Валеология: Здоровье, Болезнь, Выздоровление. 2021; : 210-214
ЭФФЕКТИВНОСТЬ ПРЕПАРАТОВ НА ОСНОВЕ ПЛАЗМЫ, ОБОГАЩЕННОЙ ТРОМБОЦИТАМИ, В ОТНОШЕНИИ РЕПАРАЦИИ РАЗЛИЧНЫХ ТКАНЕЙ
Аннотация
В последнее время количество работ по изучению плазмы, обогащенной тромбоцитами (PRP), значительно выросло. PRP представляет собой препарат, который на сегодняшний день все чаще используют при различных расстройствах не только опорно-двигательного аппарата, но и других систем. Многими авторами со всего мира считается, что данный препарат имеет значительный потенциал при репарации тканей с нарушенным заживлением. Уже описана способность PRP восстанавливать сухожилия, связки, мышцы и хрящи.
Цель. Изучить эффективность плазмы, обогащенной тромбоцитами, в отношении различных тканей.
Материалы и методы. Был выполнен обзор с использованием баз данных Pub Med, MEDLINE, Embase, PreMEDLINE, Ebase с использованием рекомендаций PRISMA-P. Из 440 первоначально идентифицированных статей были отобраны 40, посвященных PRP, однако только 15 статей были включены в обзор.
Заключение. Несмотря на большое количество данных, демонстрирующих преимущества PRP в отношении пролиферации клеток, существуют противоречивые данные. Вероятно, большая часть этих данных связана с отсутствием стандартов изготовления и использования PRP. Таким образом, существует необходимость изучения PRP на всех уровнях, включая избирательное изучение влияний факторов на разные типы тканей.
Список литературы
1. T. Molloy, Y. Wang, and G. A. C. Murrell, “The roles of growth factors in tendon and ligament healing”, Sports Medicine. 2003, doi: 10.2165/00007256-200333050-00004.
2. J. H. C. Wang, “Mechanobiology of tendon”, Journal of Biomechanics. 2006, doi: 10.1016/j.jbiomech.2005.05.011.
3. M. Sánchez, E. Anitua, J. Azofra, I. Andía, S. Padilla, and I. Mujika, “Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices,” Am. J. Sports Med., 2007, doi: 10.1177/0363546506294078.
4. R. R. Monto, “Platelet rich plasma treatment for chronic Achilles tendinosis”, Foot Ankle Int., 2012, doi: 10.3113/FAI.2012.0379.
5. R. J. De Vos et al., “Platelet-rich plasma injection for chronic Achilles tendinopathy: A randomized controlled trial”, JAMA - J. Am. Med. Assoc., 2010, doi: 10.1001/jama.2009.1986.
6. J. Zhang, K. K. Middleton, F. H. Fu, H. J. Im, and J. H. C. Wang, “HGF Mediates the Anti-inflammatory Effects of PRP on Injured Tendons”, PLoS One, 2013, doi: 10.1371/journal.pone.0067303.
7. S. Narumiya, Y. Sugimoto, and F. Ushikubi, “Prostanoid receptors: Structures, properties, and functions”, Physiological Reviews. 1999, doi: 10.1152/physrev.1999.79.4.1193.
8. M. H. Khan, Z. Li, and J. H. C. Wang, “Repeated exposure of tendon to prostaglandin-E2 leads to localized tendon degeneration”, Clin. J. Sport Med., 2005, doi: 10.1097/00042752-200501000-00006.
9. P. Blair and R. Flaumenhaft, “Platelet α-granules: Basic biology and clinical correlates”, Blood Rev., 2009, doi: 10.1016/j.blre.2009.04.001.
10. P. F. van der Meer, “Platelet concentrates, from whole blood or collected by apheresis?”, Transfusion and Apheresis Science. 2013, doi: 10.1016/j.transci.2013.02.004.
11. A. Mishra et al., “Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation.", Tissue Eng. Part C. Methods, 2009, doi: 10.1089/ten.tec.2008.0534.
12. F. Graziani, S. Ivanovski, S. Cei, F. Ducci, M. Tonetti, and M. Gabriele, “The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts”, Clin. Oral Implants Res., 2006, doi: 10.1111/j.1600-0501.2005.01203.x.
13. E. Anitua et al., “Fibroblastic response to treatment with different preparations rich in growth factors”, Cell Prolif., 2009, doi: 10.1111/j.1365-2184.2009.00583.x.
14. C. H. Jo, J. E. Kim, K. S. Yoon, and S. Shin, “Platelet-rich plasma stimulates cell proliferation and enhances matrix gene expression and synthesis in tenocytes from human rotator cuff tendons with degenerative tears,” Am. J. Sports Med., 2012, doi: 10.1177/0363546512437525.
15. X. Wang, Y. Qiu, J. Triffitt, A. Carr, Z. Xia, and A. Sabokbar, “Proliferation and differentiation of human tenocytes in response to platelet rich plasma: An in vitro and in vivo study,” J. Orthop. Res., 2012, doi: 10.1002/jor.22016.
16. D. R. Berger, C. J. Centeno, and N. J. Steinmetz, “Platelet lysates from aged donors promote human tenocyte proliferation and migration in a concentration-dependent manner,” Bone Jt. Res., 2019, doi: 10.1302/2046-3758.81.BJR-2018-0164.R1.
17. M. Franchi, A. Trirè, M. Quaranta, E. Orsini, and V. Ottani, “Collagen structure of tendon relates to function”, The Scientific World Journal. 2007, doi: 10.1100/tsw.2007.92.
18. M. G. V. Heiden, L. C. Cantley, and C. B. Thompson, “Understanding the warburg effect: The metabolic requirements of cell proliferation,” Science. 2009, doi: 10.1126/science.1160809.
