Валеология: Здоровье, Болезнь, Выздоровление. 2019; : 77-82
ЦЕЛИАКИЯ: РАСПРОСТРАНЁННОСТЬ, КЛИНИКА, СОВРЕМЕННЫЕ ДИАГНОСТИЧЕСКИЕ АСПЕКТЫ (Обзор литературы)
Аннотация
В данном обзоре литературы рассмотрены актуальные вопросы серологической диагностики, использования методов молекулярной генетики, а также клиническая картина целиакии у взрослых. Обсуждаются вопросы своевременного морфологического исследования слизистой оболочки тонкой кишки для верификации диагноза.
Список литературы
1. Rampertab S. D., Pooran N., Brar P., Singh P., Green P. H. Trends in the presentation of celiac disease. Am J Med. 2006; 119 : 355.e9–355.14. [PubMed].
2. Mäki M., Kallonen K., Lähdeaho M. L., Visakorpi J. K. Changing pattern of childhood coeliac disease in Finland. Acta Paediatr Scand. 1988;77:408–412. [PubMed].
3. Tursi A., Brandimarte G., Giorgetti G., Gigliobianco A., Lombardi D., Gasbarrini G. Low prevalence of antigliadin and anti-endomysium antibodies in subclinical/silent celiac disease. Am J Gastroenterol. 2001; 96 : 1507–1510. [PubMed].
4. Bai D., Brar P., Holleran S., Ramakrishnan R., Green P. H. Effect of gender on the manifestations of celiac disease: evidence for greater malabsorption in men. Scand J Gastroenterol. 2005; 40 : 183–187. [PubMed].
5. Ferguson A., Arranz E., O’Mahony S. Clinical and pathological spectrum of coeliac disease--active, silent, latent, potential. Gut. 1993; 34 : 150–151. [PMC free article] [PubMed].
6. Malamut G., Afchain P., Verkarre V., Lecomte T., Amiot A., Damotte D., Bouhnik Y., Colombel J. F., Delchier J. C., Allez M., et al. Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II. Gastroenterology. 2009; 136 : 81–90. [PubMed].
7. Biagi F., Corazza G. R. Defining gluten refractory enteropathy. Eur J Gastroenterol Hepatol. 2001; 13 : 561–565. [PubMed].
8. Koskinen L. L., Einarsdottir E., Korponay-Szabo I. R., Kurppa K., Kaukinen K., Sistonen P., Pocsai Z., Széles G., Adány R., Mäki M., et al. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. Tissue Antigens. 2009; 74 : 408–416.
9. Holopainen P., Naluai A. T., Moodie S., Percopo S., Coto I., Clot F., Ascher H., Sollid L., Ciclitira P., Greco L., et al. Candidate gene region 2q33 in European families with coeliac disease. Tissue Antigens. 2004; 63 : 212–222. [PubMed].
10. Van Belzen M. J., Meijer J. W., Sandkuijl L. A., Bardoel A. F., Mulder C. J., Pearson P. L., Houwen R. H., Wijmenga C. A major non-HLA locus in celiac disease maps to chromosome 19. Gastroenterology. 2003;125 : 1032–1041. [PubMed].
11. Wapenaar M. C., Monsuur A. J., van Bodegraven A. A., Weersma R. K., Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis. Gut. 2008; 57 : 463–467. [PubMed].
12. López-Vázquez A., Fuentes D., Rodrigo L., González S., Moreno M., Fernández E., Martínez-Borra J., López-Larrea C. MHC class I region plays a role in the development of diverse clinical forms of celiac disease in a Saharawi population. Am J Gastroenterol. 2004; 99 : 662–667. [PubMed].
13. Jabbar A. A. HLA and disease associations in Iraq. Dis Markers. 1993; 11 : 161–170. [PubMed].
14. Dawood F. H., Jabbar A. A., Al-Mudaris A. F., Al-Hasani M. H. Association of HLA antigens with coeliac disease among Iraqi children. Tissue Antigens. 1981; 18 : 35–39. [PubMed].
