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Валеология: Здоровье, Болезнь, Выздоровление. 2020; : 236-242

ОБЗОР ЛИТЕРАТУРНЫХ ДАННЫХ О ПИТАНИИ ДЕТЕЙ С ОНКОЛОГИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ

КАЛИЕВА А. Ж., ТУРГАМБАЕВА А. К., ЧАН МЭЙ ЙЕН

Аннотация

   Пища для больного ребенка является естественным лечебным фактором, позволяющим целенаправленно проводить коррекцию нарушенных обменных процессов и функций различных органов и систем.

   Исходные нарушения питания в значительной степени снижают эффективность лечебных мероприятий, увеличивают риск развития септических и инфекционных осложнений, отрицательно влияют на продолжительность пребывания больных в стационаре, ухудшают показатели летальности.

Список литературы

1. Creutzig U., Zimmermann M., Hannemann J., Kraemer I., Herold G., Henze G. Quality management within the competence network of paediatric oncology and haematology. Klin Padiatr. 2003;215:338–40 [PubMed] [Google Scholar].

2. Meadows A. T., Friedman D. L., Neglia J. P., Mertens A. C., Donaldson S. S., Stovall M., Hammond S., Yasui Y., Inskip P. D. Second neoplasms in survivors of childhood cancer: findings from the Childhood Cancer Survivor Study cohort. J Clin Oncol. 2009; 27 : 2356–62 [PMC free article] [PubMed] [Google Scholar].

3. Pietsch J. B., Ford C. Children with cancer: measurements of nutritional status at diagnosis. Nutr Clin Pract. 2000; 15 : 185–8 [Google Scholar].

4. Smith D. E., Stevens M. C., Booth I. W. Malnutrition at diagnosis of malignancy in childhood: common but mostly missed. Eur J Pediatr. 1991; 150 : 318–22 [PubMed] [Google Scholar].

5. Sala A., Puncher P., Barr R. D. Children, cancer, and nutrition: a dynamic triangle in review. Cancer. 2004; 100 : 677–87 [PubMed] [Google Scholar].

6. Bosaeus I., Daneryd P., Svanberg E., Lundholm K. Dietary intake and resting energy expenditure in relation to weight loss in unselected cancer patients. Int J Cancer. 2001; 93 : 380–3 [PubMed] [Google Scholar].

7. Tisdale M. J. Cancer cachexia: metabolic alterations and clinical manifestations. Nutrition. 1997; 13 : 1–7 [PubMed] [Google Scholar].

8. Han-Markey T. Nutritional considerations in pediatric oncology. Semin Oncol Nurs. 2000; 16 : 146–51 [PubMed] [Google Scholar].

9. Van Eys J. Malnutrition in children with cancer: incidence and consequences. Cancer. 1979; 43 : 2030–5 [PubMed] [Google Scholar].

10. Rickard K. A., Grosfeld J. L., Coates T. D., Weetman R., Baehner R. L. Advances in nutrition care of children with neoplastic diseases: a review of treatment, research, and application. J Am Diet Assoc. 1986; 86 : 1666–76 [PubMed] [Google Scholar].

11. Ronald D. Barr, David Gomez-Almaguer, Jose Carlos Jaime-Perez, Guillermo J. Ruiz-Argüelles. (2016) Importance of Nutrition in the Treatment of Leukemia in Children and Adolescents. Archives of Medical Research 47 : 8, pages 585-592.

12. Wright J. A., Ashenburg C. A., Whitaker R. C. Comparison of methods the categorize undernutrition in children. J Pediatr. 1994; 124 : 944–6 [PubMed] [Google Scholar].

13. Butte N. E., Garza C., de Onis M. Evaluation of the feasibility of international growth standards for school-aged children and adolescents. Food Nutr Bull. 2006; 27 No 4, Suppl 2 : 169–74 [PubMed] [Google Scholar].

14. Reilly J. J., Ventham J. C., Newell J., Aitchison T., Wallace W. H., Gibson B. E. Risk factors for excess weight gain in children treated for acute lymphoblastic leukaemia. Int J Obes Relat Metab Disord. 2000; 24 : 1537–41 [PubMed] [Google Scholar].

15. White M., Davies P., Murphy A. Validation of percent body fat indicators in pediatric oncology nutrition assessment. J Pediatr Hematol Oncol. 2008; 30 : 124–9 [PubMed] [Google Scholar].

