Валеология: Здоровье, Болезнь, Выздоровление. 2020; : 184-189
ОСОБЕННОСТИ ГЕМОДИНАМИКИ ПРИ ТЯЖЁЛОМ СЕПСИСЕ У ДЕТЕЙ ПЕРВОГО ГОДА ЖИЗНИ
Аннотация
По оценкам ВОЗ, каждый год септические состояния развиваются у 1,2 миллиона детей (исключая неонатальный период), при этом глобальная заболеваемость сепсисом не поддаётся точной оценке. Ранняя диагностика и целенаправленная терапия этого состояния способствует увеличению выживаемости. Однако дети первого года жизни являются особой категорией пациентов в связи с их анатомо-физиологическими особенностями, способствующими развитию специфической клинической картины, отличающейся от симптоматики сепсиса у детей старшего возраста и взрослых, особенно это касается гемодинамики. В данном исследовании мы постарались выявить клинические признаки нарушения кровообращения, наиболее рано проявляющиеся при тяжелом сепсисе у детей раннего возраста.
Список литературы
1. Agyeman P. K. A., Schlapbach L. J., Giannoni E., et al. Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study. Lancet Child Adolesc Heal. 2017;1 (2): 124-133.
2. Dugani S., Kissoon N. Global advocacy needed for sepsis in children. J Infect. 2017; 74: S 61-S 65.
3. Fleischmann-Struzek C., Goldfarb D. M., Schlattmann P., Schlapbach L. J., Reinhart K., Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018; 6 (3): 223-230.
4. de Souza D., Machado F. Epidemiology of Pediatric Septic Shock. J Pediatr Intensive Care. 2019; 08 (01): 003-010.
5. Tan B., Wong J. J. M., Sultana R., et al. Global Case-Fatality Rates in Pediatric Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis. JAMA Pediatr. 2019; 173 (4): 352-361.
6. Ames S. G., Davis B. S., Angus D. C., Carcillo J. A., Kahn J. M. Hospital Variation in Risk-Adjusted Pediatric Sepsis Mortality. Pediatr Crit Care Med. 2018; 19 (5): 390-396.
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8. Seymour C. W., Liu V. X., Iwashyna T. J., et al. Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315 (8): 762-774.
9. Wong H. R. Genetics and genomics in pediatric septic shock. Crit Care Med. 2012; 40 (5): 1618-1626.
10. Liu V., Escobar G. J., Greene J. D., et al. Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA - J Am Med Assoc. 2014; 312 (1): 90-92.
11. Conway E. E. Pediatric Sepsis: A Primer for the Pediatrician. Pediatr Ann. 2018; 47 (7): e 292-e 299.
12. Bradshaw C., Goodman I., Rosenberg R., Bandera C., Fierman A., Rudy B. Implementation of an inpatient pediatric sepsis identification pathway. Pediatrics. 2016; 137 (3).
13. Wheeler D. S., Wong H. R., Zingarelli B. Pediatric Sepsis - Part I: & quot; Children are not small adults! & quot; Open Inflamm J. 2011; 4: 4-15.
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15. Emr B. M., Alcamo A. M., Carcillo J. A., Aneja R. K., Mollen K. P. Pediatric Sepsis Update: How Are Children Different? Surg Infect (Larchmt). 2018; 19 (2): 176-183.
16. Wheeler D. S. Introduction to Pediatric Sepsis. Open Inflamm J. 2011; 4 (Suppl 1-M): 1-3.
17. Davis A. L., Carcillo J. A., Aneja R. K., et al. American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock. Vol. 45.; 2017.
18. Goldstein B., Giroir B., Randolph A., International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics*. Pediatr Crit Care Med. 2005; 6 (1): 2-8.
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Valeology: Health - Illnes - recovery. 2020; : 184-189
FEATURES OF HEMODYNAMICS AT SEVERE SEPSIS IN CHILDREN OF THE FIRST YEAR OF LIFE
Abstract
According to WHO estimates, every year 1.2 million children develop septic conditions (excluding the neonatal period), while the global incidence of sepsis cannot be accurately estimated. Early diagnosis and targeted therapy of this condition contributes to increased survival. However, children of the first year of life are a special category of patients due to their anatomical and physiological characteristics that contribute to the development of a specific clinical picture that is different from the symptoms of sepsis in older children and adults, especially hemodynamics. In this study, we tried to identify the clinical signs of circulatory disorders, the earliest manifestations of severe sepsis in young children.
References
1. Agyeman P. K. A., Schlapbach L. J., Giannoni E., et al. Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study. Lancet Child Adolesc Heal. 2017;1 (2): 124-133.
2. Dugani S., Kissoon N. Global advocacy needed for sepsis in children. J Infect. 2017; 74: S 61-S 65.
3. Fleischmann-Struzek C., Goldfarb D. M., Schlattmann P., Schlapbach L. J., Reinhart K., Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018; 6 (3): 223-230.
4. de Souza D., Machado F. Epidemiology of Pediatric Septic Shock. J Pediatr Intensive Care. 2019; 08 (01): 003-010.
5. Tan B., Wong J. J. M., Sultana R., et al. Global Case-Fatality Rates in Pediatric Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis. JAMA Pediatr. 2019; 173 (4): 352-361.
6. Ames S. G., Davis B. S., Angus D. C., Carcillo J. A., Kahn J. M. Hospital Variation in Risk-Adjusted Pediatric Sepsis Mortality. Pediatr Crit Care Med. 2018; 19 (5): 390-396.
7. Ministerstvo zdravookhraneniya Respubliki Kazakhstan. Zdorov'e naseleniya Respubliki Kazakhstan i deyatel'nost' organizatsii zdravookhraneniya v 2017 godu: Statisticheskii sbornik. – Astana, 2018. - 234 s.
8. Seymour C. W., Liu V. X., Iwashyna T. J., et al. Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315 (8): 762-774.
9. Wong H. R. Genetics and genomics in pediatric septic shock. Crit Care Med. 2012; 40 (5): 1618-1626.
10. Liu V., Escobar G. J., Greene J. D., et al. Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA - J Am Med Assoc. 2014; 312 (1): 90-92.
11. Conway E. E. Pediatric Sepsis: A Primer for the Pediatrician. Pediatr Ann. 2018; 47 (7): e 292-e 299.
12. Bradshaw C., Goodman I., Rosenberg R., Bandera C., Fierman A., Rudy B. Implementation of an inpatient pediatric sepsis identification pathway. Pediatrics. 2016; 137 (3).
13. Wheeler D. S., Wong H. R., Zingarelli B. Pediatric Sepsis - Part I: & quot; Children are not small adults! & quot; Open Inflamm J. 2011; 4: 4-15.
14. Dellinger R. P., Levy M. M., Rhodes A., et al. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013.
15. Emr B. M., Alcamo A. M., Carcillo J. A., Aneja R. K., Mollen K. P. Pediatric Sepsis Update: How Are Children Different? Surg Infect (Larchmt). 2018; 19 (2): 176-183.
16. Wheeler D. S. Introduction to Pediatric Sepsis. Open Inflamm J. 2011; 4 (Suppl 1-M): 1-3.
17. Davis A. L., Carcillo J. A., Aneja R. K., et al. American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock. Vol. 45.; 2017.
18. Goldstein B., Giroir B., Randolph A., International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics*. Pediatr Crit Care Med. 2005; 6 (1): 2-8.
19. Singer M., Deutschman C. S., Seymour C. W., et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315 (8): 801.
20. A. Cabrita J., Pinheiro I., Menezes Falcão L. Rethinking the concept of sepsis and septic shock. Eur J Intern Med. 2018; 54: 1-5.