15. Erkan T., Kutlu T., Yilmaz E., Cullu F., Tümay G. T. Human leukocyte antigens in Turkish pediatric celiac patients. Turk J Pediatr. 1999; 41 : 181–188. [PubMed]
16. Martín-Pagola A., Pérez-Nanclares G., Ortiz L., Vitoria J. C., Hualde I., Zaballa R., Preciado E., Castaño L., Bilbao J. R. MICA response to gliadin in intestinal mucosa from celiac patients. Immunogenetics. 2004; 56 : 549–554. [PubMed].
17. Karell K., Louka A. S., Moodie S. J., Ascher H., Clot F., Greco L., Ciclitira P. J., Sollid L. M., Partanen J. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Hum Immunol. 2003; 64 : 469–477. [PubMed].
18. Megiorni F., Mora B., Bonamico M., Barbato M., Nenna R., Maiella G., Lulli P., Mazzilli M. C. HLA-DQ and risk gradient for celiac disease. Hum Immunol. 2009; 70 : 55–59. [PubMed].
19. Sollid L. M. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol. 2002; 2 : 647–655. [PubMed].
20. Berger E., Buergin-Wolff A., Freudenberg E. Diagnostic value of the demonstration of gliadin antibodies in celiac disease. Klin. Wochenschr. 1964; 42 : 788–790. doi: 10.1007/BF01479129. [PubMed] [Cross Ref].
21. Husby S., Koletzko S., Korponay-Szabó I. R., Mearin M. L., Phillips A., Shamir R., Troncone R., Giersiepen K., Branski D., Catassi C., et al. ESPGHAN Working Group on Coeliac Disease Diagnosis; Pediatr. Gastroenterol. Nutr. 2012; 54 : 136–160. [PubMed].
22. Rubio-Tapia A., Hill I. D., Kelly C. P., Calderwood A. H., Murray J. A. American College of Gastroenterology. J. Gastroenterol. 2013; 108 : 656–676. doi: 10.1038/ajg.2013.79. [PMC free article] [PubMed] [Cross Ref].
23. Adriaanse M., Leffler D. A. Serum markers in the clinical management of celiac disease. Dig. Dis. 2015; 33 : 236–243. doi: 10.1159/000371405. [PMC free article] [PubMed] [Cross Ref].
24. Kaukinen K., Peräaho M., Lindfors K., Partanen J., Woolley N., Pikkarainen P., Karvonen A. L., Laasanen T., Sievänen H., Mäki M., et al. Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease. Aliment. Pharmacol. Ther. 2007; 25 : 1237–1245. doi: 10.1111/j.1365-2036.2007.03311.x. [PubMed] [Cross Ref].
25. Kaukinen K., Sulkanen S., Mäki M., Collin P. IgA-class transglutaminase antibodies in evaluating the efficacy of gluten-free diet in coeliac disease. Eur. J. Gastroenterol. Hepatol. 2002; 14 : 311–315. doi: 10.1097/00042737-200203000-00017. [PubMed] [Cross Ref].
26. Tursi A., Brandimarte G., Giorgetti G. M. Lack of usefulness of anti-transglutaminase antibodies in assessing histologic recovery after gluten-free diet in celiac disease. J. Clin. Gastroenterol. 2003; 37 : 387–391. doi: 10.1097/00004836-200311000-00007. [PubMed] [Cross Ref].
27. Bardella M. T., Velio P. M., Cesana B. M., Prampolini L., Casella G., Di Bella C., Lanzini A., Gambarotti M., Bassotti G., Villanacci V. Coeliac disease: A histological followup study. Histopathology. 2007; 50 : 465–471. doi: 10.1111/j.1365-2559.2007.02621.x. [PubMed] [Cross Ref].
28. Lanzini A., Lanzarotto F., Villanacci V., Mora A., Bertolazzi S., Turini D., Carella G., Malagoli A., Ferrante G., Cesana B. M., et al. Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free diet. Aliment. Pharmacol. Ther. 2009; 29 : 1299–1308. doi: 10.1111/j.1365-2036.2009.03992.x. [PubMed] [Cross Ref].
29. Rubio-Tapia A., Rahim M. W., See J. A., Lahr B. D., Wu T. T., Murray J. A. Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet. Am. J. Gastroenterol. 2010; 105 : 1412–1420. doi: 10.1038/ajg.2010.10. [PMC free article] [PubMed] [Cross Ref].