16. Duggan C. Nutritional assessment in sick or hospitalized children. : Hendricks L, Duggan C, editors., Manual pediatric nutrition. 4th ed Hamilton: B. C. Decker; 2005. P. 239–51 [Google Scholar].

17. Arends J., Zuercher G., Dossett A., Fietkau R., Hug M., Schmid I., Shang E., Zander A. Working group for developing the guidelines for parenteral nutrition of The German Association for Nutritional Medicine. Non-surgical oncology: guidelines on parenteral nutrition. Ger Med Sci. 2009; 7 : 1–14 [PMC free article] [PubMed] [Google Scholar].

18. Uderzo C., Rovelli A., Bonomi M., Fomia L., Fomia L., Pirovano L., Masera G. Total parenteral nutrition and nutritional assessment and leukaemic children undergoing bone marrow transplantation. Eur J Cancer. 1991; 27 : 758–62 [PubMed] [Google Scholar].

19. Forchielli M. L., Azzi N., Cadranel S., Paolucci G. Total parenteral nutrition in bone marrow transplant: what is the appropriate energy level? Oncology. 2003; 64 : 7–13 [PubMed] [Google Scholar].

20. Weisdorf S., Hofland C., Sharp H. L., Teasley K., Schissel K., McGlave P. B., Ramsay N., Kersey J. Total parenteral nutrition in bone marrow transplantation: a clinical evaluation. J Pediatr Gastroenterol Nutr. 1984; 3 : 95–100 [PubMed] [Google Scholar].

21. Murray S. M., Pindoria S. Nutrition support for bone marrow transplant patients. Cochrane Database Syst Rev. 2009; 21 : CD002920. [PubMed] [Google Scholar].

22. Kuhn K. S., Muscaritoli M., Wischmeyer P., Stehle P. Glutamine as indispensable nutrient in oncology: experimental and clinical evidence. Eur J Nutr. 2010; 49 : 197– [PubMed] [Google Scholar].

23. Hockenberry M. J., Hooke M. C., Gregurich M., McCarthy K. Carnitine plasma levels and fatigue in children / adolescents receiving cisplatin, ifosfamide, or doxorubicin. J Pediatr Hematol Oncol. 2009; 31 : 664–9 [PubMed] [Google Scholar].

24. Key T. J., Schatzkin A., Willett W. C., Allen N. E., Spencer E. A., Travis R. C. Diet, nutrition and the prevention of cancer. Public Health Nutr. 2004 ; 7 : 187 –200. Google Scholar Crossref Pub Med.

25. Murphy, A., Mosby, T., Rogers, P. et al. An international survey of nutritional practices in low- and middle-income countries: a report from the International Society of Pediatric Oncology (SIOP) PODC Nutrition Working Group. European Journal Clinical Nutrition 68, 1341–1345 (2014).

26. Gibson F., Soanes L. (2010) Cancer in Children and Young People, Acute Nursing Care. Wiley & Sons Ltd.

27. Bauer J.; Jurgens H.; Fruhwald M. C. (2011) Important Aspects of Nutrition in Children with cancer, American Society for Nutrition, Advances in Nutrition. 2 : 67-77.

28. NHS Choices www.nhs.uk/livewell/goodfood.

29. McCarthy, H., Dixon, M., Eaton Evans, M. J., McNulty, H. The development and evaluationof the screening tool for the assessment of malnutrition in paediatrics STAMP for use by healthcare staff .J Hum Nutr Diet 2012 Aug 25 (4), p. 311-318.

30. Royal College of Nursing (2014) Nutrition in children and young people with cancer RCN guidance. Accessed February 2016. https://www.rcn.org.uk/professional-development/publications/pub-003805.

31. Huhmann M. B., August D. A. Review of American Society for Parenteral and Enteral Nutrition (ASPEN) clinical guidelines for nutrition support in cancer patients: nutrition screening and assessment. Nutr Clin Pract. 2008; 23 : 182–8 [PubMed] [Google Scholar].

32. August D. A., Huhmann M. B. American Society for Parenteral and Enteral Nutrition (A. S. P. E. N.) Board of Directors A. S. P. E. N. clinical guidelines: nutrition support therapy during adult anticancer treatment and in hematopoietic cell transplantation. JPEN J Parenter Enteral Nutr. 2009; 33 : 472–500 [PubMed] [Google Scholar].

