. – 2002. - № 12. - Р. 376-386.
13. Friedewald W. T., Levy R. I., Fredrickson D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge // Clin. Chem. – 1972. - № 18. - Р. 499-502.
14. Rifkind B. M. High-density lipoprotein cholesterol and coronary artery disease: survey of the evidence // Am. J. Cardiol. – 1990. - № 66. – Р. 3A-6A.
15. Климов А. И. Причины и условия развития атеросклероза / А. И. Климов // Превентивная кардиология / Под ред. Г. И. Косицкого. - М: Медицина, 1977.- С. 260-321.
Valeology: Health - Illnes - recovery. 2019; : 109-113
CLINICAL AND METABOLIC CHANGES DEPENDING ON THE POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING ENZYME GENE
Abstract
This article is about the importance of studying the role of polymorphism of ACE genes and clinical and metabolic changes. The least studied to date are the genetic mechanisms of predisposition to the metabolic syndrome. The complexity of their study lies in a large number of genes that can participate in the formation of hereditary predisposition, both independently and through interaction with each other.
References
1. Kotlovskii M. Yu. Polimorfizm gena angiotenzin-prevrashchayushchego fermenta u lyudei s gipertonicheskoi bolezn'yu i khronicheskoi formoi IBS / M. Yu. Kotlovskii [i dr.] // Fundamental'nye issledovaniya. – 2011. – № 11-1. – S. 49-52.
2. Celentano A. I., Mancini F. P. et. al. Cardiovascular risk factors, angiotensin-converting enzyme gene I/D polymorphism, and left ventricular mass in systemic hypertension // Am J Cardiol.- 1999. -№ 83 (8). - R. 1196-200.
3. Moleda P. I. , Majkowska L. et. al. I/D polymorphism of angiotensin I converting enzyme gene and arterial hypertension in patients with type 2 diabetes mellitus // Pol Merkur Lekarski. - 2007. -№ 22(129). - R. 169-72.
4. Dursunoğlu D. I., Tanriverdi H. et. al. Do left ventricular mass, diameters and long-axis systolic function differ according to angiotensin converting enzyme genotypes? // Anadolu Kardiyol Derg. - 2005. -№5 (3). - R. 172-7.
5. Mittal G., Gupta V., Haque S. F., Khan A. S. Effect of angiotensin converting enzyme gene I/D polymorphism in patients with metabolic syndrome in North Indian population // Chin Med J (Engl). – 2011. - №124 (1). – R. 45-8.
6. Lee Y. J., Tsai J. C. ACE gene insertion/deletion polymorphism associated with 1998 World Health Organization definition ofmetabolic syndrome in Chinese type 2 diabetic patients // Diabetes Care. – 2002. - №25 (6). – R. 1002-8.
7. Feng Y., Niu T., Xu X., Chen C., Li Q., et al. Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes // Diabetes. - 2002. -№51 (6). – R. 1986-8.
8. Sinorita H., Madiyan M., Pramono R. B., et al. ACE gene insertion / deletion polymorphism among patients with type 2 diabetes, and its relationship withmetabolic syndrome at Sardjito Hospital Yogyakarta, Indonesia // Acta Med Indones. – 2010. -№ 42 (1). – R. 12-6.
9. Lahiri D. K., Bye S., Nunberg J. I., et al. A non-organic and non-enzymatic extraction method gives higher yields of genomic DNA from whole-blood samples than do nine other methods used // J. Biochem. Biophys. Meth. – 1992. - № 25. – R. 193–205.
10. Rigat B., Hubert C., Corvol P., Soubrier F. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene // Nucleic Acid Res. - 1992. 20; 1433. 15.
11. Odawara M., Matsunuma A., Yamashita K. Mistyping frequency of the angiotensin-converting enzyme gene polymorphism and an improved method for its avoidance // Hum Genet – 1997. - №100. – R.163–166.
12. Muhlbauer S., Wolfarth B. GenetischePolymorphismen und linksventrikulare Masse beihochtrainiertenAusdauerathleten // Jahrang. – 2002. - № 12. - R. 376-386.
13. Friedewald W. T., Levy R. I., Fredrickson D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge // Clin. Chem. – 1972. - № 18. - R. 499-502.
14. Rifkind B. M. High-density lipoprotein cholesterol and coronary artery disease: survey of the evidence // Am. J. Cardiol. – 1990. - № 66. – R. 3A-6A.
15. Klimov A. I. Prichiny i usloviya razvitiya ateroskleroza / A. I. Klimov // Preventivnaya kardiologiya / Pod red. G. I. Kositskogo. - M: Meditsina, 1977.- S. 260-321.