30. Husby S., Koletzko S., Korponay-Szabó I. R., Mearin M. L., Phillips A., Shamir R., Troncone R., Giersiepen K., Branski D., Catassi C., et al. European society for pediatric gastroenterology, hepatology, and nutrition guidelines for the diagnosis of coeliac disease. J. Pediatr. Gastroenterol. Nutr. 2012; 54 : 136–160. [PubMed].
31. Marsh M. N. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’) Gastroenterology. 1992; 102 : 330–354. doi: 10.1016/0016-5085 (92) 91819-P. [PubMed] [Cross Ref].
32. Oberhuber G., Granditsch G., Vogelsang H. The histopathology of coeliac disease: Time for a standardised report scheme for pathologist. Eur. J. Gastroenterol. Hepatol. 1999; 11 : 1185–1194. doi: 10.1097/00042737-199910000-00019. [PubMed] [Cross Ref].
33. Corazza G. R., Villanacci V. Coeliac disease some considerations on the histological diagnosis. J. Clin. Pathol. 2005; 58 : 573–574. doi: 10.1136/jcp.2004.023978. [PMC free article] [PubMed] [Cross Ref].
34. Ensari A. Gluten-sensitive enteropathy (celiac disease): Controversies in diagnosis and classification. Arch. Pathol. Lab. Med. 2010; 134 : 826–836. [PubMed]
35. Villanacci V. What is the best histopathological classification for celiac disease? Does it matter? A letter of comment to the review of Amado Salvador Pena; a new proposal. Gastroenterol. Hepatol. Bed Bench. 2015; 8 : 306–308. [PMC free article] [PubMed]
36. Ensari A. Coeliac disease: To classify or not to classify-that is the question! Gastroenterol. Hepatol. Bed Bench. 2016; 9 : 73–74. [PMC free article] [PubMed]
37. Buchanan R., Dennis S., Gendel S., Acheson D., Assimon S. A., Beru N., Bolger P., Carlson D., Carvajal R., Copp C., et al. Approaches to establish thresholds for major food allergens and for gluten in food. J. Food Prot. 2008; 71 : 1043–1088. [PubMed].
Valeology: Health - Illnes - recovery. 2019; : 77-82
CELIAC DISEASE: PREVALENCE, CLINICAL FEATURES, MODERN DIAGNOSTIC AS- PECTS
Abstract
This review of the literature addresses topical issues of serological diagnosis, the use of molecular genetics, and the clinical picture of celiac disease in adults. The issues of timely morphological examination of the mucous membrane of the small intestine to verify the diagnosis are discussed.
References
1. Rampertab S. D., Pooran N., Brar P., Singh P., Green P. H. Trends in the presentation of celiac disease. Am J Med. 2006; 119 : 355.e9–355.14. [PubMed].
2. Mäki M., Kallonen K., Lähdeaho M. L., Visakorpi J. K. Changing pattern of childhood coeliac disease in Finland. Acta Paediatr Scand. 1988;77:408–412. [PubMed].
3. Tursi A., Brandimarte G., Giorgetti G., Gigliobianco A., Lombardi D., Gasbarrini G. Low prevalence of antigliadin and anti-endomysium antibodies in subclinical/silent celiac disease. Am J Gastroenterol. 2001; 96 : 1507–1510. [PubMed].
4. Bai D., Brar P., Holleran S., Ramakrishnan R., Green P. H. Effect of gender on the manifestations of celiac disease: evidence for greater malabsorption in men. Scand J Gastroenterol. 2005; 40 : 183–187. [PubMed].
5. Ferguson A., Arranz E., O’Mahony S. Clinical and pathological spectrum of coeliac disease--active, silent, latent, potential. Gut. 1993; 34 : 150–151. [PMC free article] [PubMed].
6. Malamut G., Afchain P., Verkarre V., Lecomte T., Amiot A., Damotte D., Bouhnik Y., Colombel J. F., Delchier J. C., Allez M., et al. Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II. Gastroenterology. 2009; 136 : 81–90. [PubMed].
7. Biagi F., Corazza G. R. Defining gluten refractory enteropathy. Eur J Gastroenterol Hepatol. 2001; 13 : 561–565. [PubMed].