33. Evans W. J. Skeletal muscle loss: cachexia, sarcopenia, and inactivity. Am J Clin Nutr. 2010; 91 : S 1123–7 [PubMed] [Google Scholar].

34. Gullett N. P., Hebbar G., Ziegler T. R. Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting. Am J Clin Nutr. 2010; 91 : S 1143–7 [PMC free article] [PubMed] [Google Scholar].

35. McCulloch, R., Hemsley, J., Kelly, P. (2013) Symptom management during chemotherapy Paediatrics and Child Health 24 : 4 166- 171 Elsevier Ltd.

36. Children’s Cancer and Leukaemia Group (CCLG) (2012) Helping Your Child to Eat; A Practical Guide for Parents, Carers and Children Coping with cancer. https://www.cclg.org.uk/.

37. Dexamethasone. A self help guide for parents https://www.cclg.org.uk/.

38. “Leukaemia & Lymphoma Research patient information booklet: Dietary advice for Haematology patients with Neutropenia”. https://bloodwise.org.uk/all-blood-cancers/patient-information-booklets.

39. Kramer M. S., Kakuma R. Optimal duration of exclusive breastfeeding. Cochrane Database Syst Rev. 2002;(1) : CD003517.

40. Kramer M. S., Kakuma R. Optimal duration of exclusive breastfeeding. Cochrane Database Syst Rev. 2012;(8) : CD003517.

41. Fewtrell M., Wilson D. C., Booth I., Lucas A. Six months of exclusive breast feeding: how good is the evidence? BMJ . 2011; 342 : c5955. Google Scholar Crossref.

42. Wang D. D., Hu F. B. Precision nutrition for prevention and managementof type 2 diabetes. Lancet Diabetes Endocrinol 2018; 6 (5) : 416–26.

43. Kohlmeier M., De Caterina R., Ferguson L. R., Gorman U., Allayee H., Prasad C., Kang J. X., Nicoletti C. F., Martinez J. A. Guide andposition of the International Society of Nutrigenetics / Nutrigenomicson personalized nutrition: Part 2—Ethics, challenges and endeavors ofprecision nutrition. J Nutrigenet Nutrigenomics 2016; 9 (1) : 28–46.

44. Kau A. L., Ahern P. P., Griffin N. W., Goodman A. L., Gordon J. I. Humannutrition, the gut microbiome and the immune system. Nature 2011; 474 (7351) : 327–36.

45. Hooper L. V., Littman D. R., Macpherson A. J. Interactions between themicrobiota and the immune system. Science 2012; 336 (6086) : 1268–73.

46. Epigenetic Gene Regulation by Dietary Compounds in Cancer Prevention. McKale Montgomery, Aishwarya Srinivasan / Advances in Nutrition, Volume 10, Issue 6, November 2019, Pages 1012–1028.

47. Key T. J., Schatzkin A., Willett W. C., Allen N. E., Spencer E. A., Travis R. C. Diet, nutrition and the prevention of cancer. Public Health Nutr. 2004; 7 : 187 –200. Google Scholar Crossref Pub Med.

48. WHO. Obesity and overweight. WHO; 2017.

49. Jin B., Li Y., Robertson K. D. DNA methylation: superior or subordinate in the epigenetic hierarchy? Genes Cancer. 2011; 2 : 607 –17. Google Scholar Crossref Pub Med.

50. The association of serum levels of zinc and vitamin D with wasting among Iranian pre-school children.

51. Nasiri-Babadi P., Sadeghian M., Sadeghi O., Siassi F., Dorosty A., Esmaillzadeh A., Pouraram H. Eat Weight Disord. 2020 Jan 3. doi: 10.1007/s40519-019-00834-1. [Epub ahead of print] PMID: 31900880.

52. Nunez-Sanchez M. A., Gonzalez-Sarrias A., Romo-Vaquero M., Garcia-Villalba R., Selma M. V., Tomas-Barberan F. A., Garcia-Conesa M. T., Espin J. C. Dietary phenolics against colorectal cancer—from promising preclinical results to poor translation into clinical trials: pitfalls and future needs. Mol Nutr Food Res . 2015; 59 : 1274–91. PubMed.

53. Romo-Vaquero M., García-Villalba R., González-Sarrías A.,Beltrán D., Tomás-Barberán F. A, Espín J. C.,Selma M. V. Interindividual variability in the human metabolism of ellagic acid: contribution of Gordonibacter to urolithin production. Journal of Functional Foods. 2015; 17 : 785–91.Google Scholar.

