Валеология: Здоровье, Болезнь, Выздоровление. 2021; : 13-18
РЕТРОСПЕКТИВНЫЙ АНАЛИЗ ЛЕЧЕНИЯ ПРОТИВОВИРУСНЫМ ПРЕПАРАТОМ "РЕМДЕСИВИР" ПАЦИЕНТОВ С КОРОНАВИРУСНОЙ ИНФЕКЦИЕЙ COVID-19
Аннотация
В настоящее время одним из перспективных противовирусных препаратов для лечения COVID-19 является "Ремдесивир". Для окончательного решения вопроса о включении этого препарата в международные рекомендации для лечения COVID-19 необходимы дальнейшие исследования с оценкой его эффективности и безопасности у пациентов с COVID-19.
Список литературы
1. Wang M., Cao R., Zhang L., et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 2020; 30: 269.
2. Chen Y., Liu Q. and Guo D.: Emerging coronaviruses: Genome structure, replication and pathogenesis. J Med Virol 2020; 92 (4): 418-23.
3. Fung T. S. and Liu D. X.: Human Coronavirus: Host-Pathogen Interaction. Annu Rev Microbiol 2019; 73: 529-57.
4. Chen Y., Liu Q. and Guo D.: Emerging coronaviruses: Genome structure, replication and pathogenesis. J Med Virol 2020; 92 (4): 418-23.
5. Fung T. S. and Liu D. X.: Human Coronavirus: Host-Pathogen Interaction. Annu Rev Microbiol 2019; 73: 529-57.
6. Kortepeter M. G., Dierberg K., Shenoy E. S. and Cieslak T. J.: Medical Countermeasures Working Group of the National Ebola T, Education Center's Special Pathogens Research N. Marburg virus disease: A summary for clinicians. Int J Infect Dis 2020; 99: 233-42.
7. Siegel D., Hui H. C., Doerffler E., Clarke M. O., Chun K. and Zhang L.: Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo [2,1-f][triazin-4-amino] Adenine C Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem 2017; 60 (5): 1648-61.
8. Tchesnokov E. P., Feng J. Y., Porter D. P. and Gotte M.: Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA polymerase by Remdesivir. Viruses 2019; 11 (4): 326.
9. Pardo J., Shukla A. M., Chamarthi G. and Gupte A.: The journey of remdesivir: from Ebola to COVID-19. Drugs Context 2020; 9.
10. Клинический протокол «Коронавирусной инфекция COVID-19 у взрослых». – Одобрен Объединенной комиссией по качеству медицинских услуг Министерства здравоохранения РК от 1 апреля 2021 № 130.
Valeology: Health - Illnes - recovery. 2021; : 13-18
RETROSPECTIVE ANALYSIS OF TREATMENT ANTIVIRAL DRUG REMDESIVIR IN PATIENTS WITH CORONAVIRUS INFECTION COVID-19
Abstract
Currently, one of the promising antiviral drugs for the treatment of COVID-19 is remdesivir. For a final decision on the inclusion of this drug in the international recommendations for the treatment of COVID-19, further studies are needed to evaluate its effectiveness and safety in patients with COVID-19.
The aim of the studyis to study the clinical efficacy of remdesivir in the comprehensive therapy of patients with moderate severity of COVID-19.
References
1. Wang M., Cao R., Zhang L., et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 2020; 30: 269.
2. Chen Y., Liu Q. and Guo D.: Emerging coronaviruses: Genome structure, replication and pathogenesis. J Med Virol 2020; 92 (4): 418-23.
3. Fung T. S. and Liu D. X.: Human Coronavirus: Host-Pathogen Interaction. Annu Rev Microbiol 2019; 73: 529-57.
4. Chen Y., Liu Q. and Guo D.: Emerging coronaviruses: Genome structure, replication and pathogenesis. J Med Virol 2020; 92 (4): 418-23.
5. Fung T. S. and Liu D. X.: Human Coronavirus: Host-Pathogen Interaction. Annu Rev Microbiol 2019; 73: 529-57.
6. Kortepeter M. G., Dierberg K., Shenoy E. S. and Cieslak T. J.: Medical Countermeasures Working Group of the National Ebola T, Education Center's Special Pathogens Research N. Marburg virus disease: A summary for clinicians. Int J Infect Dis 2020; 99: 233-42.
7. Siegel D., Hui H. C., Doerffler E., Clarke M. O., Chun K. and Zhang L.: Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo [2,1-f][triazin-4-amino] Adenine C Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem 2017; 60 (5): 1648-61.
8. Tchesnokov E. P., Feng J. Y., Porter D. P. and Gotte M.: Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA polymerase by Remdesivir. Viruses 2019; 11 (4): 326.
9. Pardo J., Shukla A. M., Chamarthi G. and Gupte A.: The journey of remdesivir: from Ebola to COVID-19. Drugs Context 2020; 9.
10. Klinicheskii protokol «Koronavirusnoi infektsiya COVID-19 u vzroslykh». – Odobren Ob\"edinennoi komissiei po kachestvu meditsinskikh uslug Ministerstva zdravookhraneniya RK ot 1 aprelya 2021 № 130.