8. Koskinen L. L., Einarsdottir E., Korponay-Szabo I. R., Kurppa K., Kaukinen K., Sistonen P., Pocsai Z., Széles G., Adány R., Mäki M., et al. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. Tissue Antigens. 2009; 74 : 408–416.
9. Holopainen P., Naluai A. T., Moodie S., Percopo S., Coto I., Clot F., Ascher H., Sollid L., Ciclitira P., Greco L., et al. Candidate gene region 2q33 in European families with coeliac disease. Tissue Antigens. 2004; 63 : 212–222. [PubMed].
10. Van Belzen M. J., Meijer J. W., Sandkuijl L. A., Bardoel A. F., Mulder C. J., Pearson P. L., Houwen R. H., Wijmenga C. A major non-HLA locus in celiac disease maps to chromosome 19. Gastroenterology. 2003;125 : 1032–1041. [PubMed].
11. Wapenaar M. C., Monsuur A. J., van Bodegraven A. A., Weersma R. K., Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis. Gut. 2008; 57 : 463–467. [PubMed].
12. López-Vázquez A., Fuentes D., Rodrigo L., González S., Moreno M., Fernández E., Martínez-Borra J., López-Larrea C. MHC class I region plays a role in the development of diverse clinical forms of celiac disease in a Saharawi population. Am J Gastroenterol. 2004; 99 : 662–667. [PubMed].
13. Jabbar A. A. HLA and disease associations in Iraq. Dis Markers. 1993; 11 : 161–170. [PubMed].
14. Dawood F. H., Jabbar A. A., Al-Mudaris A. F., Al-Hasani M. H. Association of HLA antigens with coeliac disease among Iraqi children. Tissue Antigens. 1981; 18 : 35–39. [PubMed].
15. Erkan T., Kutlu T., Yilmaz E., Cullu F., Tümay G. T. Human leukocyte antigens in Turkish pediatric celiac patients. Turk J Pediatr. 1999; 41 : 181–188. [PubMed]
16. Martín-Pagola A., Pérez-Nanclares G., Ortiz L., Vitoria J. C., Hualde I., Zaballa R., Preciado E., Castaño L., Bilbao J. R. MICA response to gliadin in intestinal mucosa from celiac patients. Immunogenetics. 2004; 56 : 549–554. [PubMed].
17. Karell K., Louka A. S., Moodie S. J., Ascher H., Clot F., Greco L., Ciclitira P. J., Sollid L. M., Partanen J. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Hum Immunol. 2003; 64 : 469–477. [PubMed].
18. Megiorni F., Mora B., Bonamico M., Barbato M., Nenna R., Maiella G., Lulli P., Mazzilli M. C. HLA-DQ and risk gradient for celiac disease. Hum Immunol. 2009; 70 : 55–59. [PubMed].
19. Sollid L. M. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol. 2002; 2 : 647–655. [PubMed].
20. Berger E., Buergin-Wolff A., Freudenberg E. Diagnostic value of the demonstration of gliadin antibodies in celiac disease. Klin. Wochenschr. 1964; 42 : 788–790. doi: 10.1007/BF01479129. [PubMed] [Cross Ref].
21. Husby S., Koletzko S., Korponay-Szabó I. R., Mearin M. L., Phillips A., Shamir R., Troncone R., Giersiepen K., Branski D., Catassi C., et al. ESPGHAN Working Group on Coeliac Disease Diagnosis; Pediatr. Gastroenterol. Nutr. 2012; 54 : 136–160. [PubMed].
22. Rubio-Tapia A., Hill I. D., Kelly C. P., Calderwood A. H., Murray J. A. American College of Gastroenterology. J. Gastroenterol. 2013; 108 : 656–676. doi: 10.1038/ajg.2013.79. [PMC free article] [PubMed] [Cross Ref].
23. Adriaanse M., Leffler D. A. Serum markers in the clinical management of celiac disease. Dig. Dis. 2015; 33 : 236–243. doi: 10.1159/000371405. [PMC free article] [PubMed] [Cross Ref].