54. Nunez-Sanchez M. A., Gonzalez-Sarrias A., Garcia-Villalba R., Monedero-Saiz T., Garcia-Talavera N. V., Gomez-Sanchez M. B., Sanchez-Alvarez C., Garcia-Albert A. M., Rodriguez-Gil F. J., Ruiz-Marin Met al. Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial J Nutr Biochem. 2017; 42 : 126–33. PubMed

55. Selma M. V., Romo-Vaquero M., Garcia-Villalba R., Gonzalez-Sarrias A., Tomas-Barberan F. A., Espin J. C. The human gut microbial ecology associated with overweight and obesity determines ellagic acid metabolism. Food Funct. 2016; 7 : 1769–74. PubMed.

56. Gonzalez-Sarrias A., Garcia-Villalba R., Romo-Vaquero M., Alasalvar C., Orem A., Zafrilla P., Tomas-Barberan F. A., Selma M. V., Espin J. C. Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: a randomized clinical trial. Mol Nutr Food Res. 2017; 61 : 1600830. Google Scholar.

57. Blot W. J., Li Y., Taylor P. R., Guo W., Dawsey S., Wang G. Q., Yang C. S., Zheng S. F., Gail M., Li G. Yet al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst. 1993; 85 : 1483–92.

58. Gibson F., Soanes L. (2010) Cancer in Children and Young People, Acute Nursing Care. Wiley & Sons Ltd.

59. Jones L., Watling R. M., Wilkins S., Pizer B. (2010) Nutritional support in children and young people with cancer undergoing chemotherapy (Review). The Cochrane Collaboration. Wiley & Sons Ltd.

60. World Health Organization United Nations Children’s Fund. WHO child growth standards and the identification of severe acute malnutrition in infants and children 2009.

61. De Onis M., Onyango A. W., Borghi E., Siyam A., Nishida C., Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Org 2007; 85 : 660–667.

62. Министерство Здравоохранения Республики Казахстан. Приказ № 292 от 04. 06. 2019. «Об утверждении Дорожной карты по совершенствованию детской онкогематологической помощи в Республике Казахстан на 2019-2021 годы».

Valeology: Health - Illnes - recovery. 2020; : 236-242

REVIEW OF LITERATURE DATA ON NUTRITION IN CHILDREN WITH CANCER

KALIYEVA A. , TURGAMBAYEVA A. , CHAN MEI YEN

Abstract

      Food for a sick child is a natural therapeutic factor that allows you to purposefully correct the disturbed metabolic processes and functions of various organs and systems.
   Initial nutritional disorders significantly reduce the effectiveness of treatment measures, increase the risk of septic and infectious complications, negatively affect the length of stay of patients in hospital, worsen mortality rates.

References

1. Creutzig U., Zimmermann M., Hannemann J., Kraemer I., Herold G., Henze G. Quality management within the competence network of paediatric oncology and haematology. Klin Padiatr. 2003;215:338–40 [PubMed] [Google Scholar].

2. Meadows A. T., Friedman D. L., Neglia J. P., Mertens A. C., Donaldson S. S., Stovall M., Hammond S., Yasui Y., Inskip P. D. Second neoplasms in survivors of childhood cancer: findings from the Childhood Cancer Survivor Study cohort. J Clin Oncol. 2009; 27 : 2356–62 [PMC free article] [PubMed] [Google Scholar].

3. Pietsch J. B., Ford C. Children with cancer: measurements of nutritional status at diagnosis. Nutr Clin Pract. 2000; 15 : 185–8 [Google Scholar].

4. Smith D. E., Stevens M. C., Booth I. W. Malnutrition at diagnosis of malignancy in childhood: common but mostly missed. Eur J Pediatr. 1991; 150 : 318–22 [PubMed] [Google Scholar].

5. Sala A., Puncher P., Barr R. D. Children, cancer, and nutrition: a dynamic triangle in review. Cancer. 2004; 100 : 677–87 [PubMed] [Google Scholar].

6. Bosaeus I., Daneryd P., Svanberg E., Lundholm K. Dietary intake and resting energy expenditure in relation to weight loss in unselected cancer patients. Int J Cancer. 2001; 93 : 380–3 [PubMed] [Google Scholar].