19. C. P. Kiritsy and S. E. Lynch, “Role of growth factors in cutaneous wound healing: A review,” Critical Reviews in Oral Biology and Medicine. 1994, doi: 10.1177/10454411930040050401.
Valeology: Health - Illnes - recovery. 2021; : 210-214
THE EFFECTIVENESS OF PLATELET-RICH PLASMA-BASED DRUGS IN RELATION TO THE REPAIR OF VARIOUS TISSUES
Abstract
Recently, the number of studies on platelet-rich plasma (PRP) has increased significantly. PRP is a drug that today is increasingly used for various disorders of not only the musculoskeletal system, but also other systems. Many authors from all over the world believe that this drug has significant potential in the repair of tissues with impaired healing. The ability of PRP to repair tendons, ligaments, muscles, and cartilage has already been described.
Aim. To study the effectiveness of platelet-rich plasma against various tissues.
Materials and methods. The review was performed using Pub Med, MEDLINE, Embase, PreMEDLINE, Ebase databases using PRISMA-P recommendations. Of the 440 articles initially identified, 40 articles on PRP were selected, but only 15 articles were included in the review.
Conclusion. Despite a large body of data demonstrating the benefits of PRP in relation to cell proliferation, there are conflicting data. Probably most of this data is due to the lack of standards for the manufacture and use of PRP. Thus, there is a need to study PRP at all levels, including the selective study of the effects of factors on different types of tissues.
References
1. T. Molloy, Y. Wang, and G. A. C. Murrell, “The roles of growth factors in tendon and ligament healing”, Sports Medicine. 2003, doi: 10.2165/00007256-200333050-00004.
2. J. H. C. Wang, “Mechanobiology of tendon”, Journal of Biomechanics. 2006, doi: 10.1016/j.jbiomech.2005.05.011.
3. M. Sánchez, E. Anitua, J. Azofra, I. Andía, S. Padilla, and I. Mujika, “Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices,” Am. J. Sports Med., 2007, doi: 10.1177/0363546506294078.
4. R. R. Monto, “Platelet rich plasma treatment for chronic Achilles tendinosis”, Foot Ankle Int., 2012, doi: 10.3113/FAI.2012.0379.
5. R. J. De Vos et al., “Platelet-rich plasma injection for chronic Achilles tendinopathy: A randomized controlled trial”, JAMA - J. Am. Med. Assoc., 2010, doi: 10.1001/jama.2009.1986.
6. J. Zhang, K. K. Middleton, F. H. Fu, H. J. Im, and J. H. C. Wang, “HGF Mediates the Anti-inflammatory Effects of PRP on Injured Tendons”, PLoS One, 2013, doi: 10.1371/journal.pone.0067303.
7. S. Narumiya, Y. Sugimoto, and F. Ushikubi, “Prostanoid receptors: Structures, properties, and functions”, Physiological Reviews. 1999, doi: 10.1152/physrev.1999.79.4.1193.
8. M. H. Khan, Z. Li, and J. H. C. Wang, “Repeated exposure of tendon to prostaglandin-E2 leads to localized tendon degeneration”, Clin. J. Sport Med., 2005, doi: 10.1097/00042752-200501000-00006.
9. P. Blair and R. Flaumenhaft, “Platelet α-granules: Basic biology and clinical correlates”, Blood Rev., 2009, doi: 10.1016/j.blre.2009.04.001.
10. P. F. van der Meer, “Platelet concentrates, from whole blood or collected by apheresis?”, Transfusion and Apheresis Science. 2013, doi: 10.1016/j.transci.2013.02.004.
11. A. Mishra et al., “Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation.", Tissue Eng. Part C. Methods, 2009, doi: 10.1089/ten.tec.2008.0534.
12. F. Graziani, S. Ivanovski, S. Cei, F. Ducci, M. Tonetti, and M. Gabriele, “The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts”, Clin. Oral Implants Res., 2006, doi: 10.1111/j.1600-0501.2005.01203.x.
13. E. Anitua et al., “Fibroblastic response to treatment with different preparations rich in growth factors”, Cell Prolif., 2009, doi: 10.1111/j.1365-2184.2009.00583.x.
14. C. H. Jo, J. E. Kim, K. S. Yoon, and S. Shin, “Platelet-rich plasma stimulates cell proliferation and enhances matrix gene expression and synthesis in tenocytes from human rotator cuff tendons with degenerative tears,” Am. J. Sports Med., 2012, doi: 10.1177/0363546512437525.
15. X. Wang, Y. Qiu, J. Triffitt, A. Carr, Z. Xia, and A. Sabokbar, “Proliferation and differentiation of human tenocytes in response to platelet rich plasma: An in vitro and in vivo study,” J. Orthop. Res., 2012, doi: 10.1002/jor.22016.
16. D. R. Berger, C. J. Centeno, and N. J. Steinmetz, “Platelet lysates from aged donors promote human tenocyte proliferation and migration in a concentration-dependent manner,” Bone Jt. Res., 2019, doi: 10.1302/2046-3758.81.BJR-2018-0164.R1.
17. M. Franchi, A. Trirè, M. Quaranta, E. Orsini, and V. Ottani, “Collagen structure of tendon relates to function”, The Scientific World Journal. 2007, doi: 10.1100/tsw.2007.92.
18. M. G. V. Heiden, L. C. Cantley, and C. B. Thompson, “Understanding the warburg effect: The metabolic requirements of cell proliferation,” Science. 2009, doi: 10.1126/science.1160809.
19. C. P. Kiritsy and S. E. Lynch, “Role of growth factors in cutaneous wound healing: A review,” Critical Reviews in Oral Biology and Medicine. 1994, doi: 10.1177/10454411930040050401.