24. Kaukinen K., Peräaho M., Lindfors K., Partanen J., Woolley N., Pikkarainen P., Karvonen A. L., Laasanen T., Sievänen H., Mäki M., et al. Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease. Aliment. Pharmacol. Ther. 2007; 25 : 1237–1245. doi: 10.1111/j.1365-2036.2007.03311.x. [PubMed] [Cross Ref].
25. Kaukinen K., Sulkanen S., Mäki M., Collin P. IgA-class transglutaminase antibodies in evaluating the efficacy of gluten-free diet in coeliac disease. Eur. J. Gastroenterol. Hepatol. 2002; 14 : 311–315. doi: 10.1097/00042737-200203000-00017. [PubMed] [Cross Ref].
26. Tursi A., Brandimarte G., Giorgetti G. M. Lack of usefulness of anti-transglutaminase antibodies in assessing histologic recovery after gluten-free diet in celiac disease. J. Clin. Gastroenterol. 2003; 37 : 387–391. doi: 10.1097/00004836-200311000-00007. [PubMed] [Cross Ref].
27. Bardella M. T., Velio P. M., Cesana B. M., Prampolini L., Casella G., Di Bella C., Lanzini A., Gambarotti M., Bassotti G., Villanacci V. Coeliac disease: A histological followup study. Histopathology. 2007; 50 : 465–471. doi: 10.1111/j.1365-2559.2007.02621.x. [PubMed] [Cross Ref].
28. Lanzini A., Lanzarotto F., Villanacci V., Mora A., Bertolazzi S., Turini D., Carella G., Malagoli A., Ferrante G., Cesana B. M., et al. Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free diet. Aliment. Pharmacol. Ther. 2009; 29 : 1299–1308. doi: 10.1111/j.1365-2036.2009.03992.x. [PubMed] [Cross Ref].
29. Rubio-Tapia A., Rahim M. W., See J. A., Lahr B. D., Wu T. T., Murray J. A. Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet. Am. J. Gastroenterol. 2010; 105 : 1412–1420. doi: 10.1038/ajg.2010.10. [PMC free article] [PubMed] [Cross Ref].
30. Husby S., Koletzko S., Korponay-Szabó I. R., Mearin M. L., Phillips A., Shamir R., Troncone R., Giersiepen K., Branski D., Catassi C., et al. European society for pediatric gastroenterology, hepatology, and nutrition guidelines for the diagnosis of coeliac disease. J. Pediatr. Gastroenterol. Nutr. 2012; 54 : 136–160. [PubMed].
31. Marsh M. N. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’) Gastroenterology. 1992; 102 : 330–354. doi: 10.1016/0016-5085 (92) 91819-P. [PubMed] [Cross Ref].
32. Oberhuber G., Granditsch G., Vogelsang H. The histopathology of coeliac disease: Time for a standardised report scheme for pathologist. Eur. J. Gastroenterol. Hepatol. 1999; 11 : 1185–1194. doi: 10.1097/00042737-199910000-00019. [PubMed] [Cross Ref].
33. Corazza G. R., Villanacci V. Coeliac disease some considerations on the histological diagnosis. J. Clin. Pathol. 2005; 58 : 573–574. doi: 10.1136/jcp.2004.023978. [PMC free article] [PubMed] [Cross Ref].
34. Ensari A. Gluten-sensitive enteropathy (celiac disease): Controversies in diagnosis and classification. Arch. Pathol. Lab. Med. 2010; 134 : 826–836. [PubMed]
35. Villanacci V. What is the best histopathological classification for celiac disease? Does it matter? A letter of comment to the review of Amado Salvador Pena; a new proposal. Gastroenterol. Hepatol. Bed Bench. 2015; 8 : 306–308. [PMC free article] [PubMed]
36. Ensari A. Coeliac disease: To classify or not to classify-that is the question! Gastroenterol. Hepatol. Bed Bench. 2016; 9 : 73–74. [PMC free article] [PubMed]
37. Buchanan R., Dennis S., Gendel S., Acheson D., Assimon S. A., Beru N., Bolger P., Carlson D., Carvajal R., Copp C., et al. Approaches to establish thresholds for major food allergens and for gluten in food. J. Food Prot. 2008; 71 : 1043–1088. [PubMed].