7. Tisdale M. J. Cancer cachexia: metabolic alterations and clinical manifestations. Nutrition. 1997; 13 : 1–7 [PubMed] [Google Scholar].

8. Han-Markey T. Nutritional considerations in pediatric oncology. Semin Oncol Nurs. 2000; 16 : 146–51 [PubMed] [Google Scholar].

9. Van Eys J. Malnutrition in children with cancer: incidence and consequences. Cancer. 1979; 43 : 2030–5 [PubMed] [Google Scholar].

10. Rickard K. A., Grosfeld J. L., Coates T. D., Weetman R., Baehner R. L. Advances in nutrition care of children with neoplastic diseases: a review of treatment, research, and application. J Am Diet Assoc. 1986; 86 : 1666–76 [PubMed] [Google Scholar].

11. Ronald D. Barr, David Gomez-Almaguer, Jose Carlos Jaime-Perez, Guillermo J. Ruiz-Argüelles. (2016) Importance of Nutrition in the Treatment of Leukemia in Children and Adolescents. Archives of Medical Research 47 : 8, pages 585-592.

12. Wright J. A., Ashenburg C. A., Whitaker R. C. Comparison of methods the categorize undernutrition in children. J Pediatr. 1994; 124 : 944–6 [PubMed] [Google Scholar].

13. Butte N. E., Garza C., de Onis M. Evaluation of the feasibility of international growth standards for school-aged children and adolescents. Food Nutr Bull. 2006; 27 No 4, Suppl 2 : 169–74 [PubMed] [Google Scholar].

14. Reilly J. J., Ventham J. C., Newell J., Aitchison T., Wallace W. H., Gibson B. E. Risk factors for excess weight gain in children treated for acute lymphoblastic leukaemia. Int J Obes Relat Metab Disord. 2000; 24 : 1537–41 [PubMed] [Google Scholar].

15. White M., Davies P., Murphy A. Validation of percent body fat indicators in pediatric oncology nutrition assessment. J Pediatr Hematol Oncol. 2008; 30 : 124–9 [PubMed] [Google Scholar].

16. Duggan C. Nutritional assessment in sick or hospitalized children. : Hendricks L, Duggan C, editors., Manual pediatric nutrition. 4th ed Hamilton: B. C. Decker; 2005. P. 239–51 [Google Scholar].

17. Arends J., Zuercher G., Dossett A., Fietkau R., Hug M., Schmid I., Shang E., Zander A. Working group for developing the guidelines for parenteral nutrition of The German Association for Nutritional Medicine. Non-surgical oncology: guidelines on parenteral nutrition. Ger Med Sci. 2009; 7 : 1–14 [PMC free article] [PubMed] [Google Scholar].

18. Uderzo C., Rovelli A., Bonomi M., Fomia L., Fomia L., Pirovano L., Masera G. Total parenteral nutrition and nutritional assessment and leukaemic children undergoing bone marrow transplantation. Eur J Cancer. 1991; 27 : 758–62 [PubMed] [Google Scholar].

19. Forchielli M. L., Azzi N., Cadranel S., Paolucci G. Total parenteral nutrition in bone marrow transplant: what is the appropriate energy level? Oncology. 2003; 64 : 7–13 [PubMed] [Google Scholar].

20. Weisdorf S., Hofland C., Sharp H. L., Teasley K., Schissel K., McGlave P. B., Ramsay N., Kersey J. Total parenteral nutrition in bone marrow transplantation: a clinical evaluation. J Pediatr Gastroenterol Nutr. 1984; 3 : 95–100 [PubMed] [Google Scholar].

21. Murray S. M., Pindoria S. Nutrition support for bone marrow transplant patients. Cochrane Database Syst Rev. 2009; 21 : CD002920. [PubMed] [Google Scholar].

22. Kuhn K. S., Muscaritoli M., Wischmeyer P., Stehle P. Glutamine as indispensable nutrient in oncology: experimental and clinical evidence. Eur J Nutr. 2010; 49 : 197– [PubMed] [Google Scholar].

23. Hockenberry M. J., Hooke M. C., Gregurich M., McCarthy K. Carnitine plasma levels and fatigue in children / adolescents receiving cisplatin, ifosfamide, or doxorubicin. J Pediatr Hematol Oncol. 2009; 31 : 664–9 [PubMed] [Google Scholar].

24. Key T. J., Schatzkin A., Willett W. C., Allen N. E., Spencer E. A., Travis R. C. Diet, nutrition and the prevention of cancer. Public Health Nutr. 2004 ; 7 : 187 –200. Google Scholar Crossref Pub Med.

25. Murphy, A., Mosby, T., Rogers, P. et al. An international survey of nutritional practices in low- and middle-income countries: a report from the International Society of Pediatric Oncology (SIOP) PODC Nutrition Working Group. European Journal Clinical Nutrition 68, 1341–1345 (2014).

26. Gibson F., Soanes L. (2010) Cancer in Children and Young People, Acute Nursing Care. Wiley & Sons Ltd.

27. Bauer J.; Jurgens H.; Fruhwald M. C. (2011) Important Aspects of Nutrition in Children with cancer, American Society for Nutrition, Advances in Nutrition. 2 : 67-77.

28. NHS Choices www.nhs.uk/livewell/goodfood.

29. McCarthy, H., Dixon, M., Eaton Evans, M. J., McNulty, H. The development and evaluationof the screening tool for the assessment of malnutrition in paediatrics STAMP for use by healthcare staff .J Hum Nutr Diet 2012 Aug 25 (4), p. 311-318.

30. Royal College of Nursing (2014) Nutrition in children and young people with cancer RCN guidance. Accessed February 2016. https://www.rcn.org.uk/professional-development/publications/pub-003805.

31. Huhmann M. B., August D. A. Review of American Society for Parenteral and Enteral Nutrition (ASPEN) clinical guidelines for nutrition support in cancer patients: nutrition screening and assessment. Nutr Clin Pract. 2008; 23 : 182–8 [PubMed] [Google Scholar].

32. August D. A., Huhmann M. B. American Society for Parenteral and Enteral Nutrition (A. S. P. E. N.) Board of Directors A. S. P. E. N. clinical guidelines: nutrition support therapy during adult anticancer treatment and in hematopoietic cell transplantation. JPEN J Parenter Enteral Nutr. 2009; 33 : 472–500 [PubMed] [Google Scholar].

33. Evans W. J. Skeletal muscle loss: cachexia, sarcopenia, and inactivity. Am J Clin Nutr. 2010; 91 : S 1123–7 [PubMed] [Google Scholar].

34. Gullett N. P., Hebbar G., Ziegler T. R. Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting. Am J Clin Nutr. 2010; 91 : S 1143–7 [PMC free article] [PubMed] [Google Scholar].

35. McCulloch, R., Hemsley, J., Kelly, P. (2013) Symptom management during chemotherapy Paediatrics and Child Health 24 : 4 166- 171 Elsevier Ltd.

36. Children’s Cancer and Leukaemia Group (CCLG) (2012) Helping Your Child to Eat; A Practical Guide for Parents, Carers and Children Coping with cancer. https://www.cclg.org.uk/.

37. Dexamethasone. A self help guide for parents https://www.cclg.org.uk/.

38. “Leukaemia & Lymphoma Research patient information booklet: Dietary advice for Haematology patients with Neutropenia”. https://bloodwise.org.uk/all-blood-cancers/patient-information-booklets.

39. Kramer M. S., Kakuma R. Optimal duration of exclusive breastfeeding. Cochrane Database Syst Rev. 2002;(1) : CD003517.

40. Kramer M. S., Kakuma R. Optimal duration of exclusive breastfeeding. Cochrane Database Syst Rev. 2012;(8) : CD003517.

41. Fewtrell M., Wilson D. C., Booth I., Lucas A. Six months of exclusive breast feeding: how good is the evidence? BMJ . 2011; 342 : c5955. Google Scholar Crossref.

42. Wang D. D., Hu F. B. Precision nutrition for prevention and managementof type 2 diabetes. Lancet Diabetes Endocrinol 2018; 6 (5) : 416–26.

43. Kohlmeier M., De Caterina R., Ferguson L. R., Gorman U., Allayee H., Prasad C., Kang J. X., Nicoletti C. F., Martinez J. A. Guide andposition of the International Society of Nutrigenetics / Nutrigenomicson personalized nutrition: Part 2—Ethics, challenges and endeavors ofprecision nutrition. J Nutrigenet Nutrigenomics 2016; 9 (1) : 28–46.

44. Kau A. L., Ahern P. P., Griffin N. W., Goodman A. L., Gordon J. I. Humannutrition, the gut microbiome and the immune system. Nature 2011; 474 (7351) : 327–36.

45. Hooper L. V., Littman D. R., Macpherson A. J. Interactions between themicrobiota and the immune system. Science 2012; 336 (6086) : 1268–73.

46. Epigenetic Gene Regulation by Dietary Compounds in Cancer Prevention. McKale Montgomery, Aishwarya Srinivasan / Advances in Nutrition, Volume 10, Issue 6, November 2019, Pages 1012–1028.

47. Key T. J., Schatzkin A., Willett W. C., Allen N. E., Spencer E. A., Travis R. C. Diet, nutrition and the prevention of cancer. Public Health Nutr. 2004; 7 : 187 –200. Google Scholar Crossref Pub Med.

48. WHO. Obesity and overweight. WHO; 2017.

49. Jin B., Li Y., Robertson K. D. DNA methylation: superior or subordinate in the epigenetic hierarchy? Genes Cancer. 2011; 2 : 607 –17. Google Scholar Crossref Pub Med.

50. The association of serum levels of zinc and vitamin D with wasting among Iranian pre-school children.

51. Nasiri-Babadi P., Sadeghian M., Sadeghi O., Siassi F., Dorosty A., Esmaillzadeh A., Pouraram H. Eat Weight Disord. 2020 Jan 3. doi: 10.1007/s40519-019-00834-1. [Epub ahead of print] PMID: 31900880.

52. Nunez-Sanchez M. A., Gonzalez-Sarrias A., Romo-Vaquero M., Garcia-Villalba R., Selma M. V., Tomas-Barberan F. A., Garcia-Conesa M. T., Espin J. C. Dietary phenolics against colorectal cancer—from promising preclinical results to poor translation into clinical trials: pitfalls and future needs. Mol Nutr Food Res . 2015; 59 : 1274–91. PubMed.

53. Romo-Vaquero M., García-Villalba R., González-Sarrías A.,Beltrán D., Tomás-Barberán F. A, Espín J. C.,Selma M. V. Interindividual variability in the human metabolism of ellagic acid: contribution of Gordonibacter to urolithin production. Journal of Functional Foods. 2015; 17 : 785–91.Google Scholar.

54. Nunez-Sanchez M. A., Gonzalez-Sarrias A., Garcia-Villalba R., Monedero-Saiz T., Garcia-Talavera N. V., Gomez-Sanchez M. B., Sanchez-Alvarez C., Garcia-Albert A. M., Rodriguez-Gil F. J., Ruiz-Marin Met al. Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial J Nutr Biochem. 2017; 42 : 126–33. PubMed

55. Selma M. V., Romo-Vaquero M., Garcia-Villalba R., Gonzalez-Sarrias A., Tomas-Barberan F. A., Espin J. C. The human gut microbial ecology associated with overweight and obesity determines ellagic acid metabolism. Food Funct. 2016; 7 : 1769–74. PubMed.

56. Gonzalez-Sarrias A., Garcia-Villalba R., Romo-Vaquero M., Alasalvar C., Orem A., Zafrilla P., Tomas-Barberan F. A., Selma M. V., Espin J. C. Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: a randomized clinical trial. Mol Nutr Food Res. 2017; 61 : 1600830. Google Scholar.

57. Blot W. J., Li Y., Taylor P. R., Guo W., Dawsey S., Wang G. Q., Yang C. S., Zheng S. F., Gail M., Li G. Yet al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst. 1993; 85 : 1483–92.

58. Gibson F., Soanes L. (2010) Cancer in Children and Young People, Acute Nursing Care. Wiley & Sons Ltd.

59. Jones L., Watling R. M., Wilkins S., Pizer B. (2010) Nutritional support in children and young people with cancer undergoing chemotherapy (Review). The Cochrane Collaboration. Wiley & Sons Ltd.

60. World Health Organization United Nations Children’s Fund. WHO child growth standards and the identification of severe acute malnutrition in infants and children 2009.

61. De Onis M., Onyango A. W., Borghi E., Siyam A., Nishida C., Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Org 2007; 85 : 660–667.

62. Ministerstvo Zdravookhraneniya Respubliki Kazakhstan. Prikaz № 292 ot 04. 06. 2019. «Ob utverzhdenii Dorozhnoi karty po sovershenstvovaniyu detskoi onkogematologicheskoi pomoshchi v Respublike Kazakhstan na 2019-2021 gody».